ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v21i4.2771ppharm-2501Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWРоль вирусов в патогенезе целиакии: современное состояние вопросаThe Role of Viruses in Celiac Disease Pathogenesis: Current Statushttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич, доктор медицинских наук, профессор, заведующий кафедрой гастроэнтерологии и диетологии им. А.В. Мазурина ГБУЗ МО «Научно-исследовательский клинический институт детства Минздрава Московской области», профессор кафедры педиатрии с курсом детских хирургических болезней Медицинского института ФГАОУ ВО «Белгородский государственный национальный исследовательский университет»  Минобрнауки России

115093, г. Москва, ул. Большая Серпуховская, 62

тел.: +7 (499) 237-02-23

Anatoly I. Khavkin, MD, PhD, Professor

62, Bolshaya Serpukhovskaya Str., Moscow, 115093

tel.: +7 (499) 237-02-23

gastropedclin@gmail.comhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NalyotovAndrew V.

Налетов Андрей Васильевич, д.м.н., профессор

Донецк

Andrew V. Nalyotov, MD, PhD, Professor

Donetsk

nalyotov-a@mail.ruКуропятникП. И.KuropjatnikPolina I.

Куропятник Полина Игоревна

Донецк

Polina I. Kuropjatnik, MD

Donetsk

kuropjatnikpolina1@gmail.comНИКИ детства; НИУ БелГУРоссияResearch Clinical Institute of Childhood; Belgorod State UniversityRussian FederationДонГМУ им. М. ГорькогоРоссияDonetsk State Medical University named after M. GorkyRussian FederationЦГКБ № 1 г. ДонецкаРоссияCentral city clinical hospital No. 1Russian Federation202416092024214369374Copyright © Хавкин А.И., Налетов А.В., Куропятник П.И., 20242024Хавкин А.И., Налетов А.В., Куропятник П.И.Khavkin A.I., Nalyotov A.V., Kuropjatnik P.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2501

Цель данного обзора — представить современные сведения о связи между вирусами и целиакией. Согласно результатам современных исследований, некоторые вирусы, вероятно, играют важную роль в патогенезе целиакии. Однако воздействие вируса само по себе не приводит к развитию аутоиммунного заболевания. Согласно результатам ряда исследований, существует несколько вирусов, которые могут вызывать целиакию, и несколько путей активации, приводящих к потере переносимости пищи. На сегодняшний день доказана роль лишь некоторых штаммов реовирусов в развитии целиакии. Необходимы дальнейшие исследования, чтобы лучше понять роль вирусов в развитии целиакии и улучшить лечение и профилактику этого заболевания.

The purpose of this review is to present modern data on the correlations between viruses and celiac disease. Some viruses probably have crucial role in celiac disease pathogenesis according to the results of recent studies. However, the virus exposure itself does not lead to the development of autoimmune disease. Number of studies have demonstrated that there are several viruses that can cause celiac disease, and several activation pathways leading to food tolerance loss. Thus far, the role of some reoviruses strains has been proven in the development of celiac disease. Further research is needed for better understanding of the viruses role in the celiac disease development and to improve management and prevention of this disease.

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The authors declare that there are no conflicts of interest present.