ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v17i3.2126ppharm-1860Research ArticleВ ПРАКТИКУ ПЕДИАТРАFor Pediatricians' PracticeДетский мультисистемный воспалительный синдром, ассоциированный с новой коронавирусной инфекцией (COVID-19): актуальная информация и клиническое наблюдениеChildren’s Multisystem Inflammatory Syndrome, Associated With a New Coronavirus Infection (COVID-19): Relevant Information and Clinical Observationhttps://orcid.org/0000-0002-5153-0146КантемироваМ. Г.KantemirovaMarina G.

Кантемирова Марина Григорьевна — кандидат медицинских наук, первый заместитель директора Медицинского института РУДН, доцент кафедры педиатрии Медицинского института РУДН, консультант кардиолог МДГКБ ДЗМ

117198, Москва, ул. Миклухо-Маклая, 8

kantemirova60@mail.ruhttps://orcid.org/0000-0001-6164-027XНовиковаЮ. Ю.NovikovaYulia Yu.https://orcid.org/0000-0002-4961-384XОвсянниковД. Ю.OvsyannikovDmitry Yu.https://orcid.org/0000-0003-0509-1055КурбановаС. Х.KurbanovaSeda Kh.ГлазыринаА. А.GlazyrinaAnastasia A.https://orcid.org/0000-0002-4165-3935КоровинаО. А.KorovinaOlga A.РахалинаА. А.RakhalinaAntonina A.РомановаЮ. В.RomanovaYulia V.https://orcid.org/0000-0002-1456-8073РтищевА. Ю.RtishchevAlexey Yu.ХарькинА. В.KharkinAndrey V.https://orcid.org/0000-0002-8520-2378ПетряйкинаЕ. Е.PetryaykinaElena E.Российский университет дружбы народов Министерства науки и высшего образования Российской Федерации; Морозовская детская городская клиническая больница Департамента здравоохранения города МосквыРоссияRUDN University; Morozov Children’s City Clinical HospitalRussian FederationМорозовская детская городская клиническая больница Департамента здравоохранения города МосквыРоссияMorozov Children’s City Clinical HospitalRussian FederationМорозовская детская городская клиническая больница Департамента здравоохранения города Москвы; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Министерства здравоохранения Российской ФедерацииРоссияMorozov Children’s City Clinical Hospital; Pirogov Russian National Research Medical UniversityRussian Federation202013082020173219229Copyright © Кантемирова М.Г., Новикова Ю.Ю., Овсянников Д.Ю., Курбанова С.Х., Глазырина А.А., Коровина О.А., Рахалина А.А., Романова Ю.В., Ртищев А.Ю., Харькин А.В., Петряйкина Е.Е., 20202020Кантемирова М.Г., Новикова Ю.Ю., Овсянников Д.Ю., Курбанова С.Х., Глазырина А.А., Коровина О.А., Рахалина А.А., Романова Ю.В., Ртищев А.Ю., Харькин А.В., Петряйкина Е.Е.Kantemirova M.G., Novikova Y.Y., Ovsyannikov D.Y., Kurbanova S.K., Glazyrina A.A., Korovina O.A., Rakhalina A.A., Romanova Y.V., Rtishchev A.Y., Kharkin A.V., Petryaykina E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1860

Новая коронавирусная инфекция (COVID-19) в большинстве случаев у детей протекает легче, чем у взрослых. Однако, начиная с марта 2020 г., из ряда европейских стран и США стали поступать сообщения о детях с новым заболеванием, имеющим признаки болезни Кавасаки (БК) и синдрома токсического шока (СТШ), получившим одно из названий — детский мультисистемный воспалительный синдром (ДМВС), ассоциированный с COVID-19.

Цель работы

Цель работы. Обобщение актуальной информации о данном заболевании.

Материалы и методы

Материалы и методы. Поиск информации в базе данных PubMed, на сайтах CDC (США) и ВОЗ, анализ истории болезни наблюдавшегося пациента с ДМВС.

Результаты

Результаты. Проанализированы клиническая и лабораторно-инструментальная манифестация и исходы ДМВС у 120 детей из Италии, Франции, Швейцарии, Англии, США, имеющего сходные черты. Приведены предлагаемые международные диагностические критерии заболевания в сопоставлении с критериями фенотипически сходных заболеваний (БК, синдром шока при БК, СТШ стафилококковой и стрептококковой этиологии, синдром активации макрофагов), клиническое наблюдение пациента, алгоритм оценки и ведения больных с ДМВС.

Background

Background. New coronaviral infection (COVID-19) in most cases has less severe course in children than in adults. However, there were reports from the number of European countries and from United States (from March 2020) about children with new disease with signs of Kawasaki disease (KD) and toxic shock syndrome (TSS). So it has received one of the names children’s multisystem inflammatory syndrome (CMIS) associated with COVID-19. The aim of the study is to summarize up-to-date information about this disease.

Methods

Methods. Information search in PubMed database, CDC (USA) and WHO websites, Search for information in PubMed database, on CDC (USA) and WHO websites, analysis of the medical records of observed patient with CMIS.

Results

Results. Clinical and laboratoryinstrumental manifestation and outcomes of CMIS in 120 children from Italy, France, Switzerland, England, USA with similar signs were analyzed. Proposed international diagnostic criteria of the disease in comparison with other phenotypically similar diseases (KD, shock syndrome at KD, TSS of Staphylococcal and Streptococcal etiology, macrophage activation syndrome), clinical observation of patient, algorithm of evaluation and management of patients with CMIS are presented.

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The authors declare that there are no conflicts of interest present.