<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v12i1.1256</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-478</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПРАКТИКУ ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>For Pediatricians' Practice</subject></subj-group></article-categories><title-group><article-title>ДИАГНОСТИКА И ЛЕЧЕНИЕ ОСТРОГО СТРЕПТОКОККОВОГО ФАРИНГИТА У ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>DIAGNOSIS AND TREATMENT OF ACUTE STREPTOCOCCAL PHARYNGITIS IN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куличенко</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulichenko</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, заведующая отделением неотложной педиатрии НЦЗД, доцент кафедры клинической аллергологии и иммунологии педиатрического факультета Первого МГМУ им. И.М. Сеченова</p></bio><email xlink:type="simple">tkulichenko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей, Москва, Российская Федерация</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children's Health, Moscow, Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>21</day><month>08</month><year>2015</year></pub-date><volume>12</volume><issue>1</issue><fpage>104</fpage><lpage>111</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Куличенко Т.В., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Куличенко Т.В.</copyright-holder><copyright-holder xml:lang="en">Kulichenko T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/478">https://www.pedpharma.ru/jour/article/view/478</self-uri><abstract><p>Острый стрептококковый фарингит диагностируют у 15–30% пациентов, обратившихся в медицинское учреждение с лихорадкой и болью в горле. Обычно локальная инфекция протекает относительно легко, но в ее исходе возможны серьезные гнойные и иммунопатологические осложнения. Несмотря на высокую частоту и распространенность болезни, до настоящего времени вопросы диагностики и лечения стрептококкового тонзиллита и фарингита остаются предметом широкой дискуссии. В обзоре литературы освещаются современные принципы диагностики, возможности экспресс-тестов для выявления инфекции Streptococcus pyogenes, а также выбор антибактериальной терапии острого стрептококкового фарингита, основанный на данных доказательных исследований и систематических обзоров. Акцентированы наиболее обсуждаемые вопросы лечения, в том числе схемы курсов антибиотикотерапии, эффективность тонзиллэктомии при хроническом и рецидивирующем тонзиллите. </p></abstract><trans-abstract xml:lang="en"><p>Acute streptococcal pharyngitis is diagnosed in 15–30% of the patients seeking medical advice for fever and sore throat. The local infection is usually mild/moderate; however, it may result in severe purulent and immunopathological complications. Despite high incidence and prevalence of the disease, the issues of diagnosis and treatment of streptococcal tonsillitis and pharyngitis remain highly discussable. The literature review presents information on the modern diagnostic principles, potential of using express tests to detect Streptococcus pyogenes infection and selection of antibacterial therapy of acute streptococcal pharyngitis based on the data of evidence-based studies and systemic reviews. The article emphasizes the most discussable issues of treatment, including antibiotic therapy pattern, and effectiveness of tonsillectomy in the event of chronic or recurrent tonsillitis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стрептококковый фарингит</kwd><kwd>дети</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>Streptococcus pyogenes</kwd><kwd>экспресс-тесты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>streptococcal pharyngitis</kwd><kwd>children</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>Streptococcus pyogenes</kwd><kwd>streptatest</kwd><kwd>express tests</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Swedo S. E., Leonard H. L., Garvey M. et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998; 155: 264–271.