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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v22i3.2904</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-2649</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Ультрапереработанные продукты и их роль в развитии ожирения</article-title><trans-title-group xml:lang="en"><trans-title>Ultra-Processed Foods and Their Role in Obesity Development</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4733-3262</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Налетов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nalyotov</surname><given-names>Andrew V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Налетов Андрей Васильевич - доктор медицинских наук, профессор, заведующий кафедрой педиатрии № 2 Донецкого государственного медицинского университета им. М. Горького, главный внештатный детский специалист гастроэнтеролог Министерства здравоохранения Донецкой Народной Республики.</p><p>283003, Донецк, пр. Ильича, д. 16, тел.: +7 (949) 311-13-82</p></bio><bio xml:lang="en"><p>MD, PhD, Professor.</p><p>16, Illich Avе., Donetsk, 283003</p></bio><email xlink:type="simple">nalyotov-a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7308-7280</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хавкин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Khavkin</surname><given-names>Anatoly I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хавкин Анатолий Ильич - д.м.н., профессор.</p><p>Москва, Белгород</p></bio><bio xml:lang="en"><p>MD, PhD, Professor.</p><p>Moscow, Belgorod</p></bio><email xlink:type="simple">khavkin@nikid.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6687-3494</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мацынина</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Matsynina</surname><given-names>Maria A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мацынина Мария Александровна - к.м.н.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>MD, PhD.</p><p>Saint Petersburg</p></bio><email xlink:type="simple">m.matsynina@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-3774-2146</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковырзина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovyrzina</surname><given-names>Arina V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ковырзина Арина Витальевна – студентка.</p><p>Донецк</p></bio><bio xml:lang="en"><p>Student</p><p>Donetsk</p></bio><email xlink:type="simple">a.d.a.vv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Донецкий государственный медицинский университет им. М. Горького</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Donetsk State Medical University named after M. Gorky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский клинический институт детства; Белгородский государственный национальный исследовательский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Childhood Research Institute; Belgorod State National Research University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University named after I.I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>07</month><year>2025</year></pub-date><volume>22</volume><issue>3</issue><fpage>341</fpage><lpage>346</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Налетов А.В., Хавкин А.И., Мацынина М.А., Ковырзина А.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Налетов А.В., Хавкин А.И., Мацынина М.А., Ковырзина А.В.</copyright-holder><copyright-holder xml:lang="en">Nalyotov A.V., Khavkin A.I., Matsynina M.A., Kovyrzina A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/2649">https://www.pedpharma.ru/jour/article/view/2649</self-uri><abstract><p>Одним из наиболее негативных аспектов постиндустриального общества является рост распространенности ожирения как среди взрослых, так и среди пациентов детского возраста. Причины ожирения сложны и до сих пор до конца не изучены. Однако установлено, что в патогенезе заболевания важную роль играют факторы окружающей среды, влияющие на выбор рациона питания и двигательную активность. Изменения в рационе питания населения планеты и, в первую очередь, среди детей и подростков связаны