ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i1.2859ppharm-2580Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWСпособы возможного применения аналогов бесклеточной амниотической жидкости в практике детского врачаMethods of Possible Application of Cell-Free Amniotic Fluid Analogues in the Practice of a Pediatricianhttps://orcid.org/0009-0000-9511-5131ГасановК. Э.GasanovKyamal E.

Гасанов Кямал Эльдарович, студент 6-го курса педиатрического факультета 

 117321, Москва, ул. Островитянова, д. 1 

student

1, Ostrovityanova Str., Moscow, 117321 

kema228834@gmail.comhttps://orcid.org/0009-0000-3316-5168СорогинаЛ. В.SoroginaLidiya V.

Сорогина Лидия Валерьевна, студентка

Тюмень 

student

Tyumen

sorogina30@mail.ruhttps://orcid.org/0009-0006-8758-0272Парфенов-МамыкинМ. С.Parfenov-MamykinMikhail S.

Парфенов-Мамыкин Михаил Сергеевич, студент

Москва

student

Moscow 

parf777@yahoo.comhttps://orcid.org/0000-0002-8779-7416ЦатуроваА. А.TsaturovaAnna A.

Цатурова Анна Арменовна, студентка

Москва

student

Moscow 

mirabella.240708@gmail.comРНИМУ им. Н.И. Пирогова (Пироговский Университет)РоссияN.I. Pirogov Russian National Research Medical UniversityRussian FederationТюмГМУРНИМУ им. Н.И. Пирогова (Пироговский Университет)РоссияTyumen State Medical UniversityRussian Federation20252602202522172–78Copyright © Гасанов К.Э., Сорогина Л.В., Парфенов-Мамыкин М.С., Цатурова А.А., 20252025Гасанов К.Э., Сорогина Л.В., Парфенов-Мамыкин М.С., Цатурова А.А.Gasanov K.E., Sorogina L.V., Parfenov-Mamykin M.S., Tsaturova A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2580

Использование амниотической жидкости в качестве источника стволовых клеток представляет широкий интерес в косметологии, генетике, акушерстве, неонатологии и прочих направлениях медицины. Относительно легкий метод культивирования клеток расширяет и удешевляет возможности их применения, однако неизбирательное их использование чревато риском развития злокачественных новообразований ввиду отсутствия контроля процессов дифференцировки мультипотентных клеток в организме пациента. Но даже бесклеточная амниотическая жидкость богата множеством цитокинов, способствующих протекции энтероцитов против действия провоспалительных факторов иммунного ответа и гипоксии, а также оптимальным водно-электролитным составом. Аналог бесклеточной амниотической жидкости, в состав которого входят тканевые факторы роста, может быть средством дополнительной протекции эпителия желудочно-кишечного тракта, способствовать ингибированию развития некротического энтероколита на обратимых стадиях, что может сократить количество оперативных вмешательств у новорожденных и положительно влиять на заживление поврежденного эпителия в месте кишечных ран. Поиск научных доказательств этой гипотезы явился целью проведения данной работы.

The use of amniotic fluid as a source of stem cells is of great interest in cosmetology, genetics, obstetrics, neonatology and other areas of medicine. The relatively easy method of cell culture expands and reduces the cost of their use, but their indiscriminate use is fraught with the risk of developing malignant neoplasms due to the lack of control over the differentiation of multipotent cells in the patient’s body. The relatively easy method of cell culture expands and reduces the cost of their use, but their indiscriminate use is fraught with the risk of developing malignant neoplasms due to the lack of control over the differentiation of multipotent cells in the patient’s body. But even cell-free amniotic fluid is rich in a variety of cytokines that promote enterocyte protection against the effects of pro-inflammatory immune response factors and hypoxia, as well as optimal water-electrolyte composition. An analog of cell-free amniotic fluid, which includes tissue growth factors, can be a means of additional protection of the epithelium of the gastrointestinal tract, help inhibit the development of necrotic enterocolitis in reversible stages, which can reduce the number of surgical interventions in newborns and positively affect the healing of damaged epithelium at the site of intestinal wounds. The aim of this study was to find scientific evidence for this hypothesis.

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The authors declare that there are no conflicts of interest present.