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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v17i2.2095</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-1832</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕДАКЦИОННЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>AN EDITORIAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Первые результаты наблюдения за детьми, переболевшими COVID-19 в Москве</article-title><trans-title-group xml:lang="en"><trans-title>Primary Observational Results on Children Who Have Been Exposed to COVID-19 in Moscow</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1215-1872</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русинова</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rusinova</surname><given-names>Dina S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Русинова Дина Сергеевна, кандидат медицинских наук, главный врач ГБУЗ «Детская городская поликлиника № 133 Департамента здравоохранения города Москвы», доцент кафедры факультетской педиатрии педиатрического факультета ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России</p><p>125445, Москва, ул. Смольная, д. 55а, тел.: +7 (499) 638-30-69</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">rusinovads@zdrav.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3021-6534</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никонов</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonov</surname><given-names>Evgeniy L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2209-7531</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Namazova-Baranova</surname><given-names>Leyla S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва; Белгород</p></bio><bio xml:lang="en"><p>Moscow; Belgorod</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глазкова</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Glazkova</surname><given-names>Galina P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7398-0562</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вишнева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vishneva</surname><given-names>Elena A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8936-3590</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кайтукова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaytukova</surname><given-names>Elena V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4680-2925</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Привалова</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Privalova</surname><given-names>Tatyana E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Детская городская поликлиника № 133 Департамента здравоохранения города Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Children’s City Outpatient’s Clinic № 133 of Moscow City Health Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Департамент здравоохранения города Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow City Health Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Научно-исследовательский институт педиатрии и охраны здоровья детей Центральной клинической больницы Российской академии наук; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова; Белгородский государственный национальный исследовательский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Pediatrics and Children’s Health in «Central Clinical Hospital of the Russian Academy of Sciences»; Pirogov Russian National Research Medical University; Belgorod State National Research University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научно-исследовательский институт педиатрии и охраны здоровья детей Центральной клинической больницы Российской академии наук; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Pediatrics and Children’s Health in «Central Clinical Hospital of the Russian Academy of Sciences»; Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>10</day><month>06</month><year>2020</year></pub-date><volume>17</volume><issue>2</issue><fpage>95</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Русинова Д.С., Никонов Е.Л., Намазова-Баранова Л.С., Глазкова Г.П., Вишнева Е.А., Кайтукова Е.В., Привалова Т.Е., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Русинова Д.С., Никонов Е.Л., Намазова-Баранова Л.С., Глазкова Г.П., Вишнева Е.А., Кайтукова Е.В., Привалова Т.Е.</copyright-holder><copyright-holder xml:lang="en">Rusinova D.S., Nikonov E.L., Namazova-Baranova L.S., Glazkova G.P., Vishneva E.A., Kaytukova E.V., Privalova T.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/1832">https://www.pedpharma.ru/jour/article/view/1832</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. В мире растет число людей, инфицированных коронавирусом SARS-CoV-2, вызывающим COVID-19. Учитывая тот факт, что болезнь новая, необходимо изучение особенностей распространения и клинической картины, в частности в детской популяции.</p><p>Цель — на основании результатов практической работы медицинской организации первичного медико-санитарного звена (поликлиники; ГБУЗ «ДГП № 133 ДЗМ») в условиях пандемии проанализировать особенности распространения и клинической картины патологического процесса COVID-19 у пациентов детского возраста.