ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v18i3.2283ppharm-2020Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWСовременные методы диетотерапии аллергии к белкам коровьего молока у детей раннего возрастаCurrent Methods of Dietotherapy of Cow's Milk Protein Allergy in Infantshttps://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Намазова-Баранова Лейла Сеймуровна - доктор медицинских наук, профессор, академик Российской академии наук; телефон: 8 (499) 400-47-33; eLibrary SPIN: 1312-2147.

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Чемакина Дарья Сергеевна - кандидат медицинских наук, старший научный сотрудник отдела стандартизации и изучения основ доказательной медицины Научно-исследовательского института педиатрии и охраны здоровья детей ЦКБ РАН

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ТкаченкоМ. А.TkachenkoMikhail A.

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Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ педиатрии и охраны здоровья детей ЦКБ РАН Министерства науки и высшего образования РФ; Белгородский государственный национальный исследовательский университетРоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children's Health in Central Clinical Hospital of the Russian Academy of Sciences; Belgorod National Research UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ педиатрии и охраны здоровья детей ЦКБ РАН Министерства науки и высшего образования РФРоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children's Health in Central Clinical Hospital of the Russian Academy of SciencesRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАН Министерства науки и высшего образования РФРоссияResearch Institute of Pediatrics and Children's Health in Central Clinical Hospital of the Russian Academy of SciencesRussian FederationСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint Petersburg State Pediatric Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ педиатрии и охраны здоровья детей ЦКБ РАН Министерства науки и высшего образования РФ; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияPirogov Russian National Research Medical University; Research Institute of Pediatrics and Children's Health in Central Clinical Hospital of the Russian Academy of Sciences; Sechenov First Moscow State Medical UniversityRussian Federation202130072021183233238Copyright © Намазова-Баранова Л.С., Вишнёва Е.А., Чемакина Д.С., Новик Г.А., Ткаченко М.А., Селимзянова Л.Р., Алексеева А.А., Левина Ю.Г., Эфендиева К.Е., Калугина В.Г., Добрынина Е.А., 20212021Намазова-Баранова Л.С., Вишнёва Е.А., Чемакина Д.С., Новик Г.А., Ткаченко М.А., Селимзянова Л.Р., Алексеева А.А., Левина Ю.Г., Эфендиева К.Е., Калугина В.Г., Добрынина Е.А.Namazova-Baranova L.S., Vishneva E.A., Chemakina D.S., Novik G.A., Tkachenko M.A., Selimzyanova L.R., Alexeeva A.A., Levina Y.G., Efendieva K.E., Kalugina V.G., Dobrynina E.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/2020

В мире наблюдается прогрессивный рост числа больных аллергией. Установлено, что изменения состава микро-биома в раннем возрасте коррелируют с частотой развития атопических заболеваний. В ходе различных клинических исследований было продемонстрировано, что множество факторов, начиная с момента внутриутробного развития, влияют на становление микробиоты. У детей с атопическими заболеваниями существуют определенные особенности формирования микробного пейзажа, которые нередко предшествуют дебюту болезни. Белок коровьего молока является одним из основных аллергенов на первом году жизни. Такой тип сенсибилизации может присутствовать у детей как на искусственном, так и на грудном вскармливании, однако не является показанием к его прерыванию. В случае, когда грудное вскармливание невозможно, у детей с аллергией к белкам коровьего молока необходимо использование специализированных лечебных смесей. Применение формулы «Nutrilon Аминокислоты Syneo» эффективно устраняет симптомы аллергии и улучшает состав кишечной микробиоты у детей раннего возраста. Кроме того, ее использование дополнительно способствует снижению частоты инфекционных заболеваний и применения антибактериальных препаратов.

Nowadays there is progressive increase in the number of patients with allergy around the world. It was revealed that microbiome composition changes at early age correlate with the frequency of atopic diseases development. Various clinical studies have shown that variety of factors (even from prenatal development) influence microbiota composition. Children with atopic diseases have certain features of microflora development that can precede the disease debut. Cow’s milk protein is one of the major allergens in the first year of life. Such sensitization may be present in children on both formula and breastfeeding, however it is not the indication for its interruption. In cases when breastfeeding is not possible, we should use specialized therapeutic formulas in children with cow’s milk protein allergy. The use of the “Nutrilon Amino acids Syneo" formula effectively eliminates allergy symptoms and improves the gut microbiota composition in young children. Moreover, its use additionally reduce the frequency of infectious diseases and the use of antibacterial drugs.

