ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v19i1.2373ppharm-2118Research ArticleКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИCLINICAL RECOMMENDATIONSСовременные подходы к ведению детей с острым обструктивным ларингитом и эпиглоттитомModern Approaches to the Management of Children with Acute Obstructive Laryngitis and Epiglottitishttps://orcid.org/0000-0003-3987-8112БарановА. А.BaranovAleksander A.

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НИИ педиатрии и охраны здоровья детей ЦКБ РАН; Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияResearch Institute of Pediatrics and Children’s Health in Central Clinical Hospital of the Russian Academy of Sciences; Sechenov First Moscow State Medical UniversityRussian FederationНациональный медицинский исследовательский центр оториноларингологии ФМБА России; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияThe National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia; Pirogov Russian National Research Medical UniversityRussian FederationСмоленский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSmolensk State Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ, РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Белгородский государственный национальный исследовательский университетРоссияResearch Institute of Pediatrics and Children’s Health in Central Clinical Hospital of the Russian Academy of Sciences; Pirogov Russian National Research Medical University; Belgorod National Research UniversityRussian FederationНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ, РАН; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Central Clinical Hospital of the Russian Academy of Sciences; Pirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ, РАНРоссияResearch Institute of Pediatrics and Children’s Health in Central Clinical Hospital of the Russian Academy of SciencesRussian FederationУральский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияUral State Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова; Национальный медицинский исследовательский центр здоровья детейРоссияPirogov Russian National Research Medical University; National Medical Research Center of Children’s HealthRussian FederationСанкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSaint-Petersburg State Pediatric Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ, РАН; Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияResearch Institute of Pediatrics and Children’s Health in Central Clinical Hospital of the Russian Academy of Sciences; Sechenov First Moscow State Medical UniversityRussian Federation2022040320221914555Copyright © Баранов А.А., Дайхес Н.А., Козлов Р.С., Намазова-Баранова Л.С., Андреева И.В., Артемова И.В., Бакрадзе М.Д., Вишнева Е.А., Карасева М.С., Карнеева О.В., Ким И.А., Ковтун О.П., Куличенко Т.В., Лашкова Ю.С., Зеленкова И.В., Новик Г.А., Полякова А.С., Селимзянова Л.Р., Стецюк О.У., Таточенко В.К., Федосеенко М.В., Якушин С.Б., 20222022Баранов А.А., Дайхес Н.А., Козлов Р.С., Намазова-Баранова Л.С., Андреева И.В., Артемова И.В., Бакрадзе М.Д., Вишнева Е.А., Карасева М.С., Карнеева О.В., Ким И.А., Ковтун О.П., Куличенко Т.В., Лашкова Ю.С., Зеленкова И.В., Новик Г.А., Полякова А.С., Селимзянова Л.Р., Стецюк О.У., Таточенко В.К., Федосеенко М.В., Якушин С.Б.Baranov A.A., Daikhes N.A., Kozlov R.S., Namazova-Baranova L.S., Andreeva I.V., Artemova I.V., Bakradze M.D., Vishneva E.A., Karaseva M.S., Kаrneeva O.V., Kim I.A., Kovtun O.P., Kulichenko T.V., Lashkova Y.S., Zelenkova I.V., Novik G.A., Polyakova A.S., Selimzyanova L.R., Stetsiouk O.U., Tatochenko V.K., Fedoseenko M.V., Yakushin S.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2118

Экспертами Союза педиатров России разработаны актуальные методические рекомендации по оказанию медицинской помощи детям с острым обструктивным ларингитом и эпиглоттитом. Круп — это наиболее частая причина острой обструкции верхних дыхательных путей у детей в возрасте от 6 мес до 6 лет. Как правило, возбудителями заболевания являются респираторные вирусы. Этиологическим фактором эпиглоттита в подавляющем большинстве случаев выступает Haemophilus influenzae типа b (> 90%). Однако в настоящее время в странах с массовой иммунизацией против гемофильной инфекции эпиглоттит, вызванный данным возбудителем, чаще встречается у взрослых. В статье подробно рассмотрены вопросы этиологии, патогенеза, классификации. Особое внимание уделено диагностике, дифференциальной диагностике и терапии острого обструктивного ларингита у детей, основанным на принципах доказательности.

