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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v22i2.2869</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-2599</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Экспериментальное моделирование в офтальмологии как основа разработки новых путей профилактики слепоты и слабовидения у недоношенных детей: обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>Experimental Simulation in Ophthalmology as a Basis for the Development of New Ways to Prevent Blindness and Low Vision in Premature Infants: Literature Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4857-0374</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катаргина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Katargina</surname><given-names>Lyudmila A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Катаргина Людмила Анатольевна - д.м.н., профессор.</p><p>Москва</p></bio><bio xml:lang="en"><p>Lyudmila A. Katargina - MD, PhD, Professor.</p><p>Moscow</p></bio><email xlink:type="simple">katargina@igb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8032-4248</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павленко</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlenko</surname><given-names>Tatiana A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павленко Татьяна Аркадьевна - к.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>Tatyana А. Pavlenko, MD, PhD.</p><p>Moscow</p></bio><email xlink:type="simple">tanya1975_@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1799-5038</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Безнос</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Beznos</surname><given-names>Olga V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Безнос Ольга Валерьевна</p><p>Москва</p></bio><bio xml:lang="en"><p>Olga V. Beznos - MD.</p><p>Moscow</p></bio><email xlink:type="simple">olval2011@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3151-6910</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>Natalya A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Осипова Наталья Анатольевна, кандидат медицинских наук, старший научный сотрудник отдела патологии глаз у детей.</p><p>105062, Москва, ул. Садовая-Черногрязская, д. 14/19, тел.: +7 (495) 625-87-73</p></bio><bio xml:lang="en"><p>Natalya A. Osipova - MD, PhD.</p><p>14/19, Sadovaya Chernogryazskaya Str., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2103-1570</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Panova</surname><given-names>Anna Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Панова Анна Юрьевна - к.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>Anna Yu. Panova - MD, PhD.</p><p>Moscow</p></bio><email xlink:type="simple">annie_panova18@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Национальный медицинский исследовательский центр глазных болезней им. Гельмгольца<country>Россия</country></aff><aff xml:lang="en">National Medical Research Center for Eye Diseases named after Helmholtz<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>23</day><month>05</month><year>2025</year></pub-date><volume>22</volume><issue>2</issue><fpage>141</fpage><lpage>146</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Катаргина Л.А., Павленко Т.А., Безнос О.В., Осипова Н.А., Панова А.Ю., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Катаргина Л.А., Павленко Т.А., Безнос О.В., Осипова Н.А., Панова А.Ю.</copyright-holder><copyright-holder xml:lang="en">Katargina L.A., Pavlenko T.A., Beznos O.V., Osipova N.A., Panova A.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/2599">https://www.pedpharma.ru/jour/article/view/2599</self-uri><abstract><p>Обзор литературы содержит обобщение результатов многолетнего экспериментального исследования патогенеза ретинопатии недоношенных на крысиной модели, проводимого в ФГБУ «НМИЦ ГБ им. Гельмгольца» Минздрава России, а также данные зарубежных авторов, являющиеся основой поиска путей медикаментозной профилактики развития данного заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The literature review summarizes the results of a long-term experimental study of the pathogenesis of retinopathy of prematurity in a rat model conducted at the National Medical Research Center for Eye Diseases named after Helmholtz, as well as data from foreign authors who are the basis for finding ways to prevent the development of this disease with medication.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ретинопатия недоношенных</kwd><kwd>профилактика</kwd><kwd>слепота</kwd><kwd>слабовидение</kwd><kwd>экспериментальное исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>retinopathy of prematurity</kwd><kwd>preventive measures</kwd><kwd>blindness</kwd><kwd>low vision</kwd><kwd>experimental simulation</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Отсутствует</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>Not specified</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Quinn G. 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