Immunoprophylaxis of Respiratory Syncytial Virus Infection in Children
A. A. Baranov,
L. S. Namazova-Baranova, 
I. V. Davydova,
E. L. Bokeriya,
E. A. Vishnyova,
M. V. Fedoseyenko,
L. R. Selimzyanova
I. V. Davydova,
E. L. Bokeriya,
E. A. Vishnyova,
M. V. Fedoseyenko,
L. R. Selimzyanova https://doi.org/10.15690/pf.v12i5.1456
Abstract
The article is dedicated is to the issue of respiratory syncytial virus (RSV) infection in children. Urgency of this issue is beyond any doubt. RSV prevalence in the children hospitalized due to infections of lower airways is 18–33% in the advanced countries; up to 30% of the population become infected in the seasonal period of morbidity rise; 70% of children undergo RSV infection in the first year of life; almost every child becomes infected within the first two years of life. Infants are characterized by severe course of RSV infection; the most commonly hospitalized age group is infants aged 2–5 months. Especially severe and life-threatening course is observed in premature infants and young children with immature and/or pathological cardiorespiratory system — in patients with congenital malformations and immunodeficiencies. Specialists of the professional association of pediatricians “Union of Pediatricians of Russia” formulated and briefly described the main peculiarities of RSV infection and characterized groups of severe course risk, as well as indications and patterns of passive immunization — the only reliably effective preventive technology available at the moment, which allows preventing incapacitating consequences of RSV infection — in accordance with principles of the evidence based medicine.
About the Authors
A. A. Baranov
Scientific Center of Children’s Health of the Ministry of Health of Russia, Moscow, Russian Federation
Sechenov First Moscow State Medical University, Moscow, Russian Federation
Russian Federation
Russian Federation
L. S. Namazova-Baranova
Scientific Center of Children’s Health of the Ministry of Health of Russia, Moscow, Russian Federation
Sechenov First Moscow State Medical University, Moscow, Russian Federation
Pirogov Russian National Medical Research University, Moscow, Russian Federation
Russian Federation
Russian Federation
I. V. Davydova
Scientific Center of Children’s Health of the Ministry of Health of Russia, Moscow, Russian Federation
Pirogov Russian National Medical Research University, Moscow, Russian Federation
Russian Federation
Russian Federation
E. L. Bokeriya
Bakoulev Center for Cardiovascular Surgery of the Ministry of Health of Russia, Moscow, Russian Federation
Russian Federation
Russian Federation
E. A. Vishnyova
Scientific Center of Children’s Health of the Ministry of Health of Russia, Moscow, Russian Federation
Russian Federation
Russian Federation
M. V. Fedoseyenko
Scientific Center of Children’s Health of the Ministry of Health of Russia, Moscow, Russian Federation
Russian Federation
Russian Federation
L. R. Selimzyanova
Scientific Center of Children’s Health of the Ministry of Health of Russia, Moscow, Russian Federation
Sechenov First Moscow State Medical University, Moscow, Russian Federation
Russian Federation
Russian Federation
References
1. Таксономия вирусов на сайте Международного комитета по таксономии вирусов (ICTV). http://ictvonline.org/virus Taxonomy.asp
2. Tawar RG, Duquerroy S, Vonrhein C, Varela PF, Damier-Piolle L, Castagne N, MacLellan K, Bedouelle H, Bricogne G, Bhella D, Eleouet JF, Rey FA. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science. 2009 Nov 27; 326(5957):1279–83.
3. Shi T, McLean K, Campbell H, Nair H. Aetiological role of common respiratory viruses in acute lower respiratory infections in children under five years: A systematic review and meta-analysis. J Glob Health. 2015 Jun;5 (1):010408.
4. Langley GF, Anderson LJ. Epidemiology and prevention of respiratory syncytial virus infections among infants and young children. Pediatr Infect Dis J. 2011;30(6):510–517.
5. Jansen R. et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis. 2007; 196: 825–834.
6. Mitchell Goldstein, T. AllenMerritt, Raylene Phillips, Gilbert Martin, Sue Hall, Rami Yogev, Alan Spitzer. Respiratory Syncytial Virus (RSV) Prevention Guideline. Neonatology Today. 2014; 9 (11): 1–11.
7. Friedman JN, Rieder MJ, Walton JM. Canadian Paediatric Society, Acute Care Committee, Drug Therapy and Hazardous Substances Committee. Bronchiolitis: Recommendations for diagnosis, monitoring and management of children one to 24 months of age. Paediatr Child Health. 2014 Nov;19(9):485–98.
