ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i2.2897ppharm-2601Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL RECOMMENDATIONSСовременные клинические рекомендации по ведению пациентов с острыми тонзиллитом и фарингитомModern Clinical Guidelines for the Management of Patients with Acute Tonsillitis and Pharyngitishttps://orcid.org/0000-0003-2674-4553ДайхесН. А.DayhesNikolai A.

Москва

Moscow

https://orcid.org/0000-0003-3987-8112БарановА. А.BaranovAlexander A.

Москва

Moscow

https://orcid.org/0000-0001-9524-7513ЛобзинЮ. В.LobzinYurii V.

Москва

Moscow

https://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Москва

Moscow

https://orcid.org/0000-0001-8728-1113КозловР. С.KozlovRoman S.

Смоленск

Smolensk

https://orcid.org/0000-0003-1767-5461ПоляковД. П.PolyakovDmitriy P.

Москва

Moscow

https://orcid.org/0000-0002-2501-6389КарнееваО. В.KarneevaOlga V.

Москва

Moscow

https://orcid.org/0000-0001-9811-8397ГуровА. В.GurovAlexander V.

Москва

Moscow

https://orcid.org/0000-0001-6096-2082ТулуповД. А.TulupovDenis A.

Москва

Moscow

https://orcid.org/0000-0003-1710-3092РязанцевС. В.RyazantsevSergey V.

Санкт-Петербург

Saint-Petersburg

https://orcid.org/0000-0002-5024-6135ГаращенкоТ. И.GarashchenkoTatiana I.

Москва

Moscow

https://orcid.org/0000-0003-1078-6388КимИ. А.KimIrina A.

Москва

Moscow

https://orcid.org/0000-0001-7916-1488АндрееваИ. В.AndreevaIrina V.

Смоленск

Smolensk

https://orcid.org/0000-0001-6474-6766БакрадзеМ. Д.BakradzeMaya D.

Москва

Moscow

https://orcid.org/0000-0003-4655-3375ПоляковаА. С.PolyakovaAnastasia S.

Москва

Moscow

https://orcid.org/0000-0001-7398-0562ВишнёваЕ. А.VishnevaElena A.

Москва

Moscow

https://orcid.org/0000-0002-3678-7939СелимзяноваЛ. Р.SelimzyanovaLilia R.

Селимзянова Лилия Робертовна - кандидат медицинских наук, заведующая отделом стандартизации и изучения основ доказательной медицины НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского», врач-пульмонолог.

119333, Москва, ул. Фотиевой, д. 10, тел.: +7 (499) 400-47-33

Moscow

lilysir@mail.ruhttps://orcid.org/0000-0001-8085-4513ТаточенкоВ. К.TatochenkoVladimir K.

Москва

Moscow

https://orcid.org/0000-0002-7447-0625КуличенкоТ. В.KulichenkoTatiana V.

Москва

Moscow

Национальный медицинский исследовательский центр оториноларингологииРоссияNational Medical Research Center for OtorhinolaryngologyRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Sechenov First Moscow State Medical UniversityRussian FederationДетский научно-клинический центр инфекционных болезнейРоссияChildren’s Research and Clinical Center for Infectious DiseasesRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет); НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryRussian FederationСмоленский государственный медицинский университетРоссияSmolensk State Medical UniversityRussian FederationНациональный медицинский исследовательский центр оториноларингологии; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияNational Medical Research Center for Otorhinolaryngology; Pirogov Russian National Research Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияPirogov Russian National Research Medical UniversityRussian FederationРоссийская Федерация Российская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationСанкт-Петербургский научно-исследовательский институт оториноларингологииРоссияSaint-Petersburg Research Institute of Ear, Throat, Nose and SpeechRussian FederationНациональный медицинский центр здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет); НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Sechenov First Moscow State Medical UniversityRussian Federation202523052025222164177Copyright © Дайхес Н.А., Баранов А.А., Лобзин Ю.В., Намазова-Баранова Л.С., Козлов Р.С., Поляков Д.П., Карнеева О.В., Гуров А.В., Тулупов Д.А., Рязанцев С.В., Гаращенко Т.И., Ким И.А., Андреева И.В., Бакрадзе М.Д., Полякова А.С., Вишнёва Е.А., Селимзянова Л.Р., Таточенко В.К., Куличенко Т.В., 20252025Дайхес Н.А., Баранов А.А., Лобзин Ю.В., Намазова-Баранова Л.С., Козлов Р.С., Поляков Д.П., Карнеева О.В., Гуров А.В., Тулупов Д.А., Рязанцев С.В., Гаращенко Т.И., Ким И.А., Андреева И.В., Бакрадзе М.Д., Полякова А.С., Вишнёва Е.А., Селимзянова Л.Р., Таточенко В.К., Куличенко Т.В.Dayhes N.A., Baranov A.A., Lobzin Y.V., Namazova-Baranova L.S., Kozlov R.S., Polyakov D.P., Karneeva O.V., Gurov A.V., Tulupov D.A., Ryazantsev S.V., Garashchenko T.I., Kim I.A., Andreeva I.V., Bakradze M.D., Polyakova A.S., Vishneva E.A., Selimzyanova L.R., Tatochenko V.K., Kulichenko T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2601

Острые тонзиллит и фарингит являются распространенными инфекционными заболеваниями верхних дыхательных путей, которые могут вызывать значительный дискомфорт и осложнения у пациентов. В статье подробно рассмотрены вопросы этиологии, патогенеза, классификации тонзиллита и фарингита. Современные клинические рекомендации направлены на оптимизацию диагностики, лечения и профилактики этих состояний, обеспечивая высокое качество медицинской помощи.

Для дифференциальной диагностики вирусного и стрептококкового тонзиллофарингита можно использовать шкалы Центора, Мак-Айзека или FeverPAIN. Особое внимание уделено тактике ведения пациентов при этих заболеваниях, в том числе выбору антибактериальной терапии при стрептококковом тонзиллите. Современные клинические рекомендации подчеркивают необходимость индивидуального подхода к каждому пациенту, учитывая его возраст, сопутствующие заболевания и особенности течения инфекции. Внедрение этих рекомендаций в практику позволяет повысить эффективность лечения, снизить риск осложнений и улучшить качество жизни пациентов с острыми тонзиллитом и фарингитом.

