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ppharm

Педиатрическая фармакология

Pediatric pharmacology

1727-57762500-3089

Издательство «ПедиатрЪ»

10.15690/pf.v23i3.3066

ppharm-2835

Research Article

КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ

CLINICAL RECOMMENDATIONS

Современные клинические рекомендации по ведению пациентов с эозинофильным эзофагитом

Current Clinical Guidelines for the Management of Patients with Eosinophilic Esophagitis

https://orcid.org/0000-0002-4453-8430

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О. М.

Drapkina

Oksana M.

Москва

Moscow

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В. Т.

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Vladimir T.

Москва

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И. В.

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Igor V.

Москва

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Л. С.

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Leyla S.

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М. Р.

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Musa R.

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Evgeniy D.

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Трухманов

А. С.

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Aleksandr S.

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Лапина

Т. Л.

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Tatyana L.

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К. С.

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Ksenia S.

Москва

Moscow

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А. А.

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Anna A.

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Л. А.

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Larisa A.

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Saransk

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Д. С.

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Dmitriy S.

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Т. Н.

Budkina

Tatyana N.

Москва

Moscow

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В. А.

Bulgakova

Vilya A.

Москва

Moscow

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И. В.

Vakhlova

Irina V.

Екатеринбург

Yekaterinburg

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Э. Р.

Valitova

Elen R.

Москва

Moscow

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С. С.

Vyazankina

Svetlana S.

Москва

Moscow

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Е. В.

Gorbachev

Evgeniy V.

Москва

Moscow

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Е. В.

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Ekaterina V.

Москва

Moscow

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Н. И.

Ilyina

Natalia I.

Москва

Moscow

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Е. В.

Kaytukova

Elena V.

Москва

Moscow

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А. П.

Kiryukhin

Andrey P.

Москва

Moscow

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О. П.

Kovtun

Olga P.

Екатеринбург

Yekaterinburg

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Е. В.

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Elena V.

Москва

Moscow

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Е. А.

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Elena A.

Санкт-Петербург

St. Petersburg

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Р. О.

Kuvaev

Roman O.

Ярославль

Yaroslavl

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Т. В.

Kulichenko

Tatyana V.

Москва

Moscow

https://orcid.org/0000-0003-3250-0694

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О. М.

Kurbacheva

Oksana M.

Москва

Moscow

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Левина

Ю. Г.

Levina

Yulia G.

Москва

Moscow

https://orcid.org/0000-0002-8305-7592

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М. М.

Lokhmatov

Maksim M.

Москва

Moscow

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С. Г.

Makarova

Svetlana G.

Москва

Moscow

https://orcid.org/0000-0002-3162-2510

Ненашева

Н. М.

Nenasheva

Natalia M.

Москва

Moscow

https://orcid.org/0000-0002-5231-711X

Никонов

Е. Л.

Nikonov

Evgeniy L.

Москва

Moscow

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Новик

Г. А.

Novik

Gennadiy A.

Санкт-Петербург

St. Petersburg

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Павлов

П. В.

Pavlov

Pavel V.

Москва

Moscow

https://orcid.org/0000-0002-1662-2352

Параскевова

А. В.

Paraskevova

Anna V.

Москва

Moscow

https://orcid.org/0000-0002-8101-2155

Пирогов

С. С.

Pirogov

Sergey S.

Москва

Moscow

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Привалова

Т. Е.

Privalova

Tatyana E.

Москва

Moscow

Приворотский

В. Ф.

Privorotskiy

Valeriy F.

Санкт-Петербург

St. Petersburg

https://orcid.org/0000-0001-7048-0538

Румянцева

Д. Е.

Rumyantseva

Diana E.

Москва

Moscow

https://orcid.org/0000-0002-3678-7939

Селимзянова

Л. Р.

Selimzyanova

Lilia R.

Селимзянова Лилия Робертовна - кандидат медицинских наук, заведующая отделом стандартизации и изучения основ доказательной медицины НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского», врач-пульмонолог.

Москва, ул. Фотиевой, д. 10, тел.: +7 (499) 400-47-33

Moscow

lilysir@mail.ru

https://orcid.org/0000-0001-7876-6258

Смолкин

Ю. С.

Smolkin

Yury S.

Москва

Moscow

https://orcid.org/0000-0002-0960-1166

Сторонова

О. А.

Storonova

Olga A.

Москва

Moscow

https://orcid.org/0000-0002-3697-4283

Сурков

А. Н.

Surkov

Andrey N.

Москва

Moscow

https://orcid.org/0000-0001-5635-6100

Тертычный

А. С.

Tertychnyy

Aleksander S.

Москва

Moscow

Ткаченко

М. А.

Tkachenko

Mikhail A.

Москва

Moscow

https://orcid.org/0000-0002-3167-082X

Устинова

Н. В.

Ustinova

Natalia V.

Москва

Moscow

https://orcid.org/0000-0002-5083-6637

Фомина

Д. С.

Fomina

Daria S.

Москва

Moscow

https://orcid.org/0000-0001-7308-7280

Хавкин

А. И.

