ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v21i4.2790ppharm-2502Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВитамин D и костный метаболизм при целиакии. Возможности диетической коррекцииVitamin D and Bone Metabolism in Celiac Disease. The Possibilities of Dietary Correctionhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич, доктор медицинских наук, профессор, заведующий кафедрой гастроэнтерологии и диетологии им. А.В. Мазурина, руководитель Московского областного центра детской гастроэнтерологии и гепатологии НИКИ Минздрава Московской области, профессор кафедры педиатрии с курсом детских хирургических болезней Медицинского института ФГАОУ ВО «Белгородский государственный национальный исследовательский университет»

115093, г. Москва, ул. Большая Серпуховская, 62

тел.: +7 (499) 237-02-23

Anatoly I. Khavkin, MD, PhD, Professor

62, Bolshaya Serpukhovskaya Str., Moscow, 115093

tel. +7 (499) 237-02-23

gastropedclin@gmail.comhttps://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaValeriya P.

Новикова Валерия Павловна, д.м.н., профессор

Санкт-Петербург

Valeriya P. Novikova, MD, PhD, Professor

Saint Petersburg

novikova-vp@mail.ruhttps://orcid.org/0000-0001-6395-0407КондратьеваЕ. И.KondratyevaElena I.

Кондратьева Елена Ивановна, д.м.н., профессор

Москва

Томск

Elena I. Kondratyeva, MD, PhD, Professor

Moscow

Tomsk

elenafpk@mail.ruhttps://orcid.org/0000-0002-3043-8674ЛошковаЕ. В.LoshkovaElena V.

Лошкова Елена Владимировна, к.м.н.

Москва

Томск

Elena V. Loshkova, MD, PhD

Moscow

Tomsk

loshkova@rambler.ruhttps://orcid.org/0000-0001-5792-2012ЯнкинаГ. Н.YankinaGalina N.

Янкина Галина Николаевна, д.м.н.

Томск

Galina N. Yankina, MD, PhD

Tomsk

gal.happy@mail.ruНИКИ детства; НИУ БелГУРоссияResearch Clinical Institute of Childhood; National Research Institute of Belgorog State UniversityRussian FederationСПбГПМУРоссияSt. Petersburg State Pediatric Medical UniversityRussian FederationНИКИ детства; СибГМУРоссияResearch Clinical Institute of Childhood; Siberian State Medical UniversityRussian FederationСибГМУРоссияSiberian State Medical UniversityRussian Federation202416092024214375384Copyright © Хавкин А.И., Новикова В.П., Кондратьева Е.И., Лошкова Е.В., Янкина Г.Н., 20242024Хавкин А.И., Новикова В.П., Кондратьева Е.И., Лошкова Е.В., Янкина Г.Н.Khavkin A.I., Novikova V.P., Kondratyeva E.I., Loshkova E.V., Yankina G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2502

В обзоре описаны состояние системы витамина D и костный метаболизм при целиакии, механизмы влияния витамина D на состояние слизистой оболочки кишечника, факторы риска, способствующие патологическим изменениям костей при целиакии. Приведены исследования, посвященные оценке минеральной плотности костей, костного метаболизма и статуса витамина D у больных целиакией. Представлены результаты дискуссии о влиянии добавок кальция и витамина D на течение целиакии и состояние костной ткани при этом заболевании.

The review describes the state of the vitamin D system and bone metabolism in celiac disease, the mechanisms of the influence of vitamin D on the state of the intestinal mucosa, and risk factors that contribute to pathological changes in bones in celiac disease. Studies are presented that evaluate bone mineral density, bone metabolism, and vitamin D status in patients with celiac disease. The results of a discussion on the effect of calcium and vitamin D supplements on the course of celiac disease and the condition of bone tissue in this disease are presented.

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The authors declare that there are no conflicts of interest present.