<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v19i1.2378</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-2133</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SHORT REPORT</subject></subj-group></article-categories><title-group><article-title>Заболеваемость COVID-19 у детей с астмой и аллергией</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19 Morbidity in Children with Bronchial Asthma and Allergies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4705-7771</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобзева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobzeva</surname><given-names>Elizaveta A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997, Москва, ул. Островитянова, д. 1, стр. 7</p></bio><bio xml:lang="en"><p>1, b. 7, Ostrovityanova Str., 117997 Moscow</p></bio><email xlink:type="simple">kea-01@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2460-7718</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левина</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Levina</surname><given-names>Julia G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук; eLibrary SPIN: 4626-2800</p><p>Москва</p></bio><bio xml:lang="en"><p>MD, PhD; eLibrary SPIN: 4626-2800</p><p>Moscow</p></bio><email xlink:type="simple">julia.levina@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России; НИИ педиатрии и охраны здоровья детей ЦКБ, РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University; Research Institute of Pediatrics and Children’s Health in Central Clinical Hospital, Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>25</day><month>02</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>78</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кобзева Е.А., Левина Ю.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Кобзева Е.А., Левина Ю.Г.</copyright-holder><copyright-holder xml:lang="en">Kobzeva E.A., Levina J.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/2133">https://www.pedpharma.ru/jour/article/view/2133</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Заболеваемость новой коронавирусной инфекцией остается на высоком уровне, в том числе среди детей. Дети с бронхиальной астмой, по результатам ранее проведенных исследований, не находятся в группе риска по заболеванию и тяжелому течению COVID-19.</p><p>Цель исследования — сравнить уровень заболеваемости COVID-19 среди детей с бронхиальной астмой и без астмы в период с мая 2020 по октябрь 2021 г. с результатами, полученными в начале пандемии.</p></sec><sec><title>Методы</title><p>Методы. Разработаны онлайн-опросники с использованием Google-формы и разосланы родителям 83 пациентов в возрастной группе от 7 до 17 лет, проходившим опрос в начале пандемии. В основную группу включены 49 пациентов с диагнозом «бронхиальная астма», а в контрольную — 25 детей без диаг ностированной астмы. Результаты. В основной группе COVID-19 болели 45% (22), в контрольной — 32% (8) пациентов (р = 0,636). В основной группе легкое течение коронавирусной болезни отметили 80%, средней тяжести — 20%, в контрольной — 62 и 37% пациентов соответственно. Фебрильная лихорадка отмечалась у 40% ответивших пациентов в основной и у 33% — в контрольной группе; потеря обоняния — у 35% в основной и у 14% — в контрольной группе; пульсоксиметрию использовали 44% пациентов в основной (SpO2 — 94–98%) и 42% — в контрольной группе (SpO2 — 98–99%); в основной группе базисную терапию применяли 66%, препараты скорой помощи — 6% детей. В обеих группах ни один пациент не был госпитализирован.</p></sec><sec><title>Заключение</title><p>Заключение. Пациенты детского возраста — как с бронхиальной астмой, так и без астмы — стали чаще болеть COVID-19 по сравнению с началом пандемии. Болезнь у большинства протекала в легкой форме, не требовала госпитализации, обострения бронхиальной астмы отмечались редко, а значения сатурации не снижались &lt; 94%.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The morbidity of new coronavirus infection remains high (in children as well). Children with bronchial asthma are not at risk this disease development and severe course of COVID-19 according to the previous studies results.</p></sec><sec><title>Objective</title><p>Objective. The aim of the study is to compare the morbidity rate of COVID-19 among children with and without bronchial asthma between May 2020 and October 2021 with the results from the beginning of pandemics. Methods. Online questionnaires in Google form have been developed and sent to parents of 83 patients aged from 7 to 17 years who have been interviewed at the beginning of the pandemics. The main group includes 49 patients diagnosed with bronchial asthma, and the control group includes 25 children without bronchial asthma.</p></sec><sec><title>Results</title><p>Results. 45% (22) of patients had COVID-19 in the main group and 32% (8) — in the control group (p = 0.636). 