с популяризацией потребления продуктов, богатых энергией и подверженных высокой степени обработки. К ультрапереработанным продуктам традиционно относят фастфуд, безалкогольные напитки, упакованные сладкие или соленые закуски, хлебобулочные изделия длительного хранения с большим количеством разрыхлителей, мясные полуфабрикаты и предварительно приготовленные замороженные блюда, которые имеют длительный срок хранения и готовы к употреблению. Целью работы было провести анализ современной литературы в отношении изучения связи между потреблением ультрапереработанных продуктов и риском развития ожирения у пациентов разного возраста. Согласно результатам исследований, потребление ультрапереработанных продуктов способствует росту числа индивидуумов с избыточной массой тела — как среди взрослых, так и в детском возрасте. Представленные в статье данные имеют важное значение для лучшего понимания необходимости изменения политики общественного здравоохранения в области питания, направленной на укрепление здоровья и профилактику хронических неинфекционных заболеваний за счет снижения доли потребления ультрапереработанных продуктов среди детей и подростков.</p></abstract><trans-abstract xml:lang="en"><p>Increasing prevalence of obesity in both adults and children is one of the most negative aspects of post-industrial society. The causes of obesity are complicated and still are not investigated well. However, it has been established that environmental factors affecting dietary choices and motor activity are crucial in this disease pathogenesis. Changing diets among world’s population, and primarily among children and adolescents, are associated with popularization of the consumption of energyrich foods undergoing high degree processing. Ultra-processed foods traditionally include fast food, soft drinks, packaged sweet or salty snacks, non-perishable bakery products with big amount of baking powders, self-service meats, and preprepared frozen dishes that have long shelf life and are ready-to-eat. The aim of the study was to analyze current literature regarding relationship between ultra-processed foods consumption and obesity development risk in patients of different ages. Consumption of ultra-processed foods contributes to increase in the number of overweight individuals (both among adults and children), according to research. The data presented in the study is crucial for better understanding of the need for public health nutrition policy changes to promote health and prevent chronic noncommunicable diseases by reducing the proportion of ultra-processed foods consumed among children and adolescents.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ультрапереработанные продукты</kwd><kwd>ожирение</kwd><kwd>избыточная масса тела</kwd><kwd>дети</kwd><kwd>взрослые</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ultra-processed foods</kwd><kwd>obesity</kwd><kwd>overweight</kwd><kwd>children</kwd><kwd>adults</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Отсутствует</funding-statement><funding-statement xml:lang="en">Not specified</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Новикова В.П., Грицинская В.Л., Леонова И.А., Хавкин А.И. Ожирение у детей: роль и возможности двигательной активности в комплексном лечении // Вопросы диетологии. — 2020. — Т. 10. — № 4. — С. 24–28. — doi: https://doi.org/10.20953/2224-5448-20-4-24-28</mixed-citation><mixed-citation xml:lang="en">Novikova VP, Gritsinskaya VL, Leonova IА, Khavkin AI. Obesity in children: the role and contribution of physical activity in comprehensive treatment. Nutrition. 2020;10(4):24–28. (In Russ). doi: https://doi.org/10.20953/2224-5448-20-4-24-28</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Петеркова В.А., Безлепкина О.Б., Болотова Н.В. и др. Клинические рекомендации «Ожирение у детей» // Проблемы эндокринологии. — 2021. — Т. 67. — № 5. — С. 67–83. — doi: https://doi.org/10.14341/probl12802</mixed-citation><mixed-citation xml:lang="en">Peterkova VA, Bezlepkina OB, Bolotova NV, et al. Clinical recommendations “Obesity in children”. Problems of endocrinology. 