ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v19i2.2397ppharm-2148Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWОсобенности гастроинтестинальных нарушений у детей с расстройствами аутистического спектра: обзор литературыFeatures of Gastrointestinal Malformations in Children with Autism Spectrum Disorders: Literature Reviewhttps://orcid.org/0000-0001-8723-0199СулеймановаЗ. Я.SuleymanovaZoya Y.

Сулейманова Зоя Ядитовна - кандидат медицинских наук, доцент, ведущий научный сотрудник отдела социальной педиатрии и организации мультидисциплинарного сопровождения детей НИИ педиатрии и охраны здоровья детей НКЦ №2 РНЦХ им. акад. Б.В. Петровского.

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z.suleymanova00@gmail.comhttps://orcid.org/0000-0002-3167-082XУстиноваН. В.UstinovaNatalia V.

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ust-doctor@mail.ruhttps://orcid.org/0000-0002-4955-0121ТуртиТ. В.TurtiTatiana V.

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turtit@mail.ruНИИ педиатрии и охраны здоровья детей НКЦ №2 РНЦХ им. акад. Б.В. ПетровскогоРоссияResearch Institute of Pediatrics and Children's Health in Petrovsky National Research Centre of SurgeryRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 РНЦХ им. акад. Б.В. Петровского; Научно-практический центр психического здоровья детей и подростков им. Г.Е. СухаревойРоссияResearch Institute of Pediatrics and Children's Health in Petrovsky National Research Centre of Surgery; G.E. Sukharevskaya Research and Practical Center of Mental Well-Being of Children and AdolescentsRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 РНЦХ им. акад. Б.В. Петровского; РНИМУ им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children's Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian Federation20222104202219299104Copyright © Сулейманова З.Я., Устинова Н.В., Турти Т.В., 20222022Сулейманова З.Я., Устинова Н.В., Турти Т.В.Suleymanova Z.Y., Ustinova N.V., Turti T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2148

Расстройства аутистического спектра (РАС) — распространенные нарушения развития нервной системы, отличающиеся неоднородностью с высокой вариабельностью и гетерогенностью по тяжести психических, неврологических и соматических симптомов. Гастроинтестинальные расстройства, такие как абдоминальная боль, запор, диарея, гастроэзофагеальный рефлюкс, расстройства питания, нарушения кишечной микробиоты, часто встречаются у аутичных детей. Выявлена взаимосвязь между степенью выраженности желудочно-кишечных нарушений и тяжестью поведенческих симптомов при РАС. Существует необходимость ранней диагностики и оценки гастроинтестинальных нарушений при РАС, возможности их коррекции с целью оптимизации питания, разработки индивидуального комплексного лечения и тактики ведения с привлечением специалистов различных профилей.

Autism spectrum disorders (ASDs) are common neurodevelopmental disorders characterized by heterogeneity and high variability in severity of mental, neurological, and somatic symptoms. Such gastrointestinal malformations as abdominal pain, constipation, diarrhea, gastroesophageal reflux, nutritional disorders, intestinal microbiota disorders are common in autistic children. The association between the severity of gastrointestinal malformations and the severity of behavioral symptoms in ASDs was revealed. Early diagnosis and assessment of gastrointestinal malformations in ASDs is crucial for their further correction to optimize nutrition, to develop individual complex treatment and management with the involvement of multidisciplinary specialists.

