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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v10i6.901</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-162</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПРАКТИКУ ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>For Pediatricians' Practice</subject></subj-group></article-categories><title-group><article-title>ОПЫТ ИСПОЛЬЗОВАНИЯ ПРЕПАРАТА ТОЦИЛИЗУМАБ У МАЛЬЧИКА С СИСТЕМНОЙ ФОРМОЙ ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА</article-title><trans-title-group xml:lang="en"><trans-title>EXPERIENCE OF USING DRUG TOCILIZUMAB IN A BOY WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афонина</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zholobova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры детских болезней Первого МГМУ им. И.М. Сеченова</p></bio><bio xml:lang="en"><p>PhD, Professor at the department of childhood diseases at the First Sechenov MSMU</p></bio><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жолобова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zholobova</surname><given-names>E. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Sechenov Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>02</day><month>12</month><year>2013</year></pub-date><volume>10</volume><issue>6</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>82</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Афонина Е.Ю., Жолобова Е.С., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Афонина Е.Ю., Жолобова Е.С.</copyright-holder><copyright-holder xml:lang="en">Zholobova E.S., Zholobova E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/162">https://www.pedpharma.ru/jour/article/view/162</self-uri><abstract/><trans-abstract xml:lang="en"><p>The article presents a case of complicated diagnostics of systemic juvenile idiopathic (rheumatoid) arthritis (JIA) starting with a fever of unclear genesis. Efficacy of interleukin 6 inhibitor tocilizumab for treating the systemic JIA resistant to glucocorticosteroid and methotrexate therapy is shown.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ювенильный идиопатический артрит</kwd><kwd>системная форма ЮИА</kwd><kwd>биологическая терапия</kwd><kwd>ингибитор IL 6</kwd><kwd>тоцилизумаб</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>juvenile idiopathic arthritis</kwd><kwd>systemic JIA</kwd><kwd>biological therapy</kwd><kwd>IL 6 inhibitor</kwd><kwd>tocilizumab</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е. И. Ювенильный ревматоидный артрит: этиология, патогенез, клиника, алгоритмы диагностики и лечения. Под общ. ред. А. А. Баранова. М.: ВЕДИ. 2007. 360 с.</mixed-citation><mixed-citation xml:lang="en">Alekseeva E. I. 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