<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v15i1.1845</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-1595</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Сезон простуд в разгаре: лечим кашель</article-title><trans-title-group xml:lang="en"><trans-title>Season of Colds and Flu is in Full Swing: Treating Cough</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7222-6760</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilyina</surname><given-names>Svetlana V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ильина Светлана Владимировна, доктор медицинских наук, заведующая кафедрой детских инфекционных болезней.</p><p>664043, Иркутск, ул. Маршала Конева, д. 90, к. 4, тел.: +7 (3952) 30-04-46</p></bio><email xlink:type="simple">dr_ilina@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>27</day><month>02</month><year>2018</year></pub-date><volume>15</volume><issue>1</issue><fpage>75</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ильина С.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Ильина С.В.</copyright-holder><copyright-holder xml:lang="en">Ilyina S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/1595">https://www.pedpharma.ru/jour/article/view/1595</self-uri><abstract><p>Острый кашель является распространенным симптомом и частым поводом обращения за медицинской помощью. Пациенты с острым кашлем нередко прибегают к самолечению с использованием безрецептурных препаратов. Однако эффективность и безопасность таких средств, как правило, не проверяется в строгих условиях клинических исследований. Более того, отмечено большое число побочных эффектов в результате применения у детей подобных препаратов. В статье разбираются вопросы целесообразности медикаментозного лечения нетяжелых случаев острой респираторной инфекции, сопровождаемой кашлем.</p></abstract><trans-abstract xml:lang="en"><p>Acute cough is a common symptom and a common reason for seeking medical care. Patients with acute cough often practice selfmedication using over-the-counter (OTC) drugs. However, the efficacy and safety of OTC drugs are generally not tested in clinical settings. Moreover, a large number of side effects have been registered in children in response to OTC drugs. The article deals with the issues of the rationality of drug treatment in non-severe cases of acute respiratory infection accompanied by cough.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>кашель</kwd><kwd>безрецептурные лекарственные средства</kwd><kwd>острые респираторные инфекции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cough</kwd><kwd>over-the-counter drugs</kwd><kwd>acute respiratory infections</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Не указан</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. The pursuit of responsible use of medicines: sharing and learning from country experiences [Internet]. WHO; 2012. 78 р. [cited 2017 Oct 12]. Available from: http://www.who.int/medicines/publications/responsible_use/en/</mixed-citation><mixed-citation xml:lang="en">WHO. The pursuit of responsible use of medicines: sharing and learning from country experiences [Internet]. WHO; 2012. 78 р. [cited 2017 Oct 12]. Available from: http://www.who.int/medicines/publications/responsible_use/en/</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Worrall G. Acute cough in children. Can Fam Physician. 2011;57(3):315–318.</mixed-citation><mixed-citation xml:lang="en">Worrall G. Acute cough in children. Can Fam Physician. 2011;57(3):315–318.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Денисова М., Сидорова И. На середине пути. Обзор российского фармацевтического рынка по итогам I полугодия 2013 г. // Ремедиум. Журнал о российском рынке лекарств и медицинской технике. — 2013. — №9 — С. 16–23. [Denisova M, Sidorova I. Half the way. Review of the pharmaceutical market in the first half of 2013. Remedium: zhurnal o rossiiskom rynke lekarstv. 2013;(9):16–23. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Денисова М., Сидорова И. На середине пути. Обзор российского фармацевтического рынка по итогам I полугодия 2013 г. // Ремедиум. Журнал о российском рынке лекарств и медицинской технике. — 2013. — №9 — С. 16–23. [Denisova M, Sidorova I. Half the way. Review of the pharmaceutical market in the first half of 2013. Remedium: zhurnal o rossiiskom rynke lekarstv. 2013;(9):16–23. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sharfstein JM, North M, Serwint JR. Over the counter but no longer under the radar — pediatric cough and cold medications. N Engl J Med. 2007;357(23):2321–2324. doi: 10.1056/NEJMp0707400.</mixed-citation><mixed-citation xml:lang="en">Sharfstein JM, North M, Serwint JR. Over the counter but no longer under the radar — pediatric cough and cold medications. N Engl J Med. 2007;357(23):2321–2324. doi: 10.1056/NEJMp0707400.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Srinivasan A, Budnitz D, Shehab N, Cohen A. Infant deaths associated with cough and cold medications — two states, 2005. JAMA. 2007;297(8):800–801. doi: 10.1001/jama.297.8.800.</mixed-citation><mixed-citation xml:lang="en">Srinivasan A, Budnitz D, Shehab N, Cohen A. Infant deaths associated with cough and cold medications — two states, 2005. JAMA. 2007;297(8):800–801. doi: 10.1001/jama.297.8.800.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">fda.gov [Internet]. FDA Recommends that Over-the-Counter (OTC) Cough and Cold Products not be used for Infants and Children under 2 Years of Age. 2008 [cited 2017 Nov 9]. Available from: http://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm051137.html</mixed-citation><mixed-citation xml:lang="en">fda.gov [Internet]. FDA Recommends that Over-the-Counter (OTC) Cough and