Khavkin

Anatoly I.

Москва, Белгород

Moscow Region, Belgorod

https://orcid.org/0000-0003-0754-9605

Хакимова

Р. Ф.

Khakimova

Rezeda F.

Москва

Kazan

https://orcid.org/0000-0003-0629-3871

Шаповальянц

С. Г.

Shapovalyants

Sergey G.

Москва

Moscow

https://orcid.org/0000-0003-0317-2425

Эфендиева

К. Е.

Efendieva

Kamilla E.

Москва

Moscow

Национальный медицинский исследовательский центр терапии и профилактической медициныРоссияNational Medical Research Center for Therapy and Preventive MedicineRussian Federation

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical UniversityRussian Federation

Российский университет медициныРоссияRussian University of MedicineRussian Federation

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет); Университет МГУ-ППИ в ШэньчжэнеРоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Shenzhen MSU-BIT UniversityRussian Federation

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University; Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of SurgeryRussian Federation

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет); Государственный научный центр «Институт иммунологии»РоссияPirogov Russian National Research Medical University; State Scientific Center “Institute of Immunology”Russian Federation

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет); Научно-исследовательский институт морфологии человека им. акад. А.П. Авцына ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияPirogov Russian National Research Medical University; A.P. Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of SurgeryRussian Federation

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian Federation

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет); Городская клиническая больница № 31 им. акад. Г.М. СавельевойРоссияPirogov Russian National Research Medical University; G.M. Savelyeva City Clinical Hospital No. 31Russian Federation

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of SurgeryRussian Federation

Мордовский государственный университет им. Н.П. ОгарёваРоссияN.P. Ogarev Mordovia State UniversityRussian Federation

Российский университет медицины; Московский клинический научный центр им. А.С. ЛогиноваРоссияRussian University of Medicine; A.S. Loginov Moscow Clinical Scientific CenterRussian Federation

Национальный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center for Children’s HealthRussian Federation

Уральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation

Московский клинический научный центр им. А.С. ЛогиноваРоссияA.S. Loginov Moscow Clinical Scientific CenterRussian Federation

Городская клиническая больница № 31 им. акад. Г.М. СавельевойРоссияG.M. Savelyeva City Clinical Hospital No. 31Russian Federation

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияPirogov Russian National Research Medical UniversityRussian Federation

Санкт-Петербургский государственный педиатрический медицинский университетРоссияSt. Petersburg State Pediatric Medical UniversityRussian Federation

Клиническая онкологическая больницаРоссияClinical Oncology HospitalRussian Federation

Государственный научный центр «Институт иммунологии»РоссияState Scientific Center “Institute of Immunology”Russian Federation

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Национальный медицинский исследовательский центр здоровья детейРоссияSechenov First Moscow State Medical University; National Medical Research Center for Children’s HealthRussian Federation

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Национальный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center for Children’s HealthRussian Federation

Российская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian Federation

Московский научно-исследовательский онкологический институт им. П.А. ГерценаРоссияP.A. Hertsen Moscow Oncology Research InstituteRussian Federation

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияSechenov First Moscow State Medical University; Pediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian Federation

Институт повышения квалификации ФМБА РоссииРоссияAdvanced Training Institute of the Federal Medical and Biological Agency of RussiaRussian Federation

Союз педиатров РоссииРоссияThe Union of Pediatricians of RussiaRussian Federation

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Научно-практический центр психического здоровья детей и подростков им. Г.Е. СухаревойРоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; G.E. Sukhareva Research and Practical Center for Mental Health of Children and AdolescentsRussian Federation

Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Городская клиническая больница № 52РоссияSechenov First Moscow State Medical University; City Clinical Hospital No. 52Russian Federation

Научно-исследовательский клинический институт детства, Московская область; Медицинский институт Белгородского государственного университетаРоссияResearch and Clinical Institute of Childhood; Medical Institute of Belgorod State UniversityRussian Federation

Казанский государственный медицинский университет, Казань, Российская ФедерацияРоссияKazan State Medical UniversityRussian Federation

2026

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Copyright © Драпкина О.М., Ивашкин В.Т., Маев И.В., Намазова-Баранова Л.С., Баранов А.А., Хаитов М.Р., Михалева Л.М., Кайбышева В.О., Вишнева Е.А., Федоров Е.Д., Трухманов А.С., Лапина Т.Л., Маслёнкина К.С., Алексеева А.А., Балыкова Л.А., Бордин Д.С., Будкина Т.Н., Булгакова В.А., Вахлова И.В., Валитова Э.Р., Вязанкина С.С., Горбачев Е.В., Иванова Е.В., Ильина Н.И., Кайтукова Е.В., Кирюхин А.П., Ковтун О.П., Комарова Е.В., Корниенко Е.А., Куваев Р.О., Куличенко Т.В., Курбачева О.М., Левина Ю.Г., Лохматов М.М., Макарова С.Г., Ненашева Н.М., Никонов Е.Л., Новик Г.А., Павлов П.В., Параскевова А.В., Пирогов С.С., Привалова Т.Е., Приворотский В.Ф., Румянцева Д.Е., Селимзянова Л.Р., Смолкин Ю.С., Сторонова О.А., Сурков А.Н., Тертычный А.С., Ткаченко М.А., Устинова Н.В., Фомина Д.С., Хавкин А.И., Хакимова Р.Ф., Шаповальянц С.Г., Эфендиева К.Е., 2026

