ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v19i6.2465ppharm-2233Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВлияние COVID-19 на антибиотикорезистентность в педиатрической популяцииThe Role of COVID-19 in Antibiotic Resistance in Pediatric Populationhttps://orcid.org/0000-0002-2405-1801КузнецовК. О.KuznetsovKirill O.

Кузнецов Кирилл Олегович, д.м.н., ассистент кафедры судебной медицины

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MD, PhD

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3 Lenina Str., Ufa, 450008

kirillkuznetsov@aol.comhttps://orcid.org/0000-0002-6723-3461ТукбаеваЛ. Р.TukbaevaLaysan R.

Тукбаева Ляйсан Радиковна

Уфа

MD

Ufa

https://orcid.org/0000-0002-2121-4492КазаковаВ. В.KazakovaValeriya V.

Казакова Валерия Владиславовна

Санкт-Петербург

MD

Saint Petersburg

https://orcid.org/0000-0001-8992-0118МирзоеваК. Р.MirzoevaKamilla R.

Мирзоева Камила Рустамовна

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MD

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https://orcid.org/0000-0003-1764-6599БогомоловаЕ. А.BogomolovaEkaterina A.

Богомолова Екатерина Александровна

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MD

Ufa

https://orcid.org/0000-0002-7285-5871СалахутдиноваА. И.SalakhutdinovaAdelina I.

Салахутдинова Аделина Ильмировна

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MD

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https://orcid.org/0000-0002-0190-463XПономареваД. Ю.PonomarevaDarya Yu.

Пономарева Дарья Юрьевна

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MD

Ufa

https://orcid.org/0000-0002-9846-6655ГариповаА. Р.GaripovaAigul R.

Гарипова Айгуль Радусовна

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MD

Ufa

https://orcid.org/0000-0001-8802-0820МуцольговаМ. С.-М.MutsolgovaMarina S.-M.

Муцольгова Марина Саид-Магомедовна

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MD

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https://orcid.org/0000-0002-9051-4982ГалимхановА. Г.GalimkhanovArslan G.

Галимханов Арслан Гафурович

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MD

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https://orcid.org/0000-0001-6521-2686СахибгареевМ. И.SakhibgareevMarsel I.

Сахибгареев Марсель Ильнурович

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MD

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https://orcid.org/0000-0001-8630-7764ГужвиеваЭ. Р.GuzhvievaElina R.

Гужвиева Элина Рустемовна

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MD

Ufa

Башкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationСанкт-Петербургский ГПМУРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation202212012023196503513Copyright © Кузнецов К.О., Тукбаева Л.Р., Казакова В.В., Мирзоева К.Р., Богомолова Е.А., Салахутдинова А.И., Пономарева Д.Ю., Гарипова А.Р., Муцольгова М.С., Галимханов А.Г., Сахибгареев М.И., Гужвиева Э.Р., 20232023Кузнецов К.О., Тукбаева Л.Р., Казакова В.В., Мирзоева К.Р., Богомолова Е.А., Салахутдинова А.И., Пономарева Д.Ю., Гарипова А.Р., Муцольгова М.С., Галимханов А.Г., Сахибгареев М.И., Гужвиева Э.Р.Kuznetsov K.O., Tukbaeva L.R., Kazakova V.V., Mirzoeva K.R., Bogomolova E.A., Salakhutdinova A.I., Ponomareva D.Y., Garipova A.R., Mutsolgova M.S., Galimkhanov A.G., Sakhibgareev M.I., Guzhvieva E.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2233

Имеются данные о нерациональном использовании противомикробных препаратов в педиатрической популяции в период COVID-19. Это может привести к потенциальному развитию резистентности к антибактериальным лекарственным средствам и увеличению заболеваемости и смертности среди этой уязвимой группы населения. Целью обзорной статьи является изучение влияния COVID-19 на применение противомикробных препаратов и развитие антибиотикорезистентности, а также определение комплекса мер по ее предотвращению. Результаты недавних исследований показывают, что пандемия COVID-19 оказывает прямое и косвенное влияние на развитие резистентности к противомикробным препаратам среди педиатрического населения. Вспышка COVID-19 способствовала выявлению недостатков, присущих системам здравоохранения во всем мире. В этот период использование антибиотиков у больных коронавирусной инфекцией превышало число случаев с присоединенной бактериальной коинфекцией и иными заболеваниями, что свидетельствует о нерациональности антимикробной терапии. Даже в регионах, где программы по рациональной антибиотикотерапии действуют уже давно, были обнаружены недостатки в использовании противомикробных препаратов во время кризиса, обусловленного пандемией COVID-19. Одним из наиболее эффективных методов борьбы с антибиотикорезистентностью является совершенствование подходов в здравоохранении и повышение готовности к вспышкам инфекций. Повышение клинической компетентности медицинских работников, доступность медицинских учреждений, постоянный запас высококачественных и недорогих противомикробных препаратов, вакцин, сокращение времени проведения анализа на COVID-19, осторожное использование антибактериальных средств — вот меры, принятие которых способствует предотвращению заболеваний, обусловленных возникновением лекарственной резистентности. Для установления вышеуказанных мер защиты все заинтересованные стороны (органы здравоохранения, регулирующие агентства, политики, научное сообщество, фармацевтические компании) должны объединяться для совместной работы и достижения результатов.

There is data on the irrational use of antimicrobial drugs in pediatric population during the COVID-19 pandemic. This could lead to potential development of antibiotic resistance and increased morbidity and mortality among this vulnerable population group. The aim of this review is to study the role of COVID-19 in antimicrobial drugs administration and antibiotic resistance development, as well as to determine a set of measures for its prevention. Recent studies results have shown that COVID-19 pandemic had both direct and indirect impact on antibiotic resistance development in pediatric population. The COVID-19 outbreak has revealed weaknesses in health systems around the world. Antibiotics administration in patients with coronavirus infection during this period exceeded the number of cases with bacterial co-infection or other diseases. Thus, it indicates irrational antibiotic treatment. There were cases of inappropriate antibiotics administration during the crisis caused by the COVID-19 pandemic even in regions with long-term rational antibiotic treatment programs. One of the most viable methods to combat antibiotic resistance is to improve approaches in health care and to increase preparedness to infectious outbreaks. Increasing clinical competence of medical workers, accessibility of medical facilities, permanent supply of high-quality and cheap antibiotics, vaccines, reducing COVID-19 testing time, and adequate administration of antibacterial agents are the measures that can prevent diseases caused by drug resistance. All stakeholders (health authorities, regulating authorities, politicians, scientific community, pharmaceutical companies) have to collaborate and achieve results to implement all the mentioned above protection measures.

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The authors declare that there are no conflicts of interest present.