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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v19i1.2345</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-2127</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Комплексный подход к диагностике детей с патологией полости носа и носоглотки. Первые результаты</article-title><trans-title-group xml:lang="en"><trans-title>Complex Approach to Diagnosis of Nasal Cavity and Nasopharyngeal Pathologies in Children. Initial Results</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2209-7531</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Namazova-Baranova</surname><given-names>Leyla S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Намазова-Баранова Лейла Сеймуровна, доктор медицинских наук, профессор, академик Российской академии наук; eLibrary SPIN: 1312-2147</p><p>Москва</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Academician of the RAS; eLibrary SPIN: 1312-2147</p><p>10 Fotievoy Str., 119333 Moscow; +7 (499) 400-47-33</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4962-6998</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганковский</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gankovskiy</surname><given-names>Viktor A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ганковский Виктор Анатольевич - кандидат медицинских наук, ведущий научный сотрудник.</p><p>119333, Москва, ул. Фотиевой, д. 10, стр. 1, тел.: +7 (499) 400-47-33</p></bio><bio xml:lang="en"><p>PhD; eLibrary SPIN: 2745-7739</p><p>10 Fotievoy Str., 119333 Moscow; +7 (499) 400-47-33</p></bio><email xlink:type="simple">s.slon2012@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6158-9064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зеленкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zelenkova</surname><given-names>Irina V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зеленкова Ирина Валерьевна; eLibrary SPIN: 6206-6040</p><p>Москва</p></bio><bio xml:lang="en"><p>eLibrary SPIN: 6206-6040</p></bio><email xlink:type="simple">izelen@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7649-5933</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Губанова</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gubanova</surname><given-names>Svetlana G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Губанова Светлана Геннадьевна - кандидат медицинских наук, eLibrary SPIN: 8275-0163</p><p>Москва</p></bio><bio xml:lang="en"><p>PhD, eLibrary SPIN: 8275-0163</p><p>Moscow</p></bio><email xlink:type="simple">svetlanagub@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3197-2879</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashkov</surname><given-names>Alexander V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пашков Александр Владимирович - доктор медицинских наук, профессор; eLibrary SPIN: 2779-8496</p><p>Москва</p></bio><bio xml:lang="en"><p>MD, PhD, Professor; eLibrary SPIN: 2779-8496</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8540-3858</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каркашадзе</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karkashadze</surname><given-names>George A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каркашадзе Георгий Арчилович - кандидат медицинских наук; eLibrary SPIN: 6248-0970</p><p>Москва</p></bio><bio xml:lang="en"><p>MD, PhD; eLibrary SPIN: 6248-0970</p><p>Moscow</p></bio><email xlink:type="simple">karkaga@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Белгородский государственный национальный исследовательский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Pediatrics and Children’s Health in Central Clinical Hospital, Russian Academy of Sciences; Pirogov Russian National Research Medical University; Belgorod State National Research University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ педиатрии и охраны здоровья детей ЦКБ РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Pediatrics and Children’s Health in Central Clinical Hospital, Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Центральная государственная медицинская академия Управления делами Президента РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of Department of Presidential Affairs of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2022</year></pub-date><volume>19</volume><issue>1</issue><fpage>20</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Намазова-Баранова Л.С., Ганковский В.А., Зеленкова И.В., Губанова С.Г., Пашков А.В., Каркашадзе Г.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Намазова-Баранова Л.С., Ганковский В.А., Зеленкова И.В., Губанова С.Г., Пашков А.В., Каркашадзе Г.А.