<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v17i2.2099</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-1837</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>Функциональные свойства современных продуктов прикорма</article-title><trans-title-group xml:lang="en"><trans-title>Functional Properties of Modern Supplemental Feeding Products</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4955-0121</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Турти</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Turti</surname><given-names>Tatiana V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Турти Татьяна Владимировна, доктор медицинских наук, профессор кафедры факультетской педиатрии Педиатрического факультета ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России</p><p>117997, Москва, ул. Островитянова, д. 1, тел.: +7 (499) 259-01-08</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">turtit@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2209-7531</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Namazova-Baranova</surname><given-names>Leyla S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва; Белгород</p></bio><bio xml:lang="en"><p>Moscow; Belgorod</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8717-2539</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беляева</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyaeva</surname><given-names>Irina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бакович</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakovich</surname><given-names>Elena A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Центральная клиническая больница РАН<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University; Central Clinical Hospital of the Russian Academy of Sciences<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Центральная клиническая больница РАН; Белгородский государственный национальный исследовательский университет<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University; Central Clinical Hospital of the Russian Academy of Sciences; Belgorod State National Research University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Национальный медицинский исследовательский центр здоровья детей<country>Россия</country></aff><aff xml:lang="en">National Medical Research Center of Children’s Health<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>10</day><month>06</month><year>2020</year></pub-date><volume>17</volume><issue>2</issue><fpage>129</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Турти Т.В., Намазова-Баранова Л.С., Беляева И.А., Бакович Е.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Турти Т.В., Намазова-Баранова Л.С., Беляева И.А., Бакович Е.А.</copyright-holder><copyright-holder xml:lang="en">Turti T.V., Namazova-Baranova L.S., Belyaeva I.A., Bakovich E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/1837">https://www.pedpharma.ru/jour/article/view/1837</self-uri><abstract><p>Первая тысяча дней жизни ребенка является критическим окном формирования состояния его здоровья. Большое значение в этом периоде имеют рациональность, сбалансированность, усвояемость питания, создание условий для выработки толерантности к пище. Как показывают последние международные исследования, здоровая пища, использование функциональных продуктов могут предупредить развитие некоторых хронических неинфекционных заболеваний, таких как болезни сердечно-сосудистой системы, метаболический синдром, ожирение, сахарный диабет 2-го типа, аллергия. В период введения продуктов прикорма из-за нерационального питания неустойчивый баланс между формированием толерантности и эффекторными иммунными реакциями может быть нарушен, а функциональные расстройства желудочно-кишечного тракта — трансформироваться в патологические состояния. Актуальным является определение линейки продуктов прикорма, обладающих функциональными свойствами, и использование их в рационе ребенка из группы риска по развитию аллергии с функциональными расстройствами желудочно-кишечного тракта в период «окна толерантности».