Acute tonsillitis and pharyngitis are common infectious diseases of upper respiratory tract causing significant discomfort and various complications in patients. This article covers all the issues of tonsillitis and pharyngitis etiology, pathogenesis, classification. Modern clinical guidelines focus on optimizing the diagnosis, management, and prevention of these conditions, ensuring high quality of medical care.

Centor, McIsaac, or FeverPAIN scores can be used for differential diagnosis of viral and streptococcal tonsillopharyngitis. Particular attention is given to the management tactics of patients with these diseases, including the antibiotic therapy for streptococcal tonsillitis. Modern clinical guidelines emphasize the need for individual approach for every patient considering their age, concomitant diseases, and infection course aspects. These guidelines implementation in practice can increase the treatment efficacy, reduce the risk of any complications, and improve the quality of life of patients with acute tonsillitis and pharyngitis.

тонзиллитфарингиттонзиллофарингитБГСАдетистрептококкклинические рекомендацииtonsillitispharyngitistonsillopharyngitisgroup A beta-hemolytic streptococcus (GABHS)childrenstreptococcusclinical guidelinesОтсутствуетNot specifiedReferencesКарнеева О.В., Дайхес Н.А., Поляков Д.П. Протоколы диагностики и лечения острых тонзиллофарингитов // РМЖ. Оториноларингология. — 2015. — Т. 23. — № 6. — С. 307–311.Karneeva OV, Daikhes NA, Polyakov DP. Protokoly diagnostiki i lecheniya ostrykh tonzillofaringitov. RMJ. Otorhinolaryngology. 2015;23(6):307–311. (In Russ).Kenealy T. Sore throat. BMJ Clin Evid. 2014;2014:1509.Kenealy T. Sore throat. BMJ Clin Evid. 2014;2014:1509.Krajewska J, Krajewski W, Zub K, Zatoński T. COVID-19 in otolaryngologist practice: a review of current knowledge. Eur Arch Otorhinolaryngol. 2020;277(7):1885–1897. doi: https://doi.org/10.1007/s00405-020-05968-yKrajewska J, Krajewski W, Zub K, Zatoński T. COVID-19 in otolaryngologist practice: a review of current knowledge. Eur Arch Otorhinolaryngol. 2020;277(7):1885–1897. doi: https://doi.org/10.1007/s00405-020-05968-yPokala U, Potnuru S, Kanapalli S, et al. A Comparative Study on the General and Otolaryngological Manifestations of COVID-19 in the Hospitalized Population of the Telangana Region During the First and Second Waves. Int Arch Otorhinolaryngol. 2024;28(1):e3–e11. doi: https://doi.org/10.1055/s-0043-1777419Pokala U, Potnuru S, Kanapalli S, et al. A Comparative Study on the General and Otolaryngological Manifestations of COVID-19 in the Hospitalized Population of the Telangana Region During the First and Second Waves. Int Arch Otorhinolaryngol. 2024;28(1):e3–e11. doi: https://doi.org/10.1055/s-0043-1777419Grag K, Shubhanshu K. Effect of Covid-19 in Otorhinolaryngology Practice: A Review. Indian J Otolaryngol Head Neck Surg. 2022;74(Suppl 2):2699–2702. doi: https://doi.org/10.1007/s12070-020-02040-3Grag K, Shubhanshu K. Effect of Covid-19 in Otorhinolaryngology Practice: A Review. Indian J Otolaryngol Head Neck Surg. 2022;74(Suppl 2):2699–2702. doi: https://doi.org/10.1007/ s12070-020-02040-3Кузьменков А.Ю., Трушин И.В., Авраменко А.А. и др. AMRmap: Интернет-платформа мониторинга антибиотикорезистентности // Клиническая микробиология и антимикробная химиотерапия. — 2017. — Т. 19. — № 2. — С. 84–90.Kuzmenkov AYu, Trushin IV, Avramenko AA, et al. AMRmap: an online platform for monitoring antibiotic resistance. Clinical Microbiology and Antimicrobial Chemotherapy. 2017;19(2):84–90. (In Russ).Поляков Д.П. Современные аспекты диагностики острого стрептококкового тонзиллофарингита у детей // Вопросы современной педиатрии. — 2013. — Т. 12. — № 3. — С. 46–51. — doi: https://doi.org/10.15690/vsp.v12i3.680Polyakov DP. Current aspects of acute streptococcal tonsillopharyngitis diagnostics in children. Voprosy sovremennoi pediatrii — Current Pediatrics. 2013;12(3):46–51. (In Russ). doi: https://doi.org/10.15690/vsp.v12i3.680Pelucchi C, Grigoryan L, Galeone C, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect. 2012;18 Suppl 1:1–28. doi: https://doi.org/10.1111/j.14690691.2012.03766.xPelucchi C, Grigoryan L, Galeone C, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect. 2012;18 Suppl 1:1–28. doi: https://doi.org/10.1111/j.14690691.2012.03766.xShulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A Streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55(10):e86–e102. doi: https://doi.org/10.1093/cid/cis629Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A Streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55(10):e86–e102. doi: https://doi.org/10.1093/cid/cis629McIsaac WJ, Goel V, To T, Low DE. The validity of sore throat score in family practice. CMAJ. 2000;163(7):811–815.McIsaac WJ, Goel V, To T, Low DE. The validity of sore throat score in family practice. CMAJ. 2000;163(7):811–815.Яковлев С.В. Стратегия и тактика рационального применения антимикробных средств в амбулаторной практике // Вестник практического врача. — 2016. — № 1. — С. 23–28.Yakovlev SV. Strategiya i taktika ratsional’nogo primeneniya antimikrobnykh sredstv v ambulatornoi praktike. Vestnik prakticheskogo vracha. 2016;(1):23–28. (In Russ).Oliver J, Malliya Wadu E, Pierse N, et al. Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis. PLoS Negl Trop Dis. 2018;12(3):e0006335. doi: https://doi.org/10.1371/journal.pntd.0006335Oliver J, Malliya Wadu E, Pierse N, et al. Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis. PLoS Negl Trop Dis. 2018;12(3):e0006335. doi: https://doi.org/10.1371/journal.pntd.0006335Low DE. Non Pneumococcal streptococcal infections, rheumatic fever. In: Goldman’s Cecil Medicine. Goldman L, Schafer AI, eds. 24th edn. Philadelphia: Elsevier Saunders; 2012. Vol. 2. pp. 1823–1829.Low DE. Non Pneumococcal streptococcal infections, rheumatic fever. In: Goldman’s Cecil Medicine. Goldman L, Schafer AI, eds. 24th edn. Philadelphia: Elsevier Saunders; 2012. Vol. 2. pp. 1823–1829.Choby BA. Diagnosis and treatment of streptococcal pharyngitis. Am Fam Physician. 2009;79(5):383–390.Choby BA. Diagnosis and treatment of streptococcal pharyngitis. Am Fam Physician. 2009;79(5):383–390.Дарманян А.С. Совершенствование методов диагностики и лечения острых тонзиллитов у детей: дис. … канд. мед. наук. — М.; 2010. — 129 с.Darmanyan AS. Sovershenstvovanie metodov diagnostiki i lecheniya ostrykh tonzillitov u detei. [dissertation]. Moscow; 2010. 129 p. (In Russ).Boccazzi A, Garotta M, Pontari S, Agostoni CV. Streptococcal tonsillopharyngitis: clinical vs. microbiological diagnosis. Infez Med. 2011;19(2):100–105.Boccazzi A, Garotta M, Pontari S, Agostoni CV. Streptococcal tonsillopharyngitis: clinical vs. microbiological diagnosis. Infez Med. 2011;19(2):100–105.Centor RM, Witherspoon JM, Dalton HP, et al. The diagnosis of strep throat in adults in the emergency room. Med Decis Making. 1981;1(3):239–246. doi: https://doi.org/10.1177/0272989X8100100304Centor RM, Witherspoon JM, Dalton HP, et al. The diagnosis of strep throat in adults in the emergency room. Med Decis Making. 1981;1(3):239–246. doi: https://doi.org/10.1177/0272989X8100100304McIsaac WJ, White D, Tannenbaum D, Low DE. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. Can Med Assoc J. 1998;158(1):75–83.McIsaac WJ, White D, Tannenbaum D, Low DE. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. Can Med Assoc J. 1998;158(1):75–83.Little P, Hobbs FD, Moore M, et al. Clinical score and rapid antigen detection test to guide antibiotic use for sore throats: randomised controlled trial of PRISM (primary care streptococcal management). BMJ. 2013;347:f5806. doi: https://doi.org/10.1136/bmj.f5806Little P, Hobbs FD, Moore M, et al. Clinical score and rapid antigen detection test to guide antibiotic use for sore throats: randomised controlled trial of PRISM (primary care streptococcal management). BMJ. 2013;347:f5806. doi: https://doi.org/10.1136/bmj.f5806Fine AM, Nizet V, Mandl KD. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med. 2012;172(11):847–852. doi: https://doi.org/10.1001/archinternmed.2012.950Fine AM, Nizet V, Mandl KD. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med. 2012;172(11):847–852. doi: https://doi.org/10.1001/archinternmed.2012.950Fornes Vivas R, Robledo Díaz L, Carvajal Roca E, et al. Utility of clinical criteria for the adequate diagnosis of the pharingoamigdalitis in the pediatric emergency service. Rev Esp Salud Publica. 2019;93:e201911061.Fornes Vivas R, Robledo Díaz L, Carvajal Roca E, et al. Utility of clinical criteria for the adequate diagnosis of the pharingoamigdalitis in the pediatric emergency service. Rev Esp Salud Publica. 2019;93:e201911061.Thai TN, Dale AP, Ebell MH. Signs and symptoms of Group A versus Non-Group A strep throat: A meta-analysis. Fam Pract. 2018;35(3):231–238. doi: https://doi.org/10.1093/fampra/cmx072Thai TN, Dale AP, Ebell MH. Signs and symptoms of Group A versus Non-Group A strep throat: A meta-analysis. Fam Pract. 2018;35(3):231–238. doi: https://doi.org/10.1093/fampra/ cmx072Cohen JF, Bertille N, Cohen R, Chalumeau M. Rapid antigen detection test for group A streptococcus in children with pharyngitis. Cochrane Database Syst Rev. 2016;7(7):CD010502. doi: https://doi.org/10.1002/14651858.CD010502.pub2Cohen JF, Bertille N, Cohen R, Chalumeau M. Rapid antigen detection test for group A streptococcus in children with pharyngitis. Cochrane Database Syst Rev. 2016;7(7):CD010502. doi: https://doi.org/10.1002/14651858.CD010502.pub2Stewart EH, Davis B, Clemans-Taylor BL, et al. Rapid antigen group A streptococcus test to diagnose pharyngitis: a systematic review and meta-analysis. PLoS One. 2014;9(11):e111727. doi: https://doi.org/10.1371/journal.pone.0111727Stewart EH, Davis B, Clemans-Taylor BL, et al. Rapid antigen group A streptococcus test to diagnose pharyngitis: a systematic review and meta-analysis. PLoS One. 2014;9(11):e111727. doi: https://doi.org/10.1371/journal.pone.0111727Giraldez-Garcia C, Rubio B, Gallegos-Braun JF, et al. Diagnosis and management of acute pharyngitis in a paediatric population: a cost-effectiveness analysis. Eur J Pediatr. 2011;170(8):1059– 1067. doi: https://doi.org/10.1007/s00431-011-1410-0Giraldez-Garcia C, Rubio B, Gallegos-Braun JF, et al. Diagnosis and management of acute pharyngitis in a paediatric population: a cost-effectiveness analysis. Eur J Pediatr. 2011;170(8):1059– 1067. doi: https://doi.org/10.1007/s00431-011-1410-0Snow V, Mottur-Pilson C, Cooper RJ, Hoffman JR. Principles of appropriate antibiotic use for acute pharyngitis in adults. Ann Intern Med. 2001;134(6):506–508. doi: https://doi.org/10.7326/00034819-134-6-200103200-00018Snow V, Mottur-Pilson C, Cooper RJ, Hoffman JR. Principles of appropriate antibiotic use for acute pharyngitis in adults. Ann Intern Med. 2001;134(6):506–508. doi: https://doi.org/10.7326/00034819-134-6-200103200-00018Роспотребнадзор. Инфекционная заболеваемость в Российской Федерации 2015, 2016, 2017, 2018, 2019, 2020. Доступно по: https://www.rospotrebnadzor.ru/activities/statisticalmaterials. Ссылка активна на 06.04.2025.Rospotrebnadzor. Infektsionnaya zabolevaemost’ v Rossiiskoi Federatsii 2015, 2016, 2017, 2018, 2019, 2020. (In Russ). Доступно по: https://www.rospotrebnadzor.ru/activities/statisticalmaterials. Ссылка активна на 06.04.2025.