ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v21i4.2774ppharm-2498Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL RECOMMENDATIONSСовременные клинические рекомендации по ведению пациентов с аллергическим ринитомCurrent Clinical Guidelines for the Management of Patients with Allergic Rhinitishttps://orcid.org/0000-0002-7691-4584АстафьеваН. Г.Astaf’evaNatal’ya G.

Саратов

Saratov

https://orcid.org/0000-0003-3987-8112БарановА. А.BaranovAleksander A.

Москва

Moscow

https://orcid.org/0000-0001-7398-0562ВишневаЕ. А.VishnevaElena A.

Москва

Moscow

https://orcid.org/0000-0002-7691-4584ДайхесН. А.DaykhesNikolay A.

Москва

Moscow

https://orcid.org/0000-0002-3960-830XЖестковА. В.ZhestkovAleksander V.

Саратов

Saratov

ИльинаН. А.Il’inaNatal’ya A.

Москва

Moscow

https://orcid.org/0000-0002-5721-1699КарнееваО. В.KarneevaOlga V.

Москва

Moscow

https://orcid.org/0000-0001-9590-9302КарповаЕ. П.KarpovaElena P.

Москва

Moscow

https://orcid.org/0000-0003-1078-6388КимИ. А.KimIrina A.

Москва

Moscow

https://orcid.org/0000-0002-0149-0676КрюковА. И.KryukovAndrey I.

Москва

Moscow

https://orcid.org/0000-0003-3250-0694КурбачеваО. М.KurbachevaOksana M.

Москва

Moscow

https://orcid.org/0000-0002-7806-9484МешковаР. Я.MeshkovaRaisa Ya.

Смоленск

Smolensk

https://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Намазова-Баранова Лейла Сеймуровна, доктор медицинских наук, профессор, академик РАН, заведующая кафедрой факультетской педиатрии педиатрического факультета ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, руководитель НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского», президент Союза педиатров России

119333, Москва, ул. Фотиевой, д. 10

тел.: +7 (499) 400-47-33

Moscow

lsnamazova@yandex.ruhttps://orcid.org/0000-0002-3162-2510НенашеваН. М.NenashevaNatal’ya M.

Москва

Moscow

https://orcid.org/0000-0002-7571-5460НовикГ. А.NovikGennagiy A.

Санкт-Петербург

Saint-Petersburg

https://orcid.org/0000-0002-3897-8384НосуляЕ. М.NosulyaEvgeniy M.

Москва

Moscow

https://orcid.org/0000-0002-4164-4094ПавловаК. С.PavlovaKseniya S.

Москва

Moscow

https://orcid.org/0000-0001-5039-8473ПампураА. Н.PampuraAleksander N.

Москва

Moscow

https://orcid.org/0000-0001-7414-1293СвистушкинВ. М.SvistushkinValeriy M.

Москва

Moscow

https://orcid.org/0000-0002-3678-7939СелимзяноваЛ. Р.SelimzyanovaLiliya R.

Москва

Moscow

https://orcid.org/0000-0003-4961-9640ХаитовМ. Р.KhaitovMusa R.

Москва

Moscow

https://orcid.org/0000-0003-0317-2425ЭфендиеваК. Е.EfendievaKamilla E.

Москва

Moscow

СГМУ им. В.И. РазумовскогоРоссияSaratov State Medical University n.a. V.I. RazumovskyRussian FederationНИИ педиатрии и охраны здоровья НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; I.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationПервый МГМУ им. И.М. Сеченова (Сеченовский Университет); РНИМУ им. Н.И. ПироговаРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University); Pirogov Russian National Research Medical UniversityRussian FederationНМИЦОРоссияNational Medical Research Center of OtorhinolaryngologyRussian FederationГНЦ «Институт иммунологии»РоссияNational Research Center — Institute of ImmunologyRussian FederationРМАПОРоссияRussian Medical Academy of Postgraduate EducationRussian FederationРНИМУ им. Н.И. Пирогова; НИКИО им. Л.И. СвержевскогоРоссияPirogov Russian National Research Medical University; L.I. Sverzhevskiy Scientific and Research Clinical Institute of OtorhinolaryngologyRussian FederationГНЦ «Институт иммунологии»; МГМСУ им. А.И. ЕвдокимоваРоссияNational Research Center — Institute of Immunology; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian FederationСмоленская государственная медицинская академияРоссияSmolensk State Medical AcademyRussian FederationНИИ педиатрии и охраны здоровья НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationСПбГПМУРоссияSaint-Petersburg State Pediatric Medical UniversityRussian FederationНИКИО им. Л.И. СвержевскогоРоссияL.I. Sverzhevskiy Scientific and Research Clinical Institute of OtorhinolaryngologyRussian FederationРНИМУ им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationПервый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationНИИ педиатрии и охраны здоровья НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); РНИМУ им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; I.M. Sechenov First Moscow State Medical University (Sechenov University); Pirogov Russian National Research Medical UniversityRussian Federation202414092024214320343Copyright © Астафьева Н.Г., Баранов А.А., Вишнева Е.А., Дайхес Н.А., Жестков А.В., Ильина Н.А., Карнеева О.В., Карпова Е.П., Ким И.А., Крюков А.И., Курбачева О.М., Мешкова Р.Я., Намазова-Баранова Л.С., Ненашева Н.М., Новик Г.А., Носуля Е.М., Павлова К.С., Пампура А.Н., Свистушкин В.М., Селимзянова Л.Р., Хаитов М.Р., Эфендиева К.Е., 20242024Астафьева Н.Г., Баранов А.А., Вишнева Е.А., Дайхес Н.А., Жестков А.В., Ильина Н.А., Карнеева О.В., Карпова Е.П., Ким И.А., Крюков А.И., Курбачева О.М., Мешкова Р.Я., Намазова-Баранова Л.С., Ненашева Н.М., Новик Г.А., Носуля Е.М., Павлова К.С., Пампура А.Н., Свистушкин В.М., Селимзянова Л.Р., Хаитов М.Р., Эфендиева К.Е.Astaf’eva N.G., Baranov A.A., Vishneva E.A., Daykhes N.A., Zhestkov A.V., Il’ina N.A., Karneeva O.V., Karpova E.P., Kim I.A., Kryukov A.I., Kurbacheva O.M., Meshkova R.Y., Namazova-Baranova L.S., Nenasheva N.M., Novik G.A., Nosulya E.M., Pavlova K.S., Pampura A.N., Svistushkin V.M., Selimzyanova L.R., Khaitov M.R., Efendieva K.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2498

В статье представлены современные подходы к диагностике и терапии пациентов с аллергическим ринитом. Документ был разработан профессиональной ассоциацией детских специалистов — Союзом педиатров России — совместно с ведущими специалистами Российской ассоциации аллергологов и клинических иммунологов, Национальной медицинской ассоциации оториноларингологов и регулярно актуализируется с учетом последних данных по эффективности и безопасности различных медицинских вмешательств.

В статье изложены сведения об эпидемиологии аллергического ринита, приведены характерные диагностические признаки заболевания, позволяющие максимально своевременно установить правильный диагноз и с учетом персонализированного подхода назначить эффективную терапию.

The article presents modern approaches to the diagnosis and therapy of patients with allergic rhinitis. The document was developed by the professional association of pediatric specialists — the Union of Pediatricians of Russia — together with leading specialists of the Russian Association of Allergologists and Clinical Immunologists, the National Medical Association of Otorhinolaryngologists and is regularly updated taking into account the latest data on the effectiveness and safety of various medical interventions. The article provides information about the epidemiology of allergic rhinitis, provides characteristic diagnostic signs of the disease, allowing for establishment as timely as possible of a correct diagnosis and, taking into account a personalized approach, prescribe effective therapy.