</p></abstract><trans-abstract xml:lang="en"><p>The first thousand days of the child’s life are the critical window for formation of his health. Rationality, balance, availability of nutrition, creation of conditions for development of tolerance to food have the highest importance in this period. Healthy food and use of functional products can prevent the development of certain chronic non-communicable diseases such as cardiovascular diseases, metabolic syndrome, obesity, type 2 diabetes, allergies according to recent international studies. The unstable balance between formation of tolerance and effector immune reactions can be disrupted due to improper feeding during the implementation of supplemental feeding. Thus, functional gastrointestinal disorders can transform into pathological conditions. It is relevant to determine the range of supplemental feeding products that have functional properties, and so to use them during this window of tolerance in the diet of the child who has risk of development of allergies with functional gastrointestinal disorders.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>младенец</kwd><kwd>аллергия</kwd><kwd>пищевая аллергия</kwd><kwd>функциональные расстройства желудочно-кишечного тракта</kwd><kwd>продукты прикорма</kwd><kwd>функциональные продукты</kwd><kwd>пребиотики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infant</kwd><kwd>allergy</kwd><kwd>food allergy</kwd><kwd>functional gastrointestinal disorders</kwd><kwd>supplemental feeding products</kwd><kwd>functional product</kwd><kwd>prebiotics</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Не указан.</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>Not specified.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лейк Э, Арнольд Т. Первые 1000 дней жизни ребенка оказывают влияние на всю его дальнейшую жизнь. Улучшение положения дел в области питания детей в целях построения справедливого мира. Презентация нового доклада ЮНИСЕФ «Улучшение положения дел в области питания детей: неотложная и достижимая цель в решении проблем глобального развития» [интернет]. — Дублин, 2013. Доступно по: https://studylib.ru/doc/2746761/2013---unicef. Ссылка активна на 16.01.2020.</mixed-citation><mixed-citation xml:lang="en">Leyk E, Arnol’d T. Pervyye 1000 dney zhizni rebenka okazyvayut vliyaniye na vsyu ego dal’neysh·chyu zhizn’. Uluchsheniye polozheniya del v oblasti pitaniya detey v tselyakh postroyeniya spravedlivogo mira. Prezentatsiya novogo doklada YUNISEF “Uluchsheniye polozheniya del v oblasti pitaniya detey: neotlozhnaya i dostizhimaya tsel’ v reshenii problem global’nogo razvitiya” [Internet]. Dublin; 2013. (In Russ). Доступно по: https://studylib.ru/doc/2746761/2013---unicef. Ссылка активна на 16.01.2020.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kalach N, Bellaïche M, Elias-Billon I, Dupont C. Family history of atopy in infants with cow’s milk protein allergy: A French population-based study. Arch Pediatr. 2019;26(4):226–231. doi: 10.1016/j.arcped.2019.02.014.</mixed-citation><mixed-citation xml:lang="en">Kalach N, Bellaïche M, Elias-Billon I, Dupont C. Family history of atopy in infants with cow’s milk protein allergy: A French population-based study. Arch Pediatr. 2019;26(4):226–231. doi: 10.1016/j.arcped.2019.02.014.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Agostoni C, Przyrembel H. The timing of introduction of complementary foods and later health. World Rev Nutr Diet. 2013;108:63–70. doi: 10.1159/000351486.</mixed-citation><mixed-citation xml:lang="en">Agostoni C, Przyrembel H. The timing of introduction of complementary foods and later health. World Rev Nutr Diet. 2013;108:63–70. doi: 10.1159/000351486.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Новик Г.А. Стратегия формирования толерантности у детей с пищевой аллергией // Вопросы современной педиатрии. — 2015. — Т.14. — №1. — С. 70–77. doi: 10.15690/vsp.v14i1.1265.</mixed-citation><mixed-citation xml:lang="en">Novik GA. Strategy of food tolerance development in children with food allergy. Current pediatrics. 2015;14(1):70–77. (In Russ). doi: 10.15690/vsp.v14i1.1265.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Takiishi T, Fenero CI, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017;5(4):e1373208. doi: 10.1080/21688370.2017.1373208.</mixed-citation><mixed-citation xml:lang="en">Takiishi T, Fenero CI, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017;5(4):e1373208. doi: 10.1080/21688370.2017.1373208.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chelakkot C, Ghim J, Ryu SH. Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med. 2018;50(8):103. doi: 10.1038/s12276-018-0126-x.</mixed-citation><mixed-citation xml:lang="en">Chelakkot C, Ghim J, Ryu SH. Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med. 2018;50(8):103. doi: 10.1038/s12276-018-0126-x.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Yu JC, Khodadadi H, Malik A, et al. Innate Immunity of Neonates and Infants. Front Immunol. 