ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v20i5.2634ppharm-2360Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWЛатентный дефицит железа у детей раннего возраста: современные профилактические стратегииLatent Iron Deficiency in Tender-Age Infants: Modern Preventive Measureshttps://orcid.org/0000-0002-8717-2539БеляеваИ. А.BelyaevaIrina A.

Беляева Ирина Анатольевна, доктор медицинских наук, профессор Российской академии наук, заведующая отделом преконцепционной, антенатальной и неонатальной медицины НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. Б.В. Петровского» Минобрнауки России, профессор кафедры факультетской педиатрии педиатрического факультета ФГАОУ РНИМУ им. Н.И. Пирогова Минздрава России, врач-неонатолог ГБУЗ МДКБ ДЗМ

119333, Москва, ул. Фотиевой, д. 10, к. 1

тел.: +7 (905) 728-58-02

Irina A. Belyaeva, MD, PhD, Professor of the RAS

10/1 Fotievoy Str., Moscow, 119333

tel.: +7 (905) 728-58-02

irinaneo@mail.ruhttps://orcid.org/0000-0002-6677-2914БомбардироваЕ. П.BombardirovaElena P.

Бомбардирова Елена Петровна, д.м.н., профессор

Москва

Elena P. Bombardirova, MD, PhD, Professor

Moscow

babalena92@mail.ruhttps://orcid.org/0000-0002-4955-0121ТуртиТ. В.TurtiTatyana V.

Турти Татьяна Владимировна, д.м.н., профессор

Москва

Tatyana V. Turti, MD, PhD, Professor

Moscow

turtit@mail.ruНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова; Морозовская детская городская клиническая больница ДЗМРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Morozovskaya Children’s City HospitalRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова; НИИ организации здравоохранения и медицинского менеджментаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian Federation202317112023205478489Copyright © Беляева И.А., Бомбардирова Е.П., Турти Т.В., 20232023Беляева И.А., Бомбардирова Е.П., Турти Т.В.Belyaeva I.A., Bombardirova E.P., Turti T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2360

В статье представлены важные для педиатров практические сведения о состоянии обеспеченности организма ребенка раннего возраста эссенциальным микроэлементом — железом, а также о причинах развития и стадийности железодефицитных состояний у детей. Охарактеризованы клинические и лабораторные критерии идентификации этих состояний, изложены данные об их распространенности у детей первых лет жизни. Представлены результаты современных исследований, показавших связи железодефицитных состояний с отсроченными нарушениями развития детей, в том числе когнитивного. Подробно описаны алиментарные факторы, ассоциированные с обеспечением организма железом, и диетологические стратегии, включая связанные со своевременным введением, полноценностью и разнообразием прикорма, которые направлены на эффективную и безопасную профилактику латентных железодефицитов.

This article presents practical data, topical for pediatricians, on the child’s body provision with the essential trace element — iron; and on iron deficiency conditions development and staging in children. Clinical and laboratory criteria for the identification of such conditions are defined; data on their prevalence in tender-age infants is outlined. The results of modern studies showing the correlations between iron deficiency and delayed developmental conditions in children (including cognitive ones) are presented. Alimental factors (associated with body provision with iron) and nutritional strategies (associated with supplemental feeding timely administration, adequacy, and diversity) are described in detail. They are focused on effective and safe prevention of latent iron deficiency.

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Nutritionspecific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews. Cochrane Database Syst Rev. 2021;9(9):CD013092. doi: https://doi.org/10.1002/14651858.CD013092.pub2Lucotte G, Dieterlen F. A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation? Blood Cells Mol Dis. 2003;31(2):262–267. doi: https://doi.org/10.1016/s1079-9796(03)00133-5Troesch B, Egli I, Zeder C, et al. Optimization of a phytasecontaining micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. Am J Clin Nutr. 2009;89(2):539–544. doi: https://doi.org/10.3945/ajcn.2008.27026Lönnerdal B. Excess iron intake as a factor in growth, infections, and development of infants and young children. Am J Clin Nutr. 2017;106(Suppl 6):1681S–1687S. doi: https://doi.org/10.3945/ajcn.117.156042Hackl LS, Abizari AD, Speich C, et al. Micronutrient-fortified rice can be a significant source of dietary bioavailable iron in schoolchildren from rural Ghana. Sci Adv. 2019;5:eaau0790. doi: https://doi.org/10.1126/sciadv.aau0790Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomised trial. Lancet. 2013;382(9886):29–40. doi: https://doi.org/10.1016/S0140-6736(13)60437-7Caroli M, Vania A, Tomaselli MA, et al. Breastfed and Formula-Fed Infants: Need of a Different Complementary Feeding Model? Nutrients. 2021;13(11):3756. doi: https://doi.org/10.3390/nu13113756Caroli M, Vania A, Tomaselli MA, et al. Breastfed and Formula-Fed Infants: Need of a Different Complementary Feeding Model? Nutrients. 2021;13(11):3756. doi: https://doi.org/10.3390/nu13113756Tang M, Sheng XY, Krebs NF, Hambidge KM. Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China. Food Nutr Bull. 2014;35(4 Suppl):S188–S192. doi: https://doi.org/10.1177/15648265140354S304Tang M, Sheng XY, Krebs NF, Hambidge KM. Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China. Food Nutr Bull. 2014;35(4 Suppl):S188–S192. doi: https://doi.org/10.1177/15648265140354S304Chen W, Zheng D, Yang C. The Emerging Roles of Ferroptosis in Neonatal Diseases. J Inflamm Res. 2023;16:2661–2674. doi: https://doi.org/10.2147/JIR.S414316Chen W, Zheng D, Yang C. The Emerging Roles of Ferroptosis in Neonatal Diseases. J Inflamm Res. 2023;16:2661–2674. doi: https://doi.org/10.2147/JIR.S414316Lucotte G, Dieterlen F. A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation? Blood Cells Mol Dis. 2003;31(2):262–267. doi: https://doi.org/10.1016/s1079-9796(03)00133-5Lucotte G, Dieterlen F. A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation? Blood Cells Mol Dis. 2003;31(2):262–267. doi: https://doi.org/10.1016/s1079-9796(03)00133-5Lönnerdal B. Excess iron intake as a factor in growth, infections, and development of infants and young children. Am J Clin Nutr. 2017;106(Suppl 6):1681S–1687S. doi: https://doi.org/10.3945/ajcn.117.156042Lönnerdal B. Excess iron intake as a factor in growth, infections, and development of infants and young children. Am J Clin Nutr. 2017;106(Suppl 6):1681S–1687S. doi: https://doi.org/10.3945/ajcn.117.156042Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomised trial. Lancet. 2013;382(9886):29–40. doi: https://doi.org/10.1016/S0140-6736(13)60437-7Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomised trial. Lancet. 2013;382(9886):29–40. doi: https://doi.org/10.1016/S0140-6736(13)60437-7

The authors declare that there are no conflicts of interest present.