</mixed-citation><mixed-citation xml:lang="en">Swedo S.E., Leonard H.L., Garvey M. et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998;155:264–271.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Initiative for Vaccine Research (IVR). Bacterial infections. Group A Streptococcus. Accessed March 20, 2013. URL: www.who.int/vaccine_research/diseases/soa_bacterial/en/index3.html</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Initiative for Vaccine Research (IVR). Bacterial infections. Group A Streptococcus. Accessed March 20, 2013. Available at: www.who.int/vaccine_research/diseases/soa_bacterial/en/index3.html</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">CDC. Acute pharyngitis in adults: physician information sheet (adults). Accessed March 20, 2013. URL: www.cdc.gov/getsmart/campaign-materials/info-sheets/adult-acute-pharyngitis.html</mixed-citation><mixed-citation xml:lang="en">CDC. Acute pharyngitis in adults: physician information sheet (adults). Accessed March 20, 2013. Available at: www.cdc.gov/getsmart/campaign-materials/info-sheets/adult-acute-pharyngitis.html</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Shaikh N., Leonard E., Martin J. M. Prevalence of Streptococcal pharyngitis and Streptococcal carriage in children: А meta-analysis. Pediatrics. 2010; 126 (3 Sept. 1): e557–e564.</mixed-citation><mixed-citation xml:lang="en">Shaikh N., Leonard E., Martin J.M. Prevalence of Streptococcal pharyngitis and Streptococcal carriage in children: А meta-analysis. Pediatrics. 2010;126(3Sept.1):e557−e564.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dajani A., Taubert K., Ferrieri P., Peter G., Shulman S. Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals. Committee on rheumatic fever, endocarditis, and kawasaki disease of the council on cardiovascular disease in the young, the american heart association. Pediatrics. 1995; 96 (4 Pt. 1): 758–764.</mixed-citation><mixed-citation xml:lang="en">Dajani A., Taubert K., Ferrieri P., Peter G., Shulman S. Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals. Committee on rheumatic fever, endocarditis, and kawasaki disease of the council on cardiovascular disease in the young, the american heart association. Pediatrics. 1995;96(4Pt.1):758–764.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Linder J. A., Stafford R. S. Antibiotic treatment of adults with sore throat by community primary care physicians. JAMA. 2001; 286: 1181–6.</mixed-citation><mixed-citation xml:lang="en">Linder J.A., Stafford R.S. Antibiotic treatment of adults with sore throat by community primary care physicians. JAMA. 2001;286:1181−6.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов С. Н., Страчунский Л. С., Рачина С. А. Фармакотерапия острого тонзиллофарингита в амбулаторной практике: результаты многоцентрового фармакоэпидемиологического исследования. Тер. архив. 2004; 76 (5): 45–51.</mixed-citation><mixed-citation xml:lang="en">Kozlov S.N., Strachunskii L.S., Rachina S.A. Pharmacotherapy tonsillopharyngitis acute in outpatients: results of a multicenter pharmacoepidemiological study. Ter. arkhiv = Ter. archive. 2004;76(5):45−51.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shaikh N., Swaminathan N., Hooper E. G. Accuracy and precision of the signs and symptoms of Streptococcal pharyngitis in children: A systematic review. Journal of Pediatrics. 2012; 160 (Issue 3): 487–493.e3.</mixed-citation><mixed-citation xml:lang="en">Shaikh N., Swaminathan N., Hooper E.G. Accuracy and precision of the signs and symptoms of Streptococcal pharyngitis in children: A systematic review. Journal of Pediatrics. 2012; 160 (Issue 3): 487−493.e3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Calvino O., Llor C., Gomez F., Gonzalez E., Sarvise C., Hernandez S. Association between C-reactive protein rapid test and group A Streptococcusinfection in acute pharyngitis. J Am Board Fam Med. 2014 May-Jun; 27 (3): 424–6. Doi: 10.3122/jabfm.2014.03.130315.