ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v17i2.2094ppharm-1831Research ArticleРЕДАКЦИОННЫЕ СТАТЬИAN EDITORIAL ARTICLEКоронавирусная инфекция (COVID-19) у детей (состояние на апрель 2020)Coronaviral Infection (COVID-19) in Children (Situation on April 2020)https://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Намазова-Баранова Лейла Сеймуровна, доктор медицинских наук, профессор, академик РАН, заведующая кафедрой факультетской педиатрии педиатрического факультета ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России, руководитель НИИ педиатрии и охраны здоровья детей ЦКБ РАН Министерства науки и высшего образования РФ, президент Союза педиатров России, профессор Королевского колледжа терапевтов Ирландии

119333, Москва, ул. Фотиевой, д. 10, тел.: +7 (499) 400-47-33

Moscow; Belgorod

lsnamazova@yandex.ruНаучно-исследовательский институт педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Белгородский государственный национальный исследовательский университетРоссияResearch Institute of Pediatrics and Children’s Health in «Central Clinical Hospital of the Russian Academy of Sciences»; Pirogov Russian National Research Medical University; Belgorod State National Research UniversityRussian Federation2020100620201728594Copyright © Намазова-Баранова Л.С., 20202020Намазова-Баранова Л.С.Namazova-Baranova L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1831

Дорогие друзья, коллеги!

Прошло не так много времени с момента опубликования моего прошлого обзора, но появилось так много новостей, что они поменяли некоторые наши представления о болезни и о методах ее лечения самым кардинальным образом! И это интересно как с медицинской, так и с философской точки зрения. С философской — потому что 1–2 мес нашей прошлой, «доковидной», жизни пролетали как одно мгновение, а сегодня — это огромный путь, который мы проделываем, наблюдая за новой инфекцией и продолжая искать эффективные средства ее сдерживания и контроля. А о медицинской составляющей мы сейчас и поговорим.

Dear friends, colleagues!

Not so much time has passed since my last published review on this topic, bit so many news has appeared that has completely changed our vision of the disease and its treatment! It is interesting in both, medical and philosophical way. From philosophical point of view: 1–2 months of our previous pre-COVID life flew quick as lightning but now it is long period while we are observing this new infection and looking for new ways of management and its control. Then as now we are going to discuss its medical part.

коронавирусная инфекцияCOVID-19SARS-COV-2диагностикаклинические проявленияпрофилактикалечениедетиcoronaviral infectionCOVID-19SARS-COV-2diagnosticsclinical signspreventiontreatmentchildrenНе указан.Not specified.ReferencesJiang S, Shi Z, Shu Y, et al. A distinct name is needed for the new coronavirus. Lancet. 2020;395(10228):949. doi: 10.1016/S0140-6736(20)30419-0.Jiang S, Shi Z, Shu Y, et al. A distinct name is needed for the new coronavirus. Lancet. 2020;395(10228):949. doi: 10.1016/S0140-6736(20)30419-0.Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage В beta-coronaviruses. Nat Microbiol. 2020;5(4):562–569. doi: 10.1038/s41564-020-0688-y.Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage В beta-coronaviruses. Nat Microbiol. 2020;5(4):562–569. doi: 10.1038/s41564-020-0688-y.Dong Y, Мо Х, Нu Y, et al. Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China. Pediatrics. 2020. doi: 10.1542/peds.2020-0702Dong Y, Мо Х, Нu Y, et al. Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China. Pediatrics. 2020. doi: 10.1542/peds.2020-0702Du Z, Xu X, Wu Y, et al. Serial Interval of COVID-19 among Publicly Reported Confirmed Cases. Emerg Infect Dis. 2020;26(6):1341–1343. doi: 10.3201/eid2606.200357.Du Z, Xu X, Wu Y, et al. Serial Interval of COVID-19 among Publicly Reported Confirmed Cases. Emerg Infect Dis. 2020;26(6):1341–1343. doi: 10.3201/eid2606.200357.Wu P, Duan F, Luo C, et al. Characteristics of ocular findings of patients with Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmology. 2020;138(5):575–578. doi: 10.1001/jamaophthalmol.2020.1291.Wu P, Duan F, Luo C, et al. Characteristics of ocular findings of patients with Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmology. 