ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v15i3.1906ppharm-1633Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCASE REPORTРеакция Яриша–Герксгеймера у ребенка с внебольничной пневмонией: клинический случайThe Jarisch-Herxheimer Reaction in a Child with Community-Acquired Pneumonia: a Clinical Casehttps://orcid.org/0000-0001-8085-4513ТаточенкоВ. К.TatochenkoVladimir K.

Таточенко Владимир Кириллович, доктор медицинских наук, профессор, главный научный сотрудник, отделение диагностики и восстановительного лечения НИИ педиатрии 

Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1

tatovk@yandex.ruhttps://orcid.org/0000-0001-6474-6766БакрадзеМ. Д.BakradzeMaya D.https://orcid.org/0000-0002-6548-5737АгаронянА. Г.AgaronianAsmikНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian Federation201806072018153255259Copyright © Таточенко В.К., Бакрадзе М.Д., Агаронян А.Г., 20182018Таточенко В.К., Бакрадзе М.Д., Агаронян А.Г.Tatochenko V.K., Bakradze M.D., Agaronian A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1633

Реакция Яриша–Герксгеймера (ЯГ) — шокоподобное состояние в ответ на противомикробную терапию вследствие высвобождения токсинов из распадающихся микробных тел. Реакция возникает преимущественно у больных спирохетозами, реже при бруцеллезе, бартонеллезе, риккетсиозах, возможна также при сепсисе и менингококцемии. Реакция ЯГ при внебольничной пневмонии у детей ранее не описана. Приводим собственное наблюдение подобной реакции у ребенка с верхнедолевой пневмонией, связанной с лечением амоксициллином и разрешившейся после введения преднизолона.

КОНФЛИКТ ИНТЕРЕСОВ

Авторы статьи подтвердили отсутствие конфликта интересов, о котором необходимо сообщить.

The Jarisch-Herxheimer reaction (JHR) is a shock-like state in response to antimicrobial therapy due to the release of toxins from decomposing microbial bodies. The reaction mainly occurs in patients with spirochetosis, less often in patients with brucellosis, bartonellosis, rickettsiosis, and can be possibly observed in patients with sepsis or meningococcemia. The JHR in children with community-acquired pneumonia has not been previously described. The article provides the author’s own observation of a similar reaction in a child with upper lobe pneumonia associated with amoxicillin treatment and resolved after the administration of prednisolone.