</mixed-citation><mixed-citation xml:lang="en">Calviño O., Llor C., Gómez F., González E., Sarvisé C., Hernández S. Association between C-reactive protein rapid test and group A Streptococcusinfection in acute pharyngitis. J Am Board Fam Med. 2014 May-Jun; 27 (3): 424−6. Doi: 10.3122/jabfm.2014.03.130315.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chiappini E., Regoli M., Bonsignori F. et al. Analysis of different recom mendations from international guidelines for the management of acute pharyngitis in adults and children. Clin Ther. 2011; 33 (1): 48–58.</mixed-citation><mixed-citation xml:lang="en">Chiappini E., Regoli M., Bonsignori F. et al. Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children. Clin Ther. 2011; 33 (1): 48−58.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shet A., Kaplan E. L. Clinical use and interpretation of group a streptococcal antibody tests: a practical approach for the pediatrician or primary care physician. Pediatr Infect Dis J. 2002; 21: 420–6; quiz 27–30.</mixed-citation><mixed-citation xml:lang="en">Shet A., Kaplan E.L. Clinical use and interpretation of group a streptococcal antibody tests: a practical approach for the pediatrician or primary care physician. Pediatr Infect Dis J. 2002; 21: 420–6; quiz 27–30.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson D. R., Kurlan R., Leckman J., Kaplan E. L. The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications. Clin Infect Dis. 2010; 50: 481–90.</mixed-citation><mixed-citation xml:lang="en">Johnson D.R., Kurlan R., Leckman J., Kaplan E.L. The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications. Clin Infect Dis. 2010; 50: 481–90.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Centor R. M., Witherspoon J. M., Dalton H. P., Brody C. E., Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Making. 1981; 1: 239–46.</mixed-citation><mixed-citation xml:lang="en">Centor R.M., Witherspoon J.M., Dalton H.P., Brody C.E., Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Making. 1981; 1: 239–46.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wald E. R., Green M. D., Schwartz B., Barbadora K. A Strepto coccal score card revisited. Pediatr Emerg Care. 1998; 14: 109–11.</mixed-citation><mixed-citation xml:lang="en">Wald E.R., Green M.D., Schwartz B., Barbadora K. A Streptococcal score card revisited. Pediatr Emerg Care. 1998; 14: 109–11.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Attia M. W., Zaoutis T., Klein J. D., Meier F. A. Performance of a predictive model for streptococcal pharyngitis in children. Arch Pediatr Adolesc Med. 2001; 155: 687–91.</mixed-citation><mixed-citation xml:lang="en">Attia M.W., Zaoutis T., Klein J.D., Meier F.A. Performance of a predictive model for streptococcal pharyngitis in children. Arch Pediatr Adolesc Med. 2001; 155: 687–91.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Linder J. A., Chan J. C., Bates D. W. Evaluation and treatment of pharyngitis in primary care practice: the difference between guidelines is largely academic. Arch Intern Med. 2006; 166: 1374–9.</mixed-citation><mixed-citation xml:lang="en">Linder J.A., Chan J.C., Bates D.W. Evaluation and treatment of pharyngitis in primary care practice: the difference between guidelines is largely academic. Arch Intern Med. 2006; 166: 1374–9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bisno A. L. Acute pharyngitis: etiology and diagnosis. Pediatrics. 1996; 97: 949–54.</mixed-citation><mixed-citation xml:lang="en">Bisno A.L. Acute pharyngitis: etiology and diagnosis. Pediatrics. 1996; 97: 949–54.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Snow V., Mottur-Pilson C., Cooper R. J., Hoffman J. R. Principles of appropriate antibiotic use for acute pharyngitis in adults. Ann Intern Med. 2001; 134: 506–8.</mixed-citation><mixed-citation xml:lang="en">Snow V., Mottur-Pilson C., Cooper R.J., Hoffman J.R. Principles of appropriate antibiotic use for acute pharyngitis in adults. Ann Intern Med. 2001; 134: 506–8.