аллергический ринитклинические рекомендациидиагностикаАСИТдетиallergic rhinitisclinical guidelinesdiagnosisACITchildrenОтсутствует.Not specified.ReferencesАллергология и иммунология: национальное руководство / под ред. Р.М. Хаитова, Н.И. Ильиной. — М.: ГЭОТАР-Медиа; 2009. — 656 с.Allergologiya i immunologiya: National guidelines. Khaitov RM, Il’ina NI, eds. Moscow: GEOTAR-Media; 2009. 656 p. (In Russ).Астафьева Н.Г., Баранов А.А., Вишнева Е.А. и др. Аллергический ринит // Российский аллергологический журнал. — 2022. — Т. 19. — № 1. — С. 100–141. — doi: https://doi.org/10.36691/RJA1524Astafieva NG, Baranov AA, Vishneva EA, et al. Allergic rhinitis. Russian Journal of Allergy. 2022;19(1): 100–141. (In Russ). doi: https://doi.org/10.36691/RJA1524Хаитов М.Р., Намазова-Баранова Л.С., Чучалин А.Г. и др. ARIA 2016: Современные направления оказания медицинской помощи больным аллергическим ринитом в свете требований прецизионной медицины // Российский аллергологический журнал. — 2017. — Т. 14. — № 3. — С. 46–54.Khaitov MR, Namazova-Baranova LS, Chuchalin AG, et al. ARIA 2016: Integrated care pathways for predictive medicine across the life cycle. Russian Journal of Allergy. 2017;14(3):46–54. (In Russ).Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2016 revision. J Allergy Clin Immunol. 2017;140(4):950–958. doi: https://doi.org/10/1016/j/jaci.2017.03.050Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2016 revision. J Allergy Clin Immunol. 2017;140(4):950–958. doi: https://doi.org/10/1016/j/jaci.2017.03.050Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy. 2008;63(Suppl):8–160. doi: https://doi.org/10.1111/j.1398-9995.2007.01620.xBousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy. 2008;63(Suppl):8–160. doi: https://doi.org/10.1111/j.1398-9995.2007.01620.xХаитов М.Р., Намазова-Баранова Л.С., Ильина Н.И. и др. ARIA 2019: алгоритмы оказания помощи при аллергическом рините в России // Российский аллергологический журнал. — 2020. — Т. 17. — № 1. — С. 7–22. — doi: https://doi.org/10.36691/RAJ.2020.17.1.001Khaitov M, Namazova-Baranova L, Ilyina N, et al. 2019 ARIA: care pathways for allergic rhinitis in Russia. Russian Journal of Allergy. 2020;17(1):7–22. (In Russ). doi: https://doi.org/10.36691/RAJ.2020.17.1.001Wise SK, Lin SY, Toskala E, et al. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Int Forum Allergy Rhinol. 2018;8(2):108–352. doi: https://doi.org/10.1002/alr.22073Wise SK, Lin SY, Toskala E, et al. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Int Forum Allergy Rhinol. 2018;8(2):108–352. doi: https://doi.org/10.1002/alr.22073Global atlas of allergy. Akdis CA, Agache I, eds. European Academy of Allergy and Clinical Immunology; 2014. 388 p.Global atlas of allergy. Akdis CA, Agache I, eds. European Academy of Allergy and Clinical Immunology; 2014. 388 p.Гущин И.С. Аллергическое воспаление и его фармакологический контроль. — М.: Фармарус Принт; 1998. — 250 с.Gushchin IS. Allergicheskoe vospalenie i ego farmakologicheskii kontrol’. Moscow: Farmarus Print; 1998. 250 p. (In Russ).Ильина Н.И., Курбачева О.М., Павлова К.С., Ильина Е.В. Скрининговое эпидемиологическое исследование (GA2LEN) по выявлению аллергических заболеваний и заболеваний органов дыхания в России // Российский аллергологический журнал. — 2009. — Т. 3. — С. 1.Il’ina NI, Kurbacheva OM, Pavlova KS, Il’ina EV. Skriningovoe epidemiologicheskoe issledovanie (GA2LEN) po vyyavleniyu allergicheskikh zabolevanii i zabolevanii organov dykhaniya v Rossii. Russian Journal of Allergy. 2009;(3):1. (In Russ).Ильина Н.И., Лусс Л.В., Курбачева О.М. и др. Влияние климатических факторов на спектр и структуру аллергических заболеваний на примере Московского региона // Российский аллергологический журнал. — 2014. — Т. 11. — № 2. — С. 25–31.Ilyina NI, Luss LV, Kurbacheva OM, et al. The influence of climatic factors on the spectrum and structure of allergic diseases in the case of the Moscow region. Russian Journal of Allergy. 2014;11(2): 25–31. (In Russ).]Хаитов Р.М., Ильина Н.И., Курбачева О.М., Павлова К.С. Традиции, достижения и инновации в современной аллергологии // Физиология и патология иммунной системы. — 2010. — Т. 14. — № 1. — С. 3–14.Khaitov RM, Ilina NI, Kurbacheva OM, Pavlova KS. Traditions, success and innovations in modern allergology. Physiology and Pathology of Immune System. 2010;14(1):3–14. (In Russ).Asher MI, Weiland SK. The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Streering Committee. Clin Exp Allergy. 1998;28(Suppl 5):52–66; discussion 90–91. doi: https://doi.org/10.1046/j.1365-2222.1998.028s5052.xAsher MI, Weiland SK. The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Streering Committee. Clin Exp Allergy. 1998;28(Suppl 5):52–66; discussion 90–91. doi: https://doi.org/10.1046/j.1365-2222.1998.028s5052.xBauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J. 2004;24(5):758–764. doi: https://doi.org/10.1183/09031936.04.00013904Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J. 2004;24(5):758–764. doi: https://doi.org/10.1183/09031936.04.00013904Van Cauwenberge PB, Ciprandi G, Vermeiren J. Epidemiology of allergic rhinitis: Monograph. Brussel: UCB Institute of Allergy; 2001. 27 p.Van Cauwenberge PB, Ciprandi G, Vermeiren J. Epidemiology of allergic rhinitis: Monograph. Brussel: UCB Institute of Allergy; 2001. 27 p.White Book on Allergy. Pawankar R, Canonica GW, Holgate ST, et al., eds. The World Allergy Organization; 2013. 248 p.White Book on Allergy. Pawankar R, Canonica GW, Holgate ST, et al., eds. The World Allergy Organization; 2013. 248 p.Ant K, Pearce N, Anderson HR, et al. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The international Study of Asthma and Allergies in Childhood ISAAC Phase Three. Allergy. 2009;64(1):123–148. doi: https://doi.org/10.1111/j.1398-9995.2008.01884.xAnt K, Pearce N, Anderson HR, et al. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The international Study of Asthma and Allergies in Childhood ISAAC Phase Three. Allergy. 2009;64(1):123–148. doi: https://doi.org/10.1111/j.1398-9995.2008.01884.xTomilova AYu, Namazova-Baranova LS, Torshkhoeva RM, et al. Prevalence of allergic rhinitis in Russian adolescents. European Respiratory Journal. 2011;38(S55):4286.Tomilova AYu, Namazova-Baranova LS, Torshkhoeva RM, et al. Prevalence of allergic rhinitis in Russian adolescents. European Respiratory Journal. 2011;38(S55):4286.Намазова-Баранова Л.С., Алексеева А.А., Алтунин В.В. и др. Аллергия у детей: от теории — к практике. — М.: ПедиатрЪ; 2011. — 668 с. — (Современная педиатрия: от теории — к практике).Namazova-Baranova LS, Alekseeva AA, Altunin VV, et al. Allergiya u detei: ot teorii — k praktike. Moscow: Pediatr; 2011. 668 p. (Sovremennaya pediatriya: ot teorii — k praktike). (In Russ).Corren J. The impact of allergic rhinitis on bronchial asthma. J Allergy Clin Immunol. 1998;101(2 Pt 2):S352–S356. doi: https://doi.org/10.1016/s0091-6749(98)70218-0Corren J. The impact of allergic rhinitis on bronchial asthma. J Allergy Clin Immunol. 1998;101(2 Pt 2):S352–S356. doi: https://doi.org/10.1016/s0091-6749(98)70218-0Gergen PJ, Turkeltaub PC. The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976- 80 (NHANES II). J Allergy Clin Immunol. 1992;90(4 Pt 1):579–588. doi: https://doi.org/10.1016/0091-6749(92)90130-tGergen PJ, Turkeltaub PC. The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976- 80 (NHANES II). J Allergy Clin Immunol. 1992;90(4 Pt 1):579–588. doi: https://doi.org/10.1016/0091-6749(92)90130-tGreisner WA 3rd, Settipane RJ, Settipane GA. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc. 1998;19(4):185–188. doi: https://doi.org/10.2500/108854198778557836Greisner WA 3rd, Settipane RJ, Settipane GA. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc. 1998;19(4):185–188. doi: https://doi.org/10.2500/108854198778557836Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol. 2002;109(3):419–425. doi: https://doi.org/10.1067/mai.2002.121701Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol. 2002;109(3):419–425. doi: https://doi.org/10.1067/mai.2002.121701Tohidinik HR, Mallah N, Takkouche B. History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis. World Allergy Organ J. 2019;12(10):100069. doi: https://doi.org/10.1016/j.waojou.2019.100069Tohidinik HR, Mallah N, Takkouche B. History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis. World Allergy Organ J. 2019;12(10):100069. doi: https://doi.org/10.1016/j.waojou.2019.100069Vignola AM, Chanez P, Godard P, Bousquet J. Relationships between rhinitis and asthma. Allergy. 1998;53(9):833–839. doi: https://doi.org/10.1111/j.1398-9995.1998.tb03988.xVignola AM, Chanez P, Godard P, Bousquet J. Relationships between rhinitis and asthma. Allergy. 1998;53(9):833–839. doi: https://doi.org/10.1111/j.1398-9995.1998.tb03988.xRondón C, Campo P, Togias A, et al. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol. 2012;129(6):1460–1467. doi: https://doi.org/10.1016/j.jaci.2012.02.032Rondón C, Campo P, Togias A, et al. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol. 2012;129(6):1460–1467. doi: https://doi.org/10.1016/j.jaci.2012.02.032Курбачева О.М., Павлова К.С. Аллергический ринит и аллергический конъюнктивит: одна болезнь — две клинические формы // Российский аллергологический журнал. — 2015. — Т. 12. — № 3. — С. 22–29. — doi: https://doi.org/10.36691/RJA441Kurbacheva OM, Pavlova KS. Allergic rhinitis and allergic conjunctivitis: one disease — two clinical forms. Russian Journal of Allergy. 