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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v10i5.825</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-177</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>СКОРОСТЬ ПУЛЬСОВОЙ ВОЛНЫ И ЦЕНТРАЛЬНОЕ ДАВЛЕНИЕ В АОРТЕ У ДЕТЕЙ С ОЖИРЕНИЕМ ПО РЕЗУЛЬТАТАМ НЕИНВАЗИВНОЙ АРТЕРИОГРАФИИ</article-title><trans-title-group xml:lang="en"><trans-title>PULSE WAVE VELOCITY AND CENTRAL AORTIC PRESSURE IN OBESE CHILDREN ACCORDING TO THE NON-INVASIVE ARTERIOGRAPHY RESULTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кожевникова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozhevnikova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, заведующая отделением инструментальной и лабораторной диагностики КДЦНаучного центра здоровья детей РАМН</p></bio><bio xml:lang="en"><p>MD, head of the instrumental and laboratory diagnostics department of the CDC at the Scientific Center of Children’s Health</p></bio><email xlink:type="simple">Kozhevnikova@nczd.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Namazova-Baranova</surname><given-names>L. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логачёва</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Logachyova</surname><given-names>O. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маргиева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Margieva</surname><given-names>T. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Широкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shirokova</surname><given-names>I. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахимова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakhimova</surname><given-names>A. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балабанов</surname><given-names>А. C.</given-names></name><name name-style="western" xml:lang="en"><surname>Balabanov</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научный центр здоровья детей РАМН<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация&#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова&#13;
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation&#13;
First Sechenov Moscow State Medical University&#13;
Pirogov Russian National Medical Research University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация&#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>01</day><month>10</month><year>2013</year></pub-date><volume>10</volume><issue>5</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>59</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кожевникова О.В., Намазова-Баранова Л.С., Логачёва О.С., Маргиева Т.В., Широкова И.В., Рахимова А.Н., Балабанов А.C., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Кожевникова О.В., Намазова-Баранова Л.С., Логачёва О.С., Маргиева Т.В., Широкова И.В., Рахимова А.Н., Балабанов А.C.</copyright-holder><copyright-holder xml:lang="en">Kozhevnikova O.V., Namazova-Baranova L.S., Logachyova O.S., Margieva T.V., Shirokova I.V., Rakhimova A.N., Balabanov A.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/177">https://www.pedpharma.ru/jour/article/view/177</self-uri><abstract/><trans-abstract xml:lang="en"><p>The article presents information value of non-invasive arteriography, which reveals early signs of cardiovascular pathology formation in children, using a large number of trials in children. The authors examined predictors of cardiovascular catastrophes’ development, confirmed in adults: aortic wall’s stiffness, central aortic pressure and pulse pressure – that have not been sufficiently studied in children yet. The article shows that the high-technology method of non-invasive arteriography allows revealing changes of these parameters in children on the preclinical stage. It also shows their correlation with body mass index, fatty hepatosis, direct correlation of weight gain with connection of pulse wave velocity and central blood pressure and importance of follow-up evaluation of these parameters. Heterogeneity of the group of obese children in terms of these parameters is a premise for development of individual approach to control and prevention of cardiovascular complications’ development risk in childhood.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериография</kwd><kwd>жесткость стенки аорты</kwd><kwd>скорость распространения пульсовой волны</kwd><kwd>ожирение</kwd><kwd>профилактика</kwd><kwd>предикторы</kwd><kwd>сердечно-сосудистые изменения</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arteriography</kwd><kwd>aortic wall’s stiffness</kwd><kwd>pulse wave velocity</kwd><kwd>obesity</kwd><kwd>prevention</kwd><kwd>predictors</kwd><kwd>cardiovascular alterations</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А. А. Научные и практические проблемы российской педиатрии на современном этапе. Педиатрия. Журнал им. Г. Н. Сперанского. 