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Brien J. H., Bass J. W. Streptococcal pharyngitis: optimal site for throat culture. J Pediatr. 1985; 106: 781–3.</mixed-citation><mixed-citation xml:lang="en">Brien J.H., Bass J.W. Streptococcal pharyngitis: optimal site for throat culture. J Pediatr. 1985; 106: 781–3.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gerber M. A. Comparison of throat cultures and rapid strep tests for diagnosis of streptococcal pharyngitis. Pediatr Infect Dis J. 1989; 8: 820–4.</mixed-citation><mixed-citation xml:lang="en">Gerber M.A. Comparison of throat cultures and rapid strep tests for diagnosis of streptococcal pharyngitis. Pediatr Infect Dis J. 1989; 8: 820–4.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kellogg J. A. Suitability of throat culture procedures for detection of group A streptococci and as reference standards for evaluation of streptococcal antigen detection kits. J Clin Microbiol. 1990; 28: 165–9.</mixed-citation><mixed-citation xml:lang="en">Kellogg J.A. Suitability of throat culture procedures for detection of group A streptococci and as reference standards for evaluation of streptococcal antigen detection kits. J Clin Microbiol. 1990; 28: 165–9.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Randolph M. F., Gerber M. A., DeMeo K. K., Wright L. Effect of antibiotic therapy on the clinical course of streptococcal pharyngitis. J Pediatr. 1985; 106: 870–5.</mixed-citation><mixed-citation xml:lang="en">Randolph M.F., Gerber M.A., DeMeo K.K., Wright L. Effect of antibiotic therapy on the clinical course of streptococcal pharyngitis. J Pediatr. 1985; 106: 870–5.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gerber M. A., Shulman S. T. Rapid diagnosis of pharyngitis caused by group A streptococci. Clin Microbiol Rev. 2004; 17: 571–80.</mixed-citation><mixed-citation xml:lang="en">Gerber M.A., Shulman S.T. Rapid diagnosis of pharyngitis caused by group A streptococci. Clin Microbiol Rev. 2004; 17: 571–80.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Little P., Hobbs F. D., Moore M. et al. PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study. Health Technol Assess. 2014 Jan; 18 (6): vii–xxv, 1–101. Doi: 10.3310/hta18060.</mixed-citation><mixed-citation xml:lang="en">Little P., Hobbs F.D., Moore M. et al. PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study. Health Technol Assess. 2014 Jan; 18 (6): vii−xxv, 1−101. Doi: 10.3310/hta18060.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Edouard S., Michel-Lepage A., Raoult D. Does it make sense to detect Streptococcus pyogenes during tonsillitis in Europe to prevent acute rheumatic fever? Clin Microbiol Infect. 2014 Oct 8. Doi: 10.1111/1469-0691.12802. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Edouard S., Michel-Lepage A., Raoult D. Does it make sense to detect Streptococcus pyogenes during tonsillitis in Europe to prevent acute rheumatic fever? Clin Microbiol Infect. 2014 Oct 8. Doi: 10.1111/1469-0691.12802. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tanz R. R., Shulman S. T., Shortridge V. D. et al. Communitybased surveillance in the united states of macrolide-resistant pediatric pharyngeal group A streptococci during 3 respiratory disease seasons. Clin Infect Dis. 2004; 39: 1794–801.</mixed-citation><mixed-citation xml:lang="en">Tanz R.R., Shulman S.T., Shortridge V.D. et al. Community-based surveillance in the united states of macrolide-resistant pediatric pharyngeal group A streptococci during 3 respiratory disease seasons. Clin Infect Dis. 2004; 39: 1794–801.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Dingle T. C., Abbott A. N., Fang F. C. Reflexive culture in ado lescents and adults with group a streptococcal pharyngitis. Clin Infect Dis. 2014 Sep 1; 59 (5): 643–50. Doi: 10.1093/cid/ciu400.[Epub 2014 May 27].</mixed-citation><mixed-citation xml:lang="en">Dingle T.C., Abbott A.N., Fang F.C. Reflexive culture in adolescents and adults with group a streptococcal pharyngitis. Clin Infect Dis. 2014Sep1;59(5):643−50. Doi: 10.1093/cid/ciu400. [Epub 2014 May 27].