ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i6.2988ppharm-2734Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWУльтракороткая целиакия: клинические, иммунофенотипические, морфологические, генетические особенностиUltra-Short Celiac Disease: Clinical, Immunophenotypic, Morphological, and Genetic Featureshttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич - доктор медицинских наук, профессор, руководитель Московского областного центра детской гастроэнтерологии и гепатологии им. А.В. Мазурина Научно-исследовательского клинического института детства; профессор кафедры педиатрии Медицинского института Белгородского государственного национального исследовательского университета.

115093, Москва, ул. Большая Серпуховская, д. 62; тел.: (499) 237-0223

MD, PhD, Professor.

62, Bolshaya Serpukhovskaya Str., Moscow, 115093

khavkin@nikid.ruhttps://orcid.org/0000-0002-3043-8674ЛошковаЕ. В.LoshkovaElena V.

Лошкова Елена Владимировна - к.м.н.

Томск, Москва

MD, PhD.

Tomsk, Moscow

loshkova@rambler.ruhttps://orcid.org/0000-0003-3364-610XЯблоковаЕ. А.YablokovaEkaterina A.

Яблокова Екатерина Александровна - к.м.н.

Мытищи, Москва

MD, PhD.

Mytishchi, Moscow

yablokova_e_a@staff.sechenov.ruhttps://orcid.org/0000-0001-5792-2012ЯнкинаГ. Н.YankinaGalina N.

Янкина Галина Николаевна - д.м.н.

Томск

MD, PhD.

Tomsk

gal.happy@mail.ruhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NalyotovAndrew V.

Налетов Андрей Васильевич - д.м.н., профессор.

Донецк

MD, PhD, Professor.

Donetsk

nalyotov-a@mail.ruhttps://orcid.org/0000-0002-2133-665XЖелевВ. А.ZhelevVictor A.

Желев Виктор Александрович - д.м.н., профессор.

Томск

MD, PhD, Professor.

Tomsk

dozd5@yandex.ruhttps://orcid.org/0009-0008-7135-7361БудкинА. В.BudkinAlexandr V.

Будкин Александр Владимирович

Томск

MD.

Tomsk

pyos13@gmail.comhttps://orcid.org/0009-0005-7887-8168ЗавражнаяК. Д.ZavrazhnayaKristina D.

Завражная Кристина Дмитриевна

Мытищи

MD.

Mytishchi

kristina_zavrazhnaya@mail.ruhttps://orcid.org/0009-0005-4065-074XПоповаА. Д.PopovaAnastasiya D.

Попова Анастасия Дмитриевна

Томск

MD.

Tomsk

npd19072003@mail.ruhttps://orcid.org/0009-0008-5732-9823ФедосоваМ. В.FedosovaMarina V.

Федосова Марина Витальевна

Томск

MD.

Tomsk

fvmarr21@mail.ruНаучно-исследовательский институт детства; Белгородский государственный национальный исследовательский университетРоссияScientific Research Institute of Childhood; Belgorod State National Research UniversityRussian FederationСибирский государственный медицинский университет; Медико-генетический научный центр им. акад. Н.П. БочковаРоссияSiberian State Medical University; Research Centre for Medical GeneticsRussian FederationНаучно-исследовательский институт детства; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияScientific Research Institute of Childhood; Sechenov First Moscow State Medical UniversityRussian FederationСибирский государственный медицинский университетРоссияSiberian State Medical UniversityRussian FederationДонецкий государственный медицинский университет им. М. ГорькогоРоссияDonetsk State Medical University named after M. GorkyRussian FederationОбластной дом ребенкаРоссияRegional orphanageRussian FederationНаучно-исследовательский институт детстваРоссияScientific Research Institute of ChildhoodRussian Federation202520012026226732738Copyright © Хавкин А.И., Лошкова Е.В., Яблокова Е.А., Янкина Г.Н., Налетов А.В., Желев В.А., Будкин А.В., Завражная К.Д., Попова А.Д., Федосова М.В., 20262026Хавкин А.И., Лошкова Е.В., Яблокова Е.А., Янкина Г.Н., Налетов А.В., Желев В.А., Будкин А.В., Завражная К.Д., Попова А.Д., Федосова М.В.Khavkin A.I., Loshkova E.V., Yablokova E.A., Yankina G.N., Nalyotov A.V., Zhelev V.A., Budkin A.V., Zavrazhnaya K.D., Popova A.D., Fedosova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2734

Ультракороткая целиакия является одним из фенотипов обычной целиакии и характеризуется обнаружением гиперрегенераторной атрофии и/или интраэпителиального лимфоцитоза в луковице двенадцатиперстной кишки при отсутствии повреждения слизистой оболочки в ее дистальном отделе, серологической позитивностью, присутствием HLA-DQ2. Однако частота серопозитивности и носительства классических гаплотипов HLA-DQ2 отличается от таковой при обычной целиакии, что вызывает значительные трудности на этапе дифференциально-диагностического поиска. Данные о распространенности, клинических проявлениях, гистологических поражениях, генетических особенностях и исходе ультракороткой целиакии немногочисленны и нуждаются в накоплении. Настоящий обзор посвящен анализу результатов исследований ультракороткой целиакии и описанию клинических, иммунологических и генетических особенностей этого фенотипа болезни.

Ultra-short celiac disease is one of the phenotypes of common celiac disease, it is characterized by hyper-regenerative atrophy and/or intraepithelial lymphocytosis in duodenal bulb along with no mucosal damage in distal duodenum, serological positivity, the presence of HLA-DQ2. However, seropositivity and classical HLA-DQ2 haplotypes frequency differs from usual celiac disease, thus, there are significant difficulties in differential diagnosis. Data on prevalence, clinical manifestations, histological lesions, genetic features, and outcome of ultra-short celiac disease is insufficient and should be accumulated. This review focuses on analyzing the studies results about ultra-short celiac disease and describes the clinical, immunological, and genetic features of this disease phenotype.

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The authors declare that there are no conflicts of interest present.