детивнебольничная пневмонияреакция Яриша–Герксгеймерапарадоксальная реакцияшокchildrencommunity-acquired pneumoniaJarisch-Herxheimer reactionparadoxical responseshockReferencesТаточенко В.К. Болезни органов дыхания у детей. Практическое руководство. Новое, доп. изд. — М.: ПедиатрЪ; 2015. — С. 210–215. [Tatochenko VK. Bolezni organov dykhaniya u detei. Prakticheskoe rukovodstvo. New, revised ed. Moscow: Pediatr»; 2015. pp. 210–215. (In Russ).]Таточенко В.К. Болезни органов дыхания у детей. Практическое руководство. Новое, доп. изд. — М.: ПедиатрЪ; 2015. — С. 210–215. [Tatochenko VK. Bolezni organov dykhaniya u detei. Prakticheskoe rukovodstvo. New, revised ed. Moscow: Pediatr»; 2015. pp. 210–215. (In Russ).]Koton Y, Bisharat N. Tick-borne relapsing fever with severe Jarisch-Herxheimer reaction. Isr Med Assoc J. 2018;1(20):62–63.Koton Y, Bisharat N. Tick-borne relapsing fever with severe Jarisch-Herxheimer reaction. Isr Med Assoc J. 2018;1(20):62–63.Wang C, He S, Yang H, et al. Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. Sex Transm Infect. 2017. doi: 10.1136/sextrans-2016-053083.Wang C, He S, Yang H, et al. Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. Sex Transm Infect. 2017. doi: 10.1136/sextrans-2016-053083.Guerrier G, Lefèvre P, Chouvin C, D’Ortenzio E. Jarisch– Herxheimer reaction among patients with leptospirosis: incidence and risk factors. Am J Trop Med Hyg. 2017;96(4):791–794. doi: 10.4269/ajtmh.16-0457.Guerrier G, Lefèvre P, Chouvin C, D’Ortenzio E. Jarisch– Herxheimer reaction among patients with leptospirosis: incidence and risk factors. Am J Trop Med Hyg. 2017;96(4):791–794. doi: 10.4269/ajtmh.16-0457.Конева О.А., Барскова В.Г., Ананьева Л.П., Алекберова З.С. Реакция Яриша–Герксхеймера при хронической болезни Лайма // Научно-практическая ревматология. — 2002. — Т.40. — №3 — С. 62–65. [Koneva OA, Barskova VG, Ananieva LP, Alekberova ZS. Yarish-Gerksheimer reaction in chronic Lyme disease (case reports). Science-practical rheumatology. 2002;40(3):62–65. (In Russ).]Конева О.А., Барскова В.Г., Ананьева Л.П., Алекберова З.С. Реакция Яриша–Герксхеймера при хронической болезни Лайма // Научно-практическая ревматология. — 2002. — Т.40. — №3 — С. 62–65. [Koneva OA, Barskova VG, Ananieva LP, Alekberova ZS. Yarish-Gerksheimer reaction in chronic Lyme disease (case reports). Science-practical rheumatology. 2002;40(3):62–65. (In Russ).]Nizic T, Velikanje E, Ruzic-Sabljic E, Arnez M. Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin. Wien Klin Wochenschr. 2012;124(13–14):427– 433. doi: 10.1007/s00508-012-0194-1.Nizic T, Velikanje E, Ruzic-Sabljic E, Arnez M. Solitary erythema migrans in children: comparison of treatment with clarithromycin and amoxicillin. Wien Klin Wochenschr. 2012;124(13–14):427– 433. doi: 10.1007/s00508-012-0194-1.Guerrier G, Doherty T. Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. Trans R Soc Trop Med Hyg. 2011;105(9):483–490. doi: 10.1016/j.trstmh.2011.04.004.Guerrier G, Doherty T. Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. Trans R Soc Trop Med Hyg. 2011;105(9):483–490. doi: 10.1016/j.trstmh.2011.04.004.Webster G, Schiffman JD, Dosanjh AS, et al. Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. Pediatr Infect Dis J. 2002;21(6):571–573. doi: 10.1097/00006454-200206000-00020.Webster G, Schiffman JD, Dosanjh AS, et al. Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. Pediatr Infect Dis J. 2002;21(6):571–573. doi: 10.1097/00006454-200206000-00020.Belum GR, Belum VR, Chaitanya Arudra SK, Reddy BS. The Jarisch–Herxheimer reaction: revisited. Travel Med Infect Dis. 2013;11(4):231–237. doi: 10.1016/j.tmaid.2013.04.001.Belum GR, Belum VR, Chaitanya Arudra SK, Reddy BS. The Jarisch–Herxheimer reaction: revisited. Travel Med Infect Dis. 2013;11(4):231–237. doi: 10.1016/j.tmaid.2013.04.001.Abroug N, Khochtali S, Ksiaa I, et al. Jarisch-Herxheimer reaction after antitubercular treatment of an intraocular tuberculosis. Tunis Med. 2015;93(3):201–203.Abroug N, Khochtali S, Ksiaa I, et al. Jarisch-Herxheimer reaction after antitubercular treatment of an intraocular tuberculosis. Tunis Med. 2015;93(3):201–203.Berkowitz F, Vallabh P, Altman D, et al. Jarische-Herxheimer reaction in meningococcal meningitis. Am J Dis Child. 1983;137(6):599. doi: 10.1001/archpedi.1983.02140320075018.Berkowitz F, Vallabh P, Altman D, et al. Jarische-Herxheimer reaction in meningococcal meningitis. Am J Dis Child. 1983;137(6):599. doi: 10.1001/archpedi.1983.02140320075018.Moss H, Collier JM, Collier S. ‘An unusual response of dental sepsis to antibiotics: parallels with the Jarisch-Herxheimer reaction’. BMJ Case Rep. 2012;2012:bcr0720114500. doi: 10.1136/ bcr.07.2011.4500..Moss H, Collier JM, Collier S. ‘An unusual response of dental sepsis to antibiotics: parallels with the Jarisch-Herxheimer reaction’. BMJ Case Rep. 2012;2012:bcr0720114500. doi: 10.1136/ bcr.07.2011.4500..Kaplanski G, Granel B, Vaz T, Durand JM. Jarisch-Herxheimer reaction complicating the treatment of chronic Q fever endocarditis: elevated TNFalpha and IL-6 serum levels. J Infect. 1998;37(1):83– 84. doi: 10.1016/S0163-4453(98)91120-3.Kaplanski G, Granel B, Vaz T, Durand JM. Jarisch-Herxheimer reaction complicating the treatment of chronic Q fever endocarditis: elevated TNFalpha and IL-6 serum levels. J Infect. 1998;37(1):83– 84. doi: 10.1016/S0163-4453(98)91120-3.Vidal V, Scragg IG, Cutler SJ, et al. Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever. Nat Med. 1998;4(12):1416–1420. doi: 10.1038/4007.Vidal V, Scragg IG, Cutler SJ, et al. Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever. Nat Med. 1998;4(12):1416–1420. doi: 10.1038/4007.Negussie Y, Remick DG, Deforge LE, et al. Detection of plasma Tumor-Necrosis-Factor, Interleukin-6, and Interleukin-8 during the Jarisch-Herxheimer reaction of relapsing fever. J Exp Med. 1992;175(5):1207–1212. doi: 10.1084/jem.175.5.1207.Negussie Y, Remick DG, Deforge LE, et al. Detection of plasma Tumor-Necrosis-Factor, Interleukin-6, and Interleukin-8 during the Jarisch-Herxheimer reaction of relapsing fever. J Exp Med. 1992;175(5):1207–1212. doi: 10.1084/jem.175.5.1207.Cuevas LE, Borgnolo G, Hailu B, et al. Tumour necrosis factor, interleukin-6 and C-reactive protein in patients with louse-borne relapsing fever in Ethiopia. Ann Trop Med Parasitol. 1995;89(1):49– 54. doi: 10.1080/00034983.1995.11812928.Cuevas LE, Borgnolo G, Hailu B, et al. Tumour necrosis factor, interleukin-6 and C-reactive protein in patients with louse-borne relapsing fever in Ethiopia. Ann Trop Med Parasitol. 1995;89(1):49– 54. doi: 10.1080/00034983.1995.11812928.Nadelman RB, Luger SW, Frank E, et al. Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease. Ann Intern Med. 1992;117(4):273–280. doi: 10.7326/0003-4819-117-4-273.Nadelman RB, Luger SW, Frank E, et al. Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease. Ann Intern Med. 1992;117(4):273–280. doi: 10.7326/0003-4819-117-4-273.Сорокина М.Н., Иванова В.В., Скрипченко Н.В. Бактериальные менингиты у детей. — М.; 2003. — С. 192–201. [Sorokina MN, Ivanova VV, Skripchenko NV. Bakterial’nye meningity u detei. Moscow; 2003. pp. 192–201. (In Russ).]Сорокина М.Н., Иванова В.В., Скрипченко Н.