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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v10i5.823</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-175</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ПОКАЗАТЕЛЕЙ ВОСПАЛИТЕЛЬНОГО ОТВЕТА И СОСТОЯНИЯ ПЕРИФЕРИЧЕСКОГО ГЕМОПОЭЗА ПРИ НЕСПЕЦИФИЧЕСКОМ ЯЗВЕННОМ КОЛИТЕ У ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>ASSESSMENT OF INFLAMMATORY RESPONSE INDICATORS AND PERIPHERAL HEMOPOIESIS AT NON-SPECIFIC ULCERATIVE COLITIS IN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ботвиньева</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Botvinyeva</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>главный научный сотрудник лаборатории экспериментальной иммунологии и вирусологии НИИ педиатрии Научного центра здоровья детей РАМН, доктор медицинских наук, профессор</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гордеева</surname><given-names>О. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Gordeevа</surname><given-names>O. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapov</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Namazova-Baranovа</surname><given-names>L. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зубкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zubkova</surname><given-names>I. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анушенко</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Anushenko</surname><given-names>A. O.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джгаркава</surname><given-names>И. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhgarkava</surname><given-names>I. Z.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солошенко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gevorkyan</surname><given-names>A. K.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Геворкян</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Soloshenko</surname><given-names>M. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация&#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация&#13;
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва,&#13;
Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation&#13;
First Sechenov Moscow State Medical University, Russian Federation&#13;
Pirogov Russian National Medical Research University, Moscow, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation&#13;
First Sechenov Moscow State Medical University, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва, Российская Федерация&#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Children’s Health, Moscow, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>01</day><month>10</month><year>2013</year></pub-date><volume>10</volume><issue>5</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>52</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ботвиньева В.В., Гордеева О.Б., Потапов А.С., Намазова-Баранова Л.С., Зубкова И.В., Анушенко А.О., Джгаркава И.З., Солошенко М.А., Геворкян А.К., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Ботвиньева В.В., Гордеева О.Б., Потапов А.С., Намазова-Баранова Л.С., Зубкова И.В., Анушенко А.О., Джгаркава И.З., Солошенко М.А., Геворкян А.К.</copyright-holder><copyright-holder xml:lang="en">Botvinyeva V.V., Gordeevа O.B., Potapov A.S., Namazova-Baranovа L.S., Zubkova I.V., Anushenko A.O., Dzhgarkava I.Z., Gevorkyan A.K., Soloshenko M.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/175">https://www.pedpharma.ru/jour/article/view/175</self-uri><abstract><p>В статье приведен анализ лабораторных тестов, свидетельствующих об ответе организма на системное воспаление. Выявленная взаимосвязь этих показателей с изменениями периферического звена кроветворения при хронических воспалительных заболеваниях кишечника позволит объективно подойти к диагностике функциональных нарушенийпри неспецифическом язвенном колите в детском возрасте. Предпринята попытка разработки новых подходов к анализу лабораторных показателей, которые помогут оценить индивидуальную динамику процессов при системной воспалительной реакции организма и выбрать адекватную терапию основного заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The article presents the analysis of laboratory tests, which indicate the response of the body to systemic inflammation. The revealed interconnection of these parameters with peripheral hematosis alterations at chronic inflammatory diseases will allow objectively approaching the diagnostics of functional disorders at non-specific ulcerative colitis in children. The authors attempted to develop new approaches to the analysis of laboratory indicators, which will help to evaluate individual dynamics of processes at the systemic inflammatory response of the body and select adequate therapy of the primary disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>системный воспалительный ответ</kwd><kwd>язвенный колит</kwd><kwd>показатели периферической крови</kwd><kwd>маркеры воспаления</kwd></kwd-group><kwd-group xml:lang="en"><kwd>systemic inflammatory response</kwd><kwd>ulcerative colitis</kwd><kwd>peripheral blood parameters</kwd><kwd>inflammatory markers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Александрова Ю. Н. О системе цитокинов. Педиатрия. 2007; 86 (3): 124–128.</mixed-citation><mixed-citation xml:lang="en">Aleksandrova Yu. N. 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