Experts of the Union of Pediatricians of Russia have developed modern guidelines on the management of children with acute obstructive laryngitis and epiglottitis. Croup is the most common cause of acute upper respiratory obstruction in children aged from 6 months to 6 years. Usually respiratory viruses are the pathogenic agents of the disease. The etiological factor of epiglottitis is Haemophilus influenzae type b in the vast majority of cases (> 90%). However, nowadays, epiglottitis caused by this pathogen agent is more common in adults in countries with mass immunization against hemophilic infection. This article considers in detail etiology, pathogenesis, and classification issues. Special attention is given to diagnosis, differential diagnosis, and therapy (via evidence-based approach) of acute obstructive laryngitis in children.

острый обструктивный ларингиткрупэпиглоттитдетиacute obstructive laryngitiscroupepiglottitischildrenНе указанNot specifiedReferencesWall SR, Wat D, Spiller OB, et al. The viral aetiology of croup and recurrent croup. Arch Dis Child. 2009;94(5):359–360. doi: https://doi.org/10.1136/adc.2008.142984Wall SR, Wat D, Spiller OB, et al. The viral aetiology of croup and recurrent croup. Arch Dis Child. 2009;94(5):359–360. doi: https://doi.org/10.1136/adc.2008.142984Worrall G. Croup. Can Fam Physician. 2008;54(4):573–574.Worrall G. Croup. Can Fam Physician. 2008;54(4):573–574.Aravapalli S, Sahai S. Haemophilus influenzae type b epiglottitis in a 3-year-old boy. Consult Pediatr. 2013;12(6):263–265.Aravapalli S, Sahai S. Haemophilus influenzae type b epiglottitis in a 3-year-old boy. Consult Pediatr. 2013;12(6):263–265.Guardiani E, Bliss M, Harley E. Supraglottitis in the era following widespread immunization against Haemophilus influenzae type B: evolving principles in diagnosis and management. Laryngoscope. 2010;120(11):2183–2188. doi: https://doi.org/10.1002/lary.21083Guardiani E, Bliss M, Harley E. Supraglottitis in the era following widespread immunization against Haemophilus influenzae type B: evolving principles in diagnosis and management. Laryngoscope. 2010;120(11):2183–2188. doi: https://doi.org/10.1002/lary.21083Bjornson CL, Johnson DW. Croup in children. CMAJ. 2013; 185(15):1317–1323. doi: https://doi.org/10.1503/cmaj.121645Bjornson CL, Johnson DW. Croup in children. CMAJ. 2013; 185(15):1317–1323. doi: https://doi.org/10.1503/cmaj.121645Bjornson C, Russell K, Vandermeer B, et al. Nebulized epinephrine for croup in children. Cochrane Database Syst Rev. 2013;10:CD006619. doi: https://doi.org/10.1002/14651858.CD006619.pub3.Bjornson C, Russell K, Vandermeer B, et al. Nebulized epinephrine for croup in children. Cochrane Database Syst Rev. 2013;10:CD006619. doi: https://doi.org/10.1002/14651858.CD006619.pub3.Tovar Padua LJ, Cherry JD. Croup and Epiglottitis (Supraglottitis). In: Feigin and Cherry’s textbook of pediatric infectious diseases. Cherry J, Harrison G, Kaplan S, et al., eds. 8th ed. Philadelphia: Elsevier, Inc; 2019. pp. 175–190.Tovar Padua LJ, Cherry JD. Croup and Epiglottitis (Supraglottitis). In: Feigin and Cherry’s textbook of pediatric infectious diseases. Cherry J, Harrison G, Kaplan S, et al., eds. 8th ed. Philadelphia: Elsevier, Inc; 2019. pp. 175–190.Takeuchi M, Yasunaga H, Horiguchi H, Fushimi K. The burden of epiglottitis among Japanese children before the Haemophilus influenzae type b vaccination era: an analysis using a nationwide administrative database. J Infect Chemother. 2013;19(5):876–879. doi: https://doi.org/10.1007/s10156-013-0585-xTakeuchi M, Yasunaga H, Horiguchi H, Fushimi K. The burden of epiglottitis among Japanese children before the Haemophilus influenzae type b vaccination era: an analysis using a nationwide administrative database. J Infect Chemother. 