ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v11i4.1057ppharm-66Research ArticleРЕДАКЦИОННЫЙ КОММЕНИТАРИЙEDITORIAL COMMENTОЦЕНКА ЭФФЕКТИВНОСТИ ВАКЦИНАЦИИ: ОСНОВНЫЕ ПОДХОДЫ И СПОРНЫЕ ВОПРОСЫASSESSMENT OF VACCINATION PROGRAM EFFECTIVENESS: BASIC APPROACHES AND ISSUESБрикоН. И.BrikoN. I.dr_ilina@yahoo.comЛобзинЮ. В.LobzinYu. V.dr_ilina@yahoo.comБарановА. А.BaranovA. A.baranova@nczd.ruНамазова-БарановаЛ. С.Namazova-BaranovaL. S.namazova@nczd.ruИльинаС. В.Il'inaS. V.

доктор медицинских наук, заведующая кафедрой детских инфекций ИГМУ Адрес: 664043, Иркутск, ул. Конева, д. 90

dr_ilina@yahoo.comКоролёваИ. С.KorolevaI. S.dr_ilina@yahoo.comХаритС. М.KharitS. M.dr_ilina@yahoo.comСидоренкоС. В.SidorenkoS. V.dr_ilina@yahoo.comТаточенкоВ. К.TatochenkoV. K.dr_ilina@yahoo.comМаянскийН. А.MayanskiiN. A.dr_ilina@yahoo.comКуличенкоТ. В.KulichenkoT. V.dr_ilina@yahoo.comПолибинР. В.PolibinR. V.dr_ilina@yahoo.comСабитовА. У.SabitovA. U.dr_ilina@yahoo.comКовтунО. П.KovtunO. P.dr_ilina@yahoo.comРоманенкоВ. В.RomanenkoV. V.dr_ilina@yahoo.comПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская ФедерацияРоссияSechenov First Moscow State Medical University, Russian FederationRussian FederationНИИ детских инфекций, Санкт-Петербург, Российская ФедерацияРоссияResearch Institute of Pediatric Infections, Saint Petersburg, Russian FederationRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация Научный центр здоровья детей, Москва, Российская ФедерацияРоссияSechenov First Moscow State Medical University, Russian Federation Scientific Center of Children’s Health, Moscow, Russian FederationRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация Научный центр здоровья детей, Москва, Российская Федерация Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Российская ФедерацияРоссияSechenov First Moscow State Medical University, Russian Federation Scientific Center of Children’s Health, Moscow, Russian Federation Pirogov Russian National Medical Research University, Moscow, Russian FederationRussian FederationИркутский государственный медицинский университет, Российская ФедерацияРоссияIrkutsk State Medical University, Russian FederationRussian FederationЦНИИ эпидемиологии, Москва, Российская ФедерацияРоссияCentral Research Institute of Epidemiology, Moscow, Russian FederationRussian FederationНаучный центр здоровья детей, Москва, Российская ФедерацияРоссияScientific Center of Children’s Health, Moscow, Russian FederationRussian FederationУральский государственный медицинский университет, Екатеринбург, Российская ФедерацияРоссияUral State Medical University, Ekaterinburg, Russian FederationRussian Federation201408082014114Педиатрическая фармакология815Copyright © Брико Н.И., Лобзин Ю.В., Баранов А.А., Намазова-Баранова Л.С., Ильина С.В., Королёва И.С., Харит С.М., Сидоренко С.В., Таточенко В.К., Маянский Н.А., Куличенко Т.В., Полибин Р.В., Сабитов А.У., Ковтун О.П., Романенко В.В., 20142014Брико Н.И., Лобзин Ю.В., Баранов А.А., Намазова-Баранова Л.С., Ильина С.В., Королёва И.С., Харит С.М., Сидоренко С.В., Таточенко В.К., Маянский Н.А., Куличенко Т.В., Полибин Р.В., Сабитов А.У., Ковтун О.П., Романенко В.В.Briko N.I., Lobzin Y.V., Baranov A.A., Namazova-Baranova L.S., Il'ina S.V., Koroleva I.S., Kharit S.M., Sidorenko S.V., Tatochenko V.K., Mayanskii N.A., Kulichenko T.V., Polibin R.V., Sabitov A.U., Kovtun O.P., Romanenko V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/66

Статья посвящена профилактике пневмококковых инфекций, которые являются одними из ведущих в структуре заболеваемости детей раннего возраста. Учитывая включение вакцинации против данной инфекции в российский  Национальный календарь профилактических прививок,  в свете прогнозирования ожидаемого эффекта массовой иммунизации авторы анализируют международные подходы к оценке результативности вакцинации. Обсуждаются сложности трактовки эпидемиологических, иммунологических и клинических данных при отсутствии исследований по прямому сравнению препаратов. Показана необходимость многокомпонентного подхода к оценке эффективности программ иммунизации, включающего оптимизацию эпидемиологического надзора, утверждение стандартного определения случая, учет результатов предрегистрационных клинических исследований вакцин и пострегистрационного наблюдения в сходных популяциях.

 

The article is dedicated to prevention of pneumococcal infections, which remain among the most common diseases in infants. The authors analyze international approaches to vaccination effectiveness assessment in light of predicting the expected effect of cohort immunization, given introduction of vaccination against this infection to the Russian National Immunization Calendar. The article presents a discussion of difficulties in interpreting epidemiological, immunological and clinical data in the absence of studies on directcomparison of drugs. The authors demonstrate the need in multicomponent approach to immunization program effectiveness analysis, which would include optimization of epidemiological vigilance, adoption of the standard definition of a case, registration of results of prelicensure clinical trials of vaccines and postlicensure follow-up in similar groups of patients.

 

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The authors declare that there are no conflicts of interest present.