ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v20i5.2629ppharm-2359Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL RECOMMENDATIONSСовременные подходы к ведению пациентов с крапивницейModern Approaches to the Management of Patients with Urticariahttps://orcid.org/0000-0003-3987-8112БарановА. А.BaranovAleksander A.

Москва

Moscow

https://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Намазова-Баранова Лейла Сеймуровна, доктор медицинских наук, профессор, академик РАН, заведующая кафедрой факультетской педиатрии педиатрического факультета ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, руководитель НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского», президент Союза педиатров России

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тел.: +7 (499) 400-47-33

Moscow

Isnamazova@yandex.ruhttps://orcid.org/0000-0002-3556-969XИльинаН. И.Il’inaNatalya I.

Москва

Moscow

https://orcid.org/0000-0002-7625-0503КубановА. А.KubanovAlexey A.

Москва

Moscow

https://orcid.org/0000-0002-6378-8582АравийскаяЕ. Р.AraviyskayaElena R.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-7691-4584АстафьеваН. Г.AstafievaNatalya G.

Саратов

Saratov

https://orcid.org/0000-0003-0353-3147БазаевВ. Т.BazaevVitaliy T.

Владикавказ

Vladikavkaz

https://orcid.org/0000-0003-1587-9137БорзоваЕ. Ю.BorzovaElena Yu.

Москва

Moscow

https://orcid.org/0000-0001-7398-0562ВишневаЕ. А.VishnevaElena A.

Москва

Moscow

ГаллямоваЮ. А.GallyamovaYulia A.

Москва

Moscow

https://orcid.org/0000-0002-8279-2173ДанилычеваИ. В.DanilychevaInna V.

Москва

Moscow

https://orcid.org/0000-0002-4609-2591ЕлисютинаО. Г.ElisyutinaOlga G.

Москва

Moscow

https://orcid.org/0000-0002-2553-0484ЗнаменскаяЛ. Ф.ZnamenskayaLudmila F.

Москва

Moscow

https://orcid.org/0000-0002-3781-8661КалугинаВ. Г.KaluginaVera G.

Москва

Moscow

https://orcid.org/0000-0003-3805-8489КарамоваА. Е.KaramovaArphenya E.

Москва

Moscow

https://orcid.org/0000-0002-1589-5623ЛевинаЮ. Г.LevinaYulia G.

Москва

Moscow

https://orcid.org/0000-0002-7806-9484МешковаР. Я.MeshkovaRaisa Ya.

Смоленск

Smolensk

https://orcid.org/0000-0003-2482-1754ОлисоваО. Ю.OlisovaOlga Yu.

Москва

Moscow

https://orcid.org/0000-0002-7571-5460НовикГ. А.NovikGennadiy A.

Санкт-Петербург

Saint Petersburg

СамцовА. В.SamtsovAlexey V.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-3678-7939СелимзяноваЛ. Р.SelimzyanovaLiliia R.

Москва

Moscow

https://orcid.org/0000-0001-7610-6061СоколовскийЕ. В.SokolovskyEvgeniy V.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0003-3358-5087ФеденкоЕ. С.FedenkoElena S.

Москва

Moscow

https://orcid.org/0000-0002-7130-9609ФедороваО. С.FedorovaOlga S.

Tomsk

https://orcid.org/0000-0002-5083-6637ФоминаД. С.FominaDaria S.

Москва

Moscow

https://orcid.org/0000-0002-0387-5481ХайрутдиновВ. Р.KhayrutdinovVladislav R.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-9688-2727ЧикинВ. В.ChikinVadim V.

Москва

Moscow

https://orcid.org/0000-0003-0268-9350ШульженкоА. Е.ShulzhenkoAndrey E.

