ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i5.2972ppharm-2703Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWОжирение и аутоиммунные заболевания. Механизмы взаимосвязиCorrelations Between Obesity and Autoimmune Diseaseshttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич, д.м.н., профессор, руководитель Московского областного центра детской гастроэнтерологии и гепатологии им. А.В. Мазурина, главный научный сотрудник; профессор кафедрыпедиатрии Медицинского института

115093, г. Москва, ул. Большая Серпуховская, д. 62, телефон: +7 (499) 237-02-23

Белгород

Anatoly I. Khavkin, MD, PhD, Professor

62, Bolshaya Serpukhovskaya Str., Moscow, 115093

Belgorod

gastropedclin@gmail.comhttps://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaValeriya P.

Новикова Валерия Павловна, д.м.н., профессор

Санкт-Петербург

Valeriya P. Novikova, MD, PhD, Professor

Saint-Petersburg

novikova-vp@mail.ruhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NalyotovAndrew V.

Налетов Андрей Васильевич, д.м.н., профессор

Донецк

Andrew V. Nalyotov, MD, PhD, Professor

 

nalyotov-a@mail.ruhttps://orcid.org/0009-0004-3031-5959ПодороваЛ. А.PodorovaLudmila A.

Подорова Людмила Андреевна

Санкт-Петербург

Ludmila A. Podorova, MD

Saint-Petersburg

podorova@list.ruhttps://orcid.org/0000-0002-1533-4498КомиссароваМ. Ю.KomissarovaMarina Yu.

Комиссарова Марина Юрьевна, к.м.н.

Санкт-Петербург

Красногорск

Marina Yu. Komissarova, MD, PhD

Saint-Petersburg

Krasnogorsk

Klinika.spb@gpmu.orghttps://orcid.org/0000-0002-7880-8056МасютаД. И.MasyutaDmitry I.

Масюта Дмитрий Иванович, к.м.н.

Донецк

Dmitry I. Masyuta, MD, PhD

 

masyutad@mail.ruНаучно-исследовательский клинический институт детства; Белгородский государственный национальный исследовательский университетРоссияChildhood Research Institute; Belgorod State National Research UniversityRussian FederationСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint-Petersburg State Pediatric Medical UniversityRussian FederationДонецкий государственный медицинский университет им. М. ГорькогоРоссияDonetsk State Medical University named after M. GorkyRussian FederationСанкт-Петербургский государственный педиатрический медицинский университет; Детский клинический центр им. Л.М. РошаляРоссияSaint-Petersburg State Pediatric Medical University; Children’s Clinical Center named after L. M. RoshalRussian Federation202506122025225624631Copyright © Хавкин А.И., Новикова В.П., Налетов А.В., Подорова Л.А., Комиссарова М.Ю., Масюта Д.И., 20252025Хавкин А.И., Новикова В.П., Налетов А.В., Подорова Л.А., Комиссарова М.Ю., Масюта Д.И.Khavkin A.I., Novikova V.P., Nalyotov A.V., Podorova L.A., Komissarova M.Y., Masyuta D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2703

Хроническое вялотекущее воспаление, характерное для ожирения, может лежать в основе развития аутоиммунных заболеваний. В патогенезе играют роль увеличение секреции адипокинов, таких как лептин и резистин, а также повышенная секреция провоспалительных цитокинов. Хроническое воспаление при ожирении способствует ускоренному апоптозу β-клеток поджелудочной железы, демиелинизации и повреждению аксонов нейронов, изменению состояния микробиома кишечника и нарушению синтеза гормонов щитовидной железы, что ведет к развитию таких состояний, как сахарный диабет 1-го типа, рассеянный склероз, воспалительные заболевания кишечника и аутоиммунный тиреоидит. Своевременная терапия ожирения может лежать в основе предотвращения развития аутоиммунных заболеваний.

Chronic subacute inflammation typical for obesity may underlie the development of autoimmune diseases. Increased adipokines (such as leptin and resistin) and proinflammatory cytokines secretion are crucial in pathogenesis. Chronic inflammation in obesity promotes accelerated pancreatic β-cells apoptosis, leads to demyelination and damage to neuronal axons, intestinal microbiome changes, and impaired synthesis of thyroid hormones. Altogether, it can result in development of such conditions as type 1 diabetes mellitus, disseminated sclerosis, inflammatory bowel diseases, and autoimmune thyroiditis. Timely management obesity may prevent autoimmune diseases development.

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The authors declare that there are no conflicts of interest present.