ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v10i3.693ppharm-215Research ArticleФАРМАКОЭКОНОМИКА В ПЕДИАТРИИPHARMACOECONOMICS IN PEDIATRICSБЕЗОПАСНОСТЬ БИОПРЕПАРАТОВ И МАЛЫХ МОЛЕКУЛ. СУЩЕСТВУЮТ ЛИ РАЗЛИЧИЯ?SAFETY OF BIOLOGICAL PREPARATIONS AND SMALL MOLECULES. ARE THERE ANY DIFFERENCES?КолбинА. С.KolbinA. S.

доктор медицинских наук, профессор кафедры фармакологии Санкт-Петербургского государственного университета, руководитель Регионального центра мониторинга безопасности лекарственных средств

PhD, professor at the pharmacology department of the Saint Petersburg State University, head of the Regional Drug Safety Monitoring Center

Alex.kolbin@mail.ruХарчевА. В.KharchevA. V.Cанкт-Петербургский государственный университет, Российская Федерация Региональный центр мониторинга безопасности лекарственных средств, Санкт-Петербург, Российская ФедерацияРоссияSaint Petersburg State University, Russian Federation Regional Drug Safety Monitoring Center, Saint Petersburg, Russian FederationRussian FederationСанкт-Петербургский государственный педиатрический медицинский университет, Российская ФедерацияРоссияSaint Petersburg State Pediatric Medical University, Russian FederationRussian Federation201303062013103Педиатрическая фармакология1725Copyright © Колбин А.С., Харчев А.В., 20132013Колбин А.С., Харчев А.В.Kolbin A.S., Kharchev A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/215

 A considerable number of biopharmaceuticals have recently been introduced into clinical practice. Their role is becoming more and more important in managing various diseases, including incapacitating and life-threatening diseases. The authors systematically reviewed literary data from 1990 to 2013 dedicated to studying adverse side reactions to medicinal proteins. The authors used international databases to search for publications dedicated to this issue. As a result, this analysis involves studies describing adverse reactions of such biopharmaceuticals as immunosuppressants and antineoplastic agents. Differences between biopharmaceuticals and small molecules in the rate of adverse phenomena, structure and severity of their manifestations are shown. Classification of adverse reactions and possibility of its use in terms of biopharmaceuticals, recommendations and conclusions for the Russian pharmacovigilance system are given.

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The authors declare that there are no conflicts of interest present.