2021;67(5):67–83. (In Russ). doi: https://doi.org/10.14341/probl12802</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Пушкарук В.В., Налетов А.В. Основные аспекты изменения образа жизни детей с ожирением, проживающих в условиях длительного военного конфликта // Вятский медицинский вестник. — 2023. — Т. 4. — № 80. — С. 31–34. — doi: https://doi.org/10.24412/2220-7880-2023-4-31-34</mixed-citation><mixed-citation xml:lang="en">Pushkaruk VV, Nalyotov AV. The main aspects of changing the lifestyle of obese children living in conditions of prolonged military conflict. Medical newsletter of Vyatka. 2023;4(80):31–34. (In Russ). doi: https://doi.org/10.24412/2220-7880-2023-4-31-34</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Налетов А.В., Пушкарук В.В. Состояние кишечной микрофлоры у детей с ожирением // Children’s medicine of the North-West. — 2022. — Т. 10. — № 1. — 70–74.</mixed-citation><mixed-citation xml:lang="en">Nalyotov AV, Pushkaruk VV. The state of the intestinal microflora in obese children. Children’s medicine of the North-West. 2022;10(1):70–74. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dinu M, Tristan Asensi M, Pagliai G, et al. Consumption of ultra-processed foods is inversely associated with adherence to the Mediterranean diet: A cross-sectional study. Nutrients. 2022;14(10):2073. doi: https://doi.org/10.3390/nu14102073</mixed-citation><mixed-citation xml:lang="en">Dinu M, Tristan Asensi M, Pagliai G, et al. Consumption of ultra-processed foods is inversely associated with adherence to the Mediterranean diet: A cross-sectional study. Nutrients. 2022;14(10):2073. doi: https://doi.org/10.3390/nu14102073</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tristan Asensi M, Pagliai G, Lotti S, et al. Adherence to the Mediterranean diet and ultra-processed foods consumption in a group of Italian patients with celiac disease. Nutrients. 2023;15(4):938. doi: https://doi.org/10.3390/nu15040938</mixed-citation><mixed-citation xml:lang="en">Tristan Asensi M, Pagliai G, Lotti S, et al. Adherence to the Mediterranean diet and ultra-processed foods consumption in a group of Italian patients with celiac disease. Nutrients. 2023;15(4):938. doi: https://doi.org/10.3390/nu15040938</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Хавкин А.И., Новикова В.П., Маталыгина О.А., Завьялова А.Н. Аллергия и ожирение: выявление общих звеньев патогенеза как основа стратегии адекватной терапии // Вопросы практической педиатрии. — 2022. — Т. 17. — № 4. — С. 59–66. — doi: https://doi.org/10.20953/1817-7646-2022-4-59-66</mixed-citation><mixed-citation xml:lang="en">Khavkin AI, Novikova VP, Matalygina OA, Zavyalova AN. Allergy and obesity: identification of common links of pathogenesis as the basis of an adequate therapy strategy. Clinical Practice in Pediatrics. 2022;17(4):59–66. (In Russ). doi: https://doi.org/10.20953/1817-7646-2022-4-59-66</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Налетов А.В., Пушкарук В.В. Микробиотический кишечный дисбаланс у детей с неалкогольной жировой болезнью печени // Мать и дитя в Кузбассе. — 2023. — Т. 4. — № 95. — С. 64–68.</mixed-citation><mixed-citation xml:lang="en">Nalyotov AV, Pushkaruk VV. Microbiotic intestinal imbalance in children with non-alcoholic fatty liver disease. Mother and Baby of Kuzbass. 2023;4(95):64–68. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Monteiro CA, Cannon G, Levy RB, et al. Ultra-processed foods: What they are and how to identify them. Public Health Nutr. 2019;22(5):936–941. doi: https://doi.org/10.1017/S1368980018003762</mixed-citation><mixed-citation xml:lang="en">Monteiro CA, Cannon G, Levy RB, et al. Ultra-processed foods: What they are and how to identify them. Public Health Nutr. 2019;22(5):936–941. doi: https://doi.org/10.1017/S1368980018003762</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Хавкин А.И., Налётов А.В., Шумилов П.В. и др. Ультрапереработанные продукты и микробиота кишечника // Вопросы детской диетологии. — 2024. — Т. 22. — № 5. — С. 79–86. — doi: https://doi.org/10.20953/1727-5784-2024-579-86</mixed-citation><mixed-citation xml:lang="en">Khavkin AI, Nalyotov AV, Shumilov PV, et al. Ultra-processed foods and gut microbiome. Pediatric Nutrition. 