ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v16i4.2053ppharm-1765Research ArticleВ ПРАКТИКУ ПЕДИАТРАFor Pediatricians' PracticeРоль эпидермального барьера в формировании пищевой аллергии у детей с генодерматозамиRole of the Epidermal Barrier in the Formation of Food Allergies in Children with Genodermatosishttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Контактная информация: Мурашкин Николай Николаевич, доктор медицинских наук, профессор, заведующий отделением дерматологии с группой лазерной хирургии ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России

m_nn2001@mail.ruhttps://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.https://orcid.org/0000-0001-6884-5171СавеловаА. А.SavelovaA. A.https://orcid.org/0000-0001-9777-0156ФедоровД. В.FedorovD. V.https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinL. A.https://orcid.org/0000-0002-4022-5592АхмадВ.AhmadWasel

Kabardino-Balkarian Republic

Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академия Управления делами Президента Российской ФедерацииРоссияNational Medical Research Center for Children’s Health; I.M. Sechenov First Moscow State Medical University (Sechenov University); Central State Medical Academy of the Administrative Department of the President of the Russian FederationRussian FederationНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center for Children’s HealthRussian FederationКабардино-Балкарский государственный университет им. Х.М. БербековаРоссияKabardino-Balkarian State University named after H.M. BerbekovRussian Federation201925122019164234240Copyright © Мурашкин Н.Н., Иванов Р.А., Савелова А.А., Федоров Д.В., Опрятин Л.А., Ахмад В., 20192019Мурашкин Н.Н., Иванов Р.А., Савелова А.А., Федоров Д.В., Опрятин Л.А., Ахмад В.Murashkin N.N., Ivanov R.A., Savelova A.A., Fedorov D.V., Opryatin L.A., Ahmad W.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1765

В статье представлены наиболее распространенные в практике врачей дерматологов и педиатров генодерматозы, ассоциированные с высоким риском развития аллергических реакций, — ихтиоз и ихтиозиформные дерматозы, синдром Нетертона и другие ихтиозиформные эритродермии, синдромы пилинг-скин и SAM, а также врожденный буллезный эпидермолиз. Описаны патогенетические аспекты транскутанной сенсибилизации, развития пищевой аллергии и вышеперечисленных генодерматозов, приведены клинические случаи из собственной практики.

The article analyzes the most significant genodermatoses associated with a high risk of allergic reactions that may occur in the practice of a dermatologist and pediatrician, such as ichthyosis and ichthyosiform dermatoses, Netherton syndrome and other ichthyosiform erythroderma, peeling skin syndrome, SAM syndrome, as well as congenital bullous epidermolysis. The article also describes in detail the pathogenetic aspects of transcutaneous sensitization, the development of food allergies and the listed above genodermatoses, two illustrative clinical cases are given.

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The authors declare that there are no conflicts of interest present.