2018;9:1759. doi: 10.3389/fimmu.2018.01759.</mixed-citation><mixed-citation xml:lang="en">Yu JC, Khodadadi H, Malik A, et al. Innate Immunity of Neonates and Infants. Front Immunol. 2018;9:1759. doi: 10.3389/fimmu.2018.01759.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pannaraj PS, Li F, Cerini C, et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA Pediatr. 2017;171(7):647–654. doi: 10.1001/jamapediatrics.2017.0378.</mixed-citation><mixed-citation xml:lang="en">Pannaraj PS, Li F, Cerini C, et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA Pediatr. 2017;171(7):647–654. doi: 10.1001/jamapediatrics.2017.0378.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Aakko J, Kumar H, Rautava S, et al. Human milk oligosaccharide categories define the microbiota composition in human colostrum. Benef Microbes. 2017;8(4):563–567. doi: 10.3920/BM2016.0185.</mixed-citation><mixed-citation xml:lang="en">Aakko J, Kumar H, Rautava S, et al. Human milk oligosaccharide categories define the microbiota composition in human colostrum. Benef Microbes. 2017;8(4):563–567. doi: 10.3920/BM2016.0185.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ho NT, Li F, Lee-Sarwar KA, et al. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nat Commun. 2018;9(1):4169. doi: 10.1038/s41467-018-06473-x.</mixed-citation><mixed-citation xml:lang="en">Ho NT, Li F, Lee-Sarwar KA, et al. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nat Commun. 2018;9(1):4169. doi: 10.1038/s41467-018-06473-x.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Borewicz K, Suarez-Diez M, Hechler C, et al. The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life. Sci Rep. 2019;9(1):2434. doi: 10.1038/s41598-018-38268-x.</mixed-citation><mixed-citation xml:lang="en">Borewicz K, Suarez-Diez M, Hechler C, et al. The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life. Sci Rep. 2019;9(1):2434. doi: 10.1038/s41598-018-38268-x.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med. 2016;8(1):39. doi: 10.1186/s13073-016-0294-z.</mixed-citation><mixed-citation xml:lang="en">Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med. 2016;8(1):39. doi: 10.1186/s13073-016-0294-z.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Korpela K, Salonen A, Vepsäläinen O, et al. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants. Microbiome. 2018;6(1):182. doi: 10.1186/s40168-018-0567-4.</mixed-citation><mixed-citation xml:lang="en">Korpela K, Salonen A, Vepsäläinen O, et al. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants. Microbiome. 2018;6(1):182. doi: 10.1186/s40168-018-0567-4.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Matamoros S, Gras-Leguen C, Le Vacon F, et al. Development of intestinal microbiota in infants and its impact on health. Trends Microbiol. 2013;21(4):167–173. doi: 10.1016/j.tim.2012.12.001.</mixed-citation><mixed-citation xml:lang="en">Matamoros S, Gras-Leguen C, Le Vacon F, et al. Development of intestinal microbiota in infants and its impact on health. Trends Microbiol. 2013;21(4):167–173. doi: 10.1016/j.tim.2012.12.001.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lohner S, Küllenberg D, Antes G, et al. Prebiotics in healthy infants and children for prevention of acute infectious diseases: a systematic review and meta-analysis. Nutr Rev. 2014;72(8):523–531. doi: 10.1111/nure.12117.</mixed-citation><mixed-citation xml:lang="en">Lohner S, Küllenberg D, Antes G, et al. Prebiotics in healthy infants and children for prevention of acute infectious diseases: a systematic review and meta-analysis. Nutr Rev. 2014;72(8):523–531. doi: 10.1111/nure.12117.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jakobsson HE, Abrahamsson TR, Jenmalm MC, et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014;63(4):559–566. doi: 10.1136/gutjnl-2012-303249.</mixed-citation><mixed-citation xml:lang="en">Jakobsson HE, Abrahamsson TR, Jenmalm MC, et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut. 2014;63(4):559–566. doi: 10.1136/gutjnl-2012-303249.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Vatanen T, Plichta DR, Somani J, et al. Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nat Microbial. 2018;4(3):470–479. doi: 10.1038/s41564-018-0321-5.</mixed-citation><mixed-citation xml:lang="en">Vatanen T, Plichta DR, Somani J, et al. Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nat Microbial. 2018;4(3):470–479. doi: 10.1038/s41564-018-0321-5.