Отвагин И.В., Соколов Н.С. Современные аспекты диагностики инфекций, вызванных стрептококками группы А // Клиническая микробиология и антимикробная химиотерапия. — 2011. — Т. 13. — № 3. — С. 223–230.Otvagin IV, Sokolov NS. Current issues of the diagnosis of infections caused by group A Streptococci. Clinical Microbiology and Antimicrobial Chemotherapy. 2011;13(3):223–230. (In Russ).ГОСТ Р 53079.4-2008. Технологии лабораторные клинические. Обеспечение качества клинических лабораторных исследований. — М.: Стандартинформ; 2009. — 66 с.GOST R 53079.42008. Tekhnologii laboratornye klinicheskie. Obespechenie kachestva klinicheskikh laboratornykh issledovanii. Moscow: Standartinform; 2009. 66 p. (In Russ).Wolford RW, Goyal A, Belgam Syed SY, Schaefer TJ. Pharyngitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available online: https://www.ncbi.nlm.nih.gov/books/NBK519550. Accessed on April 06, 2025.Wolford RW, Goyal A, Belgam Syed SY, Schaefer TJ. Pharyngitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Available online: https://www.ncbi.nlm.nih.gov/books/ NBK519550. Accessed on April 06, 2025.Windfuhr JP, Toepfner N, Steffen G, et al. Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management. Eur Arch Otorhinolaryngol. 2016;273(4):973–987. doi: https://doi.org/10.1007/s00405-015-3872-6Windfuhr JP, Toepfner N, Steffen G, et al. Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management. Eur Arch Otorhinolaryngol. 2016;273(4):973–987. doi: https://doi.org/10.1007/s00405-015-3872-6Таточенко В.К. Антибиотикои химиотерапия инфекций у детей. — М.: ИПК Континент-Пресс; 2008. — 256 с.Tatochenko VK. Antibiotikoi khimioterapiya infektsii u detei. Moscow: IPK KontinentPress; 2008. 256 p. (In Russ).Kalra MG, Higgins KE, Perez ED. Common Questions About Streptococcal Pharyngitis. Am Fam Physician. 2016;94(1):24–31.Kalra MG, Higgins KE, Perez ED. Common Questions About Streptococcal Pharyngitis. Am Fam Physician. 2016;94(1):24–31.Førsvoll J, Kristoffersen EK, Øymar K. The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review. Int J Pediatr Otorhinolaryngol. 2019;130:109795. doi: https://doi.org/10.1016/j.ijporl.2019.1097957Førsvoll J, Kristoffersen EK, Øymar K. The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review. Int J Pediatr Otorhinolaryngol. 2019;130:109795. doi: https://doi.org/10.1016/j.ijporl.2019.1097957Артюшкин С.А., Еремина Н.В. Дифференциальная диагностика и рациональная терапия вирусных поражений верхних дыхательных путей // РМЖ. Оториноларингология. — 2016. — Т. 24. — № 4. — С. 245–250.Artyushkin SA, Eremina NV. Differential diagnosis and rational therapy of upper airway diseases due to viral infections. RMJ. Otorhinolaryngology. 2016;24(4):245– 250. (In Russ).Chiappini E, Regoli M, Bonsignori F, et al. Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children. Clin Ther. 2011;33(1):48– 58. doi: https://doi.org/10.1016/j.clinthera.2011.02.001Chiappini E, Regoli M, Bonsignori F, et al. Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children. Clin Ther. 2011;33(1):48– 58. doi: https://doi.org/10.1016/j.clinthera.2011.02.001Pichichero ME. The rising incidence of penicillin treatment failures in group A streptococcal tonsillopharyngitis: an emerging role for the cephalosporins? Ped Inf Dis J. 1991;10(10 Suppl):S50– S55. doi: https://doi.org/10.1097/00006454-19911000100011Pichichero ME. The rising incidence of penicillin treatment failures in group A streptococcal tonsillopharyngitis: an emerging role for the cephalosporins? Ped Inf Dis J. 1991;10(10 Suppl):S50– S55. doi: https://doi.org/10.1097/00006454-19911000100011Zwart S, Rovers MM, de Melker RA, Hoes AW. Penicillin for acute sore throat in children: randomised, double blind trial. BMJ. 2003;327(7427):1324. doi: https://doi.org/10.1136/bmj.327.7427.1324Zwart S, Rovers MM, de Melker RA, Hoes AW. Penicillin for acute sore throat in children: randomised, double blind trial. BMJ. 2003;327(7427):1324. doi: https://doi.org/10.1136/bmj.327.7427.1324Сидоренко С.В., Яковлев С.В., Спичак Т.В. и др. Стратегия и тактика рационального применения антимикробных средств в амбулаторной практике. Евразийские клинические рекомендации. 2016 год // Consilium Medicum. Педиатрия (Прил.). — 2017. — № 1. — С. 17–25.Sidorenko SV, Yakovlev SV, Spichak TV, et al. Strategy and tactics of the rational use of antimicrobial drugs in outpatient practice. Eurasian clinical guidelines. 2016.Андреева И.В., Стецюк О.У., Егорова О.А. Инфекции дыхательных путей в педиатрической практике: сложные ответы на простые вопросы // РМЖ. Мать и дитя. — 2020. — Т. 30. — № 2. — С. 105–111. — doi: https://doi.org/10.32364/26188430-2020-3-2-105-111Andreeva IV, Stetsyuk OU, Egorova OA. Respiratory tract infections in pediatrics: difficult answers to simple questions. Russian Journal of Woman and Child Health. 2020;3(2):105–111. doi: https://doi.org/10.32364/2618-84302020-3-2-105-111Резолюция Экспертного совета «Принципы рациональной антибиотикотерапии респираторных инфекций у детей. Сохраним антибиотики для будущих поколений». 31 марта 2018 г., Москва // Педиатрия (Прил. к журн. Consilium Medicum). — 2018. — № 3. — С. 10–15. — doi: https://doi.org/10.26442/24138460_2018.3.10-15Resolution of the Expert Council “Principles of rational antibiotic therapy of respiratory infections in children. Let’s preserve antibiotics for future generations”. March 31, 2018, Moscow. Pediatrics (Suppl. Consilium Medicum). 2018;(3):10–15. (In Russ). doi: https://doi.org/10.26442/2413-8460_2018.3.1015Стецюк О.У., Андреева И.В., Егорова О.