ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v10i2.647ppharm-237Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРЕФЕРЕНТНЫЕ ЗНАЧЕНИЯ СКОРОСТИ РАСПРОСТРАНЕНИЯ ПУЛЬСОВОЙ ВОЛНЫ ПО АОРТЕ У ЗДОРОВЫХ ДЕТЕЙ В ВОЗРАСТЕ ОТ 3 ДО 18 ЛЕТREFERENCE VALUES OF AORTIC PULSE WAVE VELOCITY IN A LARGE HEALTHY POPULATION AGED BETWEEN 3 AND18 YEARSХидвегиЕржебет ВалерияHidvegiErzsebet Valeriapediatriccor@gmail.comИйешМ.IllyesM.pediatriccor@gmail.comБенцурБ.BenczurB.pediatriccor@gmail.comБочкеиРената М.BocskeiRenata M.pediatriccor@gmail.comРадгеберЛ.RatgeberL.pediatriccor@gmail.comЛеккеиЖ.LenkeyZ.pediatriccor@gmail.comМолнарФеренш Т.MolnarFerenc T.pediatriccor@gmail.comЦиракиА.CzirakiA.pediatriccor@gmail.comHeart Institute, Faculty of Medicine, University of Pecs, HungaryВенгрияHeart Institute, Faculty of Medicine, University of Pecs, HungaryHungaryFaculty of Health Sciences Institute of Public Health and Health Promotion, University of Pecs, Pecs, HungaryВенгрияFaculty of Health Sciences Institute of Public Health and Health Promotion, University of Pecs, Pecs, HungaryHungaryDepartment of Hydrodynamic Systems, Budapest University of Technology and Economics, Budapest, HungaryВенгрияDepartment of Hydrodynamic Systems, Budapest University of Technology and Economics, Budapest, HungaryHungary201301042013102Педиатрическая фармакология7278Copyright © Хидвеги Е., Ийеш М., Бенцур Б., Бочкеи Р., Радгебер Л., Леккеи Ж., Молнар Ф., Цираки А., 20132013Хидвеги Е., Ийеш М., Бенцур Б., Бочкеи Р., Радгебер Л., Леккеи Ж., Молнар Ф., Цираки А.Hidvegi E., Illyes M., Benczur B., Bocskei R., Ratgeber L., Lenkey Z., Molnar F., Cziraki A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/237Цель

Цель. Измерение скорости распространения пульсовой волны (СРПВ) по аорте является маркером стратификации риска развития сердечно-сосудистых заболеваний у взрослых. Доказано, что у детей с различными заболеваниями отмечается ухудшение сосудистой функции, но, к сожалению, только в нескольких исследованиях определены нормальные значения скорости распространения пульсовой волны у детей. Цель нашего исследования ― определить референтные значения СРПВ у здоровых детей,  используя новейшие технологии. Пациенты и методы. С помощью неинвазивного  окклюзионного осциллометрического аппарата обследовано 3374 здоровых ребенка (из них 1802 мальчики) в возрасте от 3 до 18 лет. Результаты. Средние значения СРПВ увеличиваются от 5,5±0,3 до 6,5±03 м/с (р<0,05) у мальчиков и с 5,6±0,3 до 6,4±03 м/с (р<0,05) у девочек. Тем не менее данное повышение не постоянное. У детей обоих полов в возрасте от 3 до 8 лет увеличения СРПВ не отмечается. Первое отчетливое повышение СРПВ происходит в возрасте 12,1 лет у мальчиков и в 10,4 года у девочек.  В возрасте от 3 до 8 лет отмечалось непрерывное постепенное нарастание систолического артериального давления, измеренного на плече, и среднего артериального давления, при этом показатели СРПВ оставались неизменными. С 9 лет показатели артериального давления и ригидности аорты изменялись одновременно. Заключение. В проведенном исследовании представлена самая большая на сегодняшний день база данных по артериальной ригидности, полученная у здоровых детей и подростков в возрасте от 3 до 18 лет с помощью простого исследования, адаптированного для широкого применения в педиатрической практике, даже у детей раннего возраста.

Objective

Objective: The measurement of aortic pulse wave velocity (PWVao) is an accepted marker in stratifying individual cardiovascular risk in adults. There is an increasing volume of evidence concerning impaired vascular function in different diseases in paediatric populations, but, unfortunately, only a few studies are available on the measurement of normal PWVao values in children. The aim of our study was to determine the reference values of PWVao in a large healthy population using a newly developed technique. Methods: Three thousand, three hundred and seventyfour healthy individuals (1802 boys) aged 3–18 years were examined by an invasively validated, occlusive, oscillometric device. Results: The mean PWVao values increased from 5.5_0.3 to 6.5_0.3 m/s (P<0.05) in boys and from 5.6_0.3 to 6.4_0.3 m/s (P<0.05) in girls. The increase, however, was not constant, and the values exhibited a flat period between the ages of 3 and 8 years in both sexes. The first pronounced increase occurred at the age of 12.1 years in boys and 10.4 years in girls. Moreover, between the ages of 3 and 8 years, the brachial SBP and mean blood pressures increased continuously and gradually, whereas the PWVao remained unchanged. By contrast, beyond the age of 9 years, blood pressure and aortic stiffness trends basically moved together. Conclusion: Our study provides the largest database to date concerning arterial stiffness in healthy children and adolescents between the ages of 3 and 18 years, and the technology adopted proved easy to use in large paediatric populations, even at a very young age.

 

 

 

 

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The authors declare that there are no conflicts of interest present.