ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v10i5.821ppharm-173Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРАСПРОСТРАНЕННОСТЬ СЕНСИБИЛИЗАЦИИ И ЧУВСТВИТЕЛЬНОСТЬ КОЖИ К ГИСТАМИНУ У ДЕТЕЙ ШКОЛЬНОГО ВОЗРАСТА г. ТОМСКА И ТОМСКОЙ ОБЛАСТИSENSITIZATION SPREAD AND SKIN SENSITIVITY TO HISTAMINE IN CHILDREN OF SCHOOL AGE IN TOMSK AND TOMSK REGIONКамалтыноваЕ. М.KamaltynovaE. M.

кандидат медицинских наук, доцент кафедры факультетской педиатрии с курсом детских болезней лечебного факультета СибГМУ

MD, assistant professor of the intermediate level pediatrics department with a course in children’s diseases at the medical faculty of the SibSMU

eleant21@yandex.ruДеевИ. А.DeevI. A.ОгородоваЛ. М.OgorodovaL. M.фон МуциусЭ.Von MutsiusE.ИллиС.IlliS.ФедотоваМ. М.FedotovaM. M.КарбаиноваЕ. А.KarbainovaE. A.АфанасьеваД. C.AfanasyevaD. S.Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию Росздрава, ТомскРоссияSiberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service on Surveillance in Healthcare, TomskRussian FederationСибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию Росздрава, Томск, Российская ФедерацияRussian FederationSiberian State Medical University of the Federal Agency for Public Health and Human Services of the Federal Service on Surveillance in Healthcare, Tomsk, Russian FederationRussian FederationАкадемическая клиника Университета им. Людвига Максимилиана, Университетская клиника детской хириргии Хаунершен, Мюнхен, ГерманияГерманияAcademic Teaching Hospital of the Ludwig Maximilian University, Haunerschen Academic Teaching Hospital of Pediatric Surgery, Munich, GermanyGermany201301102013105Педиатрическая фармакология4045Copyright © Камалтынова Е.М., Деев И.А., Огородова Л.М., фон Муциус Э., Илли С., Федотова М.М., Карбаинова Е.А., Афанасьева Д.C., 20132013Камалтынова Е.М., Деев И.А., Огородова Л.М., фон Муциус Э., Илли С., Федотова М.М., Карбаинова Е.А., Афанасьева Д.C.Kamaltynova E.M., Deev I.A., Ogorodova L.M., von Mutsius E., Illi S., Fedotova M.M., Karbainova E.A., Afanasyeva D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/173

Study of sensitization spread is crucial to the understanding of formation mechanisms of allergic diseases symptoms and development of prevention programs. However, this parameter has been studied very insufficiently in Russia. The aim of this trial is to study spread of sensitization to allergens and skin sensitivity to histamine in the populations of urban and rural schoolchildren using the method of skin prick test. Methods: the authors examined 2,290 urban and rural schoolchildren (1-11 grades). Mixed allergens of house dust mites, cockroach, fish, birch pollen, mixed weeds and cat hair were used for the allergy test. Results: the authors revealed spread of sensitization to various allergens in various age-sex groups of urban and rural schoolchildren in Tomsk Region. Conclusion: the trial revealed that sensitization spread and skin sensitivity to histamine was higher in urban schoolchildren than in their rural peers (p<0.001). Lower sensitization spread index in rural schoolchildren may be caused the skin reactivity reduction.