А. Антибиотико-резистентность основных возбудителей ЛОР-заболеваний // РМЖ. Медицинское обозрение. — 2019. — Т. 3. — № 9-2. — С. 78–83.Stetsyuk OU, Andreeva IV, Egorova OA. Antibiotic resistance of the main ENT pathogens. RMJ. Medical Review. 2019;3(9-2):78–83. (In Russ).]Hocqueloux L, Guinard J, Buret J, et al. Do penicillins really increase the frequency of a rash when given during Epstein-Barr Virus primary infection? Clin Infect Dis. 2013;57(11):1661–1662. doi: https://doi.org/10.1093/cid/cit553Hocqueloux L, Guinard J, Buret J, et al. Do penicillins really increase the frequency of a rash when given during Epstein-Barr Virus primary infection? Clin Infect Dis. 2013;57(11):1661–1662. doi: https://doi.org/10.1093/cid/cit553Dibek Misirlioglu E, Guvenir H, Ozkaya Parlakay A, et al. Incidence of Antibiotic-Related Rash in Children with Epstein-Barr Virus Infection and Evaluation of the Frequency of Confirmed Antibiotic Hypersensitivity. Int Arch Allergy Immunol. 2018;176(1):33–38. doi: https://doi.org/10.1159/000481988Dibek Misirlioglu E, Guvenir H, Ozkaya Parlakay A, et al. Incidence of Antibiotic-Related Rash in Children with Epstein-Barr Virus Infection and Evaluation of the Frequency of Confirmed Antibiotic Hypersensitivity. Int Arch Allergy Immunol. 2018;176(1):33–38. doi: https://doi.org/10.1159/000481988Mahakit P, Vicente JG, Butt DI, et al. Oral clindamycin 300 mg BID compared with oral amoxicillin/clavulanic acid 1 g BID in the outpatient treatment of acute recurrent pharyngotonsillitis caused by group a beta-hemolytic streptococci: an international, multicenter, randomized, investigator-blinded, prospective trial in patients between the ages of 12 and 60 years. Clin Ther. 2006;28(1):99– 109. doi: https://doi.org/10.1016/j.clinthera.2006.01.006Mahakit P, Vicente JG, Butt DI, et al. Oral clindamycin 300 mg BID compared with oral amoxicillin/clavulanic acid 1 g BID in the outpatient treatment of acute recurrent pharyngotonsillitis caused by group a beta-hemolytic streptococci: an international, multicenter, randomized, investigator-blinded, prospective trial in patients between the ages of 12 and 60 years. Clin Ther. 2006;28(1):99– 109. doi: https://doi.org/10.1016/j.clinthera.2006.01.006Munck H, Jørgensen AW, Klug TE. Antibiotics for recurrent acute pharyngo-tonsillitis: systematic review. Eur J Clin Microbiol Infect Dis. 2018;37(7):1221–1230. doi: https://doi.org/10.1007/s10096018-3245-3Munck H, Jørgensen AW, Klug TE. Antibiotics for recurrent acute pharyngo-tonsillitis: systematic review. Eur J Clin Microbiol Infect Dis. 2018;37(7):1221–1230. doi: https://doi.org/10.1007/s10096018-3245-3Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004;113:866–882. doi: https://doi.org/10.1542/peds.113.4.866Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004;113:866–882. doi: https://doi.org/10.1542/peds.113.4.866Granizo JJ, Giménez MJ, Barberán J, et al. Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials. Rev Esp Quimioter. 2008;21(1):14–21.Granizo JJ, Giménez MJ, Barberán J, et al. Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials. Rev Esp Quimioter. 2008;21(1):14–21.Pichichero ME, Casey JR. Bacterial eradication rates with shortened courses of 2ndand 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Diagn Microbiol Infect Dis. 2007;59(2):127–130. doi: https://doi.org/10.1016/j.diagmicrobio.2007.04.010Pichichero ME, Casey JR. Bacterial eradication rates with shortened courses of 2ndand 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Diagn Microbiol Infect Dis. 2007;59(2):127–130. doi: https://doi.org/10.1016/j.diagmicrobio.2007.04.010Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007;57(3 Suppl):13S–18S. doi: https://doi.org/10.1016/j.diagmicrobio.2006.12.004Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007;57(3 Suppl):13S–18S. doi: https://doi.org/10.1016/j.diagmicrobio.2006.12.004Pichichero ME. Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007;57(3 Suppl):13S–18S. doi: https://doi.org/10.1016/j.diagmicrobio.2006.12.004Pichichero ME. Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007;57(3 Suppl):13S–18S. doi: https://doi.org/10.1016/j.diagmicrobio.2006.12.004Atanasković-Marković M, Velicković TC, Gavrović-Jankulović M, et al. Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children. Pediatr Allergy Immunol. 2005;16(4):341–347. doi: https://doi.org/10.1111/j.1399-3038.2005.00280.xAtanasković-Marković M, Velicković TC, Gavrović-Jankulović M, et al. Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children. Pediatr Allergy Immunol. 2005;16(4):341–347. doi: https://doi.org/10.1111/j.1399-3038.2005.00280.xNorton AE, Konvinse K, Phillips EJ, Broyles AD. Antibiotic Allergy in Pediatrics. Pediatrics. 2018;141(5):e20172497. doi: https://doi.org/10.1542/peds.2017-2497Norton AE, Konvinse K, Phillips EJ, Broyles AD. Antibiotic Allergy in Pediatrics. Pediatrics. 2018;141(5):e20172497. doi: https://doi.org/10.1542/peds.2017-2497Mirakian R, Leech SC, Krishna MT, et al. Management of allergy to penicillins and other beta-lactams. Clin Exp Allergy. 2015;45(2):300–327. doi: https://doi.org/10.1111/cea.12468Mirakian R, Leech SC, Krishna MT, et al. Management of allergy to penicillins and other beta-lactams. Clin Exp Allergy. 