2020;138(5):575–578. doi: 10.1001/jamaophthalmol.2020.1291.Shen K, Yang Y. Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue. World J Pediatr. 2020;1–3. doi: 10.1007/s12519-020-00344-6.Shen K, Yang Y. Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue. World J Pediatr. 2020;1–3. doi: 10.1007/s12519-020-00344-6.Molloy EJ, Bearer CF. COVID-19 in children and altered inflammatory responses. Pediatr Res. 2020. doi: 10.1038/s41390-020-0881-y.Molloy EJ, Bearer CF. COVID-19 in children and altered inflammatory responses. Pediatr Res. 2020. doi: 10.1038/s41390-020-0881-y.Cristiani L, Mancino E, Matera L, et al. Will children reveal their secret? The coronavirus dilemma. Eur Respir J. 2020;55(4):2000749. doi: 10.1183/13993003.00749-2020.Cristiani L, Mancino E, Matera L, et al. Will children reveal their secret? The coronavirus dilemma. Eur Respir J. 2020;55(4):2000749. doi: 10.1183/13993003.00749-2020.Xu Y, Li X, Zhu B, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502–505. doi: 10.1038/s41591-020-0817-4.Xu Y, Li X, Zhu B, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502–505. doi: 10.1038/s41591-020-0817-4.Zheng M, Gao Y, Wang G, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17(5):533–535. doi: 10.1038/s41423-020-0402-2.Zheng M, Gao Y, Wang G, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17(5):533–535. doi: 10.1038/s41423-020-0402-2.Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–1034. doi: 10.1016/S0140-6736(20)30628-0.Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–1034. doi: 10.1016/S0140-6736(20)30628-0.Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246–251. doi: 10.1016/j.jhin.2020.01.022.Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020;104(3):246–251. doi: 10.1016/j.jhin.2020.01.022.Van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020;82(16):1564–1567. doi: 10.1056/NEJMc2004973.Van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020;82(16):1564–1567. doi: 10.1056/NEJMc2004973.Nishiura H, Linton NM, Akhmetzhanov AR. Serial interval of novel coronavirus (COVID-19) infections. Int J Infect Dis. 2020;93:284–286. doi: 10.1016/j.ijid.2020.02.060.Nishiura H, Linton NM, Akhmetzhanov AR. Serial interval of novel coronavirus (COVID-19) infections. Int J Infect Dis. 2020;93:284–286. doi: 10.1016/j.ijid.2020.02.060.Du Z, Xu X, Wu Y, et al. Serial Interval of COVID-19 among Publicly Reported Confirmed Cases. Emerg Infect Dis. 2020;26(6):1341–1343. doi: 10.3201/eid2606.200357.Du Z, Xu X, Wu Y, et al. Serial Interval of COVID-19 among Publicly Reported Confirmed Cases. Emerg Infect Dis. 2020;26(6):1341–1343. doi: 10.3201/eid2606.200357.Кат KQ, Yung CF, Cui L, et at. A Well Infant with Coronavirus Disease 2019 (COVID-19) with High Viral Load. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa201.Кат KQ, Yung CF, Cui L, et at. A Well Infant with Coronavirus Disease 2019 (COVID-19) with High Viral Load. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa201.Cai J, Xu J, Lin D, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa198.Cai J, Xu J, Lin D, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa198.Qiu H. Wu J, Hong L, et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020;S1473-3099(20)30198-5. doi: 10.1016/S1473-3099(20)30198-5.Qiu H. Wu J, Hong L, et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020;S1473-3099(20)30198-5. doi: 10.1016/S1473-3099(20)30198-5.Xu Y, Li X, Zhu B, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502–505. doi: 10.1038/s41591-020-0817-4.Xu Y, Li X, Zhu B, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502–505. doi: 10.1038/s41591-020-0817-4.Young BE, Ong SW, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA. 2020;323(15):1488–1494. doi: 10.1001/jama.2020.3204.Young BE, Ong SW, Kalimuddin S, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA. 2020;323(15):1488–1494. doi: 10.1001/jama.2020.3204.Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc. 2020;119(3):670–673. doi: 10.1016/j.jfma.2020.02.009.Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc. 2020;119(3):670–673. doi: 10.1016/j.jfma.2020.02.009.Su L, Ma X, Yu H, et al. The different clinical characteristics of corona virus disease cases between children and their families in China — the character of children with COVIO-19. Emerg Microbes Infect. 2020;9(1):707–713. doi: 10.1080/22221751.2020.1744483.Su L, Ma X, Yu H, et al. The different clinical characteristics of corona virus disease cases between children and their families in China — the character of children with COVIO-19. Emerg Microbes Infect. 2020;9(1):707–713. doi: 10.1080/22221751.2020.1744483.Ма Х, Su L, Zhang Y, et al. Do children need a longer time to shed SARS-CoV-2 in stool than adults? J Microbiol Immunol Infect. 2020. doi: 10.1016/j.jmii.2020.03.010.Ма Х, Su L, Zhang Y, et al. Do children need a longer time to shed SARS-CoV-2 in stool than adults? J Microbiol Immunol Infect. 2020. doi: 10.1016/j.jmii.2020.03.010.Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177–1179. doi: 10.1056/NEJMc2001737.Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177–1179. doi: 10.1056/NEJMc2001737.Zeng H, Хu С, Fan J, et al. Antibodies in infants вorn to mothers with COVID-19 pneumonia. JAMA. 2020;323(18):1848–1849. doi: 10.1001/jama.2020.4861.Zeng H, Хu С, Fan J, et al. Antibodies in infants вorn to mothers with COVID-19 pneumonia. JAMA. 2020;323(18):1848–1849. doi: 10.1001/jama.2020.4861.Dong L, Tian J, He S, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020;323(18):1846–1848. doi: 10.1001/jama.2020.4621.Dong L, Tian J, He S, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020;323(18):1846–1848. doi: 10.1001/jama.2020.4621.Coronavirus disease (COVID-2019) situation reports. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.Coronavirus disease (COVID-2019) situation reports. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.Таgarro A, Epalza С, Santos М, et al. Screening and severity of Coronavirus Disease 2019 (COVID-19) in children in Madrid, Spain. JAMA Pediatr. 2020;e201346. doi: 10.1001/jamapediatrics.2020.1346.Таgarro A, Epalza С, Santos М, et al. Screening and severity of Coronavirus Disease 2019 (COVID-19) in children in Madrid, Spain. JAMA Pediatr. 2020;e201346. doi: 10.1001/jamapediatrics.2020.1346.Wei M, Yuan J, Liu Y, et al. Novel Coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 2020;323(13):1313–1314. doi: 10.1001/jama.2020.2131.Wei M, Yuan J, Liu Y, et al. Novel Coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 2020;323(13):1313–1314. doi: 10.1001/jama.2020.2131.Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663–1665. doi: 10.1056/NEJMc2005073.Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663–1665. doi: 10.1056/NEJMc2005073.Gudbjartsson DF, Helgason A, Jonsson H, et al. Spread of SARS-CoV-2 in the lcelandic Population. N Engl J Med. 2020;NEJMoa2006100. doi: 10.1056/NEJMoa2006100.Gudbjartsson DF, Helgason A, Jonsson H, et al. Spread of SARS-CoV-2 in the lcelandic Population. N Engl J Med. 2020;NEJMoa2006100. doi: 10.1056/NEJMoa2006100.Worcester S. COVID-19 characteristics differ in children vs adults. 2020. Available at: https://www.medscape.com/viewarticle/926805.Worcester S. COVID-19 characteristics differ in children vs adults. 2020. Available at: https://www.medscape.com/viewarticle/926805.Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5.Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5.Zhu N, Zhang D, Wang W, et al. A novel Coronavirus from patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017.Zhu N, Zhang D, Wang W, et al. A novel Coronavirus from patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017.Guan W, Ni Z, Hu Y, et al. Clinical characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708–1720. doi: 10.1056/NEJMoa2002032.Guan W, Ni Z, Hu Y, et al. Clinical characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708–1720. doi: 10.1056/NEJMoa2002032.Baez D. Clinical findings of 6 children with COVID-19, risks factors associated with COVID-19 death, and detection of SARS-CoV-2 in different clinical specimens. 2020.Baez D. Clinical findings of 6 children with COVID-19, risks factors associated with COVID-19 death, and detection of SARS-CoV-2 in different clinical specimens. 