ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v19i6.2491ppharm-2231Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВлияние карбамазепина на сердечно-сосудистую систему: обзор литературыEffects of Carbamazepine on Cardiovascular System: Literature Reviewhttps://orcid.org/0000-0002-7866-8751ГордеевЛ. С.GordeevLeonid S.

Гордеев Леонид Сергеевич, врач клинический фармаколог

119296, г. Москва, Ломоносовский пр-т, д. 2, стр. 1тел.: +7 (916) 066-53-65

MD

2 Lomonosovsky Ave., building 2, Moscow, 119296

leo95.95@mail.ruhttps://orcid.org/0000-0003-4214-6078КульбачинскаяЕ. К.KulbachinskayaEkaterina K.

Кульбачинская Екатерина Константиновна

Москва

MD

Moscow

katerina.mgmu@mail.ruhttps://orcid.org/0000-0002-2119-169XБерезницкаяВ. В.BereznitskayaVera V.

Березницкая Вера Васильевна, к.м.н.

Москва

MD, PhD

Moscow

vera@pedklin.ruНМИЦ здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian FederationНИКИ педиатрии и детской хирургии им. акад. Ю.Е. Вельтищева ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияVeltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical UniversityRussian Federation202212012023196484491Copyright © Гордеев Л.С., Кульбачинская Е.К., Березницкая В.В., 20232023Гордеев Л.С., Кульбачинская Е.К., Березницкая В.В.Gordeev L.S., Kulbachinskaya E.K., Bereznitskaya V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2231

Карбамазепин является противосудорожным препаратом, который нередко применяется у неврологических и психиатрических пациентов с целью лечения эпилептических приступов, нейропатической боли или биполярного расстройства. Побочные явления карбамазепина, так же как и побочные явления многих противоэпилептических средств, включают в себя кардиотоксические эффекты, такие как атриовентрикулярная блокада, брадикардия и нарушения ритма сердца. Тем не менее, у карбамазепина также описано наличие антиаритмического, нормотимического и мембраностабилизирующего действия, что обусловливает применение препарата с целью лечения нарушений сердечного ритма у детей. По данным литературы, известно применение карбамазепина в качестве антиаритмического препарата в тех случаях, когда базисная терапия оказалась неэффективной. По этому показанию препарат не зарегистрирован нигде в мире, и, таким образом, он применяется вне официальной инструкции по применению. Целью данного обзора литературы является анализ и обобщение существующих данных о действии карбамазепина на сердечно-сосудистую систему, определение степени безопасности применения карбамазепина в качестве антиаритмического препарата, а также описание различных факторов, способствующих развитию его побочных явлений.

Carbamazepine is an anticonvulsant that is commonly used in neurological and psychiatric patients to treat epileptic seizures, neuropathic pain, or bipolar disorder. Carbamazepine side effects, as well as side effects of many antiepileptic drugs, include cardiotoxic effects such as atrioventricular block, bradycardia, and cardiac rhythm disorders. However, carbamazepine has also been reported to have antiarrhythmic, normotimic, and membrane-stabilizing effects. This results in its administration to treat arrhythmias in children. Based on literature, carbamazepine administration as anti-arrhythmic drug is known in cases where the basic therapy was ineffective. The medication is not registered anywhere in the world for this purpose. Thus, it can be administered only off-label. The aim of our literature review is to analyze and summarize the existing data on carbamazepine effects on cardiovascular system, to determine its safety as anti-arrhythmic drug, and to describe various factors fostering its side effects.

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The authors declare that there are no conflicts of interest present.