детисенсибилизацияраспространенностьchildrensensitizationspreadReferencesAsher M. I., Montefort S., Bjorksten et al. ISAAC Phase Three Study. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino conjunctivitis, and eczema in childhood. ISAAC Phases One and Three repeat muliticountry cross-sectional surveys. Lancet. 2006; 368: 733–743.Asher M. I., Montefort S., Bjorksten et al. ISAAC Phase Three Study. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino conjunctivitis, and eczema in childhood. ISAAC Phases One and Three repeat muliticountry cross-sectional surveys. Lancet. 2006; 368: 733–743.Johansson S. G., Bieber T., Dahl R. et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004; 113 (5): 832–6.Johansson S. G., Bieber T., Dahl R. et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J. Allergy Clin. Immunol. 2004; 113 (5): 832–6.Pearce N., Pekkanen J., Beasley R. How much asthma is really attributable to atopy? Thorax. 1999; 54 (3): 268–72.Pearce N., Pekkanen J., Beasley R. How much asthma is really attributable to atopy? Thorax. 1999; 54 (3): 268–72.Ronmark E., Bjerg A., Perzanowski M. et al. Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J Allergy Clin Immunol. 2009; 124 (2): 357–63.Ronmark E., Bjerg A., Perzanowski M. et al. Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J. Allergy Clin. Immunol. 2009; 124 (2): 357–63.Carroll W. D., Lenney W., Child F. et al. Asthma severity and atopy: how clear is the relationship? Arch Dis Child. 2006; 91: 405–409.Carroll W. D., Lenney W., Child F. et al. Asthma severity and atopy: how clear is the relationship? Arch. Dis. Child. 2006; 91: 405–409.Ronchetti R., Villa M. P., Pagani J. et al. Immediate skin reactivity to histamine and to allergens in cohorts of 9-year-old schoolchildren studied 16 years apart. Clin Exp Allergy. 2003; 33: 1232–1237.Ronchetti R., Villa M. P., Pagani J. et al. Immediate skin reactivity to histamine and to allergens in cohorts of 9-year-old schoolchildren studied 16 years apart. Clin. Exp. Allergy. 2003; 33: 1232–1237.Bousquet J. et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy. 2011; 66: 596–604.Bousquet J. et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy. 2011; 66: 596–604.Dreborg S., Frew A. Allergen standardisation and skin tests. EAACI 1993 subcommittee on skin tests. Allergy. 1993; 14: 48–82.Dreborg S., Frew A. Allergen standardisation and skin tests. EAACI 1993 subcommittee on skin tests. Allergy. 1993; 14: 48–82.Намазова-Баранова Л. С., Огородова Л. М., Томилова А. Ю., Деев И. А. и др. Распространенность астмаподобных симптомов и диагностированной астмы в популяции подростков.Педиатрическая фармакология. 2009; 6 (3): 59–65.Namazova-Baranova L. S., Ogorodova L. M., Tomilova A. Yu., Deev I. A. et al. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2009; 6 (3): 59–65.Намазова-Баранова Л. С., Антонова Е. В., Деев И. А. и др. Эпидемиология аллергических болезней. Аллергия у детей: от теории — к практике / под ред. Л.С. Намазовой-Барановой. М.: Союз педиатров России, 2010–2011: 166–199.Namazova-Baranova L. S., Antonova E. V., Deev I. A. et al. Epidemiologiya allergicheskikh boleznei. Allergiya u detei: ot teorii — k praktike / pod red. L.S. Namazovoi-Baranovoi [Epidemiology of Allergic Diseases. Allergies in Children: from Theory to Practice. Edited by L.S. Namazova-Baranova]. Moscow, Soyuz pediatrov Rossii, 2010–2011. pp. 166–199.Vink N. M., Postma D. S., Schouten J. P. et al. Gender differences in asthma development and remission during transition through puberty: The Tracking Adolescents’ Individual Lives Survey (TRAILS) study. J Allergy Clin Immunol. 2010; 126: 498–504.Vink N. M., Postma D. S., Schouten J. P. et al. Gender differences in asthma development and remission during transition through puberty: The Tracking Adolescents’ Individual Lives Survey (TRAILS) study. J. Allergy Clin. Immunol. 2010; 126: 498–504.Busse W. W. The National Institutes of Allergy and Infectious Diseases networks on asthma in inner-city children: An approachto improved care. J Allergy Clin Immunol. 2010; 125: 529–37.Busse W. W. The National Institutes of Allergy and Infectious Diseases networks on asthma in inner-city children: An approachto improved care. J. Allergy Clin. Immunol. 