ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v10i5.820ppharm-172Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПАТТЕРНЫ СПАСТИЧНОСТИ МЫШЦ ВЕРХНИХ КОНЕЧНОСТЕЙ И ПРИМЕНЕНИЕ БОТУЛИНОТЕРАПИИ У ПАЦИЕНТОВ С ДЕТСКИМ ЦЕРЕБРАЛЬНЫМ ПАРАЛИЧОМ С ПОРАЖЕНИЕМ РУКSPASTICITY PATTERNS OF HAND MUSCLES AND BOTULINUM TOXIN THERAPY APPLICATION IN PATIENTS WITH CEREBRAL PALSY WITH UPPER LIMB INVOLVEMENTКлочковаО. А.KlochkovaO. A.

врач-педиатр отделения восстановительного лечения детей с болезнями нервной системы НИИ профилактической педиатрии и восстановительного лечения НЦЗД РАМН

pediatrician of the medical rehabilitation department for children with neurological disorders at the research institute of preventive pediatrics and medical rehabilitation of the SCCH

Klochkova_oa@nczd.ruКуренковА. Л.KurenkovA. L.Намазова-БарановаЛ. С.Namazova-BaranovaL. S.МамедъяровА. М.MamedyarovA. M.Научный центр здоровья детей РАМН, МоскваРоссияScientific Center of Children’s Health, MoscowRussian FederationНаучный центр здоровья детей РАМН, Москва, Российская ФедерацияScientific Center of Children’s Health, Moscow, Russian Federation First Sechenov Moscow State Medical University of the Ministry of Health of the Russian Federation Pirogov Russian National Medical Research University, MoscowНаучный центр здоровья детей РАМН, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава Российской Федерации Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, МоскваРоссияScientific Center of Children’s Health, Moscow, Russian Federation First Sechenov Moscow State Medical University of the Ministry of Health of the Russian Federation Pirogov Russian National Medical Research University, MoscowRussian FederationНаучный центр здоровья детей РАМН, Москва, Российская ФедерацияРоссияScientific Center of Children’s Health, Moscow, Russian FederationRussian Federation201301102013105Педиатрическая фармакология3139Copyright © Клочкова О.А., Куренков А.Л., Намазова-Баранова Л.С., Мамедъяров А.М., 20132013Клочкова О.А., Куренков А.Л., Намазова-Баранова Л.С., Мамедъяров А.М.Klochkova O.A., Kurenkov A.L., Namazova-Baranova L.S., Mamedyarov A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/172

Botulinum toxin therapy is an effective and safe method of treatment of local spasticity in patients with cerebral palsy (CP). Calculation of botulinum toxin A (BTA) dosage based on the spasticity patterns and functional capabilities of the patient proved effective for the hypertonic lower limb muscle spasm treatment and is being applied to BTA injections in hand muscles more often. The article presents contemporary scientific data and results of the original study of BTA injections efficacy for pathologic tension reduction in hand muscles of 52 patients with CP. The authors give detailed description of the upper limb spasticity patterns, their frequency and role in the pathological movement pattern formation. The authors propose BTA dosage calculation for the functional segments of upper limbs, which allows minimizing the total amount of the administered drug and avoiding excessive weakness. The authors have also conducted a follow-up analysis of changes in hand muscle tone for the period of 6 months after the first BTA injection, compared results of botulinum toxin therapy at various clinical forms of CP and given recommendations on the optimum duration of the follow-up period.

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The authors declare that there are no conflicts of interest present.