2024;22(5):79–86. (In Russ). doi: https://doi.org/10.20953/1727-5784-2024-5-79-86</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Levy RB, Barata MF, Leite MA, Andrade GC. How and why ultraprocessed foods harm human health. Proc Nutr Soc. 2024;83(1):1–8. doi: https://doi.org/10.1017/S0029665123003567</mixed-citation><mixed-citation xml:lang="en">Levy RB, Barata MF, Leite MA, Andrade GC. How and why ultraprocessed foods harm human health. Proc Nutr Soc. 2024;83(1):1–8. doi: https://doi.org/10.1017/S0029665123003567</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Fryar CD, Hughes JP, Herrick KA, Ahluwalia N. Fast food consumption among adults in the United States, 2013–2016. NCHS Data Brief. 2018;(322):1–8.</mixed-citation><mixed-citation xml:lang="en">Fryar CD, Hughes JP, Herrick KA, Ahluwalia N. Fast food consumption among adults in the United States, 2013–2016. NCHS Data Brief. 2018;(322):1–8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Elizabeth L, Machado P, Zinocker M, et al. Ultra-processed foods and health outcomes: a narrative review. Nutrients. 2020;12(7):1955. doi: https://doi.org/10.3390/nu12071955</mixed-citation><mixed-citation xml:lang="en">Elizabeth L, Machado P, Zinocker M, et al. Ultra-processed foods and health outcomes: a narrative review. Nutrients. 2020;12(7):1955. doi: https://doi.org/10.3390/nu12071955</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lane MM, Davis JA, Beattie S, et al. Ultraprocessed food and chronic noncommunicable diseases: a systematic review and metaanalysis of 43 observational studies. Obes Rev. 2021;22(3):e13146. doi: https://doi.org/10.1111/obr.13146</mixed-citation><mixed-citation xml:lang="en">Lane MM, Davis JA, Beattie S, et al. Ultraprocessed food and chronic noncommunicable diseases: a systematic review and metaanalysis of 43 observational studies. Obes Rev. 2021;22(3):e13146. doi: https://doi.org/10.1111/obr.13146</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Beslay M, Srour B, Mejean C, et al. Ultra-processed food intake in association with BMI change and risk of overweight and obesity: a prospective analysis of the French NutriNet-Sante cohort. PLoS Med. 2020;17(8):e1003256. doi: https://doi.org/10.1371/journal.pmed.1003256</mixed-citation><mixed-citation xml:lang="en">Beslay M, Srour B, Mejean C, et al. Ultra-processed food intake in association with BMI change and risk of overweight and obesity: a prospective analysis of the French NutriNet-Sante cohort. PLoS Med. 2020;17(8):e1003256. doi: https://doi.org/10.1371/journal.pmed.1003256</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Canhada SL, Luft VC, Giatti L, et al. Ultra-processed foods, incident overweight and obesity, and longitudinal changes in weight and waist circumference: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Public Health Nutr. 2020;23(6):1076–1086. doi: https://doi.org/10.1017/S1368980019002854</mixed-citation><mixed-citation xml:lang="en">Canhada SL, Luft VC, Giatti L, et al. Ultra-processed foods, incident overweight and obesity, and longitudinal changes in weight and waist circumference: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Public Health Nutr. 2020;23(6):1076–1086. doi: https://doi.org/10.1017/S1368980019002854</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li M, Shi Z. Association between ultra-processed food consumption and diabetes in Chinese adults — Results from the China Health and Nutrition Survey. Nutrients. 2022;14(20):4241. doi: https://doi.org/10.3390/nu14204241</mixed-citation><mixed-citation xml:lang="en">Li M, Shi Z. Association between ultra-processed food consumption and diabetes in Chinese adults — Results from the China Health and Nutrition Survey. Nutrients. 2022;14(20):4241. doi: https://doi.org/10.3390/nu14204241</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bonaccio M, Ruggiero E, Di Castelnuovo A, et al. Association between late-eating pattern and higher consumption of ultraprocessed food among Italian adults: Findings from the INHES study. Nutrients. 