</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Shulman S. T., Bisno A. L., Clegg H. W., Gerber M. A., Kaplan E. L. et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012; 55: 1279–1282. Doi: 10.1093/cid/cis847.</mixed-citation><mixed-citation xml:lang="en">Shulman S.T., Bisno A.L., Clegg H.W., Gerber M.A., Kaplan E.L. et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55:1279–1282. Doi: 10.1093/cid/cis847.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Куличенко Т. В., Кабалоева А. М., Лашкова Ю. С., Лазарева М. А. Диагностика острого фарингита у детей. Педиатрическая фармакология. 2014; 11 (4): 59–66.</mixed-citation><mixed-citation xml:lang="en">Kulichenko T.V., Kabaloeva A.M., Lashkova Yu.S., Lazareva M.A. Diagnosis of acute pharyngitis in children. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2014;11(4):59−66.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ruiz-Aragon J., Rodriguez Lopez R., Molina Linde J. M. Evaluation of rapid methods for detecting Streptococcus pyogenes. Systematic review and meta-analysis. An Pediatr (Barc). 2010; 72: 391–402. 31. Stewart E. H., Davis B., Clemans-Taylor B. L., Littenberg B., Estrada C. A., Centor R. M. Rapid antigen group A streptococcus test to diagnose pharyngitis: a systematic review and meta-analysis. PLoS One. 2014 Nov 4; 9 (11): e111727. Doi: 10.1371/journal. pone.0111727. eCollection 2014.</mixed-citation><mixed-citation xml:lang="en">Ruiz-Aragón J., Rodríguez López R., Molina Linde J.M. Evaluation of rapid methods for detecting Streptococcus pyogenes. Systematic review and meta-analysis. An Pediatr (Barc). 2010;72:391−402.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Fierro J. L., Prasad P. A., Localio A. R., Grundmeier R. W., Wasser man R. C., Zaoutis T. E., Gerber J. S. Variability in the diagnosis and treatment of group a streptococcal pharyngitis by primary care pediatricians. Infect Control Hosp Epidemiol. 2014 Oct; 35 (Suppl. 3): S79–85. Doi: 10.1086/677820.</mixed-citation><mixed-citation xml:lang="en">Stewart E.H., Davis B., Clemans-Taylor B.L., Littenberg B., Estrada C.A., Centor R.M. Rapid antigen group A streptococcus test to diagnose pharyngitis: a systematic review and meta-analysis. PLoS One. 2014Nov4;9(11):e111727. Doi: 10.1371/journal.pone.0111727. eCollection 2014.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Van Brusselen D., Vlieghe E., Schelstraete P., De Meulder F., Vandeputte C., Garmyn K., Laffut W., Van de Voorde P. Streptococcal pharyngitis in children: to treat or not to treat? Eur J Pediatr. 2014 Oct; 173 (10): 1275–83. Doi: 10.1007/s00431-014-2395-2. [Epub 2014 Aug 12].</mixed-citation><mixed-citation xml:lang="en">Fierro J.L., Prasad P.A., Localio A.R., Grundmeier R.W., Wasserman R.C., Zaoutis T.E., Gerber J.S. Variability in the diagnosis and treatment of group a streptococcal pharyngitis by primary care pediatricians. Infect Control Hosp Epidemiol. 2014Oct;35(Suppl.3):S79−85. Doi: http://dx.doi.org/10.1086/677820</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Spinks A., Glasziou P. P., Del Mar C. B. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013 Nov 5; 11: CD000023. Doi:10.1002/14651858.CD000023.pub4.</mixed-citation><mixed-citation xml:lang="en">Van Brusselen D., Vlieghe E., Schelstraete P., De Meulder F., Vandeputte C., Garmyn K., Laffut W., Van de Voorde P. Streptococcal pharyngitis in children: to treat or not to treat? Eur J Pediatr. 2014Oct;173(10):1275−83. Doi: 10.1007/s00431-014-2395-2. [Epub 2014 Aug 12].</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Irlam J. H., Mayosi B. M., Engel M. E., Gaziano T. A. A costeffective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis. S Afr Med J. 2013 Sep 3; 103 (12): 894–5. Doi: 10.7196/samj.7244.</mixed-citation><mixed-citation xml:lang="en">Spinks A., Glasziou P.P., Del Mar C.B. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013Nov5;11:CD000023. Doi: http://dx.doi.org/10.1002/14651858.cd000023.pub4</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Little P., Stuart B., Hobbs F. D. et al. Antibiotic prescription strategies for acute sore throat: a prospective observational cohort study. Lancet Infect Dis. 2014 Mar; 14 (3): 213–9. Doi:10.1016/S1473-3099 (13)70294-9. [Epub 2014 Jan 17].</mixed-citation><mixed-citation xml:lang="en">Irlam J.H., Mayosi B.M., Engel M.E., Gaziano T.A. A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis. S Afr Med J. 2013Sep3;103(12):894−5. Doi: http://dx.doi.org/10.7196/samj.7244</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Spurling G. K., Del Mar C. B., Dooley L., Foxlee R., Farley R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev. 2013 Apr 30; 4: CD004417. Doi: 10.1002/14651858. CD004417.pub4.</mixed-citation><mixed-citation xml:lang="en">Little P., Stuart B., Hobbs F.D. et al. Antibiotic prescription strategies for acute sore throat: a prospective observational cohort study. Lancet Infect Dis. 2014Mar;14(3):213−9. Doi: 10.1016/S1473-3099(13)70294-9. [Epub 2014 Jan 17].</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Report of the Committee on Infectious Disease. Pickering L. K., editor. 29th Edition, Group A Streptococcal Infections. Elk Grove Village, IL: American Academy of Pediatrics. 2012. Р. 668–80.</mixed-citation><mixed-citation xml:lang="en">Spurling G.K., Del Mar C.B., Dooley L., Foxlee R., Farley R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev. 2013Apr30;4:CD004417. Doi: 10.1002/14651858.CD004417.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Clegg H. W., Ryan A. G., Dallas S. D. et al. Treatment of streptococcal pharyngitis with once-daily compared with twicedaily amoxicillin: a noninferiority trial. Pediatr Infect Dis J. 2006; 25: 761–7.</mixed-citation><mixed-citation xml:lang="en">Report of the Committee on Infectious Disease. Pickering L.K., editor. 29th Edition, Group A Streptococcal Infections. Elk Grove Village, IL: American Academy of Pediatrics. 2012. Р. 668–80.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Lennon D. R., Farrell E., Martin D. R., Stewart J. M. Once-daily amoxicillin versus twice-daily penicillin V in group A beta-haemolytic streptococcal pharyngitis. Arch Dis Child. 2008; 93: 474–8.</mixed-citation><mixed-citation xml:lang="en">Clegg H.W., Ryan A.G., Dallas S.D. et al. Treatment of streptococcal pharyngitis with once-daily compared with twice-daily amoxicillin: a noninferiority trial. Pediatr Infect Dis J. 2006;25:761–7.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Casey J. R., Pichichero M. E. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004; 113: 866–882.</mixed-citation><mixed-citation xml:lang="en">Lennon D.R., Farrell E., Martin D.R., Stewart J.M. Once-daily amoxicillin versus twice-daily penicillin V in group A beta-haemolytic streptococcal pharyngitis. Arch Dis Child. 2008;93:474–8.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Gerber M. A. Antibiotic resistance in group A streptococci. Pediatr Clin North Am. 1995; 42: 539–51.</mixed-citation><mixed-citation xml:lang="en">Casey J.R., Pichichero M.E. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004;113:866–882.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Wickman P. A., Black J. A., Moland E. S., Thomson K. S. In vitro activities of DX-619 and comparison quinolones against grampositive cocci. Antimicrob Agents Chemother. 2006; 50: 2255–7.</mixed-citation><mixed-citation xml:lang="en">Gerber M.A. Antibiotic resistance in group A streptococci. Pediatr Clin North Am. 1995;42:539–51.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Logan L. K., McAuley J. B., Shulman S. T. Macrolide treatment failure in streptococcal pharyngitis resulting in acute rheumatic fever. Pediatrics. 2012; 129: e798–e802.</mixed-citation><mixed-citation xml:lang="en">Wickman P.A., Black J.A., Moland E.S., Thomson K.S. In vitro activities of DX-619 and comparison quinolones against gram-positive cocci. Antimicrob Agents Chemother. 