ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v22i1.2854ppharm-2572Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWДиетические добавки в детском возрасте — вред или польза?Dietary Supplements in Childhood — Harm or Benefit?https://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич, доктор медицинских наук, профессор, руководитель Московского областного центра детской гастроэнтерологии и гепатологии им. А.В. Мазурина; профессор кафедры педиатрии Медицинского института 

115093, Москва, ул. Большая Серпуховская, д. 62

тел.: +7 (499) 237-02-23 

MD, PhD, Professor 

62, Bolshaya Serpukhovskaya Str., Moscow, 115093 

khavkin@nikid.ruhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NalyotovAndrew V.

Налетов Андрей Васильевич, д.м.н., профессор

Донецк 

MD, PhD, Professor 

 Donetsk 

nalyotov-a@mail.ruhttps://orcid.org/0000-0001-5070-9606МарченкоН. А.MarchenkoNataliya A.

Марченко Наталия Александровна

Донецк 

MD 

 Donetsk 

nataliiasvistunova@yandex.ruhttps://orcid.org/0000-0002-3646-5227НалётоваО. С.NalyotovaOlga S.

Налётова Ольга Сергеевна, д.м.н., доцент

Донецк 

MD, PhD, Associate Professor 

 Donetsk 

olganalotova1989@gmail.comНИКИ детства; БелГУРоссияResearch and Clinical Institute for Children; Belgorod State UniversityRussian FederationДонГМУ им. М. ГорькогоРоссияDonetsk State Medical University named after M. GorkyRussian Federation2025250220252214955Copyright © Хавкин А.И., Налетов А.В., Марченко Н.А., Налётова О.С., 20252025Хавкин А.И., Налетов А.В., Марченко Н.А., Налётова О.С.Khavkin A.I., Nalyotov A.V., Marchenko N.A., Nalyotova O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2572

За последние десятилетия потребление биологически активных добавок в детском возрасте значительно увеличилось. Наиболее часто используемыми диетическими добавками являются поливитаминно-минеральные комплексы. Несмотря на наличие определенных показаний, в большинстве случаев решение о приеме биологически активных добавок для ребенка родители принимают без предварительной консультации с педиатром. Основные причины использования диетических добавок у детей — защита от инфекций, ускорение темпов роста и несбалансированное питание. Бесконтрольное применение биологически активных добавок может привести к развитию побочных реакций. Пропаганда полноценного здорового питания детей является на сегодняшний день важным аспектом поддержания здоровья детского населения. Следует помнить, что для здоровых детей с полноценным разнообразным питанием прием диетических добавок не является необходимостью, а их чрезмерное бесконтрольное потребление может даже навредить здоровью. В то же время существуют целевые группы детей, которым рацион питания может быть обогащен диетическими добавками. Среди них подростки-спортсмены, которым при повышенных физических нагрузках рекомендовано потребление белковых диетических добавок, витаминные добавки показаны в ситуациях ухудшения качества питания, при соблюдении ограничительных диет, беременности, риске возникновения дефицита витаминов, дети-вегетарианцы и веганы нуждаются в восполнении дефицита микроэлементов.

Consumption of dietary supplements in childhood has increased significantly over the past decades. The most common dietary supplements are multivitamin-mineral complexes. Commonly parents make the decision to give dietary supplements without any pediatrician consultation, despite the presence of certain indications. The major reasons to use dietary supplements in children are protection against infections, accelerated growth, and unbalanced nutrition. Uncontrolled implementation of such supplements can lead to various adverse reactions. Promotion of healthy diet among children is crucial aspect of maintaining the children health. It should be noted that dietary supplements are not necessary for healthy children with diverse diet, and their excessive uncontrolled consumption can even do harm. At the same time, there are target groups of children whose diets can be enriched with dietary supplements. Among them are adolescent athletes who, with increased physical exertion, are recommended to consume protein dietary supplements, vitamin supplements are indicated in situations of poor nutritional quality, restrictive diets, pregnancy, the risk of vitamin deficiency, vegetarians and vegans need to make up for micronutrient deficiencies.

