Non-Randomized Comparative Study of Olfaction in post-COVID-19 Children. Intermediary Results

Leyla S. Namazova-Baranova; Georgiy A. Karkashadze; Irina V. Zelenkova; Alexander A. Baranov; Elena A. Vishneva; Elena V. Kaytukova; Dina S. Rusinova; Natalia S. Sergienko; Yuliya V. Nesterova; Svetlana G. Gubanova; Viktor A. Gankovskiy; Tinatin Yu. Gogberashvili; Tatiana A. Konstantinidi; Daria A. Bushueva; Anastasiya I. Rykunova; Olga B. Gordeeva; Ekaterina V. Shirdanina; Anastasiya D. Lamasova; Elizaveta V. Leonova; Alina R. Pankova; Ekaterina Yu. Dubonosova

doi:10.15690/pf.v17i6.2201

Non-Randomized Comparative Study of Olfaction in post-COVID-19 Children. Intermediary Results

Leyla S. Namazova-Baranova, Georgiy A. Karkashadze, Irina V. Zelenkova, Alexander A. Baranov, Elena A. Vishneva, Elena V. Kaytukova, Dina S. Rusinova, Natalia S. Sergienko, Yuliya V. Nesterova, Svetlana G. Gubanova, Viktor A. Gankovskiy, Tinatin Yu. Gogberashvili, Tatiana A. Konstantinidi, Daria A. Bushueva, Anastasiya I. Rykunova, Olga B. Gordeeva, Ekaterina V. Shirdanina, Anastasiya D. Lamasova, Elizaveta V. Leonova, Alina R. Pankova, Ekaterina Yu. Dubonosova

https://doi.org/10.15690/pf.v17i6.2201

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Abstract

The aim of the study is to estimate olfaction in post-COVID-19 children.

Research methods. The study included 81 children, they were divided into two groups: those who had COVID-19 and those who had not.

Survey procedures. Pediatrician, neurologist and otolaryngologists clinical examinations, cognitive status estimation, olfactometry were performed.

Results. The olfaction perception threshold post-COVID-19 children and adolescents was higher than in children who have not undergone this infection. Changes in olfaction perception threshold did not depend on how participants and their parents informed about the sense of smell. The involvement of olfactory sensitivity in the pathological process does not depend on the infection severity itself or premorbid neurological lesion.

Conclusion. It has been shown for the first time in the Russian sample that changes in sense of smell persist in children 3–4 weeks after recovery from COVID-19.

Keywords

COVID-19, children, olfaction, olfactometry

About the Authors

Leyla S. Namazova-Baranova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University; Belgorod National Research University
Russian Federation
Moscow, Belgorod
Disclosure of interest: Not declared.

Georgiy A. Karkashadze

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Irina V. Zelenkova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Alexander A. Baranov

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Sechenov First Moscow State Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Elena A. Vishneva

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Elena V. Kaytukova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Dina S. Rusinova

Pirogov Russian National Research Medical University; Children’s City Outpatients Clinic № 133 of the Moscow Health Care Department
Russian Federation
Moscow
Disclosure of interest: Not declared.

Natalia S. Sergienko

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Yuliya V. Nesterova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Svetlana G. Gubanova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Viktor A. Gankovskiy

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Tinatin Yu. Gogberashvili

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Tatiana A. Konstantinidi

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Daria A. Bushueva

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Anastasiya I. Rykunova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Olga B. Gordeeva

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

Ekaterina V. Shirdanina

Pirogov Russian National Research Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Anastasiya D. Lamasova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Elizaveta V. Leonova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Alina R. Pankova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University
Russian Federation
Moscow
Disclosure of interest: Not declared.

Ekaterina Yu. Dubonosova

Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”
Russian Federation
Moscow
Disclosure of interest: Not declared.

References

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6. Qiu C, Cui C, Hautefort C, et al. Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study. Otolaryngol Head Neck Surg. 2020;163(4):714–721. doi: 10.1177/0194599820934376.

7. Zubair AS, McAlpine LS, Gardin T, et al. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. JAMA Neurol. 2020;77(8):1018–1027. doi: 10.1001/jamaneurol.2020.2065.

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9. Patent № 2169364 Russian Federation, IPC A61B 10/00(2006.01), A61J 1/06(2006.01), G01N 33/15(2006.01). Method of Performing Threshold olfactometry: № 99123781/14: declare 10.11.1999: publ. 20.06.2001. Domrachev AA, Afon’kin VJu, Savchenkov JuI, et al. 7 p. (In Russ).

10.

Review

For citations:

Namazova-Baranova L.S., Karkashadze G.A., Zelenkova I.V., Baranov A.A., Vishneva E.A., Kaytukova E.V., Rusinova D.S., Sergienko N.S., Nesterova Yu.V., Gubanova S.G., Gankovskiy V.A., Gogberashvili T.Yu., Konstantinidi T.A., Bushueva D.A., Rykunova A.I., Gordeeva O.B., Shirdanina E.V., Lamasova A.D., Leonova E.V., Pankova A.R., Dubonosova E.Yu. Non-Randomized Comparative Study of Olfaction in post-COVID-19 Children. Intermediary Results. Pediatric pharmacology. 2020;17(6):502-507. (In Russ.) https://doi.org/10.15690/pf.v17i6.2201

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International.

ISSN 1727-5776 (Print)
ISSN 2500-3089 (Online)

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Pediatric pharmacology

Non-Randomized Comparative Study of Olfaction in post-COVID-19 Children. Intermediary Results

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Abstract

Keywords

About the Authors

References

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