ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v11i3.1007ppharm-96Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESГЕМОДИНАМИЧЕСКИЕ ЭФФЕКТЫ ПРИ АНЕСТЕЗИИ КСЕНОНОМ У ДЕТЕЙHEMODYNAMIC EFFECTS OF XENON ANESTHESIA IN CHILDRENБыковМ. В.BykovM. V.

кандидат медицинских наук, врач анестезиолог-реаниматолог отделения анестезиологии и реанимацииНИИ неотложной детской хирургии и травматологии

MD, anesthesiologist and resuscitation specialist at the department of anesthesiology and resuscitation of the research institute of emergency pediatric surgery and traumatology

mikhail_v_bykov@mail.ruБагаевВ. Г.BagaevV. G.АмчеславскийВ. Г.AmcheslavskiyV. G.НИИ неотложной детской хирургии и травматологии, МоскваРоссияResearch institute of pediatric surgery and traumatology, MoscowRussian FederationНИИ неотложной детской хирургии и травматологии, Москва, Российская ФедерацияРоссияResearch Institute of Pediatric Surgery and Traumatology, Moscow, Russian FederationRussian Federation201403062014113Педиатрическая фармакология4247Copyright © Быков М.В., Багаев В.Г., Амчеславский В.Г., 20142014Быков М.В., Багаев В.Г., Амчеславский В.Г.Bykov M.V., Bagaev V.G., Amcheslavskiy V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/96

The study was aimed at hemodynamic effects of xenon on operative interventions in children. Patients and methods: the study involved 30 5-17-year-old children – 10 (33.3%) girls and 20 (66.7%) boys with ASA score 1-3 admitted for surgical treatment. The children underwent endotracheal anesthesia with xenon-oxygen mixture (Xe:O2 = 60-65:30%) and fentanyl (2.5‑3.5  mcg/kg per hour) for the following operations: appendectomy – 10 (33.3%) patients, herniotomy – 8 (26.7%) patients, Ivanissevich procedure – 6 (20.0%) patients, plastic surgery of posttraumatic defects of skin and soft tissues – 4 (13.3%) patients, abdominal adhesiotomy – 2 (6.7%) patients. Central hemodynamics was studied echocardiographically (Philips HD 11, the Netherlands) using the Teichholz technique along the cephalocaudal axis (parasternal access). Results: the anesthesia was notable for hemodynamic stability during the operation: as a result, a statistically significant (p < 0.05) increase in systolic, diastolic and mean arterial pressure by 10, 18 and 17%, respectively, was observed. Conclusion: the analysis demonstrated that xenon anesthesia improves lusitropic myocardial function statistically significantly increasing cardiac output by 12% by way of increasing stroke volume by 30%.

 

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The authors declare that there are no conflicts of interest present.