ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v21i1.2708ppharm-2416Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL RECOMMENDATIONSМиокардиты у детей. Этиология. Патогенез. Эпидемиология. Клиническая картинаMyocarditis in children.Etiology. Pathogenesis. Epidemiology. Clinical presentationhttps://orcid.org/0000-0001-7336-4102ВасичкинаЕ. С.VasichkinaElena S.

Васичкина Елена Сергеевна - доктор медицинских наук, заведующая НИЦ неизвестных, редких и генетически обусловленных заболеваний, профессор кафедры детских болезней НМИЦ им. В.А. Алмазова

197341, Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-68-50

MD, PhD, Professor.

2, Akkuratova Str., St. Petersburg, 197341

Vasichkinalena@mail.ruhttps://orcid.org/0000-0002-2290-0013БалыковаЛ. А.BalykovaLarisa A.

Балыкова Лариса Александровна, д.м.н., профессор

Саранск

MD, PhD, Professor.

Saransk

larisabalykova@yandex.ruhttps://orcid.org/0000-0002-0144-2885БасаргинаЕ. Н.BasarginaElena N.

Басаргина Елена Николаевна, д.м.н., профессор.

Москва

MD, PhD, Professor.

Moscow

basargina@nczd.ruhttps://orcid.org/0000-0002-7668-1282БрегельЛ. В.BregelLoudmila V.

Брегель Людмила Владимировна - д.м.н., профессор.

Иркутск

MD, PhD, Professor.

Irkutsk

loudmilabregel@yandex.ruhttps://orcid.org/0000-0002-3219-2145ДегтяреваЕ. А.DegtyarevaElena A.

Дегтярева Елена Александровна - д.м.н., профессор.

Москва

MD, PhD, Professor.

Moscow

dgp48@yandex.ruhttps://orcid.org/0000-0001-8195-5682КовалевИ. А.KovalevIgor A.

Ковалев Игорь Александрович - д.м.н., профессор.

Москва

MD, PhD, Professor.

Moscow

igor.kovalev64@mail.ruhttps://orcid.org/0000-0001-6776-2614КотлуковаН. П.KotlukovaNatalia P.

Котлукова Наталья Павловна - д.м.н., профессор.

Москва

MD, PhD, Professor.

Moscow

natali130@yandex.ruhttps://orcid.org/0000-0002-5273-6859ЛеонтьеваИ. В.LeontievaIrina V.

Леонтьева Ирина Викторовна - д.м.н., профессор.

Москва

MD, PhD, Professor.

Moscow

lirina2006@mail.ruhttps://orcid.org/0000-0001-7362-2685ЯковлеваЛ. В.YakovlevaLyudmila V.

Яковлева Людмила Викторовна - д.м.н., профессор.

Уфа

MD, PhD, Professor.

Ufa

fock20051@mail.ruhttps://orcid.org/0000-0002-7511-3240ГрозноваО. С.GroznovaOlga S.

Грознова Ольга Сергеевна - д.м.н. профессор.

Москва

MD, PhD, Professor.

Moscow

ogroznova@gmail.comНМИЦ им. В.А. АлмазоваРоссияV.A. Almazov Center Department of Children’s DiseasesRussian FederationНациональный исследовательский Мордовский государственный университет им. Н.П. ОгареваРоссияN.P. Ogarev National Research Mordovia State UniversityRussian FederationНМИЦ здоровья детейРоссияNational Medical Research Center for Children’s HealthRussian FederationИГМАПО — филиал РМАНПОРоссияIrkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education”Russian FederationРУДН, Медицинский институтРоссияPeoples’ Friendship University of RussiaRussian FederationНИКИ педиатрии и детской хирургии им. акад. Ю.Е. Вельтищева РНИМУ им. Н.И. ПироговаРоссияYu.E. Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the N.I. Pirogov Russian National Research Medical UniversityRussian FederationРНИМУ им. Н.И. ПироговаРоссияN.I. Pirogov Russian National Research Medical UniversityRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationНИКИ педиатрии и детской хирургии им. акад. Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова; РНИМУ им. Н.И. Пирогова; Благотворительный фонд медико-социальных генетических проектов помощи «Геном жизни»РоссияYu.E. Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the N.I. Pirogov Russian National Research Medical University; N.I. Pirogov Russian National Research Medical University; Charity Fund for medical and social genetic aid projects “Life Genom”Russian Federation2024250220242115061Copyright © Васичкина Е.С., Балыкова Л.А., Басаргина Е.Н., Брегель Л.В., Дегтярева Е.А., Ковалев И.А., Котлукова Н.П., Леонтьева И.В., Яковлева Л.В., Грознова О.С., 20242024Васичкина Е.С., Балыкова Л.А., Басаргина Е.Н., Брегель Л.В., Дегтярева Е.А., Ковалев И.А., Котлукова Н.П., Леонтьева И.В., Яковлева Л.В., Грознова О.С.Vasichkina E.S., Balykova L.A., Basargina E.N., Bregel L.V., Degtyareva E.A., Kovalev I.A., Kotlukova N.P., Leontieva I.V., Yakovleva L.V., Groznova O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2416

Вниманию читателей будет представлена серия статей по миокардитам у детей, в основу которых положены разработанные группой авторов клинические рекомендации по данной тематике. Миокардит — воспалительное заболевание миокарда, для которого характерен широкий спектр клинических проявлений — от незначительных признаков до внезапной сердечной смерти. Учитывая отсутствие патогномоничных признаков, а также схожесть проявлений в дебюте с распространенными детскими заболеваниями, такими как респираторный дистресс, болезни желудочно-кишечного тракта, инфекционная патология, зачастую специалисты выпускают из виду вероятность диагноза «миокардит», что становится причиной позднего старта терапии и неблагоприятного исхода. Учитывая, что на долю миокардита приходится 12% случаев внезапной сердечной смерти у подростков и молодых людей, подозрение на это заболевание при дифференциальной диагностике у детей с неспецифической симптоматикой и прогрессированием заболевания может стать залогом формирования правильной стратегии лечения. Несмотря на существенные достижения в области изучения миокардитов как у взрослых, так и детей, остается еще много нерешенных вопросов. Целью данной статьи является освещение современного взгляда на этиологию, патогенез, эпидемиологию и особенности клинической картины у детей с различными вариантами миокардитов с целью повышения знаний практикующих врачей для лучшего клинического ведения пациентов с миокардитами.

Readers will be presented with a series of articles on myocarditis in children, which are based on clinical guidelines developed by a group of authors on this topic. Myocarditis is an inflammatory myocardial disease characterized by a wide range of clinical manifestations — from minor to sudden cardiac death. Given the absence of pathognomonic symptoms, as well as the similarity of manifestations in the onset with common childhood diseases such as respiratory distress, gastrointestinal diseases, infectious pathology, specialists often overlook the likelihood of a diagnosis of “myocarditis”, which causes a late start of therapy and an adverse outcome. Considering that myocarditis accounts for 12% of cases of sudden cardiac death in adolescents and young adults, suspicion of this disease in differential diagnosis in children with nonspecific symptoms and disease progression may be the key to the formation of a proper treatment strategy. Despite significant advances in the study of myocarditis in both adults and children, there are still many unresolved issues. The purpose of this article is to highlight the current view of the etiology, pathogenesis, epidemiology and clinical features in children with various types of myocarditis in order to increase the knowledge of practitioners for better clinical management of patients with myocarditis.

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The authors declare that there are no conflicts of interest present.