детиаллергияпищевая аллергияаминокислотная смесьмикробиомchildrenallergyfood allergyamino acid formulamicrobiomeПоисково-аналитическая работа по подготовке рукописи проведена при финансовой поддержке NutriciaResearch and analytics on the manuscript preparation was carried out with the financial support of NutriciaReferencesWopereis H, van Ampting MTJ, Cetinyurek-Yavuz A, et al. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow's milk allergic infants: a randomized controlled trial. Clin Transl Allergy. 2019;9:27. doi: 10.1186/s13601-019-0267-6Wopereis H, van Ampting MTJ, Cetinyurek-Yavuz A, et al. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow's milk allergic infants: a randomized controlled trial. Clin Transl Allergy. 2019;9:27. doi: 10.1186/s13601-019-0267-6Fiocchi A, Fierro V. Food Allergy. World Allergy Organization; 2017. Available online: https://www.worldallergy.org/education-and-programs/education/allergic-disease-resource-center/professionals/food-allergy. Accessed on June 30, 2021.Fiocchi A, Fierro V. Food Allergy. World Allergy Organization; 2017. Available online: https://www.worldallergy.org/education-and-programs/education/allergic-disease-resource-center/professionals/food-allergy. Accessed on June 30, 2021.Аллергия к белкам коровьего молока у детей: клинические рекомендации. — М.: Союз педиатров России; 2018. — 52 с.Allergiya k belkam korov’ego moloka u detei: Clinical guidelines. Moscow: The Union of Pediatricians of Russia; 2018. 52 p. (In Russ).Fox A, Brown T, Walsh J, et al. An update to the Milk Allergy in Primary Care guideline. Clin Transl Allergy. 2019;9:40. doi: 10.1186/s13601-019-0281-8Fox A, Brown T, Walsh J, et al. An update to the Milk Allergy in Primary Care guideline. Clin Transl Allergy. 2019;9:40. doi: 10.1186/s13601-019-0281-8Scholtens PAMJ, Oozeer R, Martin R, et al. The Early Settlers: Intestinal Microbiology in Early Life. Annu Rev Food Sci Technol. 2012;3:425-447. doi: 10.1146/annurev-food-022811-101120Scholtens PAMJ, Oozeer R, Martin R, et al. The Early Settlers: Intestinal Microbiology in Early Life. Annu Rev Food Sci Technol. 2012;3:425-447. doi: 10.1146/annurev-food-022811-101120Prince BT, Mandel MJ, Nadeau K, Singh AM. Gut Microbiome and the Development of Food Allergy and Allergic Disease. Pediatr Clin North Am. 2015;62(6):1479-1492. doi: 10.1016/j.pcl.2015.07.007Prince BT, Mandel MJ, Nadeau K, Singh AM. Gut Microbiome and the Development of Food Allergy and Allergic Disease. Pediatr Clin North Am. 2015;62(6):1479-1492. doi: 10.1016/j.pcl.2015.07.007Martin R, Nauta A, Ben Amor K, et al. Early life: gut microbiota and immune development in infancy. Benef Microbes. 2010;1(4):367-382. doi: 10.3920/BM2010.0027Martin R, Nauta A, Ben Amor K, et al. Early life: gut microbiota and immune development in infancy. Benef Microbes. 2010;1(4):367-382. doi: 10.3920/BM2010.0027Ihekweazu FD, Versalovic J. Development of the Pediatric Gut Microbiome: Impact on Health and Disease. Am J Med Sci. 2018;356(5):413-423. doi: 10.1016/j.amjms.2018.08.005Ihekweazu FD, Versalovic J. Development of the Pediatric Gut Microbiome: Impact on Health and Disease. Am J Med Sci. 2018;356(5):413-423. doi: 10.1016/j.amjms.2018.08.005Blazquez AB, Berin MC. Microbiome and food allergy. Transl Res. 2017;179:199-203. doi: 10.1016/j.trsl.2016.09.003Blazquez AB, Berin MC. Microbiome and food allergy. Transl Res. 2017;179:199-203. doi: 10.1016/j.trsl.2016.09.003Wang M, Karlsson C, Olsson C, et al. Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immunol. 2008;121(1):129-134. doi: 10.1016/j.jaci.2007.09.011Wang M, Karlsson C, Olsson C, et al. Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immunol. 2008;121(1):129-134. doi: 10.1016/j.jaci.2007.09.011Abrahamsson TR, Jakobsson HE, Andersson AF, et al. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012;129(2):434-440.e2. doi: 10.1016/j.jaci.2011.10.025Abrahamsson TR, Jakobsson HE, Andersson AF, et al. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012;129(2):434-440.e2. doi: 10.1016/j.jaci.2011.10.025Azad MB, Konya T, Guttman DS, et al. Infant gut microbiota and food sensitization: Associations in the first year of life. Clin Exp Allergy. 2015;45(3):632-643. doi: 10.1111/cea.12487Azad MB, Konya T, Guttman DS, et al. Infant gut microbiota and food sensitization: Associations in the first year of life. Clin Exp Allergy. 2015;45(3):632-643. doi: 10.1111/cea.12487Ling Z, Li Z, Liu X, et al. Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol. 2014;80(8):2546-2554. doi: 10.1128/AEM.00003-14Ling Z, Li Z, Liu X, et al. Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol. 2014;80(8):2546-2554. doi: 10.1128/AEM.00003-14Bunyavanich S, Shen N, Grishin A, et al. Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol. 2016;138(4):1122-1130. doi: 10.1016/j.jaci.2016.03.041Bunyavanich S, Shen N, Grishin A, et al. Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol. 2016;138(4):1122-1130. doi: 10.1016/j.jaci.2016.03.041Penders J, Thijs C, van den Brandt PA, et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut. 2007;56(5):661-667. doi: 10.1136/gut.2006.100164Penders J, Thijs C, van den Brandt PA, et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut. 2007;56(5):661-667. doi: 10.1136/gut.2006.100164Методическое руководство по применению аминокислотных смесей / под ред. Л.С. Намазовой-Барановой. — 2-е изд. — М.: Педиатръ; 2021. — 103 с. [Methodological guidelines on amino acid formula use. Namazova-Baranova LS, ed. 2nd ed. Moscow: Pediatr; 2021. 103 p. (In Russ).]Методическое руководство по применению аминокислотных смесей / под ред. Л.С. Намазовой-Барановой. — 2-е изд. — М.: Педиатръ; 2021. — 103 с. [Methodological guidelines on amino acid formula use. Namazova-Baranova LS, ed. 2nd ed. Moscow: Pediatr; 2021. 103 p. (In Russ).]Host A, Koletzko B, Dreborg S, et al. Dietary products used in infants for treatment and prevention of food allergy. Joint Statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child. 1999;81(1):80-84. doi: 10.1136/adc.81.1.80Host A, Koletzko B, Dreborg S, et al. Dietary products used in infants for treatment and prevention of food allergy. Joint Statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child. 1999;81(1):80-84. doi: 10.1136/adc.81.1.80Caffarelli C, Plebani A, Poiesi C, et al. Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy. Clin Exp Allergy. 2002;32(1):74-79. doi: 10.1046/j.0022-0477.2001.01262.xCaffarelli C, Plebani A, Poiesi C, et al. Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy. Clin Exp Allergy. 2002;32(1):74-79. doi: 10.1046/j.0022-0477.2001.01262.xDe Boissieu D, Matarazzo P, Dupont C. Allergy extensively hydrolyzed cow milk proteins in infants: Identification and treatment with an amino acid-based formula. J Pediatr. 1997;131(5):744-777. doi: 10.1016/S0022-3476(97)70104-5De Boissieu D, Matarazzo P, Dupont C. Allergy extensively hydrolyzed cow milk proteins in infants: Identification and treatment with an amino acid-based formula. J Pediatr. 1997;131(5):744-777. doi: 10.1016/S0022-3476(97)70104-5Isolauri E, Sutas Y Makinen-Kiljunen S, et al. Efficacy and safety of hydrolyzed cow milk and amino acid-derived formulas in infants with cow milk allergy. J Pediatr. 