2015;12(3):22–29. (In Russ). doi: https://doi.org/10.36691/RJA441Thomas M. Allergic rhinitis: evidence for impact on asthma. BMC Pulm Med. 2006;6(Suppl 1):S4. doi: https://doi.org/10.1186/1471-2466-6-S1-S4Thomas M. Allergic rhinitis: evidence for impact on asthma. BMC Pulm Med. 2006;6(Suppl 1):S4. doi: https://doi.org/10.1186/1471-2466-6-S1-S4Poorey VK, Soni S, Thakur P, Gupta A. Effect of Nasal Allergy Over Spirometric Parameters: A Prospective Study. Indian J Otolaryngol Head Neck Surg. 2016;68(1):6–10. doi: https://doi.org/10.1007/s12070-015-0876-xPoorey VK, Soni S, Thakur P, Gupta A. Effect of Nasal Allergy Over Spirometric Parameters: A Prospective Study. Indian J Otolaryngol Head Neck Surg. 2016;68(1):6–10. doi: https://doi.org/10.1007/s12070-015-0876-xTogias A. Unique mechanistic features of allergic rhinitis. J Allergy Clin Immunol. 2000;105(6 Pt 2):S599–S604. doi: https://doi.org/10.1067/mai.2000.106885Togias A. Unique mechanistic features of allergic rhinitis. J Allergy Clin Immunol. 2000;105(6 Pt 2):S599–S604. doi: https://doi.org/10.1067/mai.2000.106885Курбачева О.М., Павлова К.С., Галицкая М.А. Аллерген-специфическая иммунотерапия. Аналитический обзор современных международных и отечественных позиционных документов // Российский аллергологический журнал. — 2017. — Т. 14. — № 1. — С. 24–32. — doi: https://doi.org/10.36691/RJA333Kurbacheva OM, Pavlova KS, Galitzkaya MA. Allergen-specific immunotherapy. Analytic review of current international and Russian federal position papers. Russian Journal of Allergy. 2017;14(1):24–32. (In Russ). doi: https://doi.org/10.36691/RJA333Calderón MA, Casale TB, Togias A, et al. Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond. J Allergy Clin Immunol. 2011;127(1): 30–38. doi: https://doi.org/10.1016/j.jaci.2010.08.024Calderón MA, Casale TB, Togias A, et al. Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond. J Allergy Clin Immunol. 2011;127(1): 30–38. doi: https://doi.org/10.1016/j.jaci.2010.08.024Jacobsen L, Niggemann B, Dreborg S, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10 year follow-up on the PAT study. Allergy. 2007;62(8):943–948. doi: https://doi.org/10.1111/j.1398-9995.2007.01451.xJacobsen L, Niggemann B, Dreborg S, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10 year follow-up on the PAT study. Allergy. 2007;62(8):943–948. doi: https://doi.org/10.1111/j.1398-9995.2007.01451.xJutel M, Agache I, Bonini S, et al. Internetional consensus on allergy immunotherapy. J Allergy Clin Immunol. 2015;136(3): 556–568. doi: https://doi.org/10.1016/j.jaci.2015.04.047Jutel M, Agache I, Bonini S, et al. Internetional consensus on allergy immunotherapy. J Allergy Clin Immunol. 2015;136(3): 556–568. doi: https://doi.org/10.1016/j.jaci.2015.04.047Moller C, Dreborg S, Ferdousi HA, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol. 2002; 109(2):251–256. doi: https://doi.org/10.1067/mai.2002.121317Moller C, Dreborg S, Ferdousi HA, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol. 2002; 109(2):251–256. doi: https://doi.org/10.1067/mai.2002.121317Niggemann B, Jacobsen L, Dreborg S, et al. Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy. 2006;61(7):855–859. doi: https://doi.org/10.1111/j.1398-9995.2006.01068.xNiggemann B, Jacobsen L, Dreborg S, et al. Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy. 2006;61(7):855–859. doi: https://doi.org/10.1111/j.1398-9995.2006.01068.xPapadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma. Allergy. 2012;67(8):976–997. doi: https://doi.org/10.1111/j.1398-9995.2012.02865.xPapadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma. Allergy. 2012;67(8):976–997. doi: https://doi.org/10.1111/j.1398-9995.2012.02865.xZielen S, Devillier P, Heinrich J, et al. Sublingual immunotherapy provides long-term relief in allergic rhinitis and reduces the risk of asthma: a retrospective, real-world database analysis. Allergy. 2018;73(1):165–177. doi: https://doi.org/10.1111/all.13213Zielen S, Devillier P, Heinrich J, et al. Sublingual immunotherapy provides long-term relief in allergic rhinitis and reduces the risk of asthma: a retrospective, real-world database analysis. Allergy. 2018;73(1):165–177. doi: https://doi.org/10.1111/all.13213Bousquet PJ, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines. Allergy. 2007;62(4):367–372. doi: https://doi.org/10.1111/j.1398-9995.2006.01276.xBousquet PJ, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines. Allergy. 2007;62(4):367–372. doi: https://doi.org/10.1111/j.1398-9995.2006.01276.xBousquet J, Schunemann HJ, Hellings PW, et al. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. J Allergy Clin Immunol. 2016;138(2):367–374.e2. doi: https://doi.org/10.1016/j.jaci.2016.03.025Bousquet J, Schunemann HJ, Hellings PW, et al. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. J Allergy Clin Immunol. 2016;138(2):367–374.e2. doi: https://doi.org/10.1016/j.jaci.2016.03.025Courbis AL, Murray RB, Arnavielhe S, et al. Electronic Clinical Decision Support System for allergic rhinitis management: MASK e-CDSS. Clin Exp Allergy. 2018;48(12):1640–1653. doi: https://doi.org/10.1111/cea.13230Courbis AL, Murray RB, Arnavielhe S, et al. Electronic Clinical Decision Support System for allergic rhinitis management: MASK e-CDSS. Clin Exp Allergy. 2018;48(12):1640–1653. doi: https://doi.org/10.1111/cea.13230Тюфилин Д.С., Деев И.А., Кобякова О.С. и др. Контроль аллергического ринита: современные инструменты оценки // Бюллетень сибирской медицины. — 2019. — Т. 18. — № 2. — С. 262–273. — doi: https://doi.org/10.20538/1682-0363-2019-2-262–273Tyufilin DS, Deev IA, Kobyakova OS, et al. Allergic rhinitis control: contemporary approaches to evaluation. Bulletin of Siberian Medicine. 2019;18(2):262–273. (In Russ). doi: https://doi.org/10.20538/1682-0363-2019-2-262-273Papadopoulos NG, Bernstein JA, Demoly P, et al. Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report. Allergy. 2015;70(5):474–494. doi: https://doi.org/10.1111/all.12573Papadopoulos NG, Bernstein JA, Demoly P, et al. Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report. Allergy. 2015;70(5):474–494. doi: https://doi.org/10.1111/all.12573Курбачева О.М., Павлова К.С. Федеральные клинические рекомендации. Аллерген-специфическая иммунотерапия // Российский аллергологический журнал. — 2006. — № 4-5. — С. 55–61.Kurbacheva OM, Pavlova KS. Federal’nye klinicheskie rekomendatsii. Allergen-spetsificheskaia immunoterapiia. Russian Journal of Allergy. 2006;(4-5):55–61. (In Russ).Droste JH, Kerhof M, de Monchy JG, et al. Association of skin test reactivity, specific IgE, total IgE, and eosinophils with nasal symptoms in a community-based population study. The Dutch ECRHS Group. J Allergy Clin Immunol. 1996;97(4):922–932. doi: https://doi.org/10.1016/s0091-6749(96)80066-2Droste JH, Kerhof M, de Monchy JG, et al. Association of skin test reactivity, specific IgE, total IgE, and eosinophils with nasal symptoms in a community-based population study. The Dutch ECRHS Group. J Allergy Clin Immunol. 1996;97(4):922–932. doi: https://doi.org/10.1016/s0091-6749(96)80066-2Di Lorenzo G, Pacor ML, Amodio E, et al. Differences and similarities between allergic and nonallergic rhinitis in a large sample of adult patients with rhinitis symptoms. Int Arch Allergy Immunol. 2011;155(3):263–270. doi: https://doi.org/10.1159/000320050Di Lorenzo G, Pacor ML, Amodio E, et al. Differences and similarities between allergic and nonallergic rhinitis in a large sample of adult patients with rhinitis symptoms. Int Arch Allergy Immunol. 2011;155(3):263–270. doi: https://doi.org/10.1159/000320050Gelardi M, Passalacqua G, Fiorella ML, Quaranta N. Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations. Eur Ann Allergy Clin Immunol. 2013;45(1):25–29.Gelardi M, Passalacqua G, Fiorella ML, Quaranta N. Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations. Eur Ann Allergy Clin Immunol. 2013;45(1):25–29.Gelardi M, Peroni DG, Incorvaia C, et al. Seasonal changes in nasal cytology in mite-allergic patients. J Inflamm Res. 2014;7: 39–44. doi: https://doi.org/10.2147/JIR.S54581Gelardi M, Peroni DG, Incorvaia C, et al. Seasonal changes in nasal cytology in mite-allergic patients. J Inflamm Res. 2014;7: 39–44. doi: https://doi.org/10.2147/JIR.S54581Park SC, Kim JH, Lee KH, et al. Association of serum eosinophilia and total immunoglobulin E concentration with the risk of allergic symptoms and allergic sensitization, respectively: A 2-year followup study. Int J Pediatr Otorhinolaryngol. 2016;86:167–171. doi: https://doi.org/10.1016/j.ijporl.2016.05.005Park SC, Kim JH, Lee KH, et al. Association of serum eosinophilia and total immunoglobulin E concentration with the risk of allergic symptoms and allergic sensitization, respectively: A 2-year followup study. Int J Pediatr Otorhinolaryngol. 2016;86:167–171. doi: https://doi.org/10.1016/j.ijporl.2016.05.005Tay TR, Bosco J, Aumann H, et al. Elevated total serum immunoglobulin E (≥1000 IU/mL): implications? Intern Med J. 2016;46(7):846–849. doi: https://doi.org/10.1111/imj.13073Tay TR, Bosco J, Aumann H, et al. Elevated total serum immunoglobulin E (≥1000 IU/mL): implications? Intern Med J. 2016;46(7):846–849. doi: https://doi.org/10.1111/imj.13073Satwani H, Rehman A, Ashraf S, Hassan A. Is serum total IgE levels a good predictor of allergies in children? J Pak Med Assoc. 2009;59(10):698–702.Satwani H, Rehman A, Ashraf S, Hassan A. Is serum total IgE levels a good predictor of allergies in children? J Pak Med Assoc. 2009;59(10):698–702.Tu YL, Chang SW, Tsai HJ, et al. Total serum IgE in a populationbased study of Asian children in Taiwan: reference value and significance in the diagnosis of allergy. PLoS One. 2013;8(11):e80996. doi: https://doi.org/10.1371/journal.pone.0080996Tu YL, Chang SW, Tsai HJ, et al. Total serum IgE in a populationbased study of Asian children in Taiwan: reference value and significance in the diagnosis of allergy. PLoS One. 2013;8(11):e80996. doi: https://doi.org/10.1371/journal.pone.0080996Casale TB, Bernstein IL, Busse WW, et al. Use of an antiIgE humanized monoclonal antibody in ragweed-induced allergic rhinitis. J Allergy Clin Immunol. 