ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v10i3.695ppharm-217Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWРОЛЬ ПОКАЗАТЕЛЕЙ ЦЕНТРАЛЬНОЙ ГЕМОДИНАМИКИ, ТОЛЩИНЫ КОМПЛЕКСА ИНТИМА–МЕДИА И ЭНДОТЕЛИАЛЬНОЙ ДИСФУНКЦИИ У ДЕТЕЙ С РЕНАЛЬНОЙ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙROLE OF CENTRAL HEMODYNAMIC PARAMETERS, INTIMAL MEDIAL THICKNESS AND ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH RENAL ARTERIAL HYPERTENSIONКостюшинаИ. С.KostyushinaI. S.

врач-педиатр отделения восстановительного лечения детей с нефроурологическими заболеваниями, ожирением и метаболическими болезнями НИИ ПП и ВЛ НЦЗД РАМН

pediatrician of the medical rehabilitation department for children with nephrological-urological diseases, obesity and metabolic diseases at the research institute of preventive pediatrics and medical rehabilitation of the RAMS SCCH

ira_137@mail.ruКомароваО. В.KomarovaO. V.МазоА. М.MazoA. M.МаргиеваТ. В.MargiyevaT. V.ДворяковскийИ. В.DvoryakovskiyI. V.ЦыгинА. Н.TsyiginA. N.Научный центр здоровья детей РАМН, МоскваРоссияScientific Center of Children’s Health, MoscowRussian FederationНаучный центр здоровья детей РАМН, Москва, Российская ФедерацияРоссияScientific Center of Children’s Health, Moscow, Russian FederationRussian FederationНаучный центр здоровья детей РАМН, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, РоссияРоссияScientific Center of Children’s Health, Moscow, Russian Federation The First Sechenov Moscow State Medical University, Russian FederationRussian Federation201303062013103Педиатрическая фармакология3237Copyright © Костюшина И.С., Комарова О.В., Мазо А.М., Маргиева Т.В., Дворяковский И.В., Цыгин А.Н., 20132013Костюшина И.С., Комарова О.В., Мазо А.М., Маргиева Т.В., Дворяковский И.В., Цыгин А.Н.Kostyushina I.S., Komarova O.V., Mazo A.M., Margiyeva T.V., Dvoryakovskiy I.V., Tsyigin A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/217

The increase in arterial hypertension is one of the most sensitive markers of the renal affection grade, including patients without chronic renal diseases; its rate is in inverse proportion to renal functions. Left ventricular hypertrophy development at chronic renal disease results from the development of increased left ventricular afterload and end diastolic pressure influence; it is a compensatory mechanism, which is closely interconnected with mortality from cardiovascular diseases. Echocardiography is the most widely used method of evaluating the condition of central hemodynamics both in adults and children with arterial hypertension. However, echocardiography does not give the researcher any complete presentation of the cardiovascular system’s affection and the consequences of it in the setting of a progressing arterial hypertension. Detection of changes in the arterial wall (intimal medial thickness) and endothelial dysfunction is used to estimate the risk of developing such complications. Ultrasonic diagnostics allow to assess the wall’s structure, vascular lumen and determining the intimal medial thickness. Data from a range of foreign and domestic studies allows to suggest that the level of endothelin-1 in the blood serum and its excretion with urine may reflect the renovascular damage severity. The article presents a literary review on the given issue.

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The authors declare that there are no conflicts of interest present.