расстройства аутистического спектрадетигастроинтестинальные нарушениякишечная микробиотарасстройства питанияautism spectrum disorderschildrengastrointestinal malformationsintestinal microbiotanutritional disordersReferencesWHO. Autism. In: World Health Organization. Marth 30, 2022. (In Russ). Доступно по: https://www.who.int/ru/news-room/fact-sheets/detail/autism-spectrum-disorders. Ссылка активна на 16.03.2021.WHO. Autism. In: World Health Organization. Marth 30, 2022. (In Russ). Доступно по: https://www.who.int/ru/news-room/fact-sheets/detail/autism-spectrum-disorders. Ссылка активна на 16.03.2021.Maenner MJ, Shaw KA, Baio J, et al. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016. MMWR Surveill Summ. 2020;69(4):1-12. doi: https://doi.org/10.15585/mmwr.ss6904a1Maenner MJ, Shaw KA, Baio J, et al. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016. MMWR Surveill Summ. 2020;69(4):1-12. doi: https://doi.org/10.15585/mmwr.ss6904a1Mukaetova-Ladinska EB, Simashkova NV, Mukaetova MS, et al. Autism spectrum disorders in children and adults: the experience of reserches from different countries. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2018;118(12):92-99. (In Russ). doi: https://doi.org/10.17116/jnevro201811812177Mukaetova-Ladinska EB, Simashkova NV, Mukaetova MS, et al. Autism spectrum disorders in children and adults: the experience of reserches from different countries. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2018;118(12):92-99. (In Russ). doi: https://doi.org/10.17116/jnevro201811812177Makushkin EV, Demcheva NK. Dynamics and comparative analysis of child and adolescent incidence of mental disorders in the Russian Federation for the years 2000-2018. Rossiiskii psikhiatricheskii zhurnal = Russian Journal of Psychiatry. 2019;(4):4-15. (In Russ). doi: https://doi.org/10.24411/1560-957X-2019-11930Makushkin EV, Demcheva NK. Dynamics and comparative analysis of child and adolescent incidence of mental disorders in the Russian Federation for the years 2000-2018. Rossiiskii psikhiatricheskii zhurnal = Russian Journal of Psychiatry. 2019;(4):4-15. (In Russ). doi: https://doi.org/10.24411/1560-957X-2019-11930Christensen DL, Maenner MJ, Bilder D, et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014. MMWR Surveill Summ. 2019;68(2):1-19. doi: https://doi.org/10.15585/mmwr.ss6802a1Christensen DL, Maenner MJ, Bilder D, et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years — Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014. MMWR Surveill Summ. 2019;68(2):1-19. doi: https://doi.org/10.15585/mmwr.ss6802a1Ustinova NV, Namazova-Baranova LS. Role of Pediatrician in Early Risk Evaluation, Diagnosis and Management of Children with Autism Spectrum Disorders. Voprosy sovremennoi pediatrii — Current Pediatrics. 2021;20(2):116-121. (In Russ). doi: https://doi.org/10.15690/vsp.v20i2.2255Ustinova NV, Namazova-Baranova LS. Role of Pediatrician in Early Risk Evaluation, Diagnosis and Management of Children with Autism Spectrum Disorders. Voprosy sovremennoi pediatrii — Current Pediatrics. 2021;20(2):116-121. (In Russ). doi: https://doi.org/10.15690/vsp.v20i2.2255Hyman SL, Levy SE, Myers SM, et al. Identification, Evaluation, and Management of Children With Autism Spectrum Disorder. Pediatrics. 2020;145(1):e20193447. doi: https://doi.org/10.1542/peds.2019-3447Hyman SL, Levy SE, Myers SM, et al. Identification, Evaluation, and Management of Children With Autism Spectrum Disorder. Pediatrics. 2020;145(1):e20193447. doi: https://doi.org/10.1542/peds.2019-3447Makushkin EV, Makarov IV, Pashkovskiy VE. The prevalence of autism: genuine and imaginary. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2019;(2):80-86. (In Russ). doi: https://doi.org/10.17116/jnevro201911902180Makushkin EV, Makarov IV, Pashkovskiy VE. The prevalence of autism: genuine and imaginary. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2019;(2):80-86. (In Russ). doi: https://doi.org/10.17116/jnevro201911902180Happe F, Frith U. Annual Research Review: Looking back to look forward — changes in the concept of autism and implications for future research. J Child Psychol Psychiatry. 2020;61(3):218-232. doi: https://doi.org/10.1111/jcpp.13176Happe F, Frith U. Annual Research Review: Looking back to look forward — changes in the concept of autism and implications for future research. J Child Psychol Psychiatry. 2020;61(3):218-232. doi: https://doi.org/10.1111/jcpp.13176Richards C, Jones C, Groves L, et al. Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis. Lancet Psychiatry. 2015;2(10):909-16. doi: https://doi.org/10.1016/S2215-0366(15)00376-4Richards C, Jones C, Groves L, et al. Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis. Lancet Psychiatry. 2015;2(10):909-16. doi: https://doi.org/10.1016/S2215-0366(15)00376-4De Rubeis S, Buxbaum JD. Genetics and genomics of autism spectrum disorder: embracing complexity. Hum Mol Genet. 2015;24(R1):R24-R31. doi: https://doi.org/10.1093/hmg/ddv273De Rubeis S, Buxbaum JD. Genetics and genomics of autism spectrum disorder: embracing complexity. Hum Mol Genet. 2015;24(R1):R24-R31. doi: https://doi.org/10.1093/hmg/ddv273Sharon G, Cruz NJ, Kang DW, et al. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 2019;177(6):1600-1618.e17. doi: https://doi.org/10.1016/j.cell.2019.05.004Sharon G, Cruz NJ, Kang DW, et al. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 2019;177(6):1600-1618.e17. doi: https://doi.org/10.1016/j.cell.2019.05.004Lombardi M, Troisi J. Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies. Nutrients. 2021;13(10):3492. doi: https://doi.org/10.3390/nu13103492Lombardi M, Troisi J. Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies. Nutrients. 2021;13(10):3492. doi: https://doi.org/10.3390/nu13103492Srikantha P, Mohajeri MH. The Possible Role of the MicrobiotaGut-Brain- Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019;20(9):2115. doi: https://doi.org/10.3390/ijms20092115Srikantha P, Mohajeri MH. The Possible Role of the MicrobiotaGut-Brain- Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019;20(9):2115. doi: https://doi.org/10.3390/ijms20092115Fowlie G, Cohen N, Ming X. The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders. Int J Mol Sci. 2018;19(8):2251. doi: https://doi.org/10.3390/ijms19082251Fowlie G, Cohen N, Ming X. The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders. Int J Mol Sci. 2018;19(8):2251. doi: https://doi.org/10.3390/ijms19082251Vuong HE, Hsiao EY. Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder. Biol Psychiatry. 2017;81(5):411-423. doi: https://doi.org/10.1016/j.biopsych.2016.08.024Vuong HE, Hsiao EY. Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder. Biol Psychiatry. 2017;81(5):411-423. doi: https://doi.org/10.1016/j.biopsych.2016.08.024Cupertino M, Resende MB, Veloso I, et al. Autism spectrum disorder: a systematic review about nutritional aspects and gut-brain axis. ABCS Health Sci. 2019;44(2):120-130. doi: https://doi.org/10.7322/abcshs.v44i2.1167Cupertino M, Resende MB, Veloso I, et al. Autism spectrum disorder: a systematic review about nutritional aspects and gut-brain axis. ABCS Health Sci. 2019;44(2):120-130. doi: https://doi.org/10.7322/abcshs.v44i2.1167Hughes HK, Rose D, Ashwood P. The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders. Curr Neurol Neurosci Rep. 2018;18(11):81. doi: https://doi.org/10.1007/s11910-018-0887-6Hughes HK, Rose D, Ashwood P. The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders. Curr Neurol Neurosci Rep. 2018;18(11):81. doi: https://doi.org/10.1007/s11910-018-0887-6Campion D, Ponzo P, Alessandria C, et al. The role of microbiota in autism spectrum disorders. Minerva Gastroenterol Dietol. 