1997;100(1):110–121. doi: https://doi.org/10.1016/S0091-6749(97)70202-1Casale TB, Bernstein IL, Busse WW, et al. Use of an antiIgE humanized monoclonal antibody in ragweed-induced allergic rhinitis. J Allergy Clin Immunol. 1997;100(1):110–121. doi: https://doi.org/10.1016/S0091-6749(97)70202-1Okubo K, Okano M, Sato N, et al. Efficacy of Omalizumab for Severe Allergic Rhinitis Induced By Japanese Cedar Pollen in Patients Treated with Combination Oral Antihistamines and Nasal Corticosteroids. J Allergy Clin Immunol. 2019;143(2):AB424. doi: https://doi.org/10.1016/j.jaci.2018.12.955Okubo K, Okano M, Sato N, et al. Efficacy of Omalizumab for Severe Allergic Rhinitis Induced By Japanese Cedar Pollen in Patients Treated with Combination Oral Antihistamines and Nasal Corticosteroids. J Allergy Clin Immunol. 2019;143(2):AB424. doi: https://doi.org/10.1016/j.jaci.2018.12.955Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract. 2014;2(3):332–340. doi: https://doi.org/10.1016/j.jaip.2014.02.001Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract. 2014;2(3):332–340. doi: https://doi. org/10.1016/j.jaip.2014.02.001Павлова К.С., Куличенко Д.С., Курбачева О.М. и др. Омализумаб в лечении сезонных обострений тяжёлого аллергического ринита // Российский аллергологический журнал. — 2022. — Т. 19. — № 2. — С. 164–174. — doi: https://doi.org/10.36691/RJA1539Pavlova KS, Kulichenko DS, Kurbacheva OM, et al. Omalizumab in the severe exacerbations of seasonal allergic rhinitis. Russian Journal of Allergy. 2022;19(2):164–174. (In Russ). doi: https://doi.org/10.36691/RJA1539Chervinsky P, Casale T, Townley R, et al. Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2003;91(2):160–167. doi: https://doi.org/10.1016/S1081-1206(10)62171-0Chervinsky P, Casale T, Townley R, et al. Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2003;91(2):160–167. doi: https://doi.org/10.1016/S1081-1206(10)62171-0Ameli F, Brocchetti F, Tosca MA, et al. Nasal endoscopy in children with suspected allergic rhinitis. Laryngoscope. 2011;121(10): 2055–2059. doi: https://doi.org/10.1002/lary.22156Ameli F, Brocchetti F, Tosca MA, et al. Nasal endoscopy in children with suspected allergic rhinitis. Laryngoscope. 2011;121(10): 2055–2059. doi: https://doi.org/10.1002/lary.22156Eren E, Aktas A, Arslanoglu S, et al. Diagnosis of allergic rhinitis: inter-rater reliability and predictive value of nasal endoscopic examination: a prospective observational study. Clin Otolaryngol. 2013;38(6):481–486. doi: https://doi.org/10.1111/coa.12171Eren E, Aktas A, Arslanoglu S, et al. Diagnosis of allergic rhinitis: inter-rater reliability and predictive value of nasal endoscopic examination: a prospective observational study. Clin Otolaryngol. 2013;38(6):481–486. doi: https://doi.org/10.1111/coa.12171Jareoncharsri P, Thitadilok V, Bunnag C, et al. Nasal endoscopic findings in patients with perennial allergic rhinitis. Asian Pac J Allergy Immunol. 1999;17(4):261–267.Jareoncharsri P, Thitadilok V, Bunnag C, et al. Nasal endoscopic findings in patients with perennial allergic rhinitis. Asian Pac J Allergy Immunol. 1999;17(4):261–267.Brunner JP, Jawad BA, McCoul ED. Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities. Otolaryngol Head Neck Surg. 2017;157(3):519–523. doi: https://doi.org/10.1177/0194599817711887Brunner JP, Jawad BA, McCoul ED. Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities. Otolaryngol Head Neck Surg. 2017;157(3):519–523. doi: https:// doi.org/10.1177/0194599817711887Roll A, Hofbauer G, Ballmer-Weber BK, Schmid-Grendelmeier P. Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy. J Investig Allergol Clin Immunol. 2006;16(2):79–85.Roll A, Hofbauer G, Ballmer-Weber BK, Schmid-Grendelmeier P. Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy. J Investig Allergol Clin Immunol. 2006;16(2):79–85.Malling HJ, Corren J, Creticos PS. Allergen-specific immunotherapy. In: Allergy: Expert Consult Online and Print. Elsevier; 2011. pp. 171–180.Malling HJ, Corren J, Creticos PS. Allergen-specific immunotherapy. In: Allergy: Expert Consult Online and Print. Elsevier; 2011. pp. 171–180. 64. Pitsios C, Petalas K, Dimitriou A, et al. Workup and Clinical Assessment for Allergen Immunotherapy Candidates. Cells. 2022;11(4):653. doi: https://doi.org/10.3390/cells11040653Pitsios C, Petalas K, Dimitriou A, et al. Workup and Clinical Assessment for Allergen Immunotherapy Candidates. Cells. 2022;11(4):653. doi: https://doi.org/10.3390/cells11040653Tschopp JM, Sistek D, Schindler C, et al. Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329 randomized adults from the SAPALDIA Study. Swiss Study on Air Pollution and Lung Diseases in Adults. Allergy. 1998;53(6):608– 613. doi: https://doi.org/10.1111/j.1398-9995.1998.tb03937.xTschopp JM, Sistek D, Schindler C, et al. Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329 randomized adults from the SAPALDIA Study. Swiss Study on Air Pollution and Lung Diseases in Adults. Allergy. 1998;53(6):608– 613. doi: https://doi.org/10.1111/j.1398-9995.1998.tb03937.xNevis IF, Binkley K, Kabali C. Diagnostic accuracy of skinprick testing for allergic rhinitis: a systematic review and metaanalysis. Allergy Asthma Clin Immunol. 2016;12:20. doi: https://doi.org/10.1186/s13223-016-0126-0Nevis IF, Binkley K, Kabali C. Diagnostic accuracy of skinprick testing for allergic rhinitis: a systematic review and metaanalysis. Allergy Asthma Clin Immunol. 2016;12:20. doi: https://doi.org/10.1186/s13223-016-0126-0Health Quality Ontario. Skin Testing for Allergic Rhinitis: A Health Technology Assessment. Ont Health Technol Assess Ser. 2016;16(10):1–45.Health Quality Ontario. Skin Testing for Allergic Rhinitis: A Health Technology Assessment. Ont Health Technol Assess Ser. 2016;16(10):1–45.Liu CY, Zhang Y, Han DM, Zhang L. Evaluation of serum specific IgE for the diagnosis of allergic rhinitis with multi-allergens. Chin Med J (Engl). 2010;123(20):2836–2841.Liu CY, Zhang Y, Han DM, Zhang L. Evaluation of serum specific IgE for the diagnosis of allergic rhinitis with multi-allergens. Chin Med J (Engl). 2010;123(20):2836–2841.Jiang XD, Li GY, Dong Z, Zhu DD. Correlation analysis of two serum-specific immunoglobulin E test systems and skin-prick test in allergic rhinitis patients from northeast China. Am J Rhinol Allergy. 2011;25(2):116–119. doi: https://doi.org/10.2500/ajra.2011.25.3572Jiang XD, Li GY, Dong Z, Zhu DD. Correlation analysis of two serum-specific immunoglobulin E test systems and skin-prick test in allergic rhinitis patients from northeast China. Am J Rhinol Allergy. 2011;25(2):116–119. doi: https://doi.org/10.2500/ajra.2011.25.3572Cox L. Overview of serological-specific IgE antibody testing in children. Curr Allergy Asthma Rep. 2011;11(6):447–453. doi: https://doi.org/10.1007/s11882-011-0226-3Cox L. Overview of serological-specific IgE antibody testing in children. Curr Allergy Asthma Rep. 2011;11(6):447–453. doi: https://doi.org/10.1007/s11882-011-0226-3Hamilton RG, Oppenheimer J. Serological IgE Analyses in the Diagnostic Algorithm for Allergic Disease. J Allergy Clin Immunol Pract. 2015;3(6):833–840; quiz 841–842. doi: https://doi. org/10.1016/j.jaip.2015.08.016Hamilton RG, Oppenheimer J. Serological IgE Analyses in the Diagnostic Algorithm for Allergic Disease. J Allergy Clin Immunol Pract. 2015;3(6):833–840; quiz 841–842. doi: https://doi.org/10.1016/j.jaip.2015.08.016Steering Committee Authors; Review Panel Members. A WAO — ARIA — GA2LEN consensus document on molecularbased allergy diagnosis (PAMD@): Update 2020. World Allergy Organ J. 2020;13(2):100091. doi: https://doi.org/10.1016/j.waojou.2019.100091Steering Committee Authors; Review Panel Members. A WAO — ARIA — GA2LEN consensus document on molecularbased allergy diagnosis (PAMD@): Update 2020. World Allergy Organ J. 2020;13(2):100091. doi: https://doi.org/10.1016/j.waojou.2019.100091Ferrer M, Sanz ML, Sastre J, et al. Molecular diagnosis in Allergology: application of the microarray technique. J Investig Allergol Clin Immunol. 2009;19(1):19–24.Ferrer M, Sanz ML, Sastre J, et al. Molecular diagnosis in Allergology: application of the microarray technique. J Investig Allergol Clin Immunol. 2009;19(1):19–24.Akdis CA, Jutel M, Akdis M. Regulatory effects of histamine and histamine receptor expression in human allergic immune responses. Chem Immunol Allergy. 2008;94:67–82. doi: https:// doi.org/10.1159/000154858Akdis CA, Jutel M, Akdis M. Regulatory effects of histamine and histamine receptor expression in human allergic immune responses. Chem Immunol Allergy. 2008;94:67–82. doi: https://doi.org/10.1159/000154858Allocco FT, Votypka V, De Tineo M, et al. Effects of fexofenadine on the early response to nasal allergen challenge. Ann Allergy Asthma Immunol. 2002;89(6):578–584. doi: https://doi.org/10.1016/S1081-1206(10)62105-9Allocco FT, Votypka V, De Tineo M, et al. Effects of fexofenadine on the early response to nasal allergen challenge. Ann Allergy Asthma Immunol. 2002;89(6):578–584. doi: https://doi.org/10.1016/S1081-1206(10)62105-9Benninger M, Farrar JR, Blaiss M, et al. Evaluating approved medications to treat allergic rhinitis in the United States: an evidence-based review of efficacy for nasal symptoms by class. Ann Allergy Asthma Immunol. 2010;104(1):13–29. doi: https://doi.org/10.1016/j.anai.2009.11.020Benninger M, Farrar JR, Blaiss M, et al. Evaluating approved medications to treat allergic rhinitis in the United States: an evidence-based review of efficacy for nasal symptoms by class. Ann Allergy Asthma Immunol. 