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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v16i2.2003</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-1719</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL RECOMMENDATIONS</subject></subj-group></article-categories><title-group><article-title>Современные подходы к ведению детей с крапивницей</article-title><trans-title-group xml:lang="en"><trans-title>Modern  approaches to the management of urticaria in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3987-8112</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranov</surname><given-names>Alexander A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Академик РАН, доктор медицинских наук, профессор, почетный председатель Исполкома Союза педиатров России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2209-7531</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намазова-Баранова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Namazova-Baranova</surname><given-names>Leyla S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Академик РАН, доктор медицинских наук, профессор, председатель Исполкома Союза педиатров России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаитов</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaitov</surname><given-names>Rakhim M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Академик РАН, президент Российской ассоциации аллергологов и клинических иммунологов (РААКИ).</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильина</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Il’ina</surname><given-names>Nataliya I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Профессор, доктор медицинских наук, первый вице-президент, генеральный директор РААКИ.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7398-0562</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вишнёва</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vishneva</surname><given-names>Elena A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вишнёва Елена Александровна - кандидат медицинских наук, заместитель директора НИИ педиатрии по научной работе, заведующая отделом стандартизации и клинической фармакологии НИИ педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России.</p><p>119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-03-92.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><email xlink:type="simple">vishneva@nczd.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5665-7835</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>Anna A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, член Союза педиатров России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калугина</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalugina</surname><given-names>Vera G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Член Союза педиатров России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3678-7939</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селимзянова</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Selimzyanova</surname><given-names>Liliya R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, член Союза педиатров России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центральная клиническая больница Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Hospital of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Центральная клиническая больница Российской академии наук; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Hospital of the Russian Academy of Sciences; N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Государственный научный центр «Институт иммунологии» ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Center «Institute of Immunology» FMBA Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Центральная клиническая больница Российской академии наук; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова; Национальный медицинский исследовательский центр здоровья детей</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Hospital of the Russian Academy of Sciences; N.I. Pirogov Russian National Research Medical University; National Medical Research Center for Children’s Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Children’s Health; I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>06</month><year>2019</year></pub-date><volume>16</volume><issue>2</issue><fpage>67</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баранов А.А., Намазова-Баранова Л.С., Хаитов Р.М., Ильина Н.И., Вишнёва Е.А., Алексеева А.А., Калугина В.Г., Селимзянова Л.Р., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Баранов А.А., Намазова-Баранова Л.С., Хаитов Р.М., Ильина Н.И., Вишнёва Е.А., Алексеева А.А., Калугина В.Г., Селимзянова Л.Р.</copyright-holder><copyright-holder xml:lang="en">Baranov A.A., Namazova-Baranova L.S., Khaitov R.M., Il’ina N.I., Vishneva E.A., Alekseeva A.A., Kalugina V.G., Selimzyanova L.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/1719">https://www.pedpharma.ru/jour/article/view/1719</self-uri><abstract><p>Авторами представлены  основные положения  акт уальных к линических рекомендаций по оказанию медицинской помощи детям с крапивницей.  Рассматриваются особенности  эпидемиологии,  этиологии  и патогенеза. Подробно  освещаются этапы дифференциально-диагностического поиска. Для  пациентов  детского  возраста приведены основанные на доказательной  базе рекомендации  по лечению и предложена  ст упенчатая схема терапии.  Дано четкое разъяснение к проведению анализа  эффективности  терапии  и оценки степени  активности заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The authors presented the main provisions of the current clinical guidelines for the treatment of children with urticaria. The specifics of disease epidemiolog y, etiolog y and pathogenesis are described. The steps of dif ferential diagnosis are highlighted. For pediatric patients, treatment recommendations are provided based on the principles of evidence and a step-by-step therapy is suggested. A clear explanation is given on how to conduct an analysis of the ef fectiveness of therapy and assess the degree of disease activity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>крапивница</kwd><kwd>аллергические болезни</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>клинические рекомендации</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urticaria</kwd><kwd>allergic diseases</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>clinical guidelines</kwd><kwd>children</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Не указан</funding-statement><funding-statement xml:lang="en">Not specified</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kay AB, Ying S, Ardelean E, et al. Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin. 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