2018;64(4): 333-350. doi: https://doi.org/10.23736/S1121-421X.18.02493-5Campion D, Ponzo P, Alessandria C, et al. The role of microbiota in autism spectrum disorders. Minerva Gastroenterol Dietol. 2018;64(4): 333-350. doi: https://doi.org/10.23736/S1121-421X.18.02493-5Chakraborty P, Carpenter KLH, Major S, et al. Gastrointestinal problems are associated with increased repetitive behaviors but not social communication difficulties in young children with autism spectrum disorders. Autism. 2021;25(2):405-415. doi: https://doi.org/10.1177/1362361320959503Chakraborty P, Carpenter KLH, Major S, et al. Gastrointestinal problems are associated with increased repetitive behaviors but not social communication difficulties in young children with autism spectrum disorders. Autism. 2021;25(2):405-415. doi: https://doi.org/10.1177/1362361320959503Fattorusso A, Di Genova L, Dell'Isola GB, et al. Autism Spectrum Disorders and the Gut Microbiota. Nutrients. 2019;11(3):521. doi: https://doi.org/10.3390/nu11030521Fattorusso A, Di Genova L, Dell'Isola GB, et al. Autism Spectrum Disorders and the Gut Microbiota. Nutrients. 2019;11(3):521. doi: https://doi.org/10.3390/nu11030521Nettleton JE, Klancic T, Schick A, et al. Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice. Microorganisms. 2021;9(9): 1833. doi: https://doi.org/10.3390/microorganisms9091833Nettleton JE, Klancic T, Schick A, et al. Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice. Microorganisms. 2021;9(9): 1833. doi: https://doi.org/10.3390/microorganisms9091833Rose DR, Yang H, Serena G, et al. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018;70:354-368. doi: https://doi.org/10.1016/j.bbi.2018.03.025Rose DR, Yang H, Serena G, et al. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018;70:354-368. doi: https://doi.org/10.1016/j.bbi.2018.03.025Di Genova L, Dell'Isola GB, Mencaroni E, Esposito S. Autism Spectrum Disorders and the Gut Microbiota. Nutrients. 2019;11(3):521. doi: https://doi.org/10.3390/nu11030521Di Genova L, Dell'Isola GB, Mencaroni E, Esposito S. Autism Spectrum Disorders and the Gut Microbiota. Nutrients. 2019;11(3):521. doi: https://doi.org/10.3390/nu11030521Kang DW, Adams JB, Gregory AC, et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017;5(1):10. doi: https://doi.org/10.1186/s40168-016-0225-7Kang DW, Adams JB, Gregory AC, et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017;5(1):10. doi: https://doi.org/10.1186/s40168-016-0225-7Adams JB, Borody TJ, Kang DW, et al. Microbiota transplant therapy and autism: lessons for the clinic. Expert Rev Gastroenterol Hepatol. 2019;13(11):1033-1037. doi: https://doi.org/10.1080/17474124.2019.1687293Adams JB, Borody TJ, Kang DW, et al. Microbiota transplant therapy and autism: lessons for the clinic. Expert Rev Gastroenterol Hepatol. 2019;13(11):1033-1037. doi: https://doi.org/10.1080/17474124.2019.1687293Khoruts A, Brandt LJ. Fecal Microbiota Transplant: A Rose by Any Other Name. Am J Gastroenterol. 2019;114(7):1176. doi: https://doi.org/10.14309/ajg.0000000000000286Khoruts A, Brandt LJ. Fecal Microbiota Transplant: A Rose by Any Other Name. Am J Gastroenterol. 2019;114(7):1176. doi: https://doi.org/10.14309/ajg.0000000000000286Sun H, You Z, Jia L, et al. Autism spectrum disorder is associated with gut microbiota disorder in children. BMC Pediatr. 2019;19(1):516. doi: https://doi.org/10.1186/s12887-019-1896-6Sun H, You Z, Jia L, et al. Autism spectrum disorder is associated with gut microbiota disorder in children. BMC Pediatr. 