2023;15(6):1497. doi: https://doi.org/10.3390/nu15061497</mixed-citation><mixed-citation xml:lang="en">Bonaccio M, Ruggiero E, Di Castelnuovo A, et al. Association between late-eating pattern and higher consumption of ultraprocessed food among Italian adults: Findings from the INHES study. Nutrients. 2023;15(6):1497. doi: https://doi.org/10.3390/nu15061497</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Konieczna J, Fiol M, Colom A, et al. Does consumption of ultraprocessed foods matter for liver health? Prospective analysis among older adults with metabolic syndrome. Nutrients. 2022;14(19):4142. doi: https://doi.org/10.3390/nu14194142</mixed-citation><mixed-citation xml:lang="en">Konieczna J, Fiol M, Colom A, et al. Does consumption of ultraprocessed foods matter for liver health? Prospective analysis among older adults with metabolic syndrome. Nutrients. 2022;14(19):4142. doi: https://doi.org/10.3390/nu14194142</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mambrini SP, Menichetti F, Ravella S, et al. Ultra-processed food consumption and incidence of obesity and cardiometabolic risk factors in adults: A systematic review of prospective studies. Nutrients. 2023;15(11):2583. doi: https://doi.org/10.3390/nu15112583</mixed-citation><mixed-citation xml:lang="en">Mambrini SP, Menichetti F, Ravella S, et al. Ultra-processed food consumption and incidence of obesity and cardiometabolic risk factors in adults: A systematic review of prospective studies. Nutrients. 2023;15(11):2583. doi: https://doi.org/10.3390/nu15112583</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart RA, Wallentin L, Benatar J, et al. Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease. Eur Heart J. 2016;37(25):1993–2001. doi: https://doi.org/10.1093/eurheartj/ehw125</mixed-citation><mixed-citation xml:lang="en">Stewart RA, Wallentin L, Benatar J, et al. Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease. Eur Heart J. 2016;37(25):1993–2001. doi: https://doi.org/10.1093/eurheartj/ehw125</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chang K, Khandpur N, Neri D, et al. Association between childhood consumption of ultraprocessed food and adiposity trajectories in the Avon Longitudinal Study of Parents and Children birth cohort.jAMA Pediatr. 2021;175(9):e211573. doi: https://doi.org/10.1001/jamapediatrics.2021.1573</mixed-citation><mixed-citation xml:lang="en">Chang K, Khandpur N, Neri D, et al. Association between childhood consumption of ultraprocessed food and adiposity trajectories in the Avon Longitudinal Study of Parents and Children birth cohort.jAMA Pediatr. 2021;175(9):e211573. doi: https://doi.org/10.1001/jamapediatrics.2021.1573</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Heerman WJ, Sneed NM, Sommer EC, et al. Ultra-processed food consumption and BMI-Z among children at risk for obesity from low-income households. Pediatr Obes. 2023;18(8):e13037. doi: https://doi.org/10.1111/ijpo.13037</mixed-citation><mixed-citation xml:lang="en">Heerman WJ, Sneed NM, Sommer EC, et al. Ultra-processed food consumption and BMI-Z among children at risk for obesity from low-income households. Pediatr Obes. 2023;18(8):e13037. doi: https://doi.org/10.1111/ijpo.13037</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Livingston AS, Cudhea F, Wang L, et al. Effect of reducing ultraprocessed food consumption on obesity among US children and adolescents aged 7–18 years: evidence from a simulation model. BMJ Nutr Prev Health. 2021;4(2):397–404. doi: https://doi.org/10.1136/bmjnph-2021-000303</mixed-citation><mixed-citation xml:lang="en">Livingston AS, Cudhea F, Wang L, et al. Effect of reducing ultraprocessed food consumption on obesity among US children and adolescents aged 7–18 years: evidence from a simulation model. BMJ Nutr Prev Health. 