2015;45(2):300–327. doi: https://doi.org/10.1111/cea.12468Granowitz EV, Brown RB. Antibiotic adverse reactions and drug interactions. Crit Care Clin. 2008;24(2):421–442, xi. doi: https://doi.org/10.1016/j.ccc.2007.12.011Granowitz EV, Brown RB. Antibiotic adverse reactions and drug interactions. Crit Care Clin. 2008;24(2):421–442, xi. doi: https://doi.org/10.1016/j.ccc.2007.12.011Har D, Solensky R. Penicillin and Beta-Lactam Hypersensitivity. Immunol Allergy Clin North Am. 2017;37(4):643–662. doi: https://doi.org/10.1016/j.iac.2017.07.001Har D, Solensky R. Penicillin and Beta-Lactam Hypersensitivity. Immunol Allergy Clin North Am. 2017;37(4):643–662. doi: https://doi.org/10.1016/j.iac.2017.07.001Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review. JAMA. 2019;321(2):188–199. doi: https://doi.org/10.1001/jama.2018.19283Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and Management of Penicillin Allergy: A Review. JAMA. 2019;321(2):188–199. doi: https://doi.org/10.1001/jama.2018.19283Zagursky RJ, Pichichero ME. Cross-reactivity in β-Lactam Allergy. J Allergy Clin Immunol Pract. 2018;6(1):72–81. doi: https://doi.org/10.1016/j.jaip.2017.08.027Zagursky RJ, Pichichero ME. Cross-reactivity in β-Lactam Allergy. J Allergy Clin Immunol Pract. 2018;6(1):72–81. doi: https://doi.org/10.1016/j.jaip.2017.08.027Крюков А.И., Кунельская Н.Л., Гуров А.В. и др. Фармакотерапия гнойно-воспалительной патологии ЛОР-органов: методические рекомендации ДЗ г. Москвы. — М.: Изд-во ДЗ г. Москвы; 2018. — С. 55.Kryukov AI, Kunel’skaya NL, Gurov AV, et al. Farmakoterapiya gnoino-vospalitel’noi patologii LOR-organov: Methodological recommendations of the Moscow City Department of Health. Moscow: Publishing house of the Moscow City Department of Health; 2018. p. 55. (In Russ).]Сидоренко С.В. Проблемы этиотропной терапии внебольничных инфекций дыхательных путей // Consilium Medicum. — 2002. — Т. 4. — № 1. — С. 4–9.Sidorenko SV. Problemy etiotropnoi terapii vnebol’nichnykh infektsii dykhatel’nykh putei. Consilium Medicum. 2002;4(1):4–9 (In Russ).Altamimi S, Khalil A, Khalaiwi KA, et al. Short-term lategeneration antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev. 2012;(8):CD004872. doi: https://doi.org/10.1002/14651858.CD004872.pub3Altamimi S, Khalil A, Khalaiwi KA, et al. Short-term lategeneration antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev. 2012;(8):CD004872. doi: https://doi.org/10.1002/14651858.CD004872.pub3van Driel ML, De Sutter AI, Habraken H, et al. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database Syst Rev. 2016;9(9):CD004406. doi: https://doi.org/10.1002/14651858.CD004406.pub4van Driel ML, De Sutter AI, Habraken H, et al. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database Syst Rev. 2016;9(9):CD004406. doi: https://doi.org/10.1002/14651858.CD004406.pub4Waitayangkoon P, Moon SJ, Tirupur Ponnusamy JJ, et al. Long-Term Safety Profiles of Macrolides and Tetracyclines: A Systematic Review and Meta-Analysis. J Clin Pharmacol. 2024;64(2):164–177. doi: https://doi.org/10.1002/jcph.2358Waitayangkoon P, Moon SJ, Tirupur Ponnusamy JJ, et al. Long-Term Safety Profiles of Macrolides and Tetracyclines: A Systematic Review and Meta-Analysis. J Clin Pharmacol. 2024;64(2):164–177. doi: https://doi.org/10.1002/jcph.2358Hansen MP, Scott AM, McCullough A, et al. Adverse events in people taking macrolide antibiotics versus placebo for any indication. Cochrane Database Syst Rev. 2019;1(1):CD011825. doi: https://doi.org/10.1002/14651858.CD011825.pub2Hansen MP, Scott AM, McCullough A, et al. Adverse events in people taking macrolide antibiotics versus placebo for any indication. Cochrane Database Syst Rev. 2019;1(1):CD011825. doi: https://doi.org/10.1002/14651858.CD011825.pub2Шпынев К.В., Кречикова О.И., Кречиков В.А., Козлов Р.С. Streptococcus pyogenes: характеристика микроорганизма, выделение, идентификация и определение чувствительности к антибактериальным препаратам // Клиническая микробиология и антимикробная химиотерапия. — 2007. — Т. 9. — № 2. — С. 104–120.Shpynev KV, Kretchikova OI, Kretchikov VA, Kozlov RS. Streptococcus pyogenes: Characteristics of the Pathogen, Isolation, Identification and Susceptibility Testing. Clinical Microbiology and Antimicrobial Chemotherapy. 2007;9(2):104–120. (In Russ).Андреева И.В., Стецюк О.У., Азовскова О.В., Козлов Р.С. Терапия острого тонзиллофарингита: современные рекомендации и российские особенности // Клиническая микробиология и антимикробная химиотерапия. — 2013. — Т. 15. — № 3. — С. 198–211.Andreeva IV, Stetsiouk ОU, Azovskova ОV, Kozlov RS. Treatment of Acute Tonsillitis/Pharyngitis: Current Guidelines and Russian Local Situation. Clinical Microbiology and Antimicrobial Chemotherapy. 2013;15(3):198–211. (In Russ).Casey JR, Pichichero ME. Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis. Clin Infect Dis. 2005;40(12):1748–1755. doi: https://doi.org/10.1086/430307Casey JR, Pichichero ME. Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis. Clin Infect Dis. 2005;40(12):1748–1755. doi: https://doi.org/10.1086/430307Kaplan EL, Gooch III WM, Notario GF, Craft JC. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin Infect Dis. 2001;32(12):1798–1802. doi: https://doi.org/10.1086/320745Kaplan EL, Gooch III WM, Notario GF, Craft JC. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin Infect Dis. 2001;32(12):1798–1802. doi: https://doi.org/10.1086/320745Addy LD, Martin MV. Clindamycin and dentistry. Br Dent J. 2005;199(1):23–26. doi: https://doi.org/10.1038/sj.bdj.4812535Addy LD, Martin MV. Clindamycin and dentistry. Br Dent J. 2005;199(1):23–26. doi: https://doi.org/10.1038/sj.bdj.4812535Bombassaro AM, Wetmore SJ, John MA. Clostridium difficile colitis following antibiotic prophylaxis for dental procedures. J Can Dent Assoc. 2001;67(1):20–22.Bombassaro AM, Wetmore SJ, John MA. Clostridium difficile colitis following antibiotic prophylaxis for dental procedures. J Can Dent Assoc. 