2010; 125: 529–37.Weinmayr G., Weiland S. K., Bjorksten B. et al. Atopic Sensitization and the International Variation of Asthma Symptom Prevalence in Children. Am J Respir Crit Care Med. 2007; 176: 565–574.Weinmayr G., Weiland S. K., Bjorksten B. et al. Atopic Sensitization and the International Variation of Asthma Symptom Prevalence in Children. Am. J. Respir. Crit. Care Med. 2007; 176: 565–574.Viinanen A., Munhbayarlah S., Zevgee T. et al. The protective effect of rural living against atopy in Mongolia. Allergy. 2007; 62: 272–280.Viinanen A., Munhbayarlah S., Zevgee T. et al. The protective effect of rural living against atopy in Mongolia. Allergy. 2007; 62: 272–280.Remes S. T., Pekkanen J., Soininen L. et al. Does heredity modify the association between farming and allergy in children? Acta Paediatr. 2002; 91: 1163–1169.Remes S. T., Pekkanen J., Soininen L. et al. Does heredity modify the association between farming and allergy in children? Acta Paediatr. 2002; 91: 1163–1169.Majkowska-Wojciechowska B., Pelka J., Korzon L. et al. Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children. Allergy. 2007; 62: 1044–1050.Majkowska-Wojciechowska B., Pelka J., Korzon L. et al. Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children. Allergy. 2007; 62: 1044–1050.Celedon J. C., Litonjua A. A., Ryan L. et al. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet. 2002; 360 (9335 № 7): 781–2.Celedon J. C., Litonjua A. A., Ryan L. et al. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet. 2002; 360 (9335 № 7): 781–2.Perkin M. R., Strachan D. P. Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J Allergy Clin Immunol. 2006; 117 (6): 1374–81.Perkin M. R., Strachan D. P. Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J. Allergy Clin. Immunol. 2006; 117 (6): 1374–81.von Hertzen L., Laatikainen T., Pitkanen T. et al. Microbial content of drinking water in Finnish and Russian Karelia — implications for atopy prevalence. Allergy. 2007; 62 (3): 288–92.von Hertzen L., Laatikainen T., Pitkanen T. et al. Microbial content of drinking water in Finnish and Russian Karelia — implications for atopy prevalence. Allergy. 2007; 62 (3): 288–292.Pekkarinen P. T., von Hertzen L., Laatikainen T. et al. A disparity in the association of asthma, rhinitis, and eczema with allergen-specific IgE between Finnish and Russian Karelia. Allergy. 2007; 62: 281–287.Pekkarinen P. T., von Hertzen L., Laatikainen T. et al. A disparity in the association of asthma, rhinitis, and eczema with allergen-specific IgE between Finnish and Russian Karelia. Allergy. 2007; 62: 281–287.Voor T., Julge K., Bottcher M. F. et al. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin Exp Allergy. 2005; 35: 153–159.Voor T., Julge K., Bottcher M. F. et al. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin. Exp. Allergy. 2005; 35: 153–159.Flohr C., Quinnell R. J., Britton J. Do helminth parasites protect against atopy and allergic disease? Clinical and Experimental Allergy. 2008; 39: 20–32.Flohr C., Quinnell R. J., Britton J. Do helminth parasites protect against atopy and allergic disease? Clinical and Experimental Allergy. 2008; 39: 20–32.Евдокимова Т. А., Огородова Л. М. Влияние описторхозной инвазии на клиническое течение и иммунный ответ при атопической бронхиальной астме у детей. Педиатрия. 2005; 6: 12–17.Evdokimova T. A., Ogorodova L. M. Pediatriya = Pediatrics. 2005; 6: 12–17.Огородова Л. М., Фрейдин М. Б., Федорова О. С. и др. Изучение распространенности аллергической патологии и описторхозной инвазии и их взаимосвязи у населения Томской области. Бюллетень сибирской медицины. 2006; 4: 48–52.Ogorodova L. M., Freidin M. B., Fedorova O. S. et al. Byulleten' sibirskoi meditsiny = Bulletin of siberian medicine. 2006; 4: 48–52.Огородова Л. М., Деев И. А., Федорова О. С. и др. Распространенность гельминтной инвазии Opistorchis felineus у детей в Томске и Томской области. Вопросы современной педиатрии.2011; 10 (3): 43–47.Ogorodova L. M., Deev I. A., Fedorova O. S. et al. Voprosy sovremennoi pediatrii = Current pediatrics. 2011; 10 (3): 43–47.Voor T., Julge K., Bottcher M. F. et al. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin Exp Allergy. 2005; 35: 153–159.Voor T., Julge K., Bottcher M. F. et al. Atopic sensitization and atopic dermatitis in Estonian and Swedish infants. Clin. Exp. Allergy. 2005; 35: 153–159.

The authors declare that there are no conflicts of interest present.