2010;104(1):13–29. doi: https://doi.org/10.1016/j.anai.2009.11.020Berger WE, Lumry WR, Meltzer EO, Pearlman DS. Efficacy of desloratadine, 5 mg, compared with fexofenadine, 180 mg, in patients with symptomatic seasonal allergic rhinitis. Allergy Asthma Proc. 2006;27(3):214–223. doi: https://doi.org/10.2500/aap.2006.27.2851Berger WE, Lumry WR, Meltzer EO, Pearlman DS. Efficacy of desloratadine, 5 mg, compared with fexofenadine, 180 mg, in patients with symptomatic seasonal allergic rhinitis. Allergy Asthma Proc. 2006;27(3):214–223. doi: https://doi.org/10.2500/aap.2006.27.2851Bocsan CI, Bujor AI, Miron N, et al. In vivo anti-inflammatory effect of H1 antihistamines in allergic rhinitis: a randomized clinical trial. Balkan Med J. 2015:32(4):352–358. doi: https://doi.org/10.5152/balkanmedj.2015.15884Bocsan CI, Bujor AI, Miron N, et al. In vivo anti-inflammatory effect of H1 antihistamines in allergic rhinitis: a randomized clinical trial. Balkan Med J. 2015:32(4):352–358. doi: https://doi.org/10.5152/balkanmedj.2015.15884Bousquet J, Bachert C, Canonica GW, et al. ACCEPT-1 Study Group. Efficacy of desloratadine in intermittent allergic rhinitis: a GA2LEN study. Allergy. 2009;64(10):1516–1523. doi: https://doi.org/10.1111/j.1398-9995.2009.02115.xBousquet J, Bachert C, Canonica GW, et al. ACCEPT-1 Study Group. Efficacy of desloratadine in intermittent allergic rhinitis: a GA2LEN study. Allergy. 2009;64(10):1516–1523. doi: https://doi.org/10.1111/j.1398-9995.2009.02115.xCanonica GW, Tarantini F, Compalati E, Penagos M. Efficacy of desloratadine in the treatment of allergic rhinitis: a metaanalysis of randomized, double-blind, controlled trials. Allergy. 2007;62(4):359–366. doi: https://doi.org/10.1111/j.1398-9995.2006.01277.xCanonica GW, Tarantini F, Compalati E, Penagos M. Efficacy of desloratadine in the treatment of allergic rhinitis: a metaanalysis of randomized, double-blind, controlled trials. Allergy. 2007;62(4):359–366. doi: https://doi.org/10.1111/j.1398-9995.2006.01277.xDe Blic J, Wahn U, Billard E, et al. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Pediatr Allergy Immunol. 2005;16(3):267–275. doi: https://doi.org/10.1111/j.1399-3038.2005.00216.xDe Blic J, Wahn U, Billard E, et al. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Pediatr Allergy Immunol. 2005;16(3):267–275. doi: https://doi.org/10.1111/j.1399-3038.2005.00216.xDykewicz MS, Wallace DV, Baroody F, et al. Treatment of seasonal allergic rhinitis: An evidence-based focused 2017 guideline update. Ann Allergy Asthma Immunol. 2017;119(6):489–511.e41. doi: https://doi.org/10.1016/j.anai.2017.08.012Dykewicz MS, Wallace DV, Baroody F, et al. Treatment of seasonal allergic rhinitis: An evidence-based focused 2017 guideline update. Ann Allergy Asthma Immunol. 2017;119(6):489–511.e41. doi: https://doi.org/10.1016/j.anai.2017.08.012Farré M, Pérez-Mañá C, Papaseit E, et al. Bilastine vs. hydroxyzine: occupation of brain histamine H1-receptors evaluated by positron emission tomography in healthy volunteers. Br J Clin Pharmacol. 2014;78(5):970–980. doi: https://doi.org/10.1111/bcp.12421Farré M, Pérez-Mañá C, Papaseit E, et al. Bilastine vs. hydroxyzine: occupation of brain histamine H1-receptors evaluated by positron emission tomography in healthy volunteers. Br J Clin Pharmacol. 2014;78(5):970–980. doi: https://doi.org/10.1111/bcp.12421Gillman S, Gillard M, Strolin Benedetti M. The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines. Allergy Asthma Proc. 2009;30(4): 366–376. doi: https://doi.org/10.2500/aap.2009.30.3226Gillman S, Gillard M, Strolin Benedetti M. The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines. Allergy Asthma Proc. 2009;30(4): 366–376. doi: https://doi.org/10.2500/aap.2009.30.3226Leurs R, Church MK, Taglialatela M. H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy. 2002;32(4):489–498. doi: https://doi.org/10.1046/j.0954-7894.2002.01314.xLeurs R, Church MK, Taglialatela M. H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy. 2002;32(4):489–498. doi: https://doi.org/10.1046/j.0954-7894.2002.01314.xLukat K, Rivas P, Roger A, et al. A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebocontrolled study. J Asthma Allergy. 2013;6:31–39. doi: https://doi. org/10.2147/JAA.S39496Lukat K, Rivas P, Roger A, et al. A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebocontrolled study. J Asthma Allergy. 2013;6:31–39. doi: https://doi.org/10.2147/JAA.S39496Mösges R, König V, Köberlein J. The effectiveness of modern antihistamines for treatment of allergic rhinitis — an IPD metaanalysis of 140,853 patients. Allergol Int. 2013;62(2):215–222. doi: https://doi.org/10.2332/allergolint.12-OA-0486Mösges R, König V, Köberlein J. The effectiveness of modern antihistamines for treatment of allergic rhinitis — an IPD metaanalysis of 140,853 patients. Allergol Int. 2013;62(2):215–222. doi: https://doi.org/10.2332/allergolint.12-OA-0486Muntean A, Bocsan I, Deleanu DM. The effect of H1-antihistamines on allergic inflammation in patients with allergic rhinitis. Human and Veterinary Medicine. 2016;8(4):161–165.Muntean A, Bocsan I, Deleanu DM. The effect of H1-antihistamines on allergic inflammation in patients with allergic rhinitis. Human and Veterinary Medicine. 2016;8(4):161–165.Naclerio RM. The effect of antihistamines on the immediate allergic response: a comparative review. Otolaryngol Head Neck Surg. 1993;108(6):723–730. doi: https://doi.org/10.1177/019459989310800615Naclerio RM. The effect of antihistamines on the immediate allergic response: a comparative review. Otolaryngol Head Neck Surg. 1993;108(6):723–730. doi: https://doi.org/10.1177/019459989310800615Okubo K, Suzuki T, Tanaka A, Aoki H. Efficacy and safety of rupatadine in Japanese patients with seasonal allergic rhinitis: a double-blind, randomized, multicenter, placebo-controlled clinical trial. Allergol Int. 2019;68(2):207–215. doi: https://doi.org/10.1016/j.alit.2018.08.011Okubo K, Suzuki T, Tanaka A, Aoki H. Efficacy and safety of rupatadine in Japanese patients with seasonal allergic rhinitis: a double-blind, randomized, multicenter, placebo-controlled clinical trial. Allergol Int. 2019;68(2):207–215. doi: https://doi.org/10.1016/j.alit.2018.08.011Valk P, Jetten A, Simons R. Effects of a single oral dose of bilastine 20 mg on flying ability in healthy volunteers under conditions of simulated cabin pressure. Soesterberg: TNO; 2015. 60 p.Valk P, Jetten A, Simons R. Effects of a single oral dose of bilastine 20 mg on flying ability in healthy volunteers under conditions of simulated cabin pressure. Soesterberg: TNO; 2015. 60 p.Ilyina NI, Pavlova KS. Antihistamines, anti-inflammatory and anti-allergic properties of desloratadine. Consilium Medicum. 2015;17(3):79–83. (In Russ).Ильина Н.И., Павлова К.С. Антигистминные, противовоспалительные и противоаллергические свойства дезлоратадина // Consilium Medicum. — 2015. — Т. 17. — № 3. — С. 79–83.Church MK, Maurer M, Simons FE, et al. Risk of firstgeneration H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65(4):459–466. doi: https://doi.org/10.1111/j.1398-9995.2009.02325.xChurch MK, Maurer M, Simons FE, et al. Risk of firstgeneration H(1)-antihistamines: a GA(2)LEN position paper. Allergy. 2010;65(4):459–466. doi: https://doi.org/10.1111/j.1398-9995.2009.02325.xSimons FE. Advances in H1-antihistamines. N Engl J Med. 2004;351(21):2203–2217. doi: https://doi.org/10.1056/NEJMra033121Simons FE. Advances in H1-antihistamines. N Engl J Med. 2004;351(21):2203–2217. doi: https://doi.org/10.1056/NEJMra033121Castillo M, Scott NW, Mustafa MZ, et al. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Cochrane Database Syst Rev. 2015;2015(6):CD009566. doi: https://doi.org/10.1002/14651858.CD009566.pub2Castillo M, Scott NW, Mustafa MZ, et al. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Cochrane Database Syst Rev. 2015;2015(6):CD009566. doi: https://doi.org/10.1002/14651858.CD009566.pub2Lee TA, Pickard AS. Meta-analysis of azelastine nasal spray for the treatment of allergic rhinitis. Pharmacotherapy. 2007;27(6): 852–859. doi: https://doi.org/10.1592/phco.27.6.852Lee TA, Pickard AS. Meta-analysis of azelastine nasal spray for the treatment of allergic rhinitis. Pharmacotherapy. 2007;27(6): 852–859. doi: https://doi.org/10.1592/phco.27.6.852Al Sayyad JJ, Fedorowicz Z, Alhashimi D, Jamal A. Topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database Syst Rev. 2007;2007(1):CD003163. doi: https://doi.org/10.1002/14651858.CD003163.pub4Al Sayyad JJ, Fedorowicz Z, Alhashimi D, Jamal A. Topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database Syst Rev. 2007;2007(1):CD003163. doi: https://doi.org/10.1002/14651858.CD003163.pub4Dibildox J. Safety and efficacy of mometasone furoate aqueous nasal spray in children with allergic rhinitis: results of recent clinical trials. J Allergy Clin Immunol. 2001;108(1 Suppl):S54–S58. doi: https://doi.org/10.1067/mai.2001.115567Dibildox J. Safety and efficacy of mometasone furoate aqueous nasal spray in children with allergic rhinitis: results of recent clinical trials. J Allergy Clin Immunol. 2001;108(1 Suppl):S54–S58. doi: https://doi.org/10.1067/mai.2001.115567Herman H. Once-daily administration of intranasal corticosteroids for allergic rhinitis: a comparative review of efficacy, safety, patient preference, and cost. Am J Rhinol. 2007;21(1):70–79. doi: https://doi.org/10.2500/ajr.2007.21.2896Herman H. Once-daily administration of intranasal corticosteroids for allergic rhinitis: a comparative review of efficacy, safety, patient preference, and cost. Am J Rhinol. 