ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v18i5.2332ppharm-2073Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWРаспространенность аллергических заболеваний у детей, вакцинированных против туберкулеза и гепатита В в раннем неонатальном периоде: обзор литературыPrevalence of Allergic Diseases in Children Vaccinated Against Tuberculosis and Hepatitis B in the Early Neonatal Period: Literature Reviewhttps://orcid.org/0000-0003-0797-5612ФедосеенкоМ. В.FedoseenkoMarina V.

Федосеенко Марина Владиславовна 

119333, Москва, ул. Фотиевой, д. 10, телефон: +7 (499) 400-47-33; eLibrary SPIN: 6339-5386

Marina V. Fedoseenko

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titovamarina@mail.ruhttps://orcid.org/0000-0002-7100-6026ПетроваВ. А.PetrovaVeronika A.

Петрова Вероника Александровна – врач-педиатр, заведующая учебной лабораторией кафедры факультетской педиатрии педиатрического факультета

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Veronika A. Petrova

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elveur@gmail.comhttps://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Намазова-Баранова Лейла Сеймуровна

119333, Москва, ул. Фотиевой, д. 10, телефон: +7 (499) 400-47-33; eLibrary SPIN: 1312-2147

Leyla S. Namazova-Baranova

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info@pediatr-russia.ruРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ педиатрии и охраны здоровья детей ЦКБ РАНРоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”Russian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ педиатрии и охраны здоровья детей ЦКБ РАН; Белгородский государственный национальный исследовательский университетРоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Belgorod National Research UniversityRussian Federation202117112021185392397Copyright © Федосеенко М.В., Петрова В.А., Намазова-Баранова Л.С., 20212021Федосеенко М.В., Петрова В.А., Намазова-Баранова Л.С.Fedoseenko M.V., Petrova V.A., Namazova-Baranova L.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2073Обоснование

Обоснование. У новорожденных детей Т-клеточный ответ сдвинут в сторону преобладания Th2-типа. Это делает их особо уязвимыми к воздействию различных внешних патогенов, развитию тяжелых инфекций, а также является фактором риска аллергических заболеваний. В настоящее время исследуются различные способы переключения иммунного ответа на Th1-тип, одним из которых является вакцинация.

Цель исследования – представить данные о распространенности аллергической патологии среди детей, вакцинированных против туберкулеза и гепатита В, а также о влиянии вакцинных препаратов на тип иммунного ответа.

Результаты

Результаты. Проанализированы данные как об увеличении, так и о снижении частоты развития атопических состояний у детей, вакцинированных BCG и против гепатита В: большинство из них нельзя считать достоверными. Результатами целого ряда крупных исследований не подтверждается какая-либо связь между вакцинацией и наличием аллергического заболевания у детей. Приведены данные о том, что вакцины BCG и против гепатита В сдвигают иммунный ответ в сторону активации Th1-типа.

Заключение

Заключение. Вакцинация в раннем неонатальном периоде действительно может иметь влияние на переключение иммунного ответа в сторону Th1-типа. Что, в свою очередь, способно отражаться на распространенности аллергической патологии у привитых детей. Тем не менее, имеющихся на сегодняшний день данных недостаточно для того, чтобы достоверно оценить возможный эффект вакцинации на вероятность манифестации атопических состояний в будущем.

Background

Background. T-cell response is shifted towards Th2-type predominance in newborns. This makes them particularly vulnerable to exposure of various external pathogens, development of severe infections, moreover, it is also a risk factor for allergic diseases development. Various methods of switching the immune response to Th1-type are currently under research, and one of them is vaccination.

Objective

Objective. The aim of the study is to provide data on the prevalence of allergic pathology among children vaccinated against tuberculosis and hepatitis B, as well as the effect of vaccines on immune response type.

Results

Results. Data on both increase and decrease in the prevalence of atopic conditions in children vaccinated with BCG and against hepatitis B were analyzed, thus, most of them cannot be considered reliable. The results of several large studies do not reveal any correlation between vaccination and the presence of allergic disease in children. There is data that BCG and hepatitis B vaccines shift the immune response towards Th1-type activation.

Conclusion

Conclusion. Vaccination in the early neonatal period may affect switching of the immune response towards Th1-type. That, in turn, can affect the prevalence of allergic pathology in vaccinated children. However, the data available for now is not sufficient to reliably estimate the possible effect of vaccination on atopic conditions manifestation in the future.

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The authors declare that there are no conflicts of interest present.