биологические активные добавкидетиограничительные типы питанияполивитаминно-минеральные комплексыпробиотикиdietary supplementschildrenrestrictive food typesmultivitamin-mineral complexesprobioticsОтсутствует.Not specified.ReferencesAgostoni C, Esposito S, Nobili A. Dietary supplements in infants and children: only beneficial? J Pediatr Gastroenterol Nutr. 2016;63(2):177–180. doi: https://doi.org/10.1097/MPG.0000000000001180Agostoni C, Esposito S, Nobili A. Dietary supplements in infants and children: only beneficial? J Pediatr Gastroenterol Nutr. 2016;63(2):177–180. doi: https://doi.org/10.1097/MPG.0000000000001180US Department of Health and Human Services; US Department of Agriculture. 2015–2020 Dietary Guidelines for Americans. 8th edn. Washington, DC; 2015. Available online: https://health.gov/dietaryguidelines/2015/guidelines. Accessed on: January 22, 2025.US Department of Health and Human Services; US Department of Agriculture. 2015–2020 Dietary Guidelines for Americans. 8th edn. Washington, DC; 2015. Available online: https://health.gov/dietaryguidelines/2015/guidelines. Accessed on: January 22, 2025.Stierman B, Mishra S, Gahche JJ, et al. Dietary Supplement Use in Children and Adolescents Aged ≤19 Years - United States, 2017-2018. MMWR Morb Mortal Wkly Rep. 2020;69(43):1557–1562. doi: https://doi.org/10.15585/mmwr.mm6943a1Stierman B, Mishra S, Gahche JJ, et al. Dietary Supplement Use in Children and Adolescents Aged 19 Years - United States, 2017-2018. MMWR Morb Mortal Wkly Rep. 2020;69(43):1557–1562. doi: https://doi.org/10.15585/mmwr.mm6943a1Bailey RL, Gahche JJ, Thomas PR, Dwyer JT. Why US children use dietary supplements. Pediatr Res. 2013;74(6):737–741. doi: https://doi.org/10.1038/pr.2013.160Bailey RL, Gahche JJ, Thomas PR, Dwyer JT. Why US children use dietary supplements. Pediatr Res. 2013;74(6):737–741. doi: https://doi.org/10.1038/pr.2013.160Healthy eating and use of dietary supplements in children: Mott Poll Report. C.S. Mott Children’s Hospital. National Pollon Children’s Health. 2022;40(5):1–2.Healthy eating and use of dietary supplements in children: Mott Poll Report. C.S. Mott Children’s Hospital. National Pollon Children’s Health. 2022;40(5):1–2.Liu H, Zhang S, Zou H, et al. Dietary supplement use among Chinese primary school students: across-sectional study in Hunan Province. Int J Environ Res Public Health. 2019;16(3):374. doi: https://doi.org/10.3390/ijerph16030374Liu H, Zhang S, Zou H, et al. Dietary supplement use among Chinese primary school students: across-sectional study in Hunan Province. Int J Environ Res Public Health. 2019;16(3):374. doi: https://doi.org/10.3390/ijerph16030374Piekara A, Krzywonos M, Kaczmarczyk M. What do Polish parents and caregivers think of dietary supplements for children aged 3-12? Nutrients. 2020;12(10):3076. doi: https://doi.org/10.3390/nu12103076Piekara A, Krzywonos M, Kaczmarczyk M. What do Polish parents and caregivers think of dietary supplements for children aged 3-12? Nutrients. 2020;12(10):3076. doi: https://doi.org/10.3390/nu12103076Баирова С.В., Сахно Л.В., Колтунцева И.В. и др. Актуальные подходы к питанию детей, занимающихся спортом (литературный обзор) // Детская медицина Северо-Запада. — 2024. — Т. 12. — № 3. — С. 38–48. — doi: https://doi.org/10.56871/CmN-W.2024.47.40.005Bairova SV, Sakhno LV, Koltuntseva IV, et al. Current approaches to nutrition of children involved in sports (literature review). Children’s Medicine of the North-West. 2024;12(3):38–48. (In Russ). doi: https://doi.org/10.56871/CmN-W.2024.47.40.005]Minj S, Anand S. Whey proteins and its derivatives: bioactivity, functionality, and current applications. Dairy. 2020;1(3):233–258. doi: https://doi.org/10.3390/dairy1030016Minj S, Anand S. Whey proteins and its derivatives: bioactivity, functionality, and current applications. Dairy. 