Neuroimmunological Disturbance Features in Premature Infants with Perinatal Infections
https://doi.org/10.15690/pf.v15i1.1849
Abstract
Infectious diseases in newborns are commonly intrauterine infections which affect greatly on the morbidity and mortality rates in neonates.
Background: The purpose of this study was to analyse the neurological status, taking into account the neuroimmunological indicators (neuron-specific enolase (NSE), interleukin-1β (IL1β), Interleukin-6 (IL6) in the serum of neonates with perinatal infections.
Metods: We conducted a complex clinical, laboratory, and instrumental examination of 433 infants with perinatal infections with a gestation period of 27–37 weeks. Determination of the level of NSE, IL1β, IL6 was performed with the standard method of the immune-enzyme analysis.
Results. Hypoxic ischemic, hemorrhagic, infectious lesion of the central nervous system (CNS) were more common in newborns with mixed infection and sepsis. High levels of NSE, IL6, IL1β in the serum of the examined newborns reflect a combined, deeper character of the CNS damage.
Conclusion: Significant diagnostic value of neuroimmunological indicators in the blood serum of newborns with perinatal infections makes it possible to use them as a markers for assessing the severity of the CNS lesions.About the Authors
Nailya J. Rahimova
Scientific Research Institute of Pediatrics named after K.Y. Farajova
Azerbaijan
Azerbaijan
Baku
Gyul’syum M. Gurbanova
Department of nervous diseases of Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev
Azerbaijan
Azerbaijan
Baku
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Review
For citations:
Rahimova N.J., Gurbanova G.M. Neuroimmunological Disturbance Features in Premature Infants with Perinatal Infections. Pediatric pharmacology. 2018;15(1):95-100. (In Russ.) https://doi.org/10.15690/pf.v15i1.1849
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