ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v21i6.2840ppharm-2556Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWКуркумин — новое направление дополнительной терапии язвенного колитаCurcumin as a Novel Trend in Adjunctive Therapy for Ulcerative Colitishttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич, доктор медицинских наук, профессор, руководитель Московского областного центра гастроэнтерологии и гепатологии НИКИ детства Минздрава Московской области; профессор кафедры педиатрии Медицинского института ФГАОУ  ВО НИУ «БелГУ» Минобрнауки России

115093, Москва, ул. Большая Серпуховская, д. 62

Anatoly I. Khavkin, MD, PhD, Professor 

62, Bolshaya Serpukhovskaya Str., Moscow, 115093

 

gastropedclin@gmail.comhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NaiyotovAndrew V.

Налетов Андрей Васильевич, д.м.н., профессор 

Andrew V. Nalyotov, MD, PhD, Professor

Donetsk

 

nalyotov-a@mail.ruНИКИ детства; БелГУРоссияResearch and Clinical institute for Children; Beigorod State UniversityRussian FederationДонГМУ им. М. ГорькогоРоссияDonetsk State iVledicai University named after iVI. GorkyRussian Federation202410012025216534538Copyright © Хавкин А.И., Налетов А.В., 20242024Хавкин А.И., Налетов А.В.Khavkin A.I., Naiyotov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2556

Лечение язвенного колита остается сложной задачей. Постоянно ведется поиск новых направлений терапии данного заболевания. В последние годы все больше внимания уделяется куркумину — активному полифенолу, содержащемуся в корне куркумы, который обладает многочисленными положительными эффектами на организм человека, включая противовоспалительное, антиканцерогенное и антиоксидантное свойства. Куркумин воздействует на несколько сигнальных клеточных путей и оказывает влияние на состав микробиоты кишечника. В данном обзоре обобщены современные сведения о перспективах использования куркумина в терапии язвенного колита.

Management of ulcerative colitis remains challenging. The search of new treatment approaches for this disease is constantly continuing. In recent years, the focus was changed to curcumin, active polyphenol found in turmeric roots, that has numerous positive effects on the human body such as anti-inflammatory, anti-carcinogenic, and antioxidant features. Curcumin affects several signaling cellular pathways and gut microbiota content. This review summarizes modern data on the curcumin potential use in ulcerative colitis management.

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The authors declare that there are no conflicts of interest present.