2021;4(2):397–404. doi: https://doi.org/10.1136/bmjnph-2021-000303</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ruggiero E, Esposito S, Costanzo S, et al. Ultra-processed food consumption and its correlates among Italian children, adolescents and adults from the Italian Nutrition &amp; Health Survey (INHES) cohort study. Public Health Nutr. 2021;24(18):6258–6271. doi: https://doi.org/10.1017/s1368980021002767</mixed-citation><mixed-citation xml:lang="en">Ruggiero E, Esposito S, Costanzo S, et al. Ultra-processed food consumption and its correlates among Italian children, adolescents and adults from the Italian Nutrition &amp; Health Survey (INHES) cohort study. Public Health Nutr. 2021;24(18):6258–6271. doi: https://doi.org/10.1017/s1368980021002767</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro GJS, de Ara jo Pinto A. Consumption of Ultra-Processed Foods in Brazilian Children: An Analysis of Regional Trends.j Pediatr Nurs. 2021;61:e106–e111. doi: https://doi.org/10.1016/j.pedn.2021.06.006</mixed-citation><mixed-citation xml:lang="en">Ribeiro GJS, de Ara jo Pinto A. Consumption of Ultra-Processed Foods in Brazilian Children: An Analysis of Regional Trends.j Pediatr Nurs. 2021;61:e106–e111. doi: https://doi.org/10.1016/j.pedn.2021.06.006</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolau DA, Castro AG. Characterization of adolescents’ diet with the Dietary Guidelines for the Brazilian population. Mundo Saude. 2018;42(1):98122. doi: https://doi.org/10.15343/01047809.2018420198122</mixed-citation><mixed-citation xml:lang="en">Nicolau DA, Castro AG. Characterization of adolescents’ diet with the Dietary Guidelines for the Brazilian population. Mundo Saude. 2018;42(1):98122. doi: https://doi.org/10.15343/01047809.2018420198122</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Silva JB, Elias BC, Warkentin S, et al. Factors associated with the consumption of ultra-processed food by Brazilian adolescents: National Survey of School Health, 2015. Rev Paul Pediatr. 2021;40:e2020362. doi: https://doi.org/10.1590/19840462/2022/40/2020362</mixed-citation><mixed-citation xml:lang="en">Silva JB, Elias BC, Warkentin S, et al. Factors associated with the consumption of ultra-processed food by Brazilian adolescents: National Survey of School Health, 2015. Rev Paul Pediatr. 2021;40:e2020362. doi: https://doi.org/10.1590/19840462/2022/40/2020362</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">de Melo IS, Costa C, dos Santos JV, et al. Consumption of minimally processed food is inversely associated with excess weight in adolescents living in an underdeveloped city. PLoS One. 2017;12(11):e0188401. doi: https://doi.org/10.1371/journal.pone.0188401</mixed-citation><mixed-citation xml:lang="en">de Melo IS, Costa C, dos Santos JV, et al. Consumption of minimally processed food is inversely associated with excess weight in adolescents living in an underdeveloped city. PLoS One. 2017;12(11):e0188401. doi: https://doi.org/10.1371/journal. pone.0188401</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Louzada ML, Baraldi LG, Steele EM, et al. Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults. Prev Med. 2015;81:915. doi: https://doi.org/10.1016/j.ypmed.2015.07.018</mixed-citation><mixed-citation xml:lang="en">Louzada ML, Baraldi LG, Steele EM, et al. Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults. Prev Med. 2015;81:915. doi: https://doi.org/10.1016/j.ypmed.2015.07.018</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">da Rocha BRS, Rico-Campà A, Romanos-Nanclares A, et al. Adherence to Mediterranean diet is inversely associated with the consumption of ultra-processed foods among Spanish children: the SENDO project. Public Health Nutr. 2021;24(11):3294–3303. doi: https://doi.org/10.1017/s1368980020001524</mixed-citation><mixed-citation xml:lang="en">da Rocha BRS, Rico-Campà A, Romanos-Nanclares A, et al. Adherence to Mediterranean diet is inversely associated with the consumption of ultra-processed foods among Spanish children: the SENDO project. Public Health Nutr. 2021;24(11):3294–3303. doi: https://doi.org/10.1017/s1368980020001524</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Хавкин А.И., Блат С.Ф. Микробиоценоз кишечника и иммунитет // Российский вестник перинатологии и педиатрии. — 2011. — Т. 1. — № 56. — С. 159–174.</mixed-citation><mixed-citation xml:lang="en">Khavkin AI, Blat SF. Intestinal microbiocenosis and immunity. Russian Bulletin of Perinatology and Pediatrics. 2011;1(56):159–174. (In Russ).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