2019;19(1):516. doi: https://doi.org/10.1186/s12887-019-1896-6Blagonravova AS, Zhilyaeva TV, Kvashnina DV. Dysbiosis of intestinal microbiota in autism spectrum disorders: new horizons in search for pathogenetic approaches to therapy. Part 1. Features of intestinal microbiota in autism spectrum disorders. Journal of microbiology, epidemiology and immunobiology = Zhurnal mikrobiologii, epidemiologii iimmunobiologii. 2021;98(1):65-72. (In Russ). doi: https://doi.org/10.36233/0372-9311-62Blagonravova AS, Zhilyaeva TV, Kvashnina DV. Dysbiosis of intestinal microbiota in autism spectrum disorders: new horizons in search for pathogenetic approaches to therapy. Part 1. Features of intestinal microbiota in autism spectrum disorders. Journal of microbiology, epidemiology and immunobiology = Zhurnal mikrobiologii, epidemiologii iimmunobiologii. 2021;98(1):65-72. (In Russ). doi: https://doi.org/10.36233/0372-9311-62Westwood H, Mandy W, Simic M, et al. Assessing ASD in Adolescent Females with Anorexia Nervosa using Clinical and Developmental Measures: a Preliminary Investigation. J Abnorm Child Psychol. 2018;46(1):183-192. doi: https://doi.org/10.1007/s10802-017-0301-xWestwood H, Mandy W, Simic M, et al. Assessing ASD in Adolescent Females with Anorexia Nervosa using Clinical and Developmental Measures: a Preliminary Investigation. J Abnorm Child Psychol. 2018;46(1):183-192. doi: https://doi.org/10.1007/s10802-017-0301-xLazaro CP, Ponde MP. Narratives of mothers of children with autism spectrum disorders: focus on eating behavior. Trends Psychiatry Psychother. 2017;39(3):180-187. doi: https://doi.org/10.1590/2237-6089-2017-0004Lazaro CP, Ponde MP. Narratives of mothers of children with autism spectrum disorders: focus on eating behavior. Trends Psychiatry Psychother. 2017;39(3):180-187. doi: https://doi.org/10.1590/2237-6089-2017-0004Solmi F, Bentivegna F, Bould H, et al. Trajectories of autistic social traits in childhood and adolescence and disordered eating behaviours at age 14 years: A UK general population cohort study. J Child Psychol Psychiatry. 2021;62(1):75-85. doi: https://doi.org/10.1111/jcpp.13255Solmi F, Bentivegna F, Bould H, et al. Trajectories of autistic social traits in childhood and adolescence and disordered eating behaviours at age 14 years: A UK general population cohort study. J Child Psychol Psychiatry. 2021;62(1):75-85. doi: https://doi.org/10.1111/jcpp.13255Chistol LT, Bandini LG, Must A. et al. Sensory Sensitivity and Food Selectivity in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2018;48(2):583-591. doi: https://doi.org/10.1007/s10803-017-3340-9Chistol LT, Bandini LG, Must A. et al. Sensory Sensitivity and Food Selectivity in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2018;48(2):583-591. doi: https://doi.org/10.1007/s10803-017-3340-9Dovey TM, Kumari V, Blissett J, et al. Eating behaviour, behavioural problems and sensory profiles of children with avoidant/ restrictive food intake disorder (ARFID), autistic spectrum disorders or picky eating: Same or different? Eur Psychiatry. 2019;61:56-62. doi: https://doi.org/10.1016/j.eurpsy.2019.06.008Dovey TM, Kumari V, Blissett J, et al. Eating behaviour, behavioural problems and sensory profiles of children with avoidant/ restrictive food intake disorder (ARFID), autistic spectrum disorders or picky eating: Same or different? Eur Psychiatry. 2019;61:56-62. doi: https://doi.org/10.1016/j.eurpsy.2019.06.008Holingue C, Newill C, Lee LC, et al. Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence. Autism Res. 2018;11(1):24-36. doi: https://doi.org/10.1002/aur.1854.Holingue C, Newill C, Lee LC, et al. Gastrointestinal symptoms in autism spectrum disorder: A review of the literature on ascertainment and prevalence. Autism Res. 2018;11(1):24-36. doi: https://doi.org/10.1002/aur.1854.Prosperi M, Santocchi E, Balboni G, et al. Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity. J Autism Dev Disord. 2017;47(11):3574-3588. doi: https://doi.org/10.1007/s10803-017-3271-5Prosperi M, Santocchi E, Balboni G, et al. Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity. J Autism Dev Disord. 2017;47(11):3574-3588. doi: https://doi.org/10.1007/s10803-017-3271-5Restrepo B, Angkustsiri K, Taylor SL, et al. Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms. Autism Res. 2020;13(10):1778-1789. doi: https://doi.org/10.1002/aur.2354Restrepo B, Angkustsiri K, Taylor SL, et al. Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms. Autism Res. 2020;13(10):1778-1789. doi: https://doi.org/10.1002/aur.2354Kurtz-Nelson EC, Tham SW, Ahlers K, et al. Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations. J Autism Dev Disord. 2021;51(9):3365-3373. doi: https://doi.org/10.1007/s10803-020-04774-zKurtz-Nelson EC, Tham SW, Ahlers K, et al. Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations. J Autism Dev Disord. 2021;51(9):3365-3373. doi: https://doi.org/10.1007/s10803-020-04774-zWasilewska J, Klukowski M. Gastrointestinal symptoms and autism spectrum disorder: links and risks - a possible new overlap syndrome. Pediatric Health Med Ther. 2015;6:153-166 doi: https://doi.org/10.2147/PHMT.S85717Wasilewska J, Klukowski M. Gastrointestinal symptoms and autism spectrum disorder: links and risks - a possible new overlap syndrome. Pediatric Health Med Ther. 2015;6:153-166 doi: https://doi.org/10.2147/PHMT.S85717Krigsman A, Walker SJ. Gastrointestinal disease in children with autism spectrum disorders: Etiology or consequence? World J Psychiatr. 2021;11(9):605-618. doi: https://doi.org/10.5498/wjp.v11.i9.605Krigsman A, Walker SJ. Gastrointestinal disease in children with autism spectrum disorders: Etiology or consequence? World J Psychiatr. 2021;11(9):605-618. doi: https://doi.org/10.5498/wjp.v11.i9.605Fiorentino M, Sapone A, Senger S, et al. Bloodbrain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism. 2016;7:49. doi: https://doi.org/10.1186/s13229-016-0110-zFiorentino M, Sapone A, Senger S, et al. Bloodbrain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism. 2016;7:49. doi: https://doi.org/10.1186/s13229-016-0110-zAsbjornsdottir B, Snorradottir H, Andresdottir E, et al. Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(7):1982. doi: https://doi.org/10.3390/nu12071982Asbjornsdottir B, Snorradottir H, Andresdottir E, et al. Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(7):1982. doi: https://doi.org/10.3390/nu12071982Esnafoglu E, Cirrik S, Ayyildiz SN, et al. Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic Subjects. J Pediatr. 2017;188:240-244. doi: https://doi.org/10.1016/j.jpeds.2017.04.004Esnafoglu E, Cirrik S, Ayyildiz SN, et al. Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic Subjects. J Pediatr. 2017;188:240-244. doi: https://doi.org/10.1016/j.jpeds.2017.04.004Order of the Ministry of Health of Russia dated June 13, 2019 № 396н “O vnesenii izmenenii v Poryadok provedeniya profilakticheskikh meditsinskikh osmotrov nesovershennoletnikh, utverzhdennyi prikazom Ministerstva zdravookhraneniya Rossiiskoi Federatsii ot 10 avgusta 2017 № 514n”. (In Russ). Доступно по: http://base.garant.ru/72817530. Ссылка активна на 17.04.2022.Order of the Ministry of Health of Russia dated June 13, 2019 № 396н “O vnesenii izmenenii v Poryadok provedeniya profilakticheskikh meditsinskikh osmotrov nesovershennoletnikh, utverzhdennyi prikazom Ministerstva zdravookhraneniya Rossiiskoi Federatsii ot 10 avgusta 2017 № 514n”. (In Russ). Доступно по: http://base.garant.ru/72817530. Ссылка активна на 17.04.2022.

The authors declare that there are no conflicts of interest present.