</p></sec><sec><title>Методы</title><p>Методы. В феврале 2020 г. педиатры ГБУЗ «ДГП № 133 ДЗМ» обследовали на наличие новой коронавирусной инфекции определенные категории пациентов детского возраста, а именно приехавших из-за рубежа, контактных с больным, прежде всего в семейных очагах; с марта 2020 г. врачи обследовали детей с катаральными явлениями и гипертермией. Обследование детей в феврале и марте проводилось в соответствии с утвержденными Департаментом здравоохранения города Москвы алгоритмами, едиными для взрослых и детей; в последующем обследование осуществлялось согласно методическим рекомендациям, подготовленным Министерством здравоохранения Российской Федерации для детей. Тест биоматериала на SARS-CoV-2 из зева и носа проводился пациентам в 1-й, 11-й и 13-й день болезни.</p></sec><sec><title>Результаты</title><p>Результаты. С начала пандемии COVID-19 в России в нашей поликлинике до 20 апреля 2020 г. методом полимеразной цепной реакции (ПЦР) обследовано 1900 детей (3,1% всего прикрепленного детского населения) на наличие РНК нового коронавируса. Проанализировано течение болезни у первых 100 пациентов с подтвержденным COVID-19: 58 (58%) мальчиков и 42 (42%) девочки. У 81% детей был установлен источник заражения, у 19% детей выявить источник заражения не удалось. У 11 (11%) детей, обследованных по контакту с больным родственником, болезнь протекала бессимптомно; у 89% отмечалось легкое течение COVID-19 с незначительными катаральными явлениями. Самую многочисленную группу пациентов, перенесших COVID-19, составили дети старше 10 лет (42%): в 20% случаев заболевшими были школьники от 7 до 10 лет. Нарушение обоняния, по данным наблюдения, зарегистрировано у детей в возрасте старше 10 лет в 50% случаев.</p></sec><sec><title>Заключение</title><p>Заключение. Новая коронавирусная инфекция COVID-19 у детей протекает в легкой форме, без осложнений, под «маской» обычной вирусной инфекции, однако не известно, остаются ли здоровыми те, кто перенес COVID-19 бессимптомно, или для них нужна специальная реабилитация. Критически важным является своевременная разработка четкого алгоритма с пошаговой инструкцией для каждого сотрудника при различных ситуациях в период повышенной готовности.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The number of people infected with SARS-CoV-2 causing COVID-19 is growing worldwide. It is necessary to study features of prevalence and clinical signs in pediatric population considering the fact that this disease is rather new.</p><p>The aim of the study is to analyze the features of prevalence and clinical signs of pathologic process of COVID-19 in pediatric patients according to the results of practical experience of primary care medical facility (Children’s City Outpatients Clinic № 133) under the conditions of pandemia.</p></sec><sec><title>Methods</title><p>Methods. Pediatricians of Children’s City Outpatient’s Clinic № 133 have examined certain categories of pediatric patients (especially who came from abroad or contacted with infection) for the presence of a new coronaviral infection in February 2020. Doctors have been examining children with catarrhal symptoms and hyperthermia since March 2020. The survey of children in February and March was carried out in accordance with algorithms (uniform for adults and children) approved by the Moscow City Health Department. Later, the survey was carried out in accordance with the guidelines for children prepared by the Ministry of Health of the Russian Federation. The throat and nose swabs on SARS-CoV-2 were performed for all patients on the 1st, 11th and 13th day of the disease.</p></sec><sec><title>Results</title><p>Results. 1,900 children (or 3.1% of total attached pediatric population) have been examined in our outpatient’s clinic with the polymerase chain reaction (PCR) method on the presence of the new coronavirus RNA since the beginning of the COVID-19 pandemic in Russia. The course of disease was analyzed in first 100 patients with the confirmed COVID-19 diagnosis: 58 (58%) boys and 42 (42%) girls. In 81% of cases we revealed the source of infection, in 19% – we did not. The disease was asymptomatic in 11 (11%) children examined after the contact with ill relatives; 89% had mild COVID-19 disease with light catarrhal signs. The most numerous group of patients who had COVID-19 consisted of children over 10 years of age (42%); in 20% of cases it was pupils from 7 to 10 years old. Smell disorders were reported in children over the age of 10 in 50% of all cases.</p></sec><sec><title>Conclusion</title><p>Conclusion. New coronaviral infection COVID-19 in children is taking mild course, without complications, under the «mask» of common viral infection. Thus, it is unknown either those who have undergone COVID-19 asymptomatically remain healthy or they need special rehabilitation. The timely development of clear algorithm with step-by-step instructions for various situations for every health professional is crucial during these difficult times.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>коронавирус</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>new coronaviral infection</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>coronavirus</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Отсутствует.</funding-statement><funding-statement xml:lang="en">Not specified.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Всемирная организация здравоохранения. Рекомендации ВОЗ для населения в связи c распространением коронавирусной инфекции (COVID-19) [интернет]. — ВОЗ, 2020. 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