2020;1(3):233–258. doi: https://doi.org/10.3390/dairy1030016Master PB, Macedo RC. Effects of dietary supplementation in sport and exercise: are view of evidence on milk proteins and amino acids. Crit Rev Food Sci Nutr. 2021;61(7):1225–1239. doi: https://doi.org/10.1080/10408398.2020.1756216Master PB, Macedo RC. Effects of dietary supplementation in sport and exercise: are view of evidence on milk proteins and amino acids. Crit Rev Food Sci Nutr. 2021;61(7):1225–1239. doi: https://doi.org/10.1080/10408398.2020.1756216Jager R, Kerksick CM, Campbell BI, et al. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017;14:20. doi: https://doi.org/10.1186/s12970-017-0177-8Jager R, Kerksick CM, Campbell BI, et al. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017;14:20. doi: https://doi.org/10.1186/s12970-017-0177-8Jagim AR, Kerksick CM. Creatine supplementation in children and adolescents. Nutrients. 2021;13(2):664. doi: https://doi.org/10.3390/nu13020664Jagim AR, Kerksick CM. Creatine supplementation in children and adolescents. Nutrients. 2021;13(2):664. doi: https://doi.org/10.3390/nu13020664Kaufman MW, Roche M, Fredericson M. The impact of supplements on sports performance for the trained athlete: a critical analysis. Curr Sports Med Rep. 2022;21(7):232–238. doi: https://doi.org/10.1249/JSR.0000000000000972Kaufman MW, Roche M, Fredericson M. The impact of supplements on sports performance for the trained athlete: a critical analysis. Curr Sports Med Rep. 2022;21(7):232–238. doi: https://doi.org/10.1249/JSR.0000000000000972Martini L, Pecoraro L, Salvottini C, et al. Appropriate and inappropriate vitamin supplementation in children. J Nutr Sci. 2020;9:e20. doi: https://doi.org/10.1017/jns.2020.12Martini L, Pecoraro L, Salvottini C, et al. Appropriate and inappropriate vitamin supplementation in children. J Nutr Sci. 2020;9:e20. doi: https://doi.org/10.1017/jns.2020.12Национальная программа по оптимизации обеспеченности витаминами и минеральными веществами детей России (и использованию витаминных и витамино-минеральных комплексов и обогащенных продуктов в педиатрической практике) / Союз педиатров России и др. — М.: Педиатръ; 2017. — 152 с.Natsional’naya programma po optimizatsii obespechennosti vitaminami i mineral’nymi veshchestvami detei Rossii (i ispol’zovaniyu vitaminnykh i vitamino-mineral’nykh kompleksov i obogashchennykh produktov v pediatricheskoi praktike). The Union of Pediatrician of Russia. Moscow: Pediatr; 2017. 152 p. (In Russ).]Новикова В.П., Сейц А.В. Витамин D и костный метаболизм при заболеваниях желудка и двенадцатиперстной кишки // Детская медицина Северо-Запада. — 2024. — Т. 12. — № 3. — С. 81–96. — doi: https://doi.org/10.56871/CmN-W.2024.79.24.009Novikova VP, Seits AV. Vitamin D and bone metabolism in diseases of the stomach and duodenum. Children’s Medicine of the North-West. 2024;12(3):81–96. (In Russ). doi: https://doi.org/10.56871/CmN-W.2024.79.24.009]Хавкин А.И., Налетов А.В., Масюта Д.И., Махмутов Р.Ф. Роль витамина D в патогенезе воспалительных заболеваний кишечника: обзор литературы // Вопросы современной педиатрии. — 2024. — Т. 23. — № 2. — С. 58–62. — doi: https://doi.org/10.15690/vsp.v23i2.2722Khavkin AI, Nalyotov AV, Masyuta DI, Makhmutov RF. Role of vitamin D in the pathogenesis of inflammatory bowel diseases: literature review. Voprosy sovremennoi pediatrii — Current Pediatrics. 2024;23(2):58–62. (In Russ). doi: https://doi.org/10.15690/vsp.v23i2.2722]Налетов А.В., Марченко Н.А., Хавкин А.И., Махмутов Р.Ф. Вегетарианские диеты в детском возрасте: современный взгляд на проблему // Вопросы практической педиатрии. — 2024. — Т. 19. — № 1. — С. 101–108. — doi: https://doi.org/10.20953/1817-7646-2024-101-108Nalyotov АV, Marchenko NА, Khavkin АI, Makhmutov RF. Vegetarian diets in children: the modern view. Clinical Practice in Pediatrics. 