2007;21(1):70–79. doi: https://doi.org/10.2500/ajr.2007.21.2896Penagos M, Compalati E, Tarantini F, et al. Efficacy of mometasone furoate nasal spray in the treatment of allergic rhinitis: meta-analysis of randomized, double-blind, placebocontrolled, clinical trials. Allergy. 2008;63(10):1280–1291. doi: https://doi.org/10.1111/j.1398-9995.2008.01808.xPenagos M, Compalati E, Tarantini F, et al. Efficacy of mometasone furoate nasal spray in the treatment of allergic rhinitis: meta-analysis of randomized, double-blind, placebocontrolled, clinical trials. Allergy. 2008;63(10):1280–1291. doi: https://doi.org/10.1111/j.1398-9995.2008.01808.xRodrigo GJ, Neffen H. Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review. Clin Exp Allergy. 2011;41(2):160–170. doi: https://doi.org/10.1111/j.1365-2222.2010.03654.xRodrigo GJ, Neffen H. Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review. Clin Exp Allergy. 2011;41(2):160–170. doi: https://doi.org/10.1111/j.1365-2222.2010.03654.xWu EL, Harris WC, Babcock CM, et al. Epistaxis Risk Associated with Intranasal Corticosteroid Sprays: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2019;161(1):18–27. doi: https://doi.org/10.1177/0194599819832277Wu EL, Harris WC, Babcock CM, et al. Epistaxis Risk Associated with Intranasal Corticosteroid Sprays: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2019;161(1):18–27. doi: https://doi.org/10.1177/0194599819832277Yanez A, Rodrigo GJ. Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2002;89(5):479–484. doi: https://doi.org/10.1016/S1081-1206(10)62085-6Yanez A, Rodrigo GJ. Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2002;89(5):479–484. doi: https://doi.org/10.1016/S1081-1206(10)62085-6Zieglmayer P, Zieglmayer R, Bareille P, et al. Fluticasone furoate versus placebo in symptoms of grass-pollen allergic rhinitis induced by exposure in the Vienna Challenge Chamber. Curr Med Res Opin. 2008;24(6):1833–1840. doi: https://doi.org/10.1185/03007990802155792Zieglmayer P, Zieglmayer R, Bareille P, et al. Fluticasone furoate versus placebo in symptoms of grass-pollen allergic rhinitis induced by exposure in the Vienna Challenge Chamber. Curr Med Res Opin. 2008;24(6):1833–1840. doi: https://doi.org/10.1185/03007990802155792DeWester J, Philpot EE, Westlund RE, et al. The efficacy of intranasal fluticasone propionate in the relief of ocular symptoms associated with seasonal allergic rhinitis. Allergy Asthma Proc. 2003;24(5):331–337.DeWester J, Philpot EE, Westlund RE, et al. The efficacy of intranasal fluticasone propionate in the relief of ocular symptoms associated with seasonal allergic rhinitis. Allergy Asthma Proc. 2003;24(5):331–337.Bielory L, Chun Y, Bielory BP, Canonica GW. Impact of mometasone furoate nasal spray on individual ocular symptoms of allergic rhinitis: a meta-analysis. Allergy. 2011;66(5):686–693. doi: https://doi.org/10.1111/j.1398-9995.2010.02543.xBielory L, Chun Y, Bielory BP, Canonica GW. Impact of mometasone furoate nasal spray on individual ocular symptoms of allergic rhinitis: a meta-analysis. Allergy. 2011;66(5):686–693. doi: https://doi.org/10.1111/j.1398-9995.2010.02543.xBousquet J, Meltzer EO, Couroux P, et al. Onset of action of the fixed combination intranasal azelastine-fluticasone propionate in an allergen exposure chamber. J Allergy Clin Immunol Pract. 2018;6(5):1726–1732.e6. doi: https://doi.org/10.1016/j.jaip.2018.01.031Bousquet J, Meltzer EO, Couroux P, et al. Onset of action of the fixed combination intranasal azelastine-fluticasone propionate in an allergen exposure chamber. J Allergy Clin Immunol Pract. 2018;6(5):1726–1732.e6. doi: https://doi.org/10.1016/j.jaip.2018.01.031Debbaneh PM, Bareiss AK, Wise SK, McCoul ED. Intranasal Azelastine and Fluticasone as Combination Therapy for Allergic Rhinitis: Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2019;161(3):412–418. doi: https://doi.org/10.1177/0194599819841883Debbaneh PM, Bareiss AK, Wise SK, McCoul ED. Intranasal Azelastine and Fluticasone as Combination Therapy for Allergic Rhinitis: Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2019;161(3):412–418. doi: https://doi.org/10.1177/0194599819841883Hampel FC, Ratner PH, Van Bavel J, et al. Double-blind, placebocontrolled study of azelastine and fluticasone in a single nasal spray delivery device. Ann Allergy Asthma Immunol. 2010;105(2): 168–173. doi: https://doi.org/10.1016/j.anai.2010.06.008Hampel FC, Ratner PH, Van Bavel J, et al. Double-blind, placebocontrolled study of azelastine and fluticasone in a single nasal spray delivery device. Ann Allergy Asthma Immunol. 2010;105(2): 168–173. doi: https://doi.org/10.1016/j.anai.2010.06.008Andrews CP, Mohar D, Salhi Y, et al. Efficacy and safety of twicedaily and once-daily olopatadine-mometasone combination nasal spray for seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2020;124(2):171–178.e2. doi: https://doi.org/10.1016/j.anai.2019.11.007Andrews CP, Mohar D, Salhi Y, et al. Efficacy and safety of twicedaily and once-daily olopatadine-mometasone combination nasal spray for seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2020;124(2):171–178.e2. doi: https://doi.org/10.1016/j.anai.2019.11.007Gross GN, Berman G, Amar NJ, et al. Efficacy and safety of olopatadine-mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2019;122(6):630–638.e3. doi: https://doi.org/10.1016/j. anai.2019.03.017Gross GN, Berman G, Amar NJ, et al. Efficacy and safety of olopatadine-mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2019;122(6):630–638.e3. doi: https://doi.org/10.1016/j.anai.2019.03.017Hampel FC, Pedinoff AJ, Jacobs RL, et al. Olopatadinemometasone combination nasal spray: Evaluation of efficacy and safety in patients with seasonal allergic rhinitis. Allergy Asthma Proc. 2019;40(4):261–272. doi: https://doi.org/10.2500/aap.2019.40.4223Hampel FC, Pedinoff AJ, Jacobs RL, et al. Olopatadinemometasone combination nasal spray: Evaluation of efficacy and safety in patients with seasonal allergic rhinitis. Allergy Asthma Proc. 2019;40(4):261–272. doi: https://doi.org/10.2500/aap.2019.40.4223Patel P, Salapatek AM, Tantry SK. Effect of olopatadinemometasone combination nasal spray on seasonal allergic rhinitis symptoms in an environmental exposure chamber study. Ann Allergy Asthma Immunol. 2019;122(2):160–166.e1. doi: https://doi.org/10.1016/j.anai.2018.10.011Patel P, Salapatek AM, Tantry SK. Effect of olopatadinemometasone combination nasal spray on seasonal allergic rhinitis symptoms in an environmental exposure chamber study. Ann Allergy Asthma Immunol. 2019;122(2):160–166.e1. doi: https://doi.org/10.1016/j.anai.2018.10.011Patel P, Salapatek AM, Talluri RS, et al. Pharmacokinetics of intranasal mometasone in the fixed-dose combination GSP301 versus two monotherapy intranasal mometasone formulations. Allergy Asthma Proc. 2018;39(4):232–239. doi: https://doi.org/10.2500/aap.2018.39.4134Patel P, Salapatek AM, Talluri RS, et al. Pharmacokinetics of intranasal mometasone in the fixed-dose combination GSP301 versus two monotherapy intranasal mometasone formulations. Allergy Asthma Proc. 2018;39(4):232–239. doi: https://doi.org/10.2500/aap.2018.39.4134Prenner BM, Amar NJ, Hampel FC Jr, et al. Efficacy and safety of GSP301 nasal spray in children aged 6 to 11 years with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2022;129(5): 618–626. doi: https://doi.org/10.1016/j.anai.2022.07.029Prenner BM, Amar NJ, Hampel FC Jr, et al. Efficacy and safety of GSP301 nasal spray in children aged 6 to 11 years with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2022;129(5): 618–626. doi: https://doi.org/10.1016/j.anai.2022.07.029Segall N, Prenner B, Lumry W, et al. Long-term safety and efficacy of olopatadine-mometasone combination nasal spray in patients with perennial allergic rhinitis. Allergy Asthma Proc. 2019;40(5):301–310. doi: https://doi.org/10.2500/aap.2019.40.4233Segall N, Prenner B, Lumry W, et al. Long-term safety and efficacy of olopatadine-mometasone combination nasal spray in patients with perennial allergic rhinitis. Allergy Asthma Proc. 2019;40(5):301–310. doi: https://doi.org/10.2500/aap.2019.40.4233Wei C. The efficacy and safety of H1-antihistamine versus Montelukast for allergic rhinitis: A systematic review and metaanalysis C. Biomed Pharmacother. 2016;83:989–997. doi: https://doi.org/10.1016/j.biopha.2016.08.003Wei C. The efficacy and safety of H1-antihistamine versus Montelukast for allergic rhinitis: A systematic review and metaanalysis C. Biomed Pharmacother. 2016;83:989–997. doi: https://doi.org/10.1016/j.biopha.2016.08.003Lu Y, Yin M, Cheng L. Meta-analysis of leukotriene receptor antagonist montelukast in the treatment of allergic rhinitis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014;49(8):659–667.Lu Y, Yin M, Cheng L. Meta-analysis of leukotriene receptor antagonist montelukast in the treatment of allergic rhinitis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014;49(8):659–667.Modgill V, Badyal DK, Verghese A. Efficacy and safety of montelukast add-on therapy in allergic rhinitis. Methods Findings Exp Clin Pharmacol. 2010;32(9):669–674. doi: https://doi.org/10.1358/mf.2010.32.9.1533686Modgill V, Badyal DK, Verghese A. Efficacy and safety of montelukast add-on therapy in allergic rhinitis. Methods Findings Exp Clin Pharmacol. 2010;32(9):669–674. doi: https://doi.org/10.1358/mf.2010.32.9.1533686Ngamphaiboon J. Montelukast in general pediatric practices. J Med Assoc Thai. 2005;88(Suppl 4):S348–S351.Ngamphaiboon J. Montelukast in general pediatric practices. J Med Assoc Thai. 2005;88(Suppl 4):S348–S351.Seresirikachorn K, Chitsuthipakorn W, Kanjanawasee D, et al. Leukotriene Receptor Antagonist Addition to H1-Antihistamine Is Effective for Treating Allergic Rhinitis: A Systematic Review and Meta-analysis. Am J Rhinol Allergy. 