ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v16i5.2060ppharm-1773Research ArticleВ ПРАКТИКУ ПЕДИАТРАFor Pediatricians' PracticeОсобенности микробиома кожи у детей с атопическим дерматитом и новые возможности для патогенетической терапииFeatures of Cutaneous Microbiome in Children With Atopic Dermatitis and New Pathogenetic Therapy Optionshttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Мурашкин Николай Николаевич, доктор медицинских наук, профессор, заведующий отделением дерматологии с группой лазерной хирургии; заведующий лабораторией патологии кожи у детей отдела научных исследований в педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России; профессор кафедры дерматовенерологии и косметологии ФГБУ ДПО «ЦГМА» УДП РФ; профессор кафедры педиатрии и детской ревматологии ФГБОУ ВО «Первый МГМУ им. И.М. Сеченова»

119991, Москва, Ломоносовский пр-т, д. 2, стр. 1

тел.: +7 (495) 967-14-20

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m_nn2001@mail.ruhttps://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.

Москва

Moscow

https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinLeonid A.

Москва

Moscow

https://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.

Москва

Moscow

https://orcid.org/0000-0002-8232-8936АмбарчянЭ. Т.AmbarchyanEduard T.

Москва

Moscow

https://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.

Москва

Moscow

https://orcid.org/0000-0001-9777-0156ФёдоровД. В.FedorovDmitri V.

Москва

Moscow

Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академия Управления делами Президента Российской ФедерацииРоссияNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University; Central State Medical Academy of Department of Presidential AffairsRussian FederationНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian Federation201917012020165304309Copyright © Мурашкин Н.Н., Материкин А.И., Опрятин Л.А., Епишев Р.В., Амбарчян Э.Т., Иванов Р.А., Фёдоров Д.В., 20202020Мурашкин Н.Н., Материкин А.И., Опрятин Л.А., Епишев Р.В., Амбарчян Э.Т., Иванов Р.А., Фёдоров Д.В.Murashkin N.N., Materikin A.I., Opryatin L.A., Epishev R.V., Ambarchyan E.T., Ivanov R.A., Fedorov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1773

Атопический дерматит — хроническое воспалительное заболевание, характеризующееся рецидивирующим течением, сильным зудом, эритемой, сухой кожей в результате дефектов кожного барьера и инфицированием стафилококком. Согласно действующим руководствам по лечению атопического дерматита, подготовленным дерматологическими обществами, длительное нанесение смягчающего средства непосредственно на кожу и использование его в качестве средства для купания является базисной терапией атопического дерматита. Клинические испытания доказали, что регулярное применение смягчающего средства увлажняет кожу, восстанавливает ее барьер и нормальную функцию, а также уменьшает количество глюкокортикостероидов, необходимых для лечения атопической экземы у младенцев, детей и взрослых пациентов. Результаты испытаний и многолетний клинический опыт доказали, что смягчающие средства безопасны и эффективны у пациентов с атопическим дерматитом. В данной статье представлена информация, основанная на последних знаниях, касающихся эмолентов: обзор смягчающих компонентов, их свойств, механизма действия и роли, которую они играют при атопическом дерматите, а также результаты клинических испытаний, проведенных у детей с атопическим дерматитом.

Atopic dermatitis is a chronic inflammatory disease characterized by relapsing course, severe itching, erythema and dry skin due to skin barrier defects and staphylococcus infection. According to current guidelines for the treatment of atopic dermatitis (prepared by dermatological societies) the background therapy is prolonged application of emollients directly on the skin and its use during bathing. Clinical studies have shown that repeated administration of emollients moisturizes the skin, restores its barrier and normal functioning, and reduces the amount of glucocorticosteroids needed for atopic eczema therapy in infants, children and adults. The results of trials and long-term clinical practice have proven that emollients are safe and effective in patients with atopic dermatitis. This article presents the information based on the recent data concerning emollients: their characteristics, mode of action, role in atopic dermatitis treatment, and results of clinical trials conducted in such patients.

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The authors declare that there are no conflicts of interest present.