1995;127(4):550-557. doi: 10.1016/S0022-3476(95)70111-7Isolauri E, Sutas Y Makinen-Kiljunen S, et al. Efficacy and safety of hydrolyzed cow milk and amino acid-derived formulas in infants with cow milk allergy. J Pediatr. 1995;127(4):550-557. doi: 10.1016/S0022-3476(95)70111-7Latcham F, Merino F, Lang A, et al. A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy. J Pediatr. 2003;143(1):39-47. doi: 10.1016/S0022-3476(03)00193-8Latcham F, Merino F, Lang A, et al. A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy. J Pediatr. 2003;143(1):39-47. doi: 10.1016/S0022-3476(03)00193-8Vanderhoof J, Moore N, De Boissieu D. Evaluation of an amino acid-based formula in infants not responding to extensively hydrolyzed protein formula. J Pediatr Gastroenterol Nutr. 2016;63(5):531-533. doi: 10.1097/MPG.0000000000001374Vanderhoof J, Moore N, De Boissieu D. Evaluation of an amino acid-based formula in infants not responding to extensively hydrolyzed protein formula. J Pediatr Gastroenterol Nutr. 2016;63(5):531-533. doi: 10.1097/MPG.0000000000001374Btazowski t, Kurzawa R. Alergia na biatka mleka krowiego — teoria i praktyka. Standardy Medyczne/ Pediatria. 2017;14(5):695-712.Btazowski t, Kurzawa R. Alergia na biatka mleka krowiego — teoria i praktyka. Standardy Medyczne/ Pediatria. 2017;14(5):695-712.Fox AT, Wopereis H, Van Ampting MTJ, et al. A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: a randomized controlled trial. Clin Transl Allergy. 2019;9(1):5. doi: 10.1186/s13601-019-0241-3Fox AT, Wopereis H, Van Ampting MTJ, et al. A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: a randomized controlled trial. Clin Transl Allergy. 2019;9(1):5. doi: 10.1186/s13601-019-0241-3Захарова И.Н., Лаврова Т.Е., Талызина М.Ф., Мачнева Е.Б. Новый взгляд на пребиотики: гипотезы, тенденции, доказательства // Педиатрия (Приложение к журналу Consilium Medicum). — 2017. — № 3. — С. 26-33.Zakharova IN, Lavrova TE, Talyzina MF, Machneva EB. A new look at prebiotics: hypotheses, trends, evidence. Pediatrics (Suppl. Consilium Medicum). 2017;3:26-33. (In Russ).Schouten B, van Esch BCAM, Hofman GA, et al. Oligosaccharide-Induced Whey-Specific CD25+ Regulatory T-Cells Are Involved in the Suppression of Cow Milk Allergy in Mice. J Nutr. 2010;140(4):835-841. doi: 10.3945/jn.109.116061Schouten B, van Esch BCAM, Hofman GA, et al. Oligosaccharide-Induced Whey-Specific CD25+ Regulatory T-Cells Are Involved in the Suppression of Cow Milk Allergy in Mice. J Nutr. 2010;140(4):835-841. doi: 10.3945/jn.109.116061Bruzzese E, Volpicelli M, Squeglia V, et al. A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: An observational study. Clin Nutr. 2009;28(2):156-161. doi: 10.1016/j.clnu.2009.01.008Bruzzese E, Volpicelli M, Squeglia V, et al. A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: An observational study. Clin Nutr. 2009;28(2):156-161. doi: 10.1016/j.clnu.2009.01.008Scholtens PAMJ, Alliet P, Raes M, et al. Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides. J Nutr. 2008;138(6):1141-1147. doi: 10.1093/jn/138.6.1141Scholtens PAMJ, Alliet P, Raes M, et al. Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides. J Nutr. 2008;138(6):1141-1147. doi: 10.1093/jn/138.6.1141Azagra-Boronat I, Massot-Cladera M, Knipping K, et al. Supplementation With 2'-FL and scGOS/lcFOS Ameliorates Rotavirus-Induced Diarrhea in Suckling Rats. Front Cell Infect Microbiol. 2018;8:372. doi: 10.3389/fcimb.2018.00372Azagra-Boronat I, Massot-Cladera M, Knipping K, et al. Supplementation With 2'-FL and scGOS/lcFOS Ameliorates Rotavirus-Induced Diarrhea in Suckling Rats. Front Cell Infect Microbiol. 2018;8:372. doi: 10.3389/fcimb.2018.00372Huet F, Abrahamse-Berkeveld M, Tims S, et al. Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated. J Pediatr Gastroenterol Nutr. 2016;63(4):e43-e53. doi: 10.1097/MPG.0000000000001360Huet F, Abrahamse-Berkeveld M, Tims S, et al. Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated. J Pediatr Gastroenterol Nutr. 2016;63(4):e43-e53. doi: 10.1097/MPG.0000000000001360Matsuki T, Watanabe K, Tanaka R, et al. Distribution of bifidobacterial species in human intestinal microflora examined with 16S rRNA-gene-targeted species-specific primers. Appl Environ Microbiol. 1999;65(10):4506-4512. doi: 10.1128/AEM.65.10.4506-4512.1999Matsuki T, Watanabe K, Tanaka R, et al. Distribution of bifidobacterial species in human intestinal microflora examined with 16S rRNA-gene-targeted species-specific primers. Appl Environ Microbiol. 1999;65(10):4506-4512. doi: 10.1128/AEM.65.10.4506-4512.1999Mikami K, Kimura M, Takahashi H. Influence of Maternal Bifidobacteria on the Development of Gut Bifidobacteria in Infants. Pharmaceuticals. 2012;5(6):629-642. doi: 10.3390/ph5060629Mikami K, Kimura M, Takahashi H. Influence of Maternal Bifidobacteria on the Development of Gut Bifidobacteria in Infants. Pharmaceuticals. 2012;5(6):629-642. doi: 10.3390/ph5060629Soto A, Martin V, Jimenez E, et al. Lactobacilli and Bifidobacteria in Human Breast Milk. J Pediatr Gastroenterol Nutr. 2014;59(1):78-88. doi: 10.1097/MPG.0000000000000347Soto A, Martin V, Jimenez E, et al. Lactobacilli and Bifidobacteria in Human Breast Milk. J Pediatr Gastroenterol Nutr. 2014;59(1):78-88. doi: 10.1097/MPG.0000000000000347Thibault H, Aubert-Jacquin C, Goulet O. Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants. J Pediatr Gastroenterol Nutr. 2004;39(2):147-152. doi: 10.1097/00005176-200408000-00004Thibault H, Aubert-Jacquin C, Goulet O. Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants. J Pediatr Gastroenterol Nutr. 2004;39(2):147-152. doi: 10.1097/00005176-200408000-00004Harvey BM, Langford JE, Harthoorn LF, et al. Effects on growth and tolerance and hypoallergenicity of an amino acid-based formula with synbiotics. Pediatr Res. 2014;75(2):343-351. doi: 10.1038/pr.2013.211Harvey BM, Langford JE, Harthoorn LF, et al. Effects on growth and tolerance and hypoallergenicity of an amino acid-based formula with synbiotics. Pediatr Res. 2014;75(2):343-351. doi: 10.1038/pr.2013.211Burks AW, Harthoorn LF, Van Ampting MTJ, et al. Synbiotics supplemented amino acid based formula supports adequate growth in cow's milk allergic infants. Pediatr Allergy Immunol. 2015;26(4):316-322. doi: 10.1111/pai.12390Burks AW, Harthoorn LF, Van Ampting MTJ, et al. Synbiotics supplemented amino acid based formula supports adequate growth in cow's milk allergic infants. Pediatr Allergy Immunol. 2015;26(4):316-322. doi: 10.1111/pai.12390Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83(3):677-686. doi: 10.1038/pr.2017.270Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83(3):677-686. doi: 10.1038/pr.2017.270Sorensen K, Cawood AL, Gibson GR, et al. Amino Acid Formula Containing Synbiotics in Infants with Cow's Milk Protein Allergy: A Systematic Review and Meta-Analysis. Nutrients. 2021;13(3):935. doi: 10.3390/nu13030935Sorensen K, Cawood AL, Gibson GR, et al. Amino Acid Formula Containing Synbiotics in Infants with Cow's Milk Protein Allergy: A Systematic Review and Meta-Analysis. Nutrients. 2021;13(3):935. doi: 10.3390/nu13030935

The authors declare that there are no conflicts of interest present.