8. Paediatric Respiratory Medicine. ERS Handbook 1st Edition. Editors Ernst Eber, Fabio Midulla, 2013. European Respiratory Society, 719 P.
9. Figueras-Aloy J, Carbonell-Estrany X, Quero J; IRIS Study Group. Case-control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33–35 weeks in Spain. Pediatr Infect Dis J. 2004 Sep; 23(9):815–20.
10. Joan L Robinson, Nicole Le Saux. Preventing hospitalizations for respiratory syncytial virus infection. Paediatr Child Health. 2015;20(6):321–26.
11. Stensballe LG, Kristensen K, Simoes EA, Jensen H, Nielsen J, Benn CS, Aaby P; Danish RSV Data Network. Atopic disposition, wheezing, and subsequent respiratory syncytial virus hospitalization in Danish children younger than 18 months: a nested casecontrol study. Pediatrics. 2006 Nov; 118 (5): e1360–8.
12. Orphan Lung Diseases Edited by J-F. Cordier. European Respiratory Society Monograph, Vol. 54. 2011. P. 84–103 Chapter 5. Bronchiolitis.
13. Таточенко В. К. Болезни органов дыхания у детей: практическое руководство. В. К. Таточенко. Новое изд., доп. М.: «ПедиатрЪ», 2012. 480 с.
14. Thorburn K, Harigopal S, Reddy V et al. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax 2006; 61: 611
15. UpToDate.com.
16. Committee on infectious diseases and bronchiolitis guidelines committee: Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection. Pediatrics. 2014 Vol. 134 No. 2 August 1, 2014 pp. e620–e638.
17. Ralston S. L., Lieberthal A. S., Meissner H. C., Alverson B. K., Baley J. E., Gadomski A. M., Johnson D. W., Light M. J., Maraqa N. F., Mendonca E. A., Phelan K. J., Zorc J. J., Stanko-Lopp D., Brown M. A., Nathanson I., Rosenblum E., Sayles S. 3rd, Hernandez-Cancio S.; American Academy of Pediatrics. Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis Pediatrics Vol. 134 No. 5 November 1, 2014 e1474–e1502.
18. Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection. Red Book Pediatrics. 2014;134:415–420.
19. Паливизумаб: четыре сезона в России. Баранов А. А., Иванов Д. О., Алямовская Г. А., Амирова В. Р., Антонюк И. В., Асмолова Г. А., Беляева И. А., Бокерия Е. Л., Брюханова О. А., Виноградова И. В., Власова Е. В., Галустян А. Н., Гафарова Г. В., Горев В. В., Давыдова И. В., Дегтярёв Д. Н., Дегтярёва Е. А., Долгих ВВ., Донин И. М., Захарова Н. И., Л. Ю. Зернова, Е. П. Зимина, В. В. Зуев, Е. С. Кешишян, И. А. Ковалев, И. Е. Колтунов, А. А. Корсунский, Е. В. Кривощёков, И. В. Кршеминская, С. Н. Кузнецова, В. А. Любименко, Л. С. Намазова-Баранова, Э. В. Нестеренко, С. В. Николаев, Д.Ю.Овсянников, Т.И.Павлова, М.В.Потапова, Л.В.Рычкова, А. А. Сафаров, А. И. Сафина, М. А. Скачкова, И. Г. Солдатова, Т. В. Турти, Н. А. Филатова, Р. М. Шакирова, О. С. Янулевич. Вестник Российской академии медицинских наук. 2014: 7–8; 54–68.
20. Е. А. Вишнева, Л. С. Намазова-Баранова, Р. М. Торшхоева, Т. В. Куличенко, А. Ю. Томилова, А. А. Алексеева, Т. В. Турти. Паливизумаб: новые возможности в профилактике астмы? Педиатрическая фармакология. 2011 (8) 3. С. 24–30.
Review
For citations:
Baranov A.A., Namazova-Baranova L.S., Davydova I.V., Bokeriya E.L., Vishnyova E.A., Fedoseyenko M.V., Selimzyanova L.R. Immunoprophylaxis of Respiratory Syncytial Virus Infection in Children. Pediatric pharmacology. 2015;12(5):543-549. (In Russ.) https://doi.org/10.15690/pf.v12i5.1456
Views:
3646
Email this article 