В. Бактериальные менингиты у детей. — М.; 2003. — С. 192–201. [Sorokina MN, Ivanova VV, Skripchenko NV. Bakterial’nye meningity u detei. Moscow; 2003. pp. 192–201. (In Russ).]Loveday C, Bingham JS. Changes in circulating immune complexes during the Jarisch Herxheimer reaction in secondary syphilis. Eur J Clin Microbiol Infect Dis. 1993;12(3):185–191. doi: 10.1007/ bf01967109.Loveday C, Bingham JS. Changes in circulating immune complexes during the Jarisch Herxheimer reaction in secondary syphilis. Eur J Clin Microbiol Infect Dis. 1993;12(3):185–191. doi: 10.1007/ bf01967109.Macy E, Poon KY. Self-reported antibiotic allergy incidence and prevalence: age and sex effects. Am J Med. 2009;122(8):778 e771–777. doi: 10.1016/j.amjmed.2009.01.034.Macy E, Poon KY. Self-reported antibiotic allergy incidence and prevalence: age and sex effects. Am J Med. 2009;122(8):778 e771–777. doi: 10.1016/j.amjmed.2009.01.034.Butler T. The Jarisch–Herxheimer reaction after antibiotic treatment of spirochetal infections: a review of recent cases and our understanding of pathogenesis. Am J Trop Med Hyg. 2017;96(1):46– 52. doi: 10.4269/ajtmh.16-0434.Butler T. The Jarisch–Herxheimer reaction after antibiotic treatment of spirochetal infections: a review of recent cases and our understanding of pathogenesis. Am J Trop Med Hyg. 2017;96(1):46– 52. doi: 10.4269/ajtmh.16-0434.Hori H, Sato Y, Shitara T. Congenital syphilis presenting as Jarisch-Herxheimer reaction at birth. Pediatr Int. 2015;57(2):299– 301. doi: 10.1111/ped.12417.Hori H, Sato Y, Shitara T. Congenital syphilis presenting as Jarisch-Herxheimer reaction at birth. Pediatr Int. 2015;57(2):299– 301. doi: 10.1111/ped.12417.Graciansky PD, Grupper C. Cortisone therapy in the prevention of the herxheimer reaction in early syphilis. Br J Vener Dis. 1961;37(4):247–251.Graciansky PD, Grupper C. Cortisone therapy in the prevention of the herxheimer reaction in early syphilis. Br J Vener Dis. 1961;37(4):247–251.Fekade D, Knox K, Hussein K, et al. Prevention of Jarisch– Herxheimer reactions by treatment with antibodies against tumor necrosis factor α. N Engl J Med. 1996;335(5):311–315. doi: 10.1056/nejm199608013350503.Fekade D, Knox K, Hussein K, et al. Prevention of Jarisch– Herxheimer reactions by treatment with antibodies against tumor necrosis factor α. N Engl J Med. 1996;335(5):311–315. doi: 10.1056/nejm199608013350503.Li J, Wang LN, Zheng HY. Jarisch-Herxheimer reaction among syphilis patients in China. J Eur Acad Dermatol Venereol. 2013;27(10):1304–1307. doi: 10.1111/j.1468-3083.2012.04544.x.Li J, Wang LN, Zheng HY. Jarisch-Herxheimer reaction among syphilis patients in China. J Eur Acad Dermatol Venereol. 2013;27(10):1304–1307. doi: 10.1111/j.1468-3083.2012.04544.x.Таточенко В.К., Бакрадзе М.Д., Полякова А.С., и др. Низкая эффективность антибиотиков, назначаемых амбулаторно детям с пневмонией и острым средним отитом, как следствие несоблюдения клинических рекомендаций // Педиатрическая фармакология. — 2016. — Т.13. — №5 — С. 425–430. [Tatochenko VK, Bakradze MD, Polyakova AS, et al. Amoxicillin, the main drug for treating community-acquired pneumonia and otitis media, recommended but often not followed. Pediatric pharmacology. 2016;13(5):425–430. (In Russ).] doi: 10.15690/pf.v13i5.1636.Таточенко В.К., Бакрадзе М.Д., Полякова А.С., и др. Низкая эффективность антибиотиков, назначаемых амбулаторно детям с пневмонией и острым средним отитом, как следствие несоблюдения клинических рекомендаций // Педиатрическая фармакология. — 2016. — Т.13. — №5 — С. 425–430. [Tatochenko VK, Bakradze MD, Polyakova AS, et al. Amoxicillin, the main drug for treating community-acquired pneumonia and otitis media, recommended but often not followed. Pediatric pharmacology. 2016;13(5):425–430. (In Russ).] doi: 10.15690/pf.v13i5.1636.

The authors declare that there are no conflicts of interest present.