2019;33(5):591–600. doi: https://doi.org/10.1177/1945892419844459Seresirikachorn K, Chitsuthipakorn W, Kanjanawasee D, et al. Leukotriene Receptor Antagonist Addition to H1-Antihistamine Is Effective for Treating Allergic Rhinitis: A Systematic Review and Meta-analysis. Am J Rhinol Allergy. 2019;33(5):591–600. doi: https://doi.org/10.1177/1945892419844459Xu Y, Zhang J, Wang J. The Efficacy and Safety of Selective H1-Antihistamine versus Leukotriene Receptor Antagonist for Seasonal Allergic Rhinitis: A Meta-Analysis. PLoS One. 2014;9(11):e112815. doi: https://doi.org/10.1371/journal.pone.0112815Xu Y, Zhang J, Wang J. The Efficacy and Safety of Selective H1-Antihistamine versus Leukotriene Receptor Antagonist for Seasonal Allergic Rhinitis: A Meta-Analysis. PLoS One. 2014;9(11):e112815. doi: https://doi.org/10.1371/journal.pone.0112815Nayak A. A review of montelukast in the treatment of asthma and allergic rhinitis. Expert Opin Pharmacother. 2004;5:679–686. doi: https://doi.org/10.1517/14656566.5.3.679Nayak A. A review of montelukast in the treatment of asthma and allergic rhinitis. Expert Opin Pharmacother. 2004;5:679–686. doi: https://doi.org/10.1517/14656566.5.3.679Polos PG. Montelukast is an effective monotherapy for mild asthma and for asthma with co-morbid allergic rhinitis. Prim Care Respir J. 2006;15(5):310–311; author reply 311–312. doi: https://doi.org/10.1016/j.pcrj.2006.07.003Polos PG. Montelukast is an effective monotherapy for mild asthma and for asthma with co-morbid allergic rhinitis. Prim Care Respir J. 2006;15(5):310–311; author reply 311–312. doi: https://doi.org/10.1016/j.pcrj.2006.07.003Watts K, Chavasse RJPG. Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst Rev. 2012;2012(5):CD006100. doi: https://doi.org/10.1002/14651858.CD006100.pub2Watts K, Chavasse RJPG. Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst Rev. 2012;2012(5):CD006100. doi: https://doi.org/10.1002/14651858.CD006100.pub2Ciebiada M, Górska-Ciebiada M, DuBuske LM, Górski P. Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. Ann Allergy Asthma Immunol. 2006;97(5):664–671. doi: https://doi.org/10.1016/S1081-1206(10)61098-8Ciebiada M, Górska-Ciebiada M, DuBuske LM, Górski P. Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. Ann Allergy Asthma Immunol. 2006;97(5):664–671. doi: https://doi.org/10.1016/S1081-1206(10)61098-8Gupta V, Matreja PS. Efficacy of montelukast and levocetirizine as treatment for allergic rhinitis. J Allergy Ther. 2010;1:103. doi: https://doi.org/10.4172/2155-6121.1000103Gupta V, Matreja PS. Efficacy of montelukast and levocetirizine as treatment for allergic rhinitis. J Allergy Ther. 2010;1:103. doi: https://doi.org/10.4172/2155-6121.1000103Liu G, Zhou X, Chen J, Liu F. Oral antihistamines alone vs in combination with leukotriene receptor antagonists for allergic rhinitis: a meta-analysis. Otolaryngol Head Neck Surg. 2018;158(3): 450–458. doi: https://doi.org/10.1177/0194599817752624Liu G, Zhou X, Chen J, Liu F. Oral antihistamines alone vs in combination with leukotriene receptor antagonists for allergic rhinitis: a meta-analysis. Otolaryngol Head Neck Surg. 2018;158(3): 450–458. doi: https://doi.org/10.1177/0194599817752624Khattiyawittayakun L, Seresirikachorn K, Chitsuthipakorn W, et al. Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2018;8(12):1445–1453. doi: https://doi.org/10.1002/alr.22193Khattiyawittayakun L, Seresirikachorn K, Chitsuthipakorn W, et al. Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2018;8(12):1445–1453. doi: https://doi.org/10.1002/alr.22193Yoo JK, Seikaly H, Calhoun KH. Extended use of topical nasal decongestants. Laryngoscope. 1997;107(1):40–43. doi: https://doi.org/10.1097/00005537-199701000-00010Yoo JK, Seikaly H, Calhoun KH. Extended use of topical nasal decongestants. Laryngoscope. 1997;107(1):40–43. doi: https://doi.org/10.1097/00005537-199701000-00010Okano M. Efficacy and safety of omalizumab for severe Japanese cedar pollinosis in patients treated with combination oral antihistamines and nasal corticosteroids. Poster presented at The EAACI. Lisbon, June 1–6, 2019. Poster #TP1372.Okano M. Efficacy and safety of omalizumab for severe Japanese cedar pollinosis in patients treated with combination oral antihistamines and nasal corticosteroids. Poster presented at The EAACI. Lisbon, June 1–6, 2019. Poster #TP1372.Yu C, Wang K, Cui X, et al. Clinical Efficacy and Safety of Omalizumab in the Treatment of Allergic Rhinitis: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Am J Rhinol Allergy. 2020;34(2):196–208. doi: https://doi.org/10.1177/1945892419884774Yu C, Wang K, Cui X, et al. Clinical Efficacy and Safety of Omalizumab in the Treatment of Allergic Rhinitis: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Am J Rhinol Allergy. 2020;34(2):196–208. doi: https://doi.org/10.1177/1945892419884774Kilburn SA, Lasserson TJ, McKean MC. Pet allergen control measures for allergic asthma in children and adults. Cochrane Database Syst Rev. 2001;2001(1):CD002989. doi: https://doi.org/10.1002/14651858.CD002989Kilburn SA, Lasserson TJ, McKean MC. Pet allergen control measures for allergic asthma in children and adults. Cochrane Database Syst Rev. 2001;2001(1):CD002989. doi: https://doi.org/10.1002/14651858.CD002989Sheikh A, Hurwitz B, Nurmatov U, van Schayck CP. House dust mite avoidance measures for perennial allergic rhinitis. Cochrane Database Syst Rev. 2010;2010(7):CD001563. doi: https://doi.org/10.1002/14651858.CD001563.pub3Sheikh A, Hurwitz B, Nurmatov U, van Schayck CP. House dust mite avoidance measures for perennial allergic rhinitis. Cochrane Database Syst Rev. 2010;2010(7):CD001563. doi: https://doi.org/10.1002/14651858.CD001563.pub3Head K, Snidvongs K, Glew S, et al. Saline irrigation for allergic rhinitis. Cochrane Database Syst Rev. 2018;2018(6):CD012597. doi: https://doi.org/10.1002/14651858.CD012597.pub2Head K, Snidvongs K, Glew S, et al. Saline irrigation for allergic rhinitis. Cochrane Database Syst Rev. 2018;2018(6):CD012597. doi: https://doi.org/10.1002/14651858.CD012597.pub2Hermelingmeier KE, Weber RK, Hellmich M, et al. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2012;26(5):e119– e125. doi: https://doi.org/10.2500/ajra.2012.26.3787Hermelingmeier KE, Weber RK, Hellmich M, et al. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2012;26(5):e119– e125. doi: https://doi.org/10.2500/ajra.2012.26.3787Li CL, Lin HC, Lin CY, Hsu TF. Effectiveness of Hypertonic Saline Nasal Irrigation for Alleviating Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis. J Clin Med. 2019;8(1):64. doi: https://doi.org/10.3390/jcm8010064Li CL, Lin HC, Lin CY, Hsu TF. Effectiveness of Hypertonic Saline Nasal Irrigation for Alleviating Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis. J Clin Med. 2019;8(1):64. doi: https://doi.org/10.3390/jcm8010064Valerieva A, Church MK, Staevska M, et al. Micronized cellulose powder as a means to enhance intranasal symptomsdriven treatment: patients” attitudes in a real life setting. Allergy. 2016;71(Suppl 102):13.Valerieva A, Church MK, Staevska M, et al. Micronized cellulose powder as a means to enhance intranasal symptomsdriven treatment: patients” attitudes in a real life setting. Allergy. 2016;71(Suppl 102):13.Des Roches A, Paradis L, Menardo JL, et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol. 1997;99(4):450–453. doi: https://doi.org/10.1016/s0091-6749(97)70069-1Des Roches A, Paradis L, Menardo JL, et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol. 1997;99(4):450–453. doi: https://doi.org/10.1016/s0091-6749(97)70069-1Dhami S, Nurmatov U, Arasi S, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and metaanalysis. Allergy. 2017;72(11):1597–1631. doi: https://doi.org/10.1111/all.13201Dhami S, Nurmatov U, Arasi S, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and metaanalysis. Allergy. 2017;72(11):1597–1631. doi: https://doi.org/10.1111/all.13201Feng B, Wu J, Chen B, et al. Efficacy and safety of sublingual immunotherapy for allergic rhinitis in pediatric patients: A meta-analysis of randomized controlled trials. Am J Rhinol Allergy. 2017;31(1):27–35. doi: https://doi.org/10.2500/ajra.2017.31.4382Feng B, Wu J, Chen B, et al. Efficacy and safety of sublingual immunotherapy for allergic rhinitis in pediatric patients: A meta-analysis of randomized controlled trials. Am J Rhinol Allergy. 2017;31(1):27–35. doi: https://doi.org/10.2500/ajra.2017.31.4382Kim JM, Lin SY, Suarez-Cuervo C. Allergen-specific immunotherapy for pediatric asthma and rhinoconjunctivitis: a systematic review. Pediatrics. 2013;131(6):1155–1167. doi: https://doi.org/10.1542/peds.2013-0343Kim JM, Lin SY, Suarez-Cuervo C. Allergen-specific immunotherapy for pediatric asthma and rhinoconjunctivitis: a systematic review. Pediatrics. 2013;131(6):1155–1167. doi: https://doi.org/10.1542/peds.2013-0343Li Y, Yu SY, Tang R, et al. Sublingual Immunotherapy Tablets Relieve Symptoms in Adults with Allergic Rhinitis: A Meta-analysis of Randomized Clinical Trials. Chin Med J (Engl). 2018;131(21): 2583–2588. doi: https://doi.org/10.4103/0366-6999.244108Li Y, Yu SY, Tang R, et al. Sublingual Immunotherapy Tablets Relieve Symptoms in Adults with Allergic Rhinitis: A Meta-analysis of Randomized Clinical Trials. Chin Med J (Engl). 2018;131(21): 2583–2588. doi: https://doi.org/10.4103/0366-6999.244108Mösges R, Valero Santiago A, Allekotte S, et al. Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis. Clin Transl Allergy. 