2013;19(5):876–879. doi: https://doi.org/10.1007/s10156-013-0585-xToward Optimized Practice Working Group for Croup. Guideline for the diagnosis and management of croup. Alberta, Canada; 2003. Revised 2008. Available online: www.topalbertadoctors.org/download/252/croup_guideline.pdf. Accessed on July 24, 2014.Toward Optimized Practice Working Group for Croup. Guideline for the diagnosis and management of croup. Alberta, Canada; 2003. Revised 2008. Available online: www.topalbertadoctors.org/download/252/croup_guideline.pdf. Accessed on July 24, 2014.Thompson M, Vodicka TA, Blair PS, et al. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ. 2013;347:f7027. doi: https://doi.org/10.1136/bmj.f7027Thompson M, Vodicka TA, Blair PS, et al. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ. 2013;347:f7027. doi: https://doi.org/10.1136/bmj.f7027Sasidaran K, Bansal A, Singhi S. Acute upper airway obstruction. Indian J Pediatr. 2011;78(10):1256–1261. doi: https://doi.org/10.1007/s12098-011-0414-0Sasidaran K, Bansal A, Singhi S. Acute upper airway obstruction. Indian J Pediatr. 2011;78(10):1256–1261. doi: https://doi.org/10.1007/s12098-011-0414-0Woods CR. Croup: Clinical features, evaluation, and diagnosis. In: UpToDate®. Available online: https://www.uptodate.com. Accessed on December 17, 2021.Woods CR. Croup: Clinical features, evaluation, and diagnosis. In: UpToDate®. Available online: https://www.uptodate.com. Accessed on December 17, 2021.Defendi GL. Croup Workup. In: Medscape. Available online: https://emedicine.medscape.com/article/962972-workup. Accessed on December 17, 2021.Defendi GL. Croup Workup. In: Medscape. Available online: https://emedicine.medscape.com/article/962972-workup. Accessed on December 17, 2021.Stoney PJ, Chakrabarti MK. Experience of pulse oximetry in children with croup. J Laryngol Otol. 1991;105(4):295–298. doi: https://doi.org/10.1017/s002221510011566xStoney PJ, Chakrabarti MK. Experience of pulse oximetry in children with croup. J Laryngol Otol. 1991;105(4):295–298. doi: https://doi.org/10.1017/s002221510011566xSchondelmeyer AC, Dewan ML, Brady PW, et al. Cardiorespiratory and Pulse Oximetry Monitoring in Hospitalized Children: A Delphi Process. Pediatrics. 2020;146(2):e20193336. doi: https://doi.org/10.1542/peds.2019-3336Schondelmeyer AC, Dewan ML, Brady PW, et al. Cardiorespiratory and Pulse Oximetry Monitoring in Hospitalized Children: A Delphi Process. Pediatrics. 2020;146(2):e20193336. doi: https://doi.org/10.1542/peds.2019-3336Lee PK, Booth AWG, Vidhani K. Spontaneous Respiration Using Intravenous Anesthesia and High-Flow Nasal Oxygen (STRIVE Hi) Management of Acute Adult Epiglottitis: A Case Report. A A Pract. 2018; 10(4):73–75. doi: https://doi.org/10.1213/XAA.0000000000000635Lee PK, Booth AWG, Vidhani K. Spontaneous Respiration Using Intravenous Anesthesia and High-Flow Nasal Oxygen (STRIVE Hi) Management of Acute Adult Epiglottitis: A Case Report. A A Pract. 2018; 10(4):73–75. doi: https://doi.org/10.1213/XAA.0000000000000635Kim KH, Kim YH, Lee JH, et al. Accuracy of objective parameters in acute epiglottitis diagnosis. A case-control study. Medicine (Baltimore). 2018; 97(37):e12256. doi: https://doi.org/10.1097/MD.0000000000012256Kim KH, Kim YH, Lee JH, et al. Accuracy of objective parameters in acute epiglottitis diagnosis. A case-control study. Medicine (Baltimore). 2018; 97(37):e12256. doi: https://doi.org/10.1097/MD.0000000000012256Petrocheilou A, Tanou K, Kalampouka E, et al. Viral croup: diagnosis and a treatment algorithm. Pediatr Pulmonol. 