2006;50:2255–7.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan E. L., Gooch I. W., Notario G. F., Craft J. C. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin Infect Dis. 2001; 32: 1798–802.</mixed-citation><mixed-citation xml:lang="en">Logan L.K., McAuley J.B., Shulman S.T. Macrolide treatment failure in streptococcal pharyngitis resulting in acute rheumatic fever. Pediatrics. 2012;129:e798−e802.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Van Driel M. L., De Sutter A. I., Keber N., Habraken H., Christiaens T. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database Syst Rev. 2013 Apr 30; 4: CD004406. Doi: 10.1002/14651858.CD004406.pub3.</mixed-citation><mixed-citation xml:lang="en">Kaplan E.L., Gooch I.W., Notario G.F., Craft J.C. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin Infect Dis. 2001;32:1798–802.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Zeng L., Zhang L., Hu Z., Ehle E. A., Chen Y., Liu L., Chen M. Systematic review of evidence-based guidelines on medication therapy for upper respiratory tract infection in children with AGREE instrument. PLoS One. 2014 Feb 20; 9 (2): e87711. Doi:10.1371/journal.pone.0087711. eCollection 2014.</mixed-citation><mixed-citation xml:lang="en">Van Driel M.L., De Sutter A.I., Keber N., Habraken H., Christiaens T. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database Syst Rev. 2013Apr30;4:CD004406. Doi: 10.1002/14651858.CD004406.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Altamimi S., Khalil A., Khalaiwi K. A., Milner R. A., Pusic M. V., Al Othman M. A. Short-term late-generation antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev. 2012 Aug 15; 8: CD004872. Doi:10.1002/14651858.CD004872.pub3.</mixed-citation><mixed-citation xml:lang="en">Zeng L., Zhang L., Hu Z., Ehle E.A., Chen Y. Liu L., Chen M. Systematic review of evidence-based guidelines on medication therapy for upper respiratory tract infection in children with AGREE instrument. PLoS One. 2014Feb20;9(2):e87711. Doi: 10.1371/journal.pone.0087711. eCollection 2014.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Falagas M. E., Vouloumanou E. K., Matthaiou D. K. Effectiveness and safety of short-course vs long-course antibiotic therapy for group a beta hemolytic streptococcal tonsillopharyngitis: A metaanalysis of randomized trials. Mayo Clin Proc. 2008; 83: 880–889.</mixed-citation><mixed-citation xml:lang="en">Altamimi S., Khalil A., Khalaiwi K.A., Milner R.A., Pusic M.V., Al Othman M.A. Short-term late-generation antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev. 2012Aug15;8:CD004872. Doi: 10.1002/14651858.CD004872.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Weber R. Pharyngitis. Prim Care. 2014 Mar; 41 (1): 91–8. Doi: 10.1016/j.pop.2013.10.010. [Epub 2013 Nov 21].</mixed-citation><mixed-citation xml:lang="en">Falagas M.E., Vouloumanou E.K., Matthaiou D.K. Effectiveness and safety of short-course vs long-course antibiotic therapy for group a beta hemolytic streptococcal tonsillopharyngitis: A meta-analysis of randomized trials. Mayo Clin Proc. 2008;83:880–889.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Demeslay J., De Bonnecaze G., Vairel B. et al. Possible role of anti-inflammatory drugs in complications of pharyngitis. A retrospective analysis of 163 cases. Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Nov; 131 (5): 299–303. Doi: 10.1016/j.anorl.2013.08.005. [Epub 2014 Oct 23].</mixed-citation><mixed-citation xml:lang="en">Weber R. Pharyngitis. Prim Care. 2014Mar;41(1):91−8. Doi: 10.1016/j.pop.2013.10.010. [Epub 2013 Nov 21].</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Burton M. J., Glasziou P. P., Chong L. Y., Venekamp R. P. Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2014 Nov 19; 11: CD001802. Doi: 10.1002/14651858.CD001802.pub3.