2005; 3: 4–7.</mixed-citation><mixed-citation xml:lang="en">Baranov A. A. Pediatriya. Zhurnal im. G. N. Speranskogo = PEDIATRIYA - MOSCOW. 2005; 3: 4–7.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Всемирная организация здравоохранения [Электронный ресурс] Глобальная стратегия по питанию, физической активности и здоровью. Избыточный вес и ожирение среди детей. URL: http://www.who.int/dietphysicalactivity/childhood/ru</mixed-citation><mixed-citation xml:lang="en">WHO. Available at: http://www.who.int/dietphysicalactivity/childhood/ru</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Оганов Р. Г. Эпидемиология и профилактика основных сердечно-сосудистых заболеваний. Арх. патологии. 1992; 4: 13–15.</mixed-citation><mixed-citation xml:lang="en">Oganov R. G. Arkh. patologii = Achive of pathology. 1992; 4: 13–15.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Логачева О. С., О. В. Кожевникова, А. Е. Пальцева, Л. С. Намазова-Баранова, А. К. Геворкян Современные методы раннего выявления предикторов развития сердечно-сосудистых заболеваний у детей. Педиатрическая фармакология. 2013; 10 (2): 117–120.</mixed-citation><mixed-citation xml:lang="en">Logacheva O. S., O. V. Kozhevnikova, A. E. Pal'tseva, L. S. Namazova-Baranova, A. K. Gevorkyan Pediatricheskaya farmakologiya = Pediatric pharmacology. 2013; 10 (2): 117–120.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А. А., Альбицкий В. Ю., Винярская И. В. Изучение КЖ в медицине и педиатрии. Вопросы современной педиатрии. 2005; 4 (2): 7–12.</mixed-citation><mixed-citation xml:lang="en">Baranov A. A., Al'bitskii V. Yu., Vinyarskaya I. V. Voprosy sovremennoi pediatrii = Current pediatrics. 2005; 4 (2): 7–12.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Logachyeva O. S., Kozhevnikova O. V., Namazova-Baranova L. S. Parameters of arterial stiffness and lipid metabolism in children with obesity. 7th international symposium on arterial stiffness and the 5th congress of the Hungarian society of arterial stiffness. Depresen. Hungarian. 2011. P. 25.</mixed-citation><mixed-citation xml:lang="en">Logachyeva O. S., Kozhevnikova O. V., Namazova-Baranova L. S. Parameters of arterial stiffness and lipid metabolism in children with obesity. 7th international symposium on arterial stiffness and the 5th congress of the Hungarian society of arterial stiffness. Depresen. Hungarian. 2011. P. 25.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Кожевникова О. В., Смирнов И. Е., Кучеренко А. Г., Домбровская И. А., Куприянова О. О., Иванов А. П. и др. Гормональный спектр и артериальная гипертензия у детей в пубертатном периоде. Педиатрия. 1996; 6: 25–29.</mixed-citation><mixed-citation xml:lang="en">Kozhevnikova O. V., Smirnov I. E., Kucherenko A. G., Dombrovskaya I. A., Kupriyanova O. O., Ivanov A. P. et al. Pediatriya = Pediatrics. 1996; 6: 25–29.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Всемирная организация здравоохранения [Электронный ресурс] Глобальная стратегия по питанию, физической активности и здоровью. Избыточный вес и ожирение среди детей. URL: http://www.who.int/dietphysicalactivity/childhood/ru</mixed-citation><mixed-citation xml:lang="en">WHO. Available at: http://www.who.int/dietphysicalactivity/childhood/ru</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Логачева О. С., Кожевникова О. В., Намазова-Баранова Л. С., Пальцева А. Е., Рыжкова Л. А., Широкова И. В. Новые технологии в профилактической педиатрии — артериография. Педиатрическая фармакология. 2009; 6 (5): 38–41.</mixed-citation><mixed-citation xml:lang="en">Logacheva O. S., Kozhevnikova O. V., Namazova-Baranova L. S., Pal'tseva A. E., Ryzhkova L. A., Shirokova I. V. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2009; 6 (5): 38–41.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell G. F., Hwang S. J., Vasan R. S. et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2009; 121 (4): 505–511.</mixed-citation><mixed-citation xml:lang="en">Mitchell G. F., Hwang S. J., Vasan R. S. et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2009; 121 (4): 505–511.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Cecelja M., Chowienczyk Ph. Role of arterial stiffness in cardiovascular disease. J R Soc Med Cardiovasc. 2012; 1 (4): 11.