80% of patients had mild course of disease and 20% — moderate in the main group, and 62% and 37% in the control group respectively. Febrile fever was observed in 40% of respondents in the main group and in 33% — in the control group; anosmia — in 35% in the main and in 14% — in the control group; pulse oximetry was used by 44% of patients in the main group (SpO2 94–98%) and 42% in the control group (SpO2 98–99%); 66% of patients had baseline therapy and 6% had rescue medications in the main group. No one from both groups has been hospitalized.</p></sec><sec><title>Conclusion</title><p>Conclusion. Pediatric patients both with and without bronchial asthma have COVID-19 more often compared to the pandemics beginning. The disease in most cases had mild course and did not require hospitalization, aggravations of bronchial asthma were rare, and saturation values did not decrease below 94%.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>бронхиальная астма</kwd><kwd>аллергия</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>Bronchial Asthma</kwd><kwd>allergy</kwd><kwd>children</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Не указан</funding-statement><funding-statement xml:lang="en">Not specified</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Подробная статистика по коронавирусу // Coronavirus (COVID-19). Доступно по: https://coronavirus-monitor.ru/statistika. Ссылка активна на 14.02.2022.</mixed-citation><mixed-citation xml:lang="en">Detailed statistics on coronavirus. In: Coronavirus (COVID-19). (In Russ). Доступно по: https://coronavirus-monitor.ru/statistika. Ссылка активна на 14.02.2022.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children — United States, February 12 – April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(14):422–426. doi: https://doi.org/10.15585/mmwr.mm6914e4</mixed-citation><mixed-citation xml:lang="en">CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children — United States, February 12 – April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(14):422–426. doi: https://doi.org/10.15585/mmwr.mm6914e4</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109(6):1088–1095. doi: https://doi.org/10.1111/apa.15270</mixed-citation><mixed-citation xml:lang="en">Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109(6):1088–1095. doi: https://doi.org/10.1111/apa.15270</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Евсеева Г.П., Телепнева Р.С, Книжникова Е.В. и др. COVID-19 в педиатрической популяции // Бюллетень физиологии и патологии дыхания. — 2021. — Вып. 80. — С. 100–114. — doi: https://doi.org/10.36604/1998-5029-2021-80-100-114</mixed-citation><mixed-citation xml:lang="en">Evseeva GP, Telepneva RS, Knizhnikova EV, et al. COVID19 in pediatric population. Bûlleten’ fiziologii i patologii dyhaniâ = Bulletin Physiology and Pathology of Respiration. 2021;(80): 100–114. (In Russ). doi: https://doi.org/10.36604/1998-5029-2021-80-100-114</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Han X, Li X, Xiao Y, et al. Distinct Characteristics of COVID-19 Infection in Children. Front Pediatr. 2021;9:619738. doi: https://doi.org/10.3389/fped.2021.619738</mixed-citation><mixed-citation xml:lang="en">Han X, Li X, Xiao Y, et al. Distinct Characteristics of COVID-19 Infection in Children. Front Pediatr. 2021;9:619738. doi: https://doi.org/10.3389/fped.2021.619738</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Carr TF, Kraft M. Asthma and Atopy in COVID-19: 2021 Updates. J Allergy Clin Immunol. 2022;149(2):562–564. doi: https://doi.org/10.1016/j.jaci.2021.12.762</mixed-citation><mixed-citation xml:lang="en">Carr TF, Kraft M. Asthma and Atopy in COVID-19: 2021 Updates. J Allergy Clin Immunol. 2022;149(2):562–564. doi: https://doi.org/10.1016/j.jaci.2021.12.762</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Левина Ю.Г., Намазова-Баранова Л.С., Вишнева Е.А. и др. Особенности течения бронхиальной астмы и респираторной заболеваемости у детей в период пандемии COVID-19: результаты ретроспективного сравнительного наблюдательного исследования // Вестник РАМН. — 2020. — Т. 75. — № S5. — С. 455–464. — doi: https://doi.org/10.15690/vramn1448</mixed-citation><mixed-citation xml:lang="en">Levina JG, Namazova-Baranova LS, Vishneva EA, et al. Asthma Activity and Respiratory Morbidity in Children During the COVID-19 Pandemic: Results of a Retrospective Comparative Observational Study. Annals of the Russian Academy of Medical Sciences. 2020;75(5S): 455–464. (In Russ). doi: https://doi.org/10.15690/vramn1448</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Licari A, Votto M, Brambilla I, et al. Allergy and asthma in children and adolescents during the COVID outbreak: What we know and how we could prevent allergy and asthma flares. Allergy. 2020;75(9):2402–2405. doi: https://doi.org/10.1111/all.14369</mixed-citation><mixed-citation xml:lang="en">Licari A, Votto M, Brambilla I, et al. Allergy and asthma in children and adolescents during the COVID outbreak: What we know and how we could prevent allergy and asthma flares. Allergy. 2020;75(9):2402–2405. doi: https://doi.org/10.1111/all.14369</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
