ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i3.2912ppharm-2646Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWСистематический обзор функциональных аспектов TRPC-каналов в физиологии и клинической практикеFunctional Aspects of TRPC Channels in Physiology and Clinical Practice: a Systematic Reviewhttps://orcid.org/0000-0002-4686-1231НигматуллинаР. Р.NigmatullinaRazina R.

Нигматуллина Разина Рамазановна - д.б.н., профессор.

420012, Казань, ул. Бутлерова д.49

PhD, Professor.

49, Butlerova Str., Kazan, 420012

razinar@mail.ruhttps://orcid.org/0000-0002-6662-3548СадыковаД. И.SadykovaDinara I.

Автор, ответственный за переписку:

Сахипгараева Ильнара Радиковна - практикующий врач-педиатр Детской республиканской клинической больницы.

420064, Казань, ул. Оренбургский тракт, д. 140, тел.: +7 (906) 101-91-35

MD, PhD, Professor, Corresponding member of the Academy of Sciences of the Republic of Tatarstan.

ilnara1307@mail.ruСахипгараеваИ. Р.SakhipgaraevaIlnara R.

Сахипгараева Ильнара Радиковна

Казань

MD.

Kazan

ilnara1307@mail.ruhttps://orcid.org/0000-0002-1732-7443СластниковаЕ. С.SlastnikovaEvgeniya S.

Сластникова Евгения Сергеевна - к.м.н.

Казань

MD, PhD.

Kazan

e.slastnikova@mail.ruhttps://orcid.org/0000-0003-2670-1385БезбрязовА. В.BezbryazovAleksey V.

Безбрязов Алексей Викторович

Казань

MD.

Kazan

dantor@bk.ruКазанский государственный медицинский университетРоссияKazan Medical UniversityRussian FederationДетская республиканская клиническая больницаРоссияRepublican Children’s Clinical HospitalRussian Federation202522072025223315322Copyright © Нигматуллина Р.Р., Садыкова Д.И., Сахипгараева И.Р., Сластникова Е.С., Безбрязов А.В., 20252025Нигматуллина Р.Р., Садыкова Д.И., Сахипгараева И.Р., Сластникова Е.С., Безбрязов А.В.Nigmatullina R.R., Sadykova D.I., Sakhipgaraeva I.R., Slastnikova E.S., Bezbryazov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2646

В данной статье представлен систематический обзор текущих научных исследований, посвященных роли транзиторных рецепторов потенциала, опосредуемых кальцием (TRPC), в различных патофизиологических процессах. Рассмотрены механизмы активации и регуляции канонических каналов переходного рецепторного потенциала и их значимость в контексте заболеваний, связанных с каналопатиями. Особое внимание уделено различным точкам зрения на функционирование TRPC-каналов, их взаимодействие с такими соединениями, как диацилглицерин и белок STIM1. Обзор подчеркивает важность каналов TRPC в регуляции клеточной функции, включая тонус сосудов, фильтрацию почек и гипертрофию сердца, опосредование клеточных реакций на гормоны и факторы роста. Исследования свидетельствуют о многоуровневой активности TRPC, что делает их привлекательными мишенями для фармакологических вмешательств. Являясь ключевыми элементами в патогенезе разнообразных заболеваний, от сердечно-сосудистых до неврологических и иммунных расстройств, TRPC могут стать основой для разработки инновационных терапевтических стратегий. Ключевым новшеством данного обзора являются подробно рассмотренная роль TRPC в контексте заболеваний, в частности каналопатий, и исследование возможностей их фармакологической модуляции с помощью различных стимулов, включая гормоны и нейротрансмиттеры. Работа также подчеркивает перспективы для терапевтического вмешательства, создавая возможности для разработки целенаправленных методов терапии, ориентированных на механизмы конкретных заболеваний. Цель данного обзора — проанализировать и обобщить современные научные исследования, посвященные роли TRPC в патофизиологических процессах, исследованию механизмов активации и регуляции TRPC, а также идентификации механизмов развития заболеваний при каналопатиях. Кроме того, обзор открывает новое поле для дальнейших исследований, подчеркивая важность изучения взаимодействий TRPC с другими сигнальными системами, такими как G-белки и тирозинкиназные рецепторы, что может стимулировать развитие более комплексных комбинированных терапевтических подходов. Таким образом, статья предлагает идеи в понимании сложных патофизиологических ролей TRPC и их потенциального фармакологического применения.

This article provides a systematic review of current research on the role of transient receptor potential calcium (TRPC) channels in various pathophysiological processes. The mechanisms of activation and regulation of canonical transient receptor potential channels and their significance in the context of channelopathy-related diseases are considered. Special attention has been given to various points of view on the functioning of TRPC-channels and their interaction with compounds such as diacylglycerol and STIM1 protein. The review highlights the importance of TRPC channels in regulating cellular function, including vascular tone, renal filtration, and cardiac hypertrophy, as well as mediating cellular responses to hormones and growth factors. Research suggests that TRPC channels exhibit multi-level activity, making them attractive targets for pharmacological interventions. As key elements in the pathogenesis of various diseases, from cardiovascular to neurological and immune disorders, TRPCs can serve as a foundation for the development of innovative therapeutic strategies. The article highlights the potential for therapeutic intervention, creating opportunities for the development of targeted therapies that focus on the mechanisms of specific diseases. The aim of this review is to analyze and summarize current scientific research on the role of TRPC in pathophysiological processes, the mechanisms of TRPC activation and regulation, and the identification of mechanisms for the development of diseases in channelopathies. In addition, the review opens up a new field for further research, emphasizing the importance of studying the interactions of TRPC with other signaling systems, such as G-proteins and tyrosine kinase receptors, which could lead to the development of more comprehensive combined therapeutic approaches. Thus, the article offers insights into the complex pathophysiological roles of TRPCs and their potential pharmacological applications.

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The authors declare that there are no conflicts of interest present.