2024;19(1):101–108. (In Russ). doi: https://doi.org/10.20953/1817-7646-2024-1-101-108]Национальная программа «Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции» / Союз педиатров России и др. — М.: ПедиатрЪ; 2018. — 96 с.Natsional’naya programma “Nedostatochnost’ vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii”. The Union of Pediatrician of Russia. Moscow: Pediatr; 2018. 96 p. (In Russ).]Ran L, Zhao W, Wang H, et al. Vitamin C as a supplementary therapy in relieving symptoms of the common cold: a meta-analysis of 10 randomized controlled trials. Biomed Res Int. 2020;2020:8573742. doi: https://doi.org/10.1155/2020/8573742Ran L, Zhao W, Wang H, et al. Vitamin C as a supplementary therapy in relieving symptoms of the common cold: a meta-analysis of 10 randomized controlled trials. Biomed Res Int. 2020;2020:8573742. doi: https://doi.org/10.1155/2020/8573742Налетов А.В. Ограничительные типы питания в детском возрасте — вред или польза? // Health, Food and Biotechnology. — 2022. — Т. 4. — № 1. — С. 16–23. — doi: https://doi.org/0.36107/hfb.2022.i1.s128Nalyotov АV. Restrictive types of nutrition in childhood — harm or benefit? Health, Food and Biotechnology. 2022;4(1):16–23. (In Russ). doi: https://doi.org/0.36107/hfb.2022.i1.s128]Berglund SK, Domellof M. Iron deficiency in infancy: current in sights. Curr Opin Clin Nutr Metab Care. 2021;24(3):240–245. doi: https://doi.org/10.1097/MCO.0000000000000749Berglund SK, Domellof M. Iron deficiency in infancy: current in sights. Curr Opin Clin Nutr Metab Care. 2021;24(3):240–245. doi: https://doi.org/10.1097/MCO.0000000000000749Lemale J, Mas E, Jung C, et al. Vegan diet in children and adolescents. Recommendations from the French-speaking Pediatric Hepatology, Gastroenterology and Nutrition Group (GFHGNP). Arch Pediatr. 2019;26(7):442–450. doi: https://doi.org/10.1016/j.arcped.2019.09.001Lemale J, Mas E, Jung C, et al. Vegan diet in children and adolescents. Recommendations from the French-speaking Pediatric Hepatology, Gastroenterology and Nutrition Group (GFHGNP). Arch Pediatr. 2019;26(7):442–450. doi: https://doi.org/10.1016/j.arcped.2019.09.001Налетов А.В., Мацынин А.Н., Мацынина М.А. Обеспеченность цинком – важный показатель здоровья человека // Health, Food and Biotechnology. — 2022. — Т. 4. — № 3. — С. 12–18. — doi: https://doi.org/10.36107/hfb.2022.i3.s147Naletov AV, Matsynin AN, Matsynina MA. Zinc availability is an important indicator of human health. Health, Food and Biotechnology. 022;4(3):12–18. (In Russ). doi: https://doi.org/10.36107/hfb.2022.i3.s147]Ohashi W, Fukada T. Contribution of zinc and zinc transporters in the pathogenesis of inflammatory bowel diseases. J Immunol Res. 2019;2019:8396878. doi: https://doi.org/10.1155/2019/8396878Ohashi W, Fukada T. Contribution of zinc and zinc transporters in the pathogenesis of inflammatory bowel diseases. J Immunol Res. 2019;2019:8396878. doi: https://doi.org/10.1155/2019/8396878Vaghari-Tabari M, Jafari-Gharabaghlou D, Sadeghsoltani F, et al. Zinc and selenium in inflammatory bowel disease: trace elements with key roles? Biol Trace Elem Res. 2021;199(9):3190–3204. doi: https://doi.org/10.1007/s12011-020-02444-wVaghari-Tabari M, Jafari-Gharabaghlou D, Sadeghsoltani F, et al. Zinc and selenium in inflammatory bowel disease: trace elements with key roles? Biol Trace Elem Res. 2021;199(9):3190–3204. doi: https://doi.org/10.1007/s12011-020-02444-wImdad A, Rogner J, Sherwani RN, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years. Cochrane Database Syst Rev. 2023;3(3):CD009384. doi: https://doi.org/10.1002/14651858.CD009384.pub3Imdad A, Rogner J, Sherwani RN, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years. Cochrane Database Syst Rev. 2023;3(3):CD009384. doi: https://doi.org/10.1002/14651858.CD009384.pub3Vlieg-Boerstra B, de Jong N, Meyer R, et al. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: a systematic review and meta-analysis. Allergy. 