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Турти Т.В., Беляева И.А., Сновская М.А., и др. Место современных продуктов прикорма в критическом периоде формирования здоровья ребенка // Педиатрическая фармакология. — 2018. — Т.15. — №3. — С. 270–276. doi: 10.15690/pf.v15i3.1909.</mixed-citation><mixed-citation xml:lang="en">Turti TV, Belyaeva IA, Snovskaya MA, et al. Implication of modern complementary foods in critical period for child health programming. Pediatric pharmacology. 2018;15(3):270–276. (In Russ). doi: 10.15690/pf.v15i3.1909.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Боровик Т.Э., Скворцова В.А., Яцык Г.В., и др. Функциональные нарушения желудочно-кишечного тракта у детей грудного возраста: роль диетотерапии // Лечащий врач. — 2011. — №6. — С. 66.</mixed-citation><mixed-citation xml:lang="en">Borovik TJe, Skvorcova VA, Jacyk GV, et al. Funkcional’nye narushenija zheludochno-kishechnogo trakta u detej grudnogo vozrasta: rol’ dietoterapii. Practitioner. 2011;(6):66. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pijpers MA, Bongers ME, Benninga MA, Berger MY. Functional constipation in children: a systematic review on prognosis and predictive factors. J Pediatr Gastroenterol Nutr. 2010;50(3):256–268. doi: 10.1097/MPG.0b013e3181afcdc3.</mixed-citation><mixed-citation xml:lang="en">Pijpers MA, Bongers ME, Benninga MA, Berger MY. Functional constipation in children: a systematic review on prognosis and predictive factors. J Pediatr Gastroenterol Nutr. 2010;50(3):256–268. doi: 10.1097/MPG.0b013e3181afcdc3.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Benninga MA, Faure C, Hyman PE, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016. pii: S0016-5085(16)00182-7. doi: 10.1053/j.gastro.2016.02.016.</mixed-citation><mixed-citation xml:lang="en">Benninga MA, Faure C, Hyman PE, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016. pii: S0016-5085(16)00182-7. doi: 10.1053/j.gastro.2016.02.016.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr. 2015;61(5):531–537. doi: 10.1097/MPG.0000000000000949.</mixed-citation><mixed-citation xml:lang="en">Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr. 2015;61(5):531–537. doi: 10.1097/MPG.0000000000000949.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Vandenplas Y. Algorithms for common gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2016;63(Suppl 1):S38–S40. doi: 10.1097/MPG.0000000000001220.</mixed-citation><mixed-citation xml:lang="en">Vandenplas Y. Algorithms for common gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2016;63(Suppl 1):S38–S40. doi: 10.1097/MPG.0000000000001220.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bellaiche M, Oozeer R, Gerardi-Temporel G, et al. Multiple functional gastrointestinal disorders are frequent in formula-fed infants and decrease their quality of life. Acta Paediatr. 2018;107(7):1276–1282. doi: 10.1111/apa.14348.</mixed-citation><mixed-citation xml:lang="en">Bellaiche M, Oozeer R, Gerardi-Temporel G, et al. Multiple functional gastrointestinal disorders are frequent in formula-fed infants and decrease their quality of life. Acta Paediatr. 2018;107(7):1276–1282. doi: 10.1111/apa.14348.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mahon J, Lifschitz C, Ludwig T, et al. The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England. BMJ Open. 2017;7(11):e015594. doi: 10.1136/bmjopen-2016-015594.</mixed-citation><mixed-citation xml:lang="en">Mahon J, Lifschitz C, Ludwig T, et al. The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England. BMJ Open. 2017;7(11):e015594. doi: 10.1136/bmjopen-2016-015594.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bellaiche M, Oozeer R, Gerardi-Temporel G, et al. Multiple functional gastrointestinal disorders are frequent in formula-fed infants and decrease their quality of life. Acta Paediatr. 2018; 107(7):1276–1282. doi: 10.1111/apa.14348.</mixed-citation><mixed-citation xml:lang="en">Bellaiche M, Oozeer R, Gerardi-Temporel G, et al. Multiple functional gastrointestinal disorders are frequent in formula-fed infants and decrease their quality of life. Acta Paediatr. 2018; 107(7):1276–1282. doi: 10.1111/apa.14348.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Vandenplas Y, Hauser B, Salvatore S. Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family. Pediatr Gastroenterol Hepatol Nutr. 2019;22(3):207–216. doi: 10.5223/pghn.2019.22.3.207.</mixed-citation><mixed-citation xml:lang="en">Vandenplas Y, Hauser B, Salvatore S. Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family. Pediatr Gastroenterol Hepatol Nutr. 2019;22(3):207–216. doi: 10.5223/pghn.2019.22.3.207.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Van Tilburg MA, Hyman PE, Walker L, et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. J Pediatr. 2015;166(3):684–689. doi: 10.1016/j.jpeds.2014.11.039.</mixed-citation><mixed-citation xml:lang="en">Van Tilburg MA, Hyman PE, Walker L, et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. J Pediatr. 2015;166(3):684–689. doi: 10.1016/j.jpeds.2014.11.039.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mahon J, Lifschitz C, Ludwig T, et al. The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England. BMJ Open. 2017;79(11): e015594. doi: 10.1136/bmjopen-2016-015594.</mixed-citation><mixed-citation xml:lang="en">Mahon J, Lifschitz C, Ludwig T, et al. The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England. BMJ Open. 2017;79(11): e015594. doi: 10.1136/bmjopen-2016-015594.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">McBurney MI, Davis C, Fraser CM, et al. Latulippe establishing what constitutes a healthy human gut microbiome: state of the science, regulatory considerations, and future directions. J Nutr. 2019;149(11):1882–1895. doi: 10.1093/jn/nxz154.</mixed-citation><mixed-citation xml:lang="en">McBurney MI, Davis C, Fraser CM, et al. Latulippe establishing what constitutes a healthy human gut microbiome: state of the science, regulatory considerations, and future directions. J Nutr. 2019;149(11):1882–1895. doi: 10.1093/jn/nxz154.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Food with health claims, food for special dietary uses, and nutrition labeling [Internet]. Japan Ministry of Health, Labour, and Welfare; 1991 [cited 2019 Mar 11]. Available from: https://www.mhlw.go.jp/english/topics/foodsafety/fhc/.</mixed-citation><mixed-citation xml:lang="en">Food with health claims, food for special dietary uses, and nutrition labeling [Internet]. Japan Ministry of Health, Labour, and Welfare; 1991 [cited 2019 Mar 11]. Available from: https://www.mhlw.go.jp/english/topics/foodsafety/fhc/.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada K, Sato-Mito N, Nagata J, Umegaki K. Health claim evidence requirements in Japan. J Nutr. 2008;138(6):1192S–1198S. doi: 10.1093/jn/138.6.1192S.</mixed-citation><mixed-citation xml:lang="en">Yamada K, Sato-Mito N, Nagata J, Umegaki K. Health claim evidence requirements in Japan. J Nutr. 2008;138(6):1192S–1198S. doi: 10.1093/jn/138.6.1192S.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kamioka H, Tsutani K, Origasa H, et al. Quality of systematic reviews of the foods with function claims in japan: comparative before- and after-evaluation of verification reports by the consumer affairs agency. Nutrients. 2019;11(7):1583. doi: 10.3390/nu11071583.</mixed-citation><mixed-citation xml:lang="en">Kamioka H, Tsutani K, Origasa H, et al. Quality of systematic reviews of the foods with function claims in japan: comparative before- and after-evaluation of verification reports by the consumer affairs agency. Nutrients. 2019;11(7):1583. doi: 10.3390/nu11071583.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Намазова-Баранова Л.С., Турти Т.В., Сновская М.А., и др. Оценка переносимости и безопасности монокомпонентных продуктов прикорма в питании детей раннего возраста с риском развития аллергических болезней // Вопросы современной педиатрии. — 2016. — Т.15. — №2. — С. 154–160. doi: 10.15690/vsp.v15i2.1533.</mixed-citation><mixed-citation xml:lang="en">Namazova-Baranova LS, Turti TV, Snovskaya MA, et al. Assessment of tolerability and safety of monocomponent complementary food products in the diet of infants with risk for allergic diseases. Current pediatrics. 2016;15(2):154–160. (In Russ). doi: 10.15690/vsp.v15i2.1533.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">FoodData Central is an integrated data system that provides expanded nutrient profile data and links to related agricultural and experimental research. U.S. DEPARTMENT OF AGRICULTURE. Agricultural Research Service; 2020. Available from: https://fdc.nal.usda.gov.</mixed-citation><mixed-citation xml:lang="en">FoodData Central is an integrated data system that provides expanded nutrient profile data and links to related agricultural and experimental research. U.S. DEPARTMENT OF AGRICULTURE. Agricultural Research Service; 2020. Available from: https://fdc.nal.usda.gov.