Москва

Moscow

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Sechenov First Moscow State Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. ПироговаРоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationГНЦ Институт иммунологииРоссияNRC Institute of ImmunologyRussian FederationГНЦДКРоссияState Scientific Center for Dermatovenerology and CosmetologyRussian FederationПСПбГМУ им. акад. И.П. ПавловаРоссияPavlov First Saint Petersburg State Medical UniversityRussian FederationСаратовский ГМУ им. В.И. РазумовскогоРоссияSaratov State Medical University named after V. I. RazumovskyRussian FederationСОГМАРоссияNorth Ossetian State Medical AcademyRussian FederationПервый МГМУ им. И.М. Сеченова (Сеченовский Университет); НИКИ педиатрии ФГБОУ ВО РНИМУ им. ПироговаРоссияSechenov First Moscow State Medical University; Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical UniversityRussian FederationРМАНПОРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of SurgeryRussian FederationСмолГУРоссияSmolensk State UniversityRussian FederationПервый МГМУ им. И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical UniversityRussian FederationСПбГПМУРоссияSaint Petersburg State Pediatric Medical UniversityRussian FederationВмедА им. С.М. КироваРоссияMilitary Medical Academy named after S. M. KirovRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); РНИМУ им. Н.И. ПироговаРоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of Surgery; Sechenov First Moscow State Medical University; Pirogov Russian National Research Medical UniversityRussian FederationСибГМУРоссияSiberian State Medical UniversityRussian FederationГКБ № 52 ДЗМРоссияCity Clinical Hospital No. 52 of Moscow Health DepartmentRussian FederationМГМСУ им. А.И. ЕвдокимоваРоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation202317112023205454477Copyright © Баранов А.А., Намазова-Баранова Л.С., Ильина Н.И., Кубанов А.А., Аравийская Е.Р., Астафьева Н.Г., Базаев В.Т., Борзова Е.Ю., Вишнева Е.А., Галлямова Ю.А., Данилычева И.В., Елисютина О.Г., Знаменская Л.Ф., Калугина В.Г., Карамова А.Е., Левина Ю.Г., Мешкова Р.Я., Олисова О.Ю., Новик Г.А., Самцов А.В., Селимзянова Л.Р., Соколовский Е.В., Феденко Е.С., Федорова О.С., Фомина Д.С., Хайрутдинов В.Р., Чикин В.В., Шульженко А.Е., 20232023Баранов А.А., Намазова-Баранова Л.С., Ильина Н.И., Кубанов А.А., Аравийская Е.Р., Астафьева Н.Г., Базаев В.Т., Борзова Е.Ю., Вишнева Е.А., Галлямова Ю.А., Данилычева И.В., Елисютина О.Г., Знаменская Л.Ф., Калугина В.Г., Карамова А.Е., Левина Ю.Г., Мешкова Р.Я., Олисова О.Ю., Новик Г.А., Самцов А.В., Селимзянова Л.Р., Соколовский Е.В., Феденко Е.С., Федорова О.С., Фомина Д.С., Хайрутдинов В.Р., Чикин В.В., Шульженко А.Е.Baranov A.A., Namazova-Baranova L.S., Il’ina N.I., Kubanov A.A., Araviyskaya E.R., Astafieva N.G., Bazaev V.T., Borzova E.Y., Vishneva E.A., Gallyamova Y.A., Danilycheva I.V., Elisyutina O.G., Znamenskaya L.F., Kalugina V.G., Karamova A.E., Levina Y.G., Meshkova R.Y., Olisova O.Y., Novik G.A., Samtsov A.V., Selimzyanova L.R., Sokolovsky E.V., Fedenko E.S., Fedorova O.S., Fomina D.S., Khayrutdinov V.R., Chikin V.V., Shulzhenko A.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2359

Союзом педиатров России совместно с Российской ассоциацией аллергологов и иммунологов и Российским обществом дерматовенерологов и косметологов (РОДВК) разработаны новые клинические рекомендации для диагноза «крапивница» для взрослых и детей. Крапивница является распространенным заболеванием: различные ее клинические варианты диагностируются у 15–25% людей в популяции, при этом четверть случаев приходится на хроническую крапивницу. Распространенность острой крапивницы составляет 20%, среди детского населения — 2,1–6,7%, при этом острая крапивница у детей встречается чаще, чем у взрослых. По данным систематического обзора и мета-анализа, хроническая крапивница у взрослых в общей популяции составляет 0,7 и 1,4% соответственно, у детей до 15 лет — до 1,1%. В статье рассматриваются особенности эпидемиологии, этиологии и патогенеза заболевания, особое внимание уделено вопросам дифференциально-диагностического поиска. Для пациентов детского возраста приведены рекомендации по лечению согласно принципам доказательной медицины и предложена ступенчатая схема терапии. Дано четкое разъяснение к проведению анализа эффективности терапии и оценки степени активности заболевания.

The Union of Pediatricians of Russia together with the Russian Association of Allergologists and Clinical Immunologists and the Russian Society of Dermatovenerologists and Cosmetologists have developed new clinical guidelines for the urticaria in adults and children. Urticaria is a common disease; its various clinical variants are diagnosed in 15–25% of people in the global population, and a quarter of all cases belongs to chronic urticaria. The prevalence of acute urticaria is 20%, and 2.1–6.7% in child population, whereas acute urticaria is more common in children than in adults. The prevalence of chronic urticaria in adults in the general population is 0.7 and 1.4%, and 1.1% in children under 15 years of age, according to the systematic review and meta-analysis, respectively. This article covers features of epidemiology, etiology, and pathogenesis of the disease with particular focus on differential diagnostic search. Guidelines on treatment and step-by-step therapy scheme (both based on principles of evidencebased medicine) for pediatric patients were presented. Clarification on the analysis of the therapy efficacy and the degree of disease activity was given.

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The authors declare that there are no conflicts of interest present.