2022;77(5):1373–1388. doi: https://doi.org/10.1111/all.15136Vlieg-Boerstra B, de Jong N, Meyer R, et al. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: a systematic review and meta-analysis. Allergy. 2022;77(5):1373–1388. doi: https://doi.org/10.1111/all.15136Guarner F, Sanders ME, Szajewska H, et al. World Gastroenterology Organisation (WGO) global guidelines probiotics and prebiotics. J Clin Gastroenterol. 2024;58(6):533–553. doi: https://doi.org/10.1097/MCG.0000000000002002Guarner F, Sanders ME, Szajewska H, et al. World Gastroenterology Organisation (WGO) global guidelines probiotics and prebiotics. J Clin Gastroenterol. 2024;58(6):533–553. doi: https://doi.org/10.1097/MCG.0000000000002002Guo Q, Goldenberg JZ, Humphrey C, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2019;4(4):CD004827. doi: https://doi.org/10.1002/14651858.CD004827.pub5Guo Q, Goldenberg JZ, Humphrey C, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2019;4(4):CD004827. doi: https://doi.org/10.1002/14651858.CD004827.pub5Goodman C, Keating G, Georgousopoulou E, et al. Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis. BMJ Open. 2021;11(8):e043054. doi: https://doi.org/10.1136/bmjopen-2020-043054Goodman C, Keating G, Georgousopoulou E, et al. Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis. BMJ Open. 2021;11(8):e043054. doi: https://doi.org/10.1136/bmjopen-2020-043054Collinson S, Deans A, Padua-Zamora A, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2020;12(12):CD003048. doi: https://doi.org/10.1002/14651858.CD003048.pub4Collinson S, Deans A, Padua-Zamora A, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2020;12(12):CD003048. doi: https://doi.org/10.1002/14651858.CD003048.pub4Sung V, D’Amico F, Cabana MD, et al. Lactobacillus reuteri to treat infant colic: a meta-analysis. Pediatrics. 2018;141(1):e20171811. doi: https://doi.org/10.1542/peds.2017-1811Sung V, D’Amico F, Cabana MD, et al. Lactobacillus reuteri to treat infant colic: a meta-analysis. Pediatrics. 2018;141(1):e20171811. doi: https://doi.org/10.1542/peds.2017-1811Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022:gutjnl-2022-327745. doi: https://doi.org/10.1136/gutjnl-2022-327745Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022:gutjnl-2022-327745. doi: https://doi.org/10.1136/gutjnl-2022-327745Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, et al. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: systematic review with network meta-analysis.Medicine (Baltimore). 2017;96(51):e9375. doi: https://doi.org/10.1097/MD.0000000000009375Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, et al. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: systematic review with network meta-analysis.Medicine (Baltimore). 2017;96(51):e9375. doi: https://doi.org/10.1097/MD.0000000000009375Harb T, Matsuyama M, David M, Hill RJ. Infant Colic — what works: a systematic review of interventions for breast-fed infants. J Pediatr Gastroenterol Nutr. 2016;62(5):668–686. doi: https://doi.org/10.1097/MPG.0000000000001075Harb T, Matsuyama M, David M, Hill RJ. Infant Colic — what works: a systematic review of interventions for breast-fed infants. J Pediatr Gastroenterol Nutr. 2016;62(5):668–686. doi: https://doi.org/10.1097/MPG.0000000000001075Gkiourtzis Ν, Kalopitas G, Vadarlis A, et al. The benefit of probiotics in pediatric nonalcoholic fatty liver disease: a metaanalysis of randomized control trials. J Pediatr Gastroenterol Nutr. 2022;75(3):e31–e37. doi: https://doi.org/10.1097/MPG.0000000000003537Gkiourtzis Ν, Kalopitas G, Vadarlis A, et al. The benefit of probiotics in pediatric nonalcoholic fatty liver disease: a metaanalysis of randomized control trials. J Pediatr Gastroenterol Nutr. 2022;75(3):e31–e37. doi: https://doi.org/10.1097/MPG.0000000000003537Vitellio P, Celano G, Bonfrate L, et al. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on gut microbiota in patients with lactose intolerance and persisting functional gastrointestinal symptoms: a randomised, double-blind, cross-over study. Nutrients. 2019;11(4):886. doi: https://doi.org/10.3390/nu11040886Vitellio P, Celano G, Bonfrate L, et al. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on gut microbiota in patients with lactose intolerance and persisting functional gastrointestinal symptoms: a randomised, double-blind, cross-over study. Nutrients. 2019;11(4):886. doi: https://doi.org/10.3390/nu11040886Xu HL, Zou LL, Chen MB, et al. Efficacy of probiotic adjuvant therapy for irritable bowel syndrome in children: a systematic review and meta-analysis. PloS One. 2021;16(8):e0255160. doi: https://doi.org/10.1371/journal.pone.0255160Xu HL, Zou LL, Chen MB, et al. Efficacy of probiotic adjuvant therapy for irritable bowel syndrome in children: a systematic review and meta-analysis. PloS One. 2021;16(8):e0255160. doi: https://doi.org/10.1371/journal.pone.0255160Trivić I, Niseteo T, Jadrešin O, Hojsak I. Use of probiotics in the treatment of functional abdominal pain in children – systematic review and meta-analysis. Eur J Pediatr. 2021;180(2):339–351. doi: https://doi.org/10.1007/s00431-020-03809-yTrivić I, Niseteo T, Jadrešin O, Hojsak I. Use of probiotics in the treatment of functional abdominal pain in children – systematic review and meta-analysis. Eur J Pediatr. 2021;180(2):339–351. doi: https://doi.org/10.1007/s00431-020-03809-yAndresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, doubleblind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5(7):658–666. doi: https://doi.org/10.1016/S2468-1253(20)30056-XAndresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, doubleblind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol. 2020;5(7):658–666. doi: https://doi.org/10.1016/S2468-1253(20)30056-XFord AC, Harris LA, Lacy BE, et al. Systematic review with metaanalysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment Pharmacol Ther. 2018;48(10):1044–1060. doi: https://doi.org/10.1111/apt.15001Ford AC, Harris LA, Lacy BE, et al. Systematic review with metaanalysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment Pharmacol Ther. 2018;48(10):1044–1060. doi: https://doi.org/10.1111/apt.15001Seddik H, Boutallaka H, Elkoti I, et al. Saccharomyces boulardii CNCM I-745 plus sequential therapy for Helicobacter pylori infections: a randomized, open-label trial. Eur J Clin Pharmacol. 2019;75(5):639–645. doi: https://doi.org/10.1007/s00228-019-02625-0Seddik H, Boutallaka H, Elkoti I, et al. Saccharomyces boulardii CNCM I-745 plus sequential therapy for Helicobacter pylori infections: a randomized, open-label trial. Eur J Clin Pharmacol. 2019;75(5):639–645. doi: https://doi.org/10.1007/s00228-019-02625-0Plomer M, Iii Perez M, Greifenberg DM. Effect of Bacillus clausii capsules in reducing adverse effects associated with Helicobacter pylori eradication therapy: a randomized, double-blind, controlled trial. Infect Dis Ther. 2020;9(4):867–878. doi: https://doi.org/10.1007/s40121-020-00333-2Plomer M, Iii Perez M, Greifenberg DM. Effect of Bacillus clausii capsules in reducing adverse effects associated with Helicobacter pylori eradication therapy: a randomized, double-blind, controlled trial. Infect Dis Ther. 2020;9(4):867–878. doi: https://doi.org/10.1007/s40121-020-00333-2Fiocchi A, Pawankar R, Cuello-Garcia C, et al. World Allergy Organization-McMaster University Guidelines for allergic disease prevention (GLAD-P): probiotics. World Allergy Organ J. 2015;8(1):4. doi: https://doi.org/10.1186/s40413-015-0055-2Fiocchi A, Pawankar R, Cuello-Garcia C, et al. World Allergy Organization-McMaster University Guidelines for allergic disease prevention (GLAD-P): probiotics. World Allergy Organ J. 2015;8(1):4. doi: https://doi.org/10.1186/s40413-015-0055-2

The authors declare that there are no conflicts of interest present.