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Arnarson A. Buckwheat 101: Nutrition facts and health benefits. [cited 2019 May 10] Available from: https://www.healthline.com/nutrition/foods/buckwheat#nutrients.</mixed-citation><mixed-citation xml:lang="en">Arnarson A. Buckwheat 101: Nutrition facts and health benefits. [cited 2019 May 10] Available from: https://www.healthline.com/nutrition/foods/buckwheat#nutrients.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang P, Burczynski F, Campbell C, et al. Rutin and flavonoid contents in three buckwheat species Fagopyrum esculentum, F. tataricum, and F. homotropicum and their protective effects against lipid peroxidation. Food Res Int. 2007;40(3) 356–364.</mixed-citation><mixed-citation xml:lang="en">Jiang P, Burczynski F, Campbell C, et al. Rutin and flavonoid contents in three buckwheat species Fagopyrum esculentum, F. tataricum, and F. homotropicum and their protective effects against lipid peroxidation. Food Res Int. 2007;40(3) 356–364.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Tomotake H, Shimaoka I, Kayashita J, et al. A buckwheat protein product suppresses gallstone formation and plasma cholesterol more strongly than soy protein isolate in hamsters. J Nutr. 2000;130(7):1670–1674. doi: 10.1093/jn/130.7.1670.</mixed-citation><mixed-citation xml:lang="en">Tomotake H, Shimaoka I, Kayashita J, et al. A buckwheat protein product suppresses gallstone formation and plasma cholesterol more strongly than soy protein isolate in hamsters. J Nutr. 2000;130(7):1670–1674. doi: 10.1093/jn/130.7.1670.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Z, Ishikawa W, Huang X, et al. A buckwheat protein product suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by reducing cell proliferation. J Nutr. 2001;131(6):1850–1853. doi: 10.1093/jn/131.6.1850.</mixed-citation><mixed-citation xml:lang="en">Liu Z, Ishikawa W, Huang X, et al. A buckwheat protein product suppresses 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by reducing cell proliferation. J Nutr. 2001;131(6):1850–1853. doi: 10.1093/jn/131.6.1850.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada K, Urisu A, Morita Y, et al. Immediate hypersensitive reactions to buckwheat ingestion and cross allergenicity between buckwheat and rice antigens in subjects with high levels of IgE antibodies to buckwheat. Ann Allergy Asthma Immunol. 1995;75(1):56–61.</mixed-citation><mixed-citation xml:lang="en">Yamada K, Urisu A, Morita Y, et al. Immediate hypersensitive reactions to buckwheat ingestion and cross allergenicity between buckwheat and rice antigens in subjects with high levels of IgE antibodies to buckwheat. Ann Allergy Asthma Immunol. 1995;75(1):56–61.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Arnarson A. What to know about rice. [cited 2019 May 10] Available from: https://www.medicalnewstoday.com/articles/318699</mixed-citation><mixed-citation xml:lang="en">Arnarson A. What to know about rice. [cited 2019 May 10] Available from: https://www.medicalnewstoday.com/articles/318699</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Havenaar R. Intestinal health functions of colonic microbial metabolites: a review. Benef Microbes. 2011;2(2):103–114. doi: 10.3920/BM2011.0003.</mixed-citation><mixed-citation xml:lang="en">Havenaar R. Intestinal health functions of colonic microbial metabolites: a review. Benef Microbes. 2011;2(2):103–114. doi: 10.3920/BM2011.0003.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fung KY, Cosgrove L, Lockett T, et al. A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate. Br J Nutr. 2012;108(5):820–831. doi: 10.1017/S0007114512001948.</mixed-citation><mixed-citation xml:lang="en">Fung KY, Cosgrove L, Lockett T, et al. A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate. Br J Nutr. 2012;108(5):820–831. doi: 10.1017/S0007114512001948.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Arnarson A. Corn 101: Nutrition facts and health benefits. [cited 2019 May 16] Available from: https://www.healthline.com/nutrition/foods/corn.</mixed-citation><mixed-citation xml:lang="en">Arnarson A. Corn 101: Nutrition facts and health benefits. [cited 2019 May 16] Available from: https://www.healthline.com/nutrition/foods/corn.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye disease case-control study group. JAMA. 1994;272(18):1413–1420. doi: 10.1001/jama.272.18.1413.</mixed-citation><mixed-citation xml:lang="en">Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye disease case-control study group. JAMA. 1994;272(18):1413–1420. doi: 10.1001/jama.272.18.1413.