2001;67(1):20–22.Seppala H, Nissinen A, Jarvinen H, et al. Resistance to erythromycin in group A streptococci. N Engl J Med. 1992;326:292–297. doi: https://doi.org/10.1056/NEJM199201303260503Seppala H, Nissinen A, Jarvinen H, et al. Resistance to erythromycin in group A streptococci. N Engl J Med. 1992;326:292–297. doi: https://doi.org/10.1056/NEJM199201303260503Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013;2013(11):CD000023. doi: https://doi.org/10.1002/14651858.CD000023.pub4Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013;2013(11):CD000023. doi: https://doi.org/10.1002/14651858.CD000023.pub4Linder JA, Bates DW, Lee GM, Finkelstein JA. Antibiotic treatment of children with sore throat. JAMA. 2005;294(18):2315–2322. doi: https://doi.org/10.1001/jama.294.18.2315Linder JA, Bates DW, Lee GM, Finkelstein JA. Antibiotic treatment of children with sore throat. JAMA. 2005;294(18):2315–2322. doi: https://doi.org/10.1001/jama.294.18.2315Passali D, Volonte M, Passali GS, et al. Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, singleblind study. Clin Ther. 2001;23(9):1508–1518. doi: https://doi.org/10.1016/s0149-2918(01)80123-5Passali D, Volonte M, Passali GS, et al. Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, singleblind study. Clin Ther. 2001;23(9):1508–1518. doi: https://doi.org/10.1016/s0149-2918(01)80123-5Bellussi L, Biagini C. Antiphlogistic therapy with ketoptofen lisyne salt vs nimesulide in secretive otitis media, rhinitis, pharyngitis/ tonsillitis/tracheitis. Otorinolaringologia. 1996;46(1):49–57.Bellussi L, Biagini C. Antiphlogistic therapy with ketoptofen lisyne salt vs nimesulide in secretive otitis media, rhinitis, pharyngitis/ tonsillitis/tracheitis. Otorinolaringologia. 1996;46(1):49–57.Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, et al. Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials. BMJ. 2017;358:j3887. doi: https://doi.org/10.1136/bmj.j3887Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, et al. Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials. BMJ. 2017;358:j3887. doi: https://doi.org/10.1136/bmj.j3887de Cassan S, Thompson MJ, Perera R, et al. Corticosteroids as standalone or add-on treatment for sore throat. Cochrane Database Syst Rev. 2020;5(5):CD008268. doi: https://doi.org/10.1002/14651858.CD008268.pub3de Cassan S, Thompson MJ, Perera R, et al. Corticosteroids as standalone or add-on treatment for sore throat. Cochrane Database Syst Rev. 2020;5(5):CD008268. doi: https://doi.org/10.1002/14651858.CD008268.pub3Rezk E, Nofal YH, Hamzeh A, et al. Steroids for symptom control in infectious mononucleosis. Cochrane Database Syst Rev. 2015;2015(11):CD004402. doi: https://doi.org/10.1002/14651858.CD004402.pub3Rezk E, Nofal YH, Hamzeh A, et al. Steroids for symptom control in infectious mononucleosis. Cochrane Database Syst Rev. 2015;2015(11):CD004402. doi: https://doi.org/10.1002/14651858.CD004402.pub3Olympia RP, Khine H, Avner JR. Effectiveness of oral dexamethasone in the treatment of moderate to severe pharyngitis in children. Arch Pediatr Adolesc Med. 2005;159(3):278–282. doi: https://doi.org/10.1001/archpedi.159.3.278Olympia RP, Khine H, Avner JR. Effectiveness of oral dexamethasone in the treatment of moderate to severe pharyngitis in children. Arch Pediatr Adolesc Med. 2005;159(3):278–282. doi: https://doi.org/10.1001/archpedi.159.3.278Thomas M, Del Mar C, Glasziou P. How effective are treatments other than antibiotics for acute sore throat? Br J Gen Pract. 2000;50(459):817–820.Thomas M, Del Mar C, Glasziou P. How effective are treatments other than antibiotics for acute sore throat? Br J Gen Pract. 2000;50(459):817–820.Оказание стационарной помощи детям. Руководство по лечению наиболее распространенных болезней у детей: карманный справочник. — 2-е изд. — М.: Всемирная организация здравоохранения; 2013. — 452 с.Okazanie statsionarnoi pomoshchi detyam. Rukovodstvo po lecheniyu naibolee rasprostranennykh boleznei u detei: A pocket reference. 2nd edn. Moscow: World Health Organization; 2013. 452 p. (In Russ).] Доступно по: https://apps.who.int/iris/bitstream/handle/10665/81170/9789244548370_rus.pdf. Ссылка активна на 07.04.2025.Федеральные клинические рекомендации по оказанию скорой медицинской помощи при острой лихорадке у детей / Союз педиатров России. Российское общество скорой медицинской помощи. — M.: Минздрав России; 2015. — 10 с.Federal’nye klinicheskie rekomendatsii po okazaniyu skoroi meditsinskoi pomoshchi pri ostroi likhoradke u detei. Union of Pediatricians of Russia. Russian Society of Emergency Medical Care. Moscow: Ministry of Health of Russia; 2015. 10 p. (In Russ).]Popovych V, Koshel I, Malofiichuk A, et al. A randomized, open-label, multicenter, comparative study of therapeutic efficacy, safety and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute nonbacterial tonsillitis in children aged 6 to 18 years. Am J Otolaryngol. 2019;40(2):265–273. doi: https://doi.org/10.1016/j.amjoto.2018.10.012Popovych V, Koshel I, Malofiichuk A, et al. A randomized, open-label, multicenter, comparative study of therapeutic efficacy, safety and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute nonbacterial tonsillitis in children aged 6 to 18 years. Am J Otolaryngol. 2019;40(2):265–273. doi: https://doi.org/10.1016/j.amjoto.2018.10.012Дронов И.А., Геппе Н.А., Колосова Н.Г., Великорецкая М.Д. Применение растительного лекарственного препарата комплексного действия в лечении рецидивирующего тонзиллофарингита у детей // Вопросы практической педиатрии. — 2020. — Т. 15. — № 4. — С. 16–24. — doi: https://doi.org/10.20953/1817-7646-2020-4-16-24Dronov IA, Geppe NA, Kolosova NG, Velikoretskaya MD. A combination herbal medicine in the treatment of children with recurrent tonsillopharyngitis. Voprosy prakticheskoi pediatrii = Clinical Practice in Pediatrics. 