</copyright-holder><copyright-holder xml:lang="en">Namazova-Baranova L.S., Gankovskiy V.A., Zelenkova I.V., Gubanova S.G., Pashkov A.V., Karkashadze G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/2127">https://www.pedpharma.ru/jour/article/view/2127</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Патология носа и носоглотки является актуальной и распространенной проблемой в детской оториноларингологии. Одними из основных причин затруднения носового дыхания являются аденоиды, аллергический ринит, острый ринит, риносинусит, искривление носовой перегородки. Все эти заболевания могут встречаться по отдельности и в сочетании друг с другом, причем клиническая картина может быть сходной.</p><p>Цель исследования — изучить и оценить состояние носового дыхания и обоняния у детей с различной патологией полости носа и носоглотки.</p></sec><sec><title>Методы исследования</title><p>Методы исследования. В исследование были включены 128 детей, исследуемые — поделены на 3 группы, сопоставимые по полу и возрасту: в 1-ю группу были включены дети с подтвержденным острым заболеванием ЛОР-органов, во 2-ю группу — дети с обострением различных аллергических заболеваний, 3-ю группу составили клинически здоровые дети (контрольная группа). Методика обследования: риноманометрия (РММ), ринорезистометрия (РРМ), ольфактометрия.</p></sec><sec><title>Результаты</title><p>Результаты. По данным РРМ было выявлено, что носовое сопротивление у детей с обострением аллергических заболеваний достоверно выше как до, так и после анемизации слизистой оболочки полости носа раствором назальных деконгестантов, чем у детей контрольной группы. По данным РММ у детей с различными ЛОР-заболеваниями скорость потока воздуха возрастает в среднем на 25%, у детей с аллергическими заболеваниями — в среднем на 43% после анемизации слизистой носа. Полученные результаты указывают на важную роль отека слизистой оболочки полости носа у пациентов с аллергическими заболеваниями в период обострения. Анализ наших данных РММ и РРМ свидетельствует о необходимости использования указанных методов исследования у детей.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты позволят как оптимизировать подход к диагностике, так и персонализировать лечение пациентов с различной патологией полости носа и носоглотки. В настоящий момент исследование продолжается.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Nasal cavity and nasopharyngeal pathology are crucial and common issue in pediatric otorhinolaryngology. One of the major reasons for the nasal breathing difficulties are adenoids, allergic rhinitis, acute rhinitis, rhinosinusitis, nasal septum deviation. All these diseases can occur individually and in combination with each other, while clinical signs can be similar.</p></sec><sec><title>Objective</title><p>Objective. The aim of the study is study and estimate the condition of nasal breathing and sense of smell in children with different nasal and nasopharyngeal pathology.</p></sec><sec><title>Methods</title><p>Methods. The study included 128 children, all children were divided into 3 groups comparable by gender and age. Children with confirmed acute ENT organ disease were included in the 1st group, children with allergic disease exacerbation were included in the 2nd group, and clinically healthy children (control group) were included in the 3rd group. Survey methodology: rhinomanometry (RMM), rhinoresistometry (RRM), olfactometry.</p></sec><sec><title>Results</title><p>Results. It was revealed that nasal resistance in children with allergic diseases exacerbation is significantly higher both before and after anemisation of nasal mucosa with a solution of nasal decongestants than in children of the control group (according to the RRM). The air flow rate increases by average of 25% in children with various ENT organs diseases, and in children with allergic diseases — by average of 43% after anemisation of the nasal mucosa. The obtained data shows the role of nasal mucosal edema in patients with allergic diseases during exacerbation. Analysis of our RMM and RRM data suggests the importance of further use of these methods in children.</p></sec><sec><title>Conclusion</title><p>Conclusion. The obtained results will allow us to optimize the diagnosis approach and personalize the management of patients with various nasal cavity and nasopharynx pathologies. Nowadays, the study is ongoing.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>риноманометрия</kwd><kwd>ринорезистометрия</kwd><kwd>эндоскопия полости носа и носоглотки</kwd><kwd>обоняние</kwd><kwd>ольфактометрия</kwd><kwd>аллергический ринит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rhinomanometry</kwd><kwd>rhinoresistometry</kwd><kwd>endoscopy of nasal cavity and nasopharynx</kwd><kwd>sense of smell</kwd><kwd>olfactometry</kwd><kwd>allergic rhinitis</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Не указан</funding-statement><funding-statement xml:lang="en">Not specified</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Богомильский М.Р., Чистякова В.Р. Болезни уха, горла, носа в детском возрасте: национальное руководство. Краткое издание. 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