2020.Lu X, Liqiong ZL, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663–1665. doi: 10.1056/NEJMc2005073.Lu X, Liqiong ZL, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663–1665. doi: 10.1056/NEJMc2005073.Chan JF, Yuan S, Kok K, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514–523. doi: 10.1016/S0140-6736(20)30154-9.Chan JF, Yuan S, Kok K, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514–523. doi: 10.1016/S0140-6736(20)30154-9.Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi: 10.1016/S0140-6736(20)30566-3.Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi: 10.1016/S0140-6736(20)30566-3.Zhang J, Dong X, Cao Y, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020. doi: 10.1111/all.14238.Zhang J, Dong X, Cao Y, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020. doi: 10.1111/all.14238.Boulos MN, Geraghty EM. Geographical tracking and mapping of coronavirus disease COVID-19/severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic and associated events around the world: how 21st century GIS technologies are supporting the global fight against outbreaks and epidemics. Int J Health Geogr. 2020;19(1):8. doi: 10.1186/s12942-020-00202-8.Boulos MN, Geraghty EM. Geographical tracking and mapping of coronavirus disease COVID-19/severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic and associated events around the world: how 21st century GIS technologies are supporting the global fight against outbreaks and epidemics. Int J Health Geogr. 2020;19(1):8. doi: 10.1186/s12942-020-00202-8.Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323(18):1843–1844. doi: 10.1001/jama.2020.3786.Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323(18):1843–1844. doi: 10.1001/jama.2020.3786.Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–815. doi: 10.1016/S0140-6736(20)30360-3.Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–815. doi: 10.1016/S0140-6736(20)30360-3.TheDailyStar. Coronavirus suspicion: 7-month-old baby sent to Dhaka from isolation ward in Kushtia. 2020. Available at https://www.thedailystar.net/coronavirus-suspicion-in-kushtia-7-month-old-baby-isolation-ward-1886209.TheDailyStar. Coronavirus suspicion: 7-month-old baby sent to Dhaka from isolation ward in Kushtia. 2020. Available at https://www.thedailystar.net/coronavirus-suspicion-in-kushtia-7-month-old-baby-isolation-ward-1886209.Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates воrn to mothers with COVID-19 in Wuhan, China. JAMA Pediatrics. 2020;e200878. doi: 10.1001/jamapediatrics.2020.0878.Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates воrn to mothers with COVID-19 in Wuhan, China. JAMA Pediatrics. 2020;e200878. doi: 10.1001/jamapediatrics.2020.0878.Xia W, Shao J, Guo Y, et al. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020;55(5):1169–1174. doi: 10.1002/ppul.24718.Xia W, Shao J, Guo Y, et al. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020;55(5):1169–1174. doi: 10.1002/ppul.24718.Chen ZM, Fu JF, Shu Q, et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J Pediatr. 2020;1–7. doi: 10.1007/s12519-020-00345-5.Chen ZM, Fu JF, Shu Q, et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J Pediatr. 2020;1–7. doi: 10.1007/s12519-020-00345-5.Liu W, Zhang Q, Chen J, et al. Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370–1371. doi: 10.1056/NEJMc2003717.Liu W, Zhang Q, Chen J, et al. Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370–1371. doi: 10.1056/NEJMc2003717.Zheng F, Liao C, Fan QH, et al. Clinical characteristics of children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. 2020;40(2):275–280. doi: 10.1007/s11596-020-2172-6.Zheng F, Liao C, Fan QH, et al. Clinical characteristics of children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. 2020;40(2):275–280. doi: 10.1007/s11596-020-2172-6.Marzano AV, Genovese G, Fabbrocini G, et al. Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients. J Am Acad Dermatol. 2020;S0190-9622(20)30657-5. doi: 10.1016/j.jaad.2020.04.044.Marzano AV, Genovese G, Fabbrocini G, et al. Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients. J Am Acad Dermatol. 2020;S0190-9622(20)30657-5. doi: 10.1016/j.jaad.2020.04.044.Genovese G, Colonna C, Marzano AV. Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: a diagnostic clue? Pediatr Dermatol. 