</mixed-citation><mixed-citation xml:lang="en">Demeslay J., De Bonnecaze G., Vairel B. et al. Possible role of anti-inflammatory drugs in complications of pharyngitis. A retrospective analysis of 163 cases. Eur Ann Otorhinolaryngol Head Neck Dis. 2014Nov;131(5):299−303. Doi: 10.1016/j.anorl.2013.08.005. [Epub 2014 Oct 23].</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy T. K., Lewin A. B., Parker-Athill E. C., Storch E. A., Mutch P. J. Tonsillectomies and adenoidectomies do not prevent the onset of pediatric autoimmune neuropsychiatric disorder associated with group A streptococcus. Pediatr Infect Dis J. 2013; 32 (8): 834–838.</mixed-citation><mixed-citation xml:lang="en">Burton M.J., Glasziou P.P., Chong L.Y., Venekamp R.P. Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2014 Nov 19;11:CD001802. Doi: 10.1002/14651858.CD001802.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Johansson E., Hultcrantz E. Tonsillectomy-clinical consequences twenty years after surgery? Int J Pediatr Otorhinolaryngol. 2003; 67: 981–988.</mixed-citation><mixed-citation xml:lang="en">Murphy T.K., Lewin A.B., Parker-Athill E.C., Storch E.A., Mutch P.J. Tonsillectomies and adenoidectomies do not prevent the onset of pediatric autoimmune neuropsychiatric disorder associated with group A streptococcus. Pediatr Infect Dis J. 2013;32(8):834−838.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart T., McDonald R., Currie B. Acute rheumatic fever: adherence to secondary prophylaxis and follow up of Indigenous patients in the Katherine region of the Northern Territory. Aust J Rural Health. 2007; 15: 234–240.</mixed-citation><mixed-citation xml:lang="en">Johansson E., Hultcrantz E. Tonsillectomy-clinical consequences twenty years after surgery? Int J Pediatr Otorhinolaryngol. 2003;67:981–988.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Baugh R. F., Archer S. M., Mitchell R. B. et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011; 144: S1–30.</mixed-citation><mixed-citation xml:lang="en">Stewart T., McDonald R., Currie B. Acute rheumatic fever: adherence to secondary prophylaxis and follow up of Indigenous patients in the Katherine region of the Northern Territory. Aust J Rural Health. 2007; 15: 234–240.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Ikinciogullari A., Dogu F., ikinciogullari A. et al. Is immune system influenced by adenotonsillectomy in children? Int J Pediatr Otorhinolaryngol. 2002; 66: 251–257.</mixed-citation><mixed-citation xml:lang="en">Baugh R.F., Archer S.M., Mitchell R.B. et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011;144:S1–30.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Kaygusuz I., Alpay H. C., Gudekmerdan A. et al. Evaluation of long-term impacts of tonsillectomy on immune functions of children: a follow-up study. Int J Pediatr Otorhinolaryngol. 2009; 73: 445–449.</mixed-citation><mixed-citation xml:lang="en">Ikincioğullari A., Doğu F., ikincioğullari A. et al. Is immune system influenced by adenotonsillectomy in children? Int J Pediatr Otorhinolaryngol. 2002;66:251–257.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Matthys J., De Meyere M., van Driel M. L., De Sutter A. Differences among international pharyngitis guidelines: not just academic. Ann Fam Med. 2007; 5: 436–443. Doi: 10.1370/afm.741.</mixed-citation><mixed-citation xml:lang="en">Kaygusuz I., Alpay H.C., Gödekmerdan A. et al. Evaluation of long-term impacts of tonsillectomy on immune functions of children: a follow-up study. Int J Pediatr Otorhinolaryngol. 2009;73:445–449.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Matthys J., De Meyere M., van Driel M.L., De Sutter A. Differences among international pharyngitis guidelines: not just academic. Ann Fam Med. 2007;5:436–443. Doi: 10.1370/afm.741.</mixed-citation><mixed-citation xml:lang="en">Matthys J., De Meyere M., van Driel M.L., De Sutter A. Differences among international pharyngitis guidelines: not just academic. Ann Fam Med. 2007;5:436–443. Doi: 10.1370/afm.741.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