2019:9;29. doi: https://doi.org/10.1186/s13601-019-0268-5Mösges R, Valero Santiago A, Allekotte S, et al. Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis. Clin Transl Allergy. 2019:9;29. doi: https://doi.org/10.1186/s13601-019-0268-5Purello-D’Ambrosio F, Gangemi S, Merendino RA, et al. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study. Clin Exp Allergy. 2001;31(8):1295–1302. doi: https://doi.org/10.1046/j.1365-2222.2001.01027.xPurello-D’Ambrosio F, Gangemi S, Merendino RA, et al. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study. Clin Exp Allergy. 2001;31(8):1295–1302. doi: https://doi.org/10.1046/j.1365-2222.2001.01027.xRadulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2010;2010(12):CD002893. doi: https://doi.org/10.1002/14651858.CD002893.pub2Radulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2010;2010(12):CD002893. doi: https://doi.org/10.1002/14651858.CD002893.pub2Tahamiler R, Saritzali G, Canakcioglu S. Long-term efficacy of sublingual immunotherapy in patients with perennial rhinitis. Laryngoscope. 2007;117(6):965–969. doi: https://doi.org/10.1097/MLG.0b013e31804f8141Tahamiler R, Saritzali G, Canakcioglu S. Long-term efficacy of sublingual immunotherapy in patients with perennial rhinitis. Laryngoscope. 2007;117(6):965–969. doi: https://doi.org/10.1097/MLG.0b013e31804f8141Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005;60(1):4–12. doi: https://doi.org/10.1111/j.1398-9995.2005.00699.xWilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005;60(1):4–12. doi: https://doi.org/10.1111/j.1398-9995.2005.00699.xPavlova KS, Kurbacheva OM, Galitskaya MA, Smirnov DS. Actual conception of allergen-specific immunotherapy mechanisms, potential biomarkers of efficacy and ways of enhancement. Russian Journal of Allergy. 2017;14(4-5): 5–17. (In Russ). doi: https://doi.org/10.36691/RJA290Курбачева О.М., Павлова К.С., Галицкая М.А., Смирнов Д.С. Актуальные представления о механизмах аллерген-специфической иммунотерапии, потенциальных маркерах эффективности и путях совершенствования // Российский аллергологический журнал. — 2017. — Т. 14. — № 4-5. — С. 5–17. — doi: https://doi.org/10.36691/RJA290Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol. 2014;133(3): 621–631. doi: https://doi.org/10.1016/j.jaci.2013.12.1088Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol. 2014;133(3): 621–631. doi: https://doi.org/10.1016/j.jaci.2013.12.1088Pfaar O, Demoly P, Gerth van Wijk R, et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy. 2014;69(7):854–867. doi: https://doi.org/10.1111/all.12383Pfaar O, Demoly P, Gerth van Wijk R, et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy. 2014;69(7):854–867. doi: https://doi.org/10.1111/all.12383Mishra A, Kawatra R, Gola M. Interventions for atrophic rhinitis. Cochrane Database Syst Rev. 2012;2012(2):CD008280. doi: https://doi.org/10.1002/14651858.CD008280.pub2Mishra A, Kawatra R, Gola M. Interventions for atrophic rhinitis. Cochrane Database Syst Rev. 2012;2012(2):CD008280. doi: https://doi.org/10.1002/14651858.CD008280.pub2Jose J, Coatesworth AP. Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment. Cochrane Database Syst Rev. 2010;2010(12):CD005235. doi: https://doi.org/10.1002/14651858.CD005235.pub2Jose J, Coatesworth AP. Inferior turbinate surgery for nasal obstruction in allergic rhinitis after failed medical treatment. Cochrane Database Syst Rev. 2010;2010(12):CD005235. doi: https://doi.org/10.1002/14651858.CD005235.pub2Feng S, Han M, Fan Y, et al. Acupuncture for the treatment of allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2015;29(1):57–62. doi: https://doi.org/10.2500/ajra.2015.29.4116Feng S, Han M, Fan Y, et al. Acupuncture for the treatment of allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2015;29(1):57–62. doi: https://doi.org/10.2500/ajra.2015.29.4116Zhang J, Zhang Y, Huang X, et al. Different Acupuncture Therapies for Allergic Rhinitis: Overview of Systematic Reviews and Network Meta-Analysis. Evid Based Complement Alternat Med. 2020;2020:8363027. doi: https://doi.org/10.1155/2020/8363027Zhang J, Zhang Y, Huang X, et al. Different Acupuncture Therapies for Allergic Rhinitis: Overview of Systematic Reviews and Network Meta-Analysis. Evid Based Complement Alternat Med. 2020;2020:8363027. doi: https://doi.org/10.1155/2020/8363027Maspero JF, Rosenblut A, Finn A Jr, et al. Safety and efficacy of fluticasone furoate in pediatric patients with perennial allergic rhinitis. Otolaryngol Head Neck Surg. 2008;138(1):30–37. doi: https://doi.org/10.1016/j.otohns.2007.10.023Maspero JF, Rosenblut A, Finn A Jr, et al. Safety and efficacy of fluticasone furoate in pediatric patients with perennial allergic rhinitis. Otolaryngol Head Neck Surg. 2008;138(1):30–37. doi: https://doi.org/10.1016/j.otohns.2007.10.023Nasser M, Fedorowicz Z, Aljufairi H, McKerrow W. Antihistamines used in addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database Syst Rev. 2010;2010(7):CD006989. doi: https://doi.org/10.1002/14651858.CD006989.pub2Nasser M, Fedorowicz Z, Aljufairi H, McKerrow W. Antihistamines used in addition to topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database Syst Rev. 2010;2010(7):CD006989. doi: https://doi.org/10.1002/14651858.CD006989.pub2Roberts G, Xatzipsalti M, Borrego LM, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68(9):1102–1116. doi: https://doi.org/10.1111/all.12235Roberts G, Xatzipsalti M, Borrego LM, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68(9):1102–1116. doi: https://doi.org/10.1111/all.12235RADAR. Allergicheskii rinit u detei: Recommendations and algorithm for childhood allergic rhinitis. 2nd edn., rev. and add. Moscow: Original-maket; 2017. 80 p. (In Russ).РАДАР. Аллергический ринит у детей: рекомендации и алгоритм при детском аллергическом рините. — 2-е изд., перераб. и доп. — М.: Оригинал-макет; 2017. — 80 с.Watts AM, Cripps AW, West NP, Cox AJ. Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents. Front Pharmacol. 2019;10:294. doi: https://doi.org/10.3389/fphar.2019.00294Watts AM, Cripps AW, West NP, Cox AJ. Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents. Front Pharmacol. 2019;10:294. doi: https://doi.org/10.3389/fphar.2019.00294Blaiss MS. Safety update regarding intranasal corticosteroids for the treatment of allergic rhinitis. Allergy Asthma Proc. 2011;32(6): 413–418. doi: https://doi.org/10.2500/aap.2011.32.3473Blaiss MS. Safety update regarding intranasal corticosteroids for the treatment of allergic rhinitis. Allergy Asthma Proc. 2011;32(6): 413–418. doi: https://doi.org/10.2500/aap.2011.32.3473Scadding GK, Smith PK, Blaiss M, et al. Allergic Rhinitis in Childhood and the New EUFOREA Algorithm. Front Allergy. 2021;2:706589. doi: https://doi.org/10.3389/falgy.2021.706589Scadding GK, Smith PK, Blaiss M, et al. Allergic Rhinitis in Childhood and the New EUFOREA Algorithm. Front Allergy. 2021;2:706589. doi: https://doi.org/10.3389/falgy.2021.706589Sigurdardottir ST, Jonasson K, Clausen M, et al. Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort. Allergy. 2021;76(9):2855–2865. doi: https://doi.org/10.1111/all.14857Sigurdardottir ST, Jonasson K, Clausen M, et al. Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort. Allergy. 2021;76(9):2855–2865. doi: https://doi.org/10.1111/all.14857Lopatin AS. Diagnostika i lechenie rinita i rinosinusita u beremennykh. Russian Journal of Allergy. 2006;(1):12–18. (In Russ).Лопатин АС. Диагностика и лечение ринита и риносинусита у беременных // Российский аллергологический журнал. — 2006. — № 1. — С. 12–18.Gani F, Braida A, Lombardi C, et al. Rhinitis in pregnancy. Allerg Immunol (Paris). 2003;35(8):306–313.Gani F, Braida A, Lombardi C, et al. Rhinitis in pregnancy. Allerg Immunol (Paris). 2003;35(8):306–313.Kurbacheva OM, Shvets SM. Allergicheskii rinit i beremennost’: vozmozhnosti sovremennoi terapii. Effektivnaya farmakoterapiya. 2013;(18): 74–80. (In Russ).Курбачева О.М., Швец С.М. Аллергический ринит и беременность: возможности современной терапии // Эффективная фармакотерапия. — 2013. — № 18. — С. 74–80.Gilbert C, Mazzotta P, Loebstein R, Koren G. Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review. Drug Saf. 2005;28(8):707–719. doi: https://doi.org/10.2165/00002018-200528080-00005Gilbert C, Mazzotta P, Loebstein R, Koren G. Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review. Drug Saf. 2005;28(8):707–719. doi: https://doi.org/10.2165/00002018-200528080-00005Yawn B, Knudtson M. Treating asthma and comorbid allergic rhinitis in pregnancy. J Am Board Fam Pract. 2007;20(3):289–298. doi: https://doi.org/10.3122/jabfm.2007.03.060144Yawn B, Knudtson M. Treating asthma and comorbid allergic rhinitis in pregnancy. J Am Board Fam Pract. 2007;20(3):289–298. doi: https://doi.org/10.3122/jabfm.2007.03.060144Cetirizine Pregnancy and Breastfeeding Warnings. Available online: https://www.drugs.com/pregnancy/cetirizine.html. Accessed on July 22, 2024.Cetirizine Pregnancy and Breastfeeding Warnings. Available online: https://www.drugs.com/pregnancy/cetirizine.html. Accessed on July 22, 2024.Kallen B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 3. Congenital malformations in the infants. Eur J Clin Pharmacol. 2007;63(4):383–388. doi: https://doi.org/10.1007/s00228-006-0259-zKallen B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 3. Congenital malformations in the infants. Eur J Clin Pharmacol. 2007;63(4):383–388. doi: https://doi.org/10.1007/s00228-006-0259-zKallen B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 3. Congenital malformations in the infants. Eur J Clin Pharmacol. 2007;63(4):383–388. doi: https://doi.org/10.1007/s00228-006-0259-z

The authors declare that there are no conflicts of interest present.