2026

Драпкина О.М., Ивашкин В.Т., Маев И.В., Намазова-Баранова Л.С., Баранов А.А., Хаитов М.Р., Михалева Л.М., Кайбышева В.О., Вишнева Е.А., Федоров Е.Д., Трухманов А.С., Лапина Т.Л., Маслёнкина К.С., Алексеева А.А., Балыкова Л.А., Бордин Д.С., Будкина Т.Н., Булгакова В.А., Вахлова И.В., Валитова Э.Р., Вязанкина С.С., Горбачев Е.В., Иванова Е.В., Ильина Н.И., Кайтукова Е.В., Кирюхин А.П., Ковтун О.П., Комарова Е.В., Корниенко Е.А., Куваев Р.О., Куличенко Т.В., Курбачева О.М., Левина Ю.Г., Лохматов М.М., Макарова С.Г., Ненашева Н.М., Никонов Е.Л., Новик Г.А., Павлов П.В., Параскевова А.В., Пирогов С.С., Привалова Т.Е., Приворотский В.Ф., Румянцева Д.Е., Селимзянова Л.Р., Смолкин Ю.С., Сторонова О.А., Сурков А.Н., Тертычный А.С., Ткаченко М.А., Устинова Н.В., Фомина Д.С., Хавкин А.И., Хакимова Р.Ф., Шаповальянц С.Г., Эфендиева К.Е.

Drapkina O.M., Ivashkin V.T., Maev I.V., Namazova-Baranova L.S., Baranov A.A., Khaitov M.R., Mikhaleva L.M., Kaybysheva V.O., Vishneva E.A., Fedorov E.D., Trukhmanov A.S., Lapina T.L., Maslenkina K.S., Alekseeva A.A., Balykova L.A., Bordin D.S., Budkina T.N., Bulgakova V.A., Vakhlova I.V., Valitova E.R., Vyazankina S.S., Gorbachev E.V., Ivanova E.V., Ilyina N.I., Kaytukova E.V., Kiryukhin A.P., Kovtun O.P., Komarova E.V., Kornienko E.A., Kuvaev R.O., Kulichenko T.V., Kurbacheva O.M., Levina Y.G., Lokhmatov M.M., Makarova S.G., Nenasheva N.M., Nikonov E.L., Novik G.A., Pavlov P.V., Paraskevova A.V., Pirogov S.S., Privalova T.E., Privorotskiy V.F., Rumyantseva D.E., Selimzyanova L.R., Smolkin Y.S., Storonova O.A., Surkov A.N., Tertychnyy A.S., Tkachenko M.A., Ustinova N.V., Fomina D.S., Khavkin A.I., Khakimova R.F., Shapovalyants S.G., Efendieva K.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pedpharma.ru/jour/article/view/2835

В статье представлен анализ современных клинических рекомендаций по ведению пациентов с эозинофильным эзофагитом (ЭоЭ) — хроническим иммуноопосредованным заболеванием пищевода, характеризующимся эозинофильной инфильтрацией слизистой оболочки (≥ 15 эоз./п.зр.) и клиническими проявлениями дисфункции пищевода. Освещены ключевые изменения в диагностике, рассматриваются современные подходы к лечению: диетотерапия (начиная с наименее ограничительных диет), фармакологическое лечение (ингибиторы протонной помпы, топические глюкокортикоиды, биологическая терапия) и эндоскопическая дилатация при стриктурах. Авторами подчеркивается необходимость комплексного мониторинга (клинического, эндоскопического и гистологического) для оценки ответа на терапию и длительного поддерживающего лечения ввиду хронического характера заболевания. Отдельное внимание уделено аспектам ведения педиатрических пациентов.

This article presents an analysis of current clinical guidelines for the management of patients with eosinophilic esophagitis (EoE) — a chronic immune-mediated disease of the esophagus characterized by eosinophilic infiltration of the mucosa (≥ 15 eos/hpf) and clinical manifestations of esophageal dysfunction. The review highlights key changes in diagnostic approaches and discusses contemporary treatment strategies, including dietary therapy (starting with the least restrictive diets), pharmacological treatment (proton pump inhibitors, topical steroids, biologic therapy), and endoscopic dilation for strictures. The authors emphasize the need for comprehensive monitoring (clinical, endoscopic, and histological) to assess treatment response and for long-term maintenance therapy given the chronic nature of the disease. Special attention is paid to pediatric aspects of patient management.

эозинофильный эзофагитдиагностикаклинические рекомендациидупилумабдетиэндоскопия

eosinophilic esophagitisdiagnosisclinical guidelinesdupilumabchildrenendoscopy

Отсутствует

Not specified

References1

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The authors declare that there are no conflicts of interest present.