</mixed-citation><mixed-citation xml:lang="en">Cecelja M., Chowienczyk Ph. Role of arterial stiffness in cardiovascular disease. J. R. Soc. Med. Cardiovasc. 2012; 1 (4): 11.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Рабочая группа Европейского общества гипертензии. Пересмотр Европейских рекомендаций по ведению артериальной гипертензии: документ рабочей группы Европейского общества гипертензии. Артериальная гипертензия. 2010; 1 (9): 9–28.</mixed-citation><mixed-citation xml:lang="en">Arterial'naya gipertenziya = Hipertension. 2010; 1 (9): 9–28.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Миклош И., Хидвеги Е. В., Ийеш М., Бенцур Б., Бочкеи Р., Радгебер Л. и др. Референтные значения скорости распространения пульсовой волны по аорте у здоровых детей в возрасте от 3 до 18 лет. Педиатрическая фармакология. 2013; 10 (2): 72–78.</mixed-citation><mixed-citation xml:lang="en">Miklosh I., Khidvegi E. V., Iiesh M., Bentsur B., Bochkei R., Radgeber L. et al. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2013; 10 (2): 72–78.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson I. B., MacCallum H., Flint L. et al. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol. 2000; 525 (Pt. 1): 263–270.</mixed-citation><mixed-citation xml:lang="en">Wilkinson I. B., MacCallum H., Flint L. et al. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol. 2000; 525 (Pt. 1): 263–270.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Дзяк Г. В., Колесник Т. В., Колесник Э. Л. Центральное аортальное давление на фоне длительной комбинированной антигипертензивной терапии. Укр. Мед. Часопис. 2012; 4 (90): VII/VIII. URL: http://www.umj.com.ua</mixed-citation><mixed-citation xml:lang="en">Dzyak G. V., Kolesnik T. V., Kolesnik E. L. Tsentral'noe aortal'noe davlenie na fone dlitel'noi kombinirovannoi antigipertenzivnoi terapii. Ukr. Med. Chasopis. = Ukrainian medical journal. 2012; 4 (90): VII/VIII. Available at: http://www.umj.com.ua</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rosario A. S., Kurth B. M., Stolzenberg H., Ellert U., Neuhauser H. Body mass index percentiles for children and adolescents in Germany based on a nationally representative sample (KiGGS 2003–2006). Eur J Clin Nutr. 2010; 64: 341–349.</mixed-citation><mixed-citation xml:lang="en">Rosario A. S., Kurth B. M., Stolzenberg H., Ellert U., Neuhauser H. Body mass index percentiles for children and adolescents in Germany based on a nationally representative sample (KiGGS 2003–2006). Eur. J. Clin. Nutr. 2010; 64: 341–349.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004; 114 (2 Suppl. 4): 555–576.</mixed-citation><mixed-citation xml:lang="en">National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004; 114 (2 Suppl. 4): 555–576.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Boutouyrie P., Bussy C., Lacolley P. et al. Association between local pulse pressure, mean blood pressure, and large-artery remodeling. Circulation. 1999; 100 (13): 1387–1393.</mixed-citation><mixed-citation xml:lang="en">Boutouyrie P., Bussy C., Lacolley P. et al. Association between local pulse pressure, mean blood pressure, and large-artery remodeling. Circulation. 1999; 100 (13): 1387–1393.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А. Сосуды как плацдарм и мишень артериальной гипертонии. Болезни сердца и сосудов. 2006; 1 (3): 36.</mixed-citation><mixed-citation xml:lang="en">Boitsov S. A. Bolezni serdtsa i sosudov = Heart and vascular diseases. 2006; 1 (3): 36.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Roman M. J., Okin P. M., Kizer J. R. et al. Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study. J Hypertens. 2010; 28 (2): 384–388.</mixed-citation><mixed-citation xml:lang="en">Roman M. J., Okin P. M., Kizer J. R. et al. Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study. J. Hypertens. 2010; 28 (2): 384–388.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Roman M. J., Devereux R. B., Kizer J. R. et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension. 2007; 50 (1): 197–203.</mixed-citation><mixed-citation xml:lang="en">Roman M. J., Devereux R. B., Kizer J. R. et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension. 2007; 50 (1): 197–203.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wang K. L., Cheng H. M., Chuang S. Y. et al. Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? J Hypertens. 2009; 27 (3): 461–467.</mixed-citation><mixed-citation xml:lang="en">Wang K. L., Cheng H. M., Chuang S. Y. et al. Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? J. Hypertens. 2009; 27 (3): 461–467.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