2020. doi: 10.1111/pde.14201.Genovese G, Colonna C, Marzano AV. Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: a diagnostic clue? Pediatr Dermatol. 2020. doi: 10.1111/pde.14201.Gao Y, Li T, Han M, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;0.1002/jmv.25770. doi: 10.1002/jmv.25770.Gao Y, Li T, Han M, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;0.1002/jmv.25770. doi: 10.1002/jmv.25770.Li W, Cui H, Li K, et al. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol. 2020;50(6):796–799. doi: 10.1007/s00247-020-04656-7.Li W, Cui H, Li K, et al. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol. 2020;50(6):796–799. doi: 10.1007/s00247-020-04656-7.Henry BM, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020; j/cclm.ahead-of-print/cclm-2020-0272/cclm-2020-0272.xm. doi: 10.1515/cclm-2020-0272.Henry BM, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020; j/cclm.ahead-of-print/cclm-2020-0272/cclm-2020-0272.xm. doi: 10.1515/cclm-2020-0272.Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. doi: 10.1016/S0140-6736(20)30211-7.Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. doi: 10.1016/S0140-6736(20)30211-7.Guo L, Ren L, Yang S, et at. Profiting early humorat response to diagnose novel Coronavirus Disease (COVID-19). lin Infect Dis. 2020;ciaa310. doi: 10.1093/cid/ciaa310.Guo L, Ren L, Yang S, et at. Profiting early humorat response to diagnose novel Coronavirus Disease (COVID-19). lin Infect Dis. 2020;ciaa310. doi: 10.1093/cid/ciaa310.Cui Y, Tian M, Huang D, et al. A 55-Day-Old Female Infant infected with COVID 19: presenting with pneumonia, liver injury, and heart damage. J Infect Dis. 2020;221(11):1775–1781. doi: 10.1093/infdis/jiaa113.Cui Y, Tian M, Huang D, et al. A 55-Day-Old Female Infant infected with COVID 19: presenting with pneumonia, liver injury, and heart damage. J Infect Dis. 2020;221(11):1775–1781. doi: 10.1093/infdis/jiaa113.Turner D, Huang Y, Martin-de-Carpi J, et al. COVID-19 and paediatric inflammatory bowel diseases: global experience and provisional guidance (March 2020) from the Paediatric IBD Porto group of ESPGHAN. J Pediatr Gastroenterol Nutr. 2020. doi: 10.1097/MPG.0000000000002729.Turner D, Huang Y, Martin-de-Carpi J, et al. COVID-19 and paediatric inflammatory bowel diseases: global experience and provisional guidance (March 2020) from the Paediatric IBD Porto group of ESPGHAN. J Pediatr Gastroenterol Nutr. 2020. doi: 10.1097/MPG.0000000000002729.Chan JF, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514–523. doi: 10.1016/S0140-6736(20)30154-9.Chan JF, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514–523. doi: 10.1016/S0140-6736(20)30154-9.Намазова-Баранова Л.С., Баранов А.А. Коронавирусная инфекция у детей (состояние на февраль 2020) // Педиатрическая фармакология. — 2020. — Т.17. — №1. — С. 7–11. doi: https://doi.org/10.15690/pf.v17i1.2076.Namazova-Baranova LS, Baranov AA. Coronavirus infection in children (Situation on February 2020). Pediatric pharmacology. 2020;17(1):7–11. (In Russ). doi: https://doi.org/10.15690/pf.v17i1.2076.D’Antiga L. Coronavimses and immunosuppressed patients. The facts during the third epidemic. Liver Transpl. 2020. doi: 10.1002/lt.25756.D’Antiga L. Coronavimses and immunosuppressed patients. The facts during the third epidemic. Liver Transpl. 2020. doi: 10.1002/lt.25756.Rasmussen SA, Smulian JC, Lednicky JA, et al. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415–426. doi: 10.1016/j.ajog.2020.02.017.Rasmussen SA, Smulian JC, Lednicky JA, et al. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415–426. doi: 10.1016/j.ajog.2020.02.017.Li Y, Zhao R, Zheng S, et al. Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerg Infect Dis. 2020;26(6):1335–1336. doi: 10.3201/eid2606.200287.Li Y, Zhao R, Zheng S, et al. Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerg Infect Dis. 2020;26(6):1335–1336. doi: 10.3201/eid2606.200287.Lu Q, Shi Y. Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. J Med Virol. 2020;10.1002/jmv.25740. doi: 10.1002/jmv.25740.Lu Q, Shi Y. Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. J Med Virol. 2020;10.1002/jmv.25740. doi: 10.1002/jmv.25740.Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51–60. doi: 10.21037/tp.2020.02.06.Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51–60. doi: 10.21037/tp.2020.02.06.FitzGerald GA. Misguided drug advice for COVID-19. Science. 2020;367(6485):1434. doi: 10.1126/science.abb8034.FitzGerald GA. Misguided drug advice for COVID-19. Science. 2020;367(6485):1434. doi: 10.1126/science.abb8034.Sheahan TP, Sims AC, Leist SR, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020;11(1):222. doi: 10.1038/s41467-019-13940-6.Sheahan TP, Sims AC, Leist SR, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020;11(1):222. doi: 10.1038/s41467-019-13940-6.Martinez MA. Compounds with therapeutic potential against novel respiratory 2019 coronavirus. Antimicrob Agents Chemother. 2020;64(5):e00399-20. doi: 10.1128/AAC.00399-20.Martinez MA. Compounds with therapeutic potential against novel respiratory 2019 coronavirus. Antimicrob Agents Chemother. 2020;64(5):e00399-20. doi: 10.1128/AAC.00399-20.Yao X, Ye F, Zhang M, et al. In Vitro Antiviral activity and projection of optimized dosing design of Hydroxychloroquine for the treatment of severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020;ciaa237. doi: 10.1093/cid/ciaa237.Yao X, Ye F, Zhang M, et al. In Vitro Antiviral activity and projection of optimized dosing design of Hydroxychloroquine for the treatment of severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020;ciaa237. doi: 10.1093/cid/ciaa237.Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. 2020;NEJMoa2007016. doi: 10.1056/NEJMoa2007016.Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med. 2020;NEJMoa2007016. doi: 10.1056/NEJMoa2007016.Сао В, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382(19):1787–1799. doi: 10.1056/NEJMoa2001282.Сао В, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382(19):1787–1799. doi: 10.1056/NEJMoa2001282.Gautret P, Lagier J, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;105949. doi: 10.1016/j.ijantimicag.2020.105949.Gautret P, Lagier J, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;105949. doi: 10.1016/j.ijantimicag.2020.105949.Chang R, Sun W. Repositioning chloroquine as ideal antiviral prophylactic against COVID-19 — time is now. 2020;2020030279. https://doi.org/10.20944/preprints202003.0279.v1.Chang R, Sun W. Repositioning chloroquine as ideal antiviral prophylactic against COVID-19 — time is now. 2020;2020030279. https://doi.org/10.20944/preprints202003.0279.v1.Advisory on the use of hydroxy-chloroquine as prophylaxis for SARS-CoV-2 infection. Recommendation. 2020. Available at: https://www.mohfw.gov.in/pdf/AdvisoryontheuseofHydroxychloroquinasprophylaxisforSARSCoV2infection.pdf.Advisory on the use of hydroxy-chloroquine as prophylaxis for SARS-CoV-2 infection. Recommendation. 2020. Available at: https://www.mohfw.gov.in/pdf/AdvisoryontheuseofHydroxychloroquinasprophylaxisforSARSCoV2infection.pdf.Velthuis AJ, van den Worm SH, Sims AC, et al. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010;6(11):e1001176. doi: 10.1371/journal.ppat.1001176.Velthuis AJ, van den Worm SH, Sims AC, et al. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010;6(11):e1001176. doi: 10.1371/journal.ppat.1001176.Hoffmann M, Kleine-Weber H. Schroeder S, et al. SARS-CoV-2 dCell entry depens on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;271–280.e8. doi: 10.1016/j.cell.2020.02.052.Hoffmann M, Kleine-Weber H. Schroeder S, et al. SARS-CoV-2 dCell entry depens on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;271–280.e8. doi: 10.1016/j.cell.2020.02.052.Yamamoto M, Matsuyama S, Li X, et al. Identification of nafamostat as a potent inhibitor of middle east respiratory syndrome Coronavirus S Protein-Mediated membrane fusion using the split-protein-based cell-cell fusion assay. Antimicrob Agents Chemother. 2016;60(11):6532–6539. doi: 10.1128/AAC.01043-16.Yamamoto M, Matsuyama S, Li X, et al. Identification of nafamostat as a potent inhibitor of middle east respiratory syndrome Coronavirus S Protein-Mediated membrane fusion using the split-protein-based cell-cell fusion assay. Antimicrob Agents Chemother. 2016;60(11):6532–6539. doi: 10.1128/AAC.01043-16.

The authors declare that there are no conflicts of interest present.