2014; 49(5):421–429. doi: https://doi.org/10.1002/ppul.22993Petrocheilou A, Tanou K, Kalampouka E, et al. Viral croup: diagnosis and a treatment algorithm. Pediatr Pulmonol. 2014; 49(5):421–429. doi: https://doi.org/10.1002/ppul.22993Smith DK, Andrew Mcdermott J, Sullivan JF. Croup: Diagnosis and Management. Am Fam Physician. 2018;97(9):575–580.Smith DK, Andrew Mcdermott J, Sullivan JF. Croup: Diagnosis and Management. Am Fam Physician. 2018;97(9):575–580.Оказание стационарной помощи детям. Руководство по лечению наиболее распространенных болезней у детей: карманный справочник. — 2-е изд. — М.: Всемирная организация здравоохранения; 2013. — 452 с.Okazanie statsionarnoi pomoshchi detyam. Rukovodstvo po lecheniyu naibolee rasprostranennykh boleznei u detei: Pocket guide. 2nd ed. Moscow: World Health Organization; 2013. 452 p. (In Russ).Руководство по амбулаторно-клинической педиатрии / под ред. А.А. Баранов. — 2-е изд. — М.: ГЭОТАР-Медиа; 2009.Rukovodstvo po ambulatorno-klinicheskoi pediatrii. Baranov AA, ed. 2nd ed. Moscow: GEOTAR-Media; 2009. (In Russ).Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;2013(6):CD000247. doi: https://doi.org/10.1002/14651858.CD000247.pub3Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;2013(6):CD000247. doi: https://doi.org/10.1002/14651858.CD000247.pub3Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014;2014(4):CD008965. doi: https://doi.org/10.1002/14651858.CD008965.pub4Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014;2014(4):CD008965. doi: https://doi.org/10.1002/14651858.CD008965.pub4Ruf BR, Szucs T. Reducing the burden of influenza-associated complications with antiviral therapy. Infection. 2009;37(3): 186–196. doi: https://doi.org/10.1007/s15010-009-8241-1Ruf BR, Szucs T. Reducing the burden of influenza-associated complications with antiviral therapy. Infection. 2009;37(3): 186–196. doi: https://doi.org/10.1007/s15010-009-8241-1Singh M, Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2013;(6):CD001728. doi: https://doi.org/10.1002/14651858.CD001728.pub5Singh M, Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2013;(6):CD001728. doi: https://doi.org/10.1002/14651858.CD001728.pub5Bourchier D, Dawson KP, Fergusson DM. Humidification in viral croup: a controlled trial. Aust Paediatr J. 1984;20(4):289–291. doi: https://doi.org/10.1111/j.1440-1754.1984.tb00096.xBourchier D, Dawson KP, Fergusson DM. Humidification in viral croup: a controlled trial. Aust Paediatr J. 1984;20(4):289–291. doi: https://doi.org/10.1111/j.1440-1754.1984.tb00096.xNeto GM, Kentab O, Klassen TP, Osmond MH. A randomized controlled trial of mist in the acute treatment of moderate croup. Acad Emerg Med. 2002;9(9):873–879.Neto GM, Kentab O, Klassen TP, Osmond MH. A randomized controlled trial of mist in the acute treatment of moderate croup. Acad Emerg Med. 2002;9(9):873–879.Gates A, Gates M, Vandermeer B, et al. Glucocorticoids for croup in children. Cochrane Database Syst Rev. 2018;8(8):CD001955. doi: https://doi.org/10.1002/14651858.CD001955.pub4Gates A, Gates M, Vandermeer B, et al. Glucocorticoids for croup in children. Cochrane Database Syst Rev. 2018;8(8):CD001955. doi: https://doi.org/10.1002/14651858.CD001955.pub4Garbutt JM, Conlon B, Sterkel R, et al. The comparative effectiveness of prednisolone and dexamethasone for children with croup: a community-based randomized trial. Clin Pediatr (Phila). 2013;52(11): 1014–1021. doi: https://doi.org/10.1177/0009922813504823Garbutt JM, Conlon B, Sterkel R, et al. The comparative effectiveness of prednisolone and dexamethasone for children with croup: a community-based randomized trial. Clin Pediatr (Phila). 