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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v19i1.2346</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-2128</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Безглютеновая диета у детей с дерматологической патологией</article-title><trans-title-group xml:lang="en"><trans-title>Gluten-Free Diet in Children with Dermatologic Pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0858-8780</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Опрятин</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Opryatin</surname><given-names>Leonid A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Врач отделения дерматологии с группой лазерной хирургии НИИ детской дерматологии, научный сотрудник лаборатории патологии кожи у детей отдела научных исследований в педиатрии НМИЦ здоровья детей.</p><p>119296, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (495) 967-14-20</p></bio><bio xml:lang="en"><p>MD, eLibrary SPIN: 1851-2361</p><p>Moscow</p></bio><email xlink:type="simple">opryatin.l@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0603-3394</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боровик</surname><given-names>Т. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Borovik</surname><given-names>Tatiana E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, eLibrary SPIN: 1777-2118</p></bio><bio xml:lang="en"><p>MD, PhD, Professor; eLibrary SPIN: 1777-2118</p><p>Moscow</p></bio><email xlink:type="simple">borovik@nczd.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2252-8570</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мурашкин</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Murashkin</surname><given-names>Nikolay N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор; eLibrary SPIN: 5906-9724</p></bio><bio xml:lang="en"><p>MD, PhD, Professor; eLibrary SPIN: 5906-9724</p></bio><email xlink:type="simple">m_nn2001@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НМИЦ здоровья детей</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Children’s Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НМИЦ здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>НМИЦ здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University; Central State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>27</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Опрятин Л.А., Боровик Т.Э., Мурашкин Н.Н., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Опрятин Л.А., Боровик Т.Э., Мурашкин Н.Н.</copyright-holder><copyright-holder xml:lang="en">Opryatin L.A., Borovik T.E., Murashkin N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/2128">https://www.pedpharma.ru/jour/article/view/2128</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Безглютеновая диета (БГД) представляет собой характер питания, исключающий в своем составе такой компонент злаковых культур, как глютен. Назначение данной диеты должно быть строго регламентировано по причине влияния на нутритивный статус растущего ребенка, а также на течение кожного заболевания. В связи с этим актуальным является вопрос изучения влияния БГД на течение заболеваний у различных групп пациентов дерматологического профиля.</p><p>Цель исследования — изучить влияние БГД на нутритивный статус и состояние кожного покрова пациентов с дерматологической патологией и сопутствующей целиакией, а также сенсибилизацией к глютену.</p></sec><sec><title>Методы</title><p>Методы. В исследование включали детей, госпитализированных в отделение дерматологии. Для оценки нутритивного статуса использовались данные, полученные при антропометрии — масса тела, рост, индекс массы тела (ИМТ), которые рассчитывали с помощью компьютерных программам WHO Anthro (для детей до 5 лет) и WHO AntroPlus (для детей старше 5 лет). Оценивались показатели z-score масса тела / возраст (WAZ), рост/возраст (HAZ), ИМТ/возраст (BAZ). Оценка состояния кожного патологического процесса проводилась с помощью индекса SCORAD при атопическом дерматите, PASI — при псориазе, SALT — при алопеции, VASI — при витилиго, LoSCAT — при склеродермии. Оценка антропометрических показателей и тяжести кожного заболевания проводилась в начале исследования и через 6 мес после коррекции питания.</p></sec><sec><title>Результаты</title><p>Результаты. Обследованы 1000 детей с различной дерматологической патологией, поступивших в отделение дерматологии с августа 2020 по август 2021 г. Сформированы три группы пациентов: с целиакией, сенсибилизацией к глютену и отсутствием глютен-ассоциированных состояний. Оценка антропометрических показателей продемонстрировала положительную динамику у пациентов с целиакией и сенсибилизацией к глютену на фоне БГД, а также у пациентов без глютен-ассоциированной патологии при соблюдении нормокалорийного рациона согласно возрастным нормам. Во всех трех группах отмечалась положительная динамика кожного патологического процесса.</p></sec><sec><title>Заключение</title><p>Заключение. Оценка нутритивного статуса, а также состояние кожного покрова на различных этапах исследования показали целесообразность дифференцированного подхода в назначении БГД у пациентов дерматологического профиля.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Gluten-free diet (GFD) is a nutritional pattern that excludes such component of grain crops as gluten. This diet administration should be strictly regulated due to its influence on the growing child nutritional status and on the course of skin diseases. Thus, studying the effects of GFD on the course of dermatologic diseases in various patients’ groups is crucial.</p></sec><sec><title>Objective</title><p>Objective. The aim of the study is to study the effects of GFD on nutritional status and skin condition of patients with dermatologic pathology and associated celiac disease, as well as gluten hypersensitivity.</p></sec><sec><title>Methods</title><p>Methods. The study included children hospitalized in the dermatology department. We have used obtained anthropometric data (weight, height, body mass index (BMI)) to estimate nutritional status, all calculations were performed via programs WHO Anthro (for children under 5 years old) and WHO AntroPlus (for children over 5 years old). Weight-for-age (WAZ), height-for-age (HAZ), BMI-for-age (BAZ) z-scores were evaluated. Estimation of skin pathological process was performed via SCORAD index for patients with atopic dermatitis, PASI — for psoriasis, SALT — for alopecia, VASI — for vitiligo, LoSCAT — for scleroderma. Assessment of anthropometric measures and skin disease severity was performed at study initiation and 6 months after nutrition correction.</p></sec><sec><title>Results</title><p>Results. 1000 children with various dermatologic pathologies admitted to the dermatology department during the period from August 2020 to August 2021 were examined. Three patients’ groups were formed: with celiac disease, gluten hypersensitivity, and without any gluten-associated conditions. Assessment of anthropometric measures has shown positive dynamics in patients with celiac disease and gluten hypersensitivity on GFD, as well as in patients without any gluten-associated conditions on normal caloric diet according to age norms. All three groups have shown positive dynamics for skin pathologies.</p></sec><sec><title>Conclusion</title><p>Conclusion. Estimation of nutritional status and skin conditions on various stages of the study has shown the importance of differentiated approach in GFD administration in dermatologic patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>целиакия</kwd><kwd>дерматологическая патология</kwd><kwd>нутритивный статус</kwd><kwd>безглютеновая диета</kwd><kwd>глютен</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>celiac disease</kwd><kwd>dermatologic pathology</kwd><kwd>nutritional status</kwd><kwd>gluten-free diet</kwd><kwd>gluten</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Не указан</funding-statement><funding-statement xml:lang="en">Not specified</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Humbert P, Pelletier F, Dreno B, et al. Gluten intolerance and skin diseases. 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