2020;15(4):16–24. (In Russ). doi: https://doi.org/10.20953/1817-7646-2020-4-16-24Вавилова В.П., Абрамов-Соммарива Д., Стайндл Г. и др. Клиническая эффективность и переносимость препарата Тонзилгон® Н при лечении рецидивирующих инфекций верхних дыхательных путей у детей: неинтервенционное исследование в России // РМЖ. — 2017. — № 5. — С. 350–358.Vavilova VP, Abramov-Sommariva D, Steindl H, et al. Clinical effectiveness and tolerability of Tonsilgon® N in the treatment of recurrent upper respiratory tract infections in children: a non-interventional study in Russia. RMJ. 2017(5):350–358. (In Russ).Намазова-Баранова Л.С., Харит С.М., Тузанкина И.А. и др. Результаты многоцентрового исследования применения препарата пидотимод для профилактики острых респираторных инфекций у часто болеющих детей // Вопросы современной педиатрии. — 2010. — Т. 9. — № 2. — С. 40–44.Namazova-Baranova LS, Kharit SM, Tuzankina IA, et al. Results of multicenter study of pidotimod for the prophylaxis of acute respiratory infections in frequently ailing children. Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(2):40–44. (In Russ).]Никифорова Г.Н., Волкова К.Б. Новые возможности терапии воспалительных заболеваний глотки // Consilium Medicum. — 2015. — Т. 17. — № 11. — С. 103–107.Nikiforova GN, Volkova KB. New opportunities therapy of inflammatory diseases of the pharynx. Consilium Medicum. 2015;17(11):103–107. (In Russ).]Degeorge KC, Ring DJ, Dalrymple SN. Treatment of the Common Cold. Am Fam Physician. 2019;100(5):281–289.Degeorge KC, Ring DJ, Dalrymple SN. Treatment of the Common Cold. Am Fam Physician. 2019;100(5):281–289.Пальчун В.Т., Лучихин Л.А., Крюков А.И. Воспалительные заболевания глотки: руководство для врачей. — М.: ГЭОТАР-Медиа; 2012. — 288 с.Pal’chun VT, Luchikhin LA, Kryukov AI. Vospalitel’nye zabolevaniya glotki: Guide for doctors. Moscow: GEOTARMedia; 2012. 288 p. (In Russ).]Кляритская И.Л., Максимова Е.В., Григоренко Е.И. и др. Современные аспекты диетотерапии в Российской Федерации // Крымский терапевтический журнал. — 2018. — № 2. — С. 26–31.Kliaritskaia IL, Maksimova EV, Grigorenko EI. Modern aspects of diet therapy in the Russian Federation. Crimean Journal of Internal Diseases. 2018;(2):26–31. (In Russ).Дайхес Н.А., Давудов Х.Ш., Шкода А.С., Элькун Г.Б. Рациональный выбор обезболивающей терапии у больных после тонзиллэктомии // Вестник оториноларингологии. — 2006. — № 6. — С. 66–68.Daikhes NA, Davudov KhSh, Shkoda AS, El’kun GB. Ratsional’nyi vybor obezbolivayushchei terapii u bol’nykh posle tonzillektomii. Russian Bulletin of Otorhinolaryngology. 2006;(6):66–68. (In Russ).Jain N, Lansiaux E, Reinis A. Group A streptococcal (GAS) infections amongst children in Europe: Taming the rising tide. New Microbes New Infect. 2022;51:101071. doi: https://doi.org/10.1016/j.nmni.2022.101071.Jain N, Lansiaux E, Reinis A. Group A streptococcal (GAS) infections amongst children in Europe: Taming the rising tide. New Microbes New Infect. 2022;51:101071. doi: https://doi.org/10.1016/j.nmni.2022.101071.Gregori G, Righi O, Risso P, et al. Reduction of group A betahemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study. Ther Clin Risk Manag. 2016;12:87–92. doi: https://doi.org/10.2147/TCRM.S96134Gregori G, Righi O, Risso P, et al. Reduction of group A betahemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study. Ther Clin Risk Manag. 2016;12:87–92. doi: https://doi.org/10.2147/TCRM.S96134Di Pierro F, Adami T, Rapacioli G, et al. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013;13(3):339–343. doi: https://doi.org/10.1517/14712598.2013.758711Di Pierro F, Adami T, Rapacioli G, et al. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013;13(3):339–343. doi: https://doi.org/10.1517/14712598.2013.758711Di Pierro F, Colombo M, Zanvit A, et al. Use of Streptococcus salivarius K12 in the prevention of streptococcal and viral pharyngotonsillitis in children. Drug Healthc Patient Saf. 2014;6:15–20. doi: https://doi.org/10.2147/DHPS.S59665Di Pierro F, Colombo M, Zanvit A, et al. Use of Streptococcus salivarius K12 in the prevention of streptococcal and viral pharyngotonsillitis in children. Drug Healthc Patient Saf. 2014;6:15–20. doi: https://doi.org/10.2147/DHPS.S59665Bitar MA, Saade R. The role of OM-85 BV (Broncho-Vaxom) in preventing recurrent acute tonsillitis in children. Int J Pediatr Otorhinolaryngol. 2013;77(5):670–673. doi: https://doi.org/10.1016/j.ijporl.2013.01.009Bitar MA, Saade R. The role of OM-85 BV (Broncho-Vaxom) in preventing recurrent acute tonsillitis in children. Int J Pediatr Otorhinolaryngol. 2013;77(5):670–673. doi: https://doi.org/10.1016/j.ijporl.2013.01.009Schaad UB. OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr. 2010;6(1):5–12. doi: https://doi.org/10.1007/s12519-010-0001-x.Schaad UB. OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr. 2010;6(1):5–12. doi: https://doi.org/10.1007/s12519-010-0001-x.СП 3.1.2.3149-13. Профилактика стрептококковой (группы А) инфекции: санитарно-эпидемиологические правила. Роспотребнадзор; 2013.SP 3.1.2.3149-13. Profilaktika streptokokkovoi (gruppy A) infektsii: Sanitary and epidemiological rules. Rospotrebnadzor; 2013. (In Russ).]МУ 3.1.1885-04. Эпидемиологический надзор и профилактика стрептококковой (группы A) инфекции: методические указания. Роспотребнадзор; 2004. [MU 3.1.1885-04.MU 3.1.1885-04. Epidemiologicheskii nadzor i profilaktika streptokokkovoi (gruppy A) infektsii: metodicheskie ukazaniya: Methodological guidelines. Rospotrebnadzor; 2004. (In Russ).

The authors declare that there are no conflicts of interest present.