2013;52(11): 1014–1021. doi: https://doi.org/10.1177/0009922813504823Bjornson CL, Johnson DW. Croup in the paediatric emergency department. Paediatr Child Health. 2007l;12(6):473–477. doi: https://doi.org/10.1093/pch/12.6.473Bjornson CL, Johnson DW. Croup in the paediatric emergency department. Paediatr Child Health. 2007l;12(6):473–477. doi: https://doi.org/10.1093/pch/12.6.473Elliott AC, Williamson GR. A Systematic Review and Comprehensive Critical Analysis Examining the Use of Prednisolone for the Treatment of Mild to Moderate Croup. Open Nurs J. 2017;11:241–261. doi: https://doi.org/10.2174/1874434601711010241Elliott AC, Williamson GR. A Systematic Review and Comprehensive Critical Analysis Examining the Use of Prednisolone for the Treatment of Mild to Moderate Croup. Open Nurs J. 2017;11:241–261. doi: https://doi.org/10.2174/1874434601711010241Государственный реестр лекарственных средств. Доступно по: https://grls.rosminzdrav.ru. Ссылка активна на 17.12.2021.State register of medicines. (In Russ). Доступно по: https://grls.rosminzdrav.ru. Ссылка активна на 17.12.2021.Geelhoed GC, Macdonald WB. Oral and inhaled steroids in croup: a randomized, placebo-controlled trial. Pediatr Pulmonol. 1995;20(6): 355–361. doi: https://doi.org/10.1002/ppul.1950200604Geelhoed GC, Macdonald WB. Oral and inhaled steroids in croup: a randomized, placebo-controlled trial. Pediatr Pulmonol. 1995;20(6): 355–361. doi: https://doi.org/10.1002/ppul.1950200604Kawaguchi A, Joffe A. Evidence for Clinicians: Nebulized epinephrine for croup in children. Paediatr Child Health. 2015;20(1):19–20. doi: https://doi.org/10.1093/pch/20.1.19Kawaguchi A, Joffe A. Evidence for Clinicians: Nebulized epinephrine for croup in children. Paediatr Child Health. 2015;20(1):19–20. doi: https://doi.org/10.1093/pch/20.1.19Pineau PM, Gautier J, Pineau A, et al. Intubation decision criteria in adult epiglottitis. Eur Ann Otorhinolaryngol Head Neck Dis. 2021; 138(5):329–332. doi: https://doi.org/10.1016/j.anorl.2020.12.001Pineau PM, Gautier J, Pineau A, et al. Intubation decision criteria in adult epiglottitis. Eur Ann Otorhinolaryngol Head Neck Dis. 2021; 138(5):329–332. doi: https://doi.org/10.1016/j.anorl.2020.12.001Kivekäs I, Rautiainen M. Epiglottitis, Acute Laryngitis, and Croup. In: Infections of the Ears, Nose, Throat, and Sinuses. Durand ML, Deschler DG, eds. Cham: Springer; 2018. pp. 247–255. doi: https://doi.org/10.1007/978-3-319-74835-1_20Kivekäs I, Rautiainen M. Epiglottitis, Acute Laryngitis, and Croup. In: Infections of the Ears, Nose, Throat, and Sinuses. Durand ML, Deschler DG, eds. Cham: Springer; 2018. pp. 247–255. doi: https://doi.org/10.1007/978-3-319-74835-1_20Alamri NA, Alkhateeb MA, Aboalfaraj AT, et al. An Overview on Acute Epiglottitis Diagnosis and management in Primary Health Care Center: A Literature Review. Pharmacophore. 2020; 11(5):141–144.Alamri NA, Alkhateeb MA, Aboalfaraj AT, et al. An Overview on Acute Epiglottitis Diagnosis and management in Primary Health Care Center: A Literature Review. Pharmacophore. 2020; 11(5):141–144.Woods CR. Epiglottitis (supraglottitis): Management In: UpToDate®. Available online: https://www.uptodate.com. Accessed on December 17, 2021.Woods CR. Epiglottitis (supraglottitis): Management In: UpToDate®. Available online: https://www.uptodate.com. Accessed on December 17, 2021.Gompf SG. Epiglottitis Treatment & Management. In: Medscape. Available online: https://emedicine.medscape.com/article/763612-treatment. Accessed on December 17, 2021.Gompf SG. Epiglottitis Treatment & Management. In: Medscape. Available online: https://emedicine.medscape.com/article/763612-treatment. Accessed on December 17, 2021.Gompf SG. Epiglottitis Medication. In: Medscape. Available online: https://emedicine.medscape.com/article/763612-medication. Accessed on December 17, 2021.Gompf SG. Epiglottitis Medication. In: Medscape. Available online: https://emedicine.medscape.com/article/763612-medication. Accessed on December 17, 2021.Ceftriaxone (Rx). In: Medscape. Available online: https://reference.medscape.com/drug/rocephin-ceftriaxone-342510. Accessed on December 17, 2021.Ceftriaxone (Rx). In: Medscape. Available online: https://reference.medscape.com/drug/rocephin-ceftriaxone-342510. Accessed on December 17, 2021.Иванчик Н.В., Сухорукова М.В., Чагарян А.Н. и др. Антибиотикорезистентность клинических штаммов Haemophilus influenzae в России: результаты многоцентрового эпидемиологического исследования «ПеГАС 2014–2017» / / Клиническая микробиология и антимикробная химиотерапия. — 2019. — Т. 21. — № 4. — С. 317–323. doi: https://doi.org/10.36488/cmac.2019.4.317-323Ivanchik NV, Sukhorukova MV, Chagaryan АN, et al. Antimicrobial resistance of clinical Haemophilus influenzae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017». Clinical Microbiology and Antimicrobial Chemotherapy. 2019;21(4):317–323. (In Russ). doi: https://doi.org/10.36488/cmac.2019.4.317-323Sobol SE, Zapata S. Epiglottitis and croup. Otolaryngol Clin North Am. 2008;41(3):551–566, ix. doi: https://doi.org/10.1016/j.otc.2008.01.012Sobol SE, Zapata S. Epiglottitis and croup. Otolaryngol Clin North Am. 2008;41(3):551–566, ix. doi: https://doi.org/10.1016/j.otc.2008.01.012Jefferson T, Del Mar CB, Dooley L, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev. 2011;2011(7):CD006207. doi: https://doi.org/10.1002/14651858.CD006207.pub4Jefferson T, Del Mar CB, Dooley L, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev. 2011;2011(7):CD006207. doi: https://doi.org/10.1002/14651858.CD006207.pub4Eichner M, Schwehm M, Eichner L, Gerlier L. Direct and indirect effects of influenza vaccination. BMC Infect Dis. 2017;17(1):308. doi: https://doi.org/10.1186/s12879-017-2399-4Eichner M, Schwehm M, Eichner L, Gerlier L. Direct and indirect effects of influenza vaccination. BMC Infect Dis. 2017;17(1):308. doi: https://doi.org/10.1186/s12879-017-2399-4Prutsky GJ, Domecq JP, Elraiyah T, et al. Influenza vaccines licensed in the United States in healthy children: a systematic review and network meta-analysis (Protocol). Syst Rev. 2012;1:65. doi: https://doi.org/10.1186/2046-4053-1-65Prutsky GJ, Domecq JP, Elraiyah T, et al. Influenza vaccines licensed in the United States in healthy children: a systematic review and network meta-analysis (Protocol). Syst Rev. 2012;1:65. doi: https://doi.org/10.1186/2046-4053-1-65Butler DF, Myers AL. Changing Epidemiology of Haemophilus influenzae in Children. Infect Dis Clin North Am. 2018;32(1): 119–128. doi: https://doi.org/10.1016/j.idc.2017.10.005Butler DF, Myers AL. Changing Epidemiology of Haemophilus influenzae in Children. Infect Dis Clin North Am. 2018;32(1): 119–128. doi: https://doi.org/10.1016/j.idc.2017.10.005Cooper T, Kuruvilla G, Persad R, El-Hakim H. Atypical croup: association with airway lesions, atopy, and esophagitis. Otolaryngol Head Neck Surg. 2012;147(2):209–204. doi: https://doi.org/10.1177/0194599812447758Cooper T, Kuruvilla G, Persad R, El-Hakim H. Atypical croup: association with airway lesions, atopy, and esophagitis. Otolaryngol Head Neck Surg. 2012;147(2):209–204. doi: https://doi.org/10.1177/0194599812447758

The authors declare that there are no conflicts of interest present.