ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i1.2855ppharm-2579Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWЭлектрическая нестабильность миокарда у детей разного возраста: диагностика, прогностическая значимость и принципы коррекции (обзор литературы)Electrical instability of the myocardium in children of different ages: diagnosis, prognostic significance and principles of correction (literature review)https://orcid.org/0000-0002-2290-0013БалыковаЛ. А.BalykovaLarisa A.

Балыкова Лариса Александровна, доктор медицинских наук, профессор, член-корреспондент РАН, заведующая кафедрой педиатрии, директор медицинского института 

430005, г. Саранск, ул. Большевистская, д. 68

тел.: +7 (8342) 32-19-83 

MD, PhD, Professor, Corresponding Member of the RAS 

 68, Bolshevistskaya Str., 430005, Saransk 

larisabalykova@yandex.ruhttps://orcid.org/0000-0002-2121-8346ВладимировД. О.VladimirovDenis O.

Владимиров Денис Олегович

Саранск 

MD

Saransk 

d.o.vladimirov@yandex.ruhttps://orcid.org/0000-0002-1193-3178ТягушеваЕ. Н.TyagushevaEvgenia N.

Тягушева Евгения Николаевна, студентка

Саранск 

student

Saransk

evgenia.tyagusheva@yandex.ruhttps://orcid.org/0000-0002-9049-5662ШирманкинаМ. В.ShirmankinaMarina V.

Ширманкина Марина Васильевна

Саранск 

MD

Saransk

shirmankina99@mail.ruhttps://orcid.org/0000-0003-3990-9353КраснопольскаяА. В.KrasnopolskayaAnna V.

Краснопольская Анна Валерьевна, к.м.н.

Саранск 

MD, PhD

Saransk

abalykova@gmail.ruhttps://orcid.org/0000-0002-5332-8240НауменкоЕ. И.NaumenkoElena I.

Науменко Елена Ивановна, к.м.н.  

Саранск 

MD, PhD

Saransk

ei-naumenko@yandex.ruМГУ им. Н.П. ОгарёваРоссияN.P. Ogarev Mordovia State UniversityRussian Federation20252602202522162–71Copyright © Балыкова Л.А., Владимиров Д.О., Тягушева Е.Н., Ширманкина М.В., Краснопольская А.В., Науменко Е.И., 20252025Балыкова Л.А., Владимиров Д.О., Тягушева Е.Н., Ширманкина М.В., Краснопольская А.В., Науменко Е.И.Balykova L.A., Vladimirov D.O., Tyagusheva E.N., Shirmankina M.V., Krasnopolskaya A.V., Naumenko E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2579

Электрическая нестабильность миокарда (ЭНМ) представляет собой изменение электрофизиологических свойств миокарда, сопряженное с различной степенью риска реализации жизнеугрожающих состояний. На сегодняшний день особенно остро стоит проблема диагностики и клинической интерпретации ЭНМ у новорожденных детей ввиду анатомо-физиологических особенностей и коморбидных состояний, а также у детей и подростков с органическими болезнями сердца. Изучение гетерогенности электрокардиографической (ЭКГ) морфологии кардиоциклов может иметь прогностическую ценность для предотвращения аритмических событий. В статье представлен обзор современных научных данных о признаках ЭНМ у детей, в том числе периода новорожденности, сформированных в две большие группы: нарушения деполяризации и реполяризации. Обсуждаются ЭКГ-критерии ЭНМ у детей разного возраста с врожденными (первичными) электрическими заболеваниями и приобретенными состояниями, в том числе с COVID-19. Освещены методы медикаментозной коррекции ЭНМ у новорожденных и детей в последующие возрастные периоды. Совокупность представленных данных диктует необходимость дальнейшего изучения прогностической значимости ЭМН и методов ее коррекции.

varying degrees of risk of life-threatening conditions. Today, the problem of diagnosis and clinical interpretation of EIM in newborns is particularly acute due to anatomical and physiological features and comorbid conditions, as well as in children and adolescents with organic heart diseases. Studying the heterogeneity of electrocardiographic (ECG) morphology of cardiac cycles may have prognostic value for the prevention of arrhythmic events. The article provides an overview of modern scientific data on the signs of EIM in children, including the newborn period, formed into two large groups: depolarization and repolarization disorders. ECG criteria for EIM in children of different ages with congenital (primary) electrical diseases and acquired conditions, including COVID-19, are discussed. The methods of medical correction of ENM in newborns and children in subsequent age periods are highlighted. The totality of the data presented dictates the need for further study of the prognostic significance of EIM and methods of its correction.

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The authors declare that there are no conflicts of interest present.