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Bjarnadottir A. Broccoli 101: Nutrition facts and health benefits. [cited 2019 May 10] Available from: https://www.healthline.com/nutrition/foods/broccoli.</mixed-citation><mixed-citation xml:lang="en">Bjarnadottir A. Broccoli 101: Nutrition facts and health benefits. [cited 2019 May 10] Available from: https://www.healthline.com/nutrition/foods/broccoli.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Vasanthi HR, Mukherjee S, Das DK. Potential health benefits of broccolia chemico-biological overview. Mini Rev Med Chem. 2009;9(6):749–759. doi: 10.2174/138955709788452685.</mixed-citation><mixed-citation xml:lang="en">Vasanthi HR, Mukherjee S, Das DK. Potential health benefits of broccolia chemico-biological overview. Mini Rev Med Chem. 2009;9(6):749–759. doi: 10.2174/138955709788452685.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Broccoli or sulforaphane: is it the source or dose that matters? Molecules. 2019;24(19):3593. doi: 10.3390/molecules24193593.</mixed-citation><mixed-citation xml:lang="en">Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Broccoli or sulforaphane: is it the source or dose that matters? Molecules. 2019;24(19):3593. doi: 10.3390/molecules24193593.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Elliott B. The Top 8 Health Benefits of Cauliflower. [cited 2019 May 16] Available from:https://www.healthline.com/nutrition/benefits-of-cauliflower</mixed-citation><mixed-citation xml:lang="en">Elliott B. The Top 8 Health Benefits of Cauliflower. [cited 2019 May 16] Available from:https://www.healthline.com/nutrition/benefits-of-cauliflower</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Мой здоровый рацион: виртуальный тренер и диетолог. Калорийность Мясо кролика. Химический состав и пищевая ценность [интернет]. Доступно по: https://health-diet.ru/base_of_food/sostav/159.php. Ссылка активна на 16.01.2020.</mixed-citation><mixed-citation xml:lang="en">Moy zdorovyy ratsion: virtual’nyy trener i diyetolog. Kaloriynost’ Myaso krolika. Khimicheskiy sostav i pishchevaya tsennost’ [Internet]. (In Russ). Доступно по: https://health-diet.ru/base_of_food/sostav/159.php. Ссылка активна на 16.01.2020.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Химический состав российских пищевых продуктов. Справочник / Под ред. член-корр. МАИ, проф. И.М. Скурихина и акад. РАМН, проф. В.А. Тутельяна. — М.: ДеЛи-принт, 2002. — 236 с.</mixed-citation><mixed-citation xml:lang="en">Khimicheskiy sostav rossiyskikh pishchevykh produktov. Spravochnik. Ed by I.M. Skurikhin, V.A. Tutel’yan. Moscow: Delhi-print; 2002. 236 р. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Dalle Zotte A, Szendro Z. The role of rabbit meat as functional food. Meat Sci. 2011;88(3):319–331. doi: 10.1016/j.meatsci.2011.02.017.</mixed-citation><mixed-citation xml:lang="en">Dalle Zotte A, Szendro Z. The role of rabbit meat as functional food. Meat Sci. 2011;88(3):319–331. doi: 10.1016/j.meatsci.2011.02.017.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Мой здоровый рацион: виртуальный тренер и диетолог. Калорийность Индейка 1-й кат. Химический состав и пищевая ценность [интернет]. Доступно по: https://health-diet.ru/base_of_food/sostav/776.php. Ссылка активна на 16.01.2020.</mixed-citation><mixed-citation xml:lang="en">Moy zdorovyy ratsion: virtual’nyy trener i diyetolog. Kaloriynost’ Indeyka 1-y kat. Khimicheskiy sostav i pishchevaya tsennost’ [Internet]. (In Russ). Доступно по: https://health-diet.ru/base_of_food/sostav/776.php. Ссылка активна на 16.01.2020.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Carlson JL, Erickson JM, Lloyd BB, Slavin JL. Health effects and sources of prebiotic dietary fiber. Curr Dev Nutr. 2018;2(3): nzy005. doi: 10.1093/cdn/nzy005.</mixed-citation><mixed-citation xml:lang="en">Carlson JL, Erickson JM, Lloyd BB, Slavin JL. Health effects and sources of prebiotic dietary fiber. Curr Dev Nutr. 2018;2(3): nzy005. doi: 10.1093/cdn/nzy005.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Benninga MA, Faure C, Hyman PE, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016;150:1443–1455.e2. doi: 10.1053/j.gastro.2016.02.016.</mixed-citation><mixed-citation xml:lang="en">Benninga MA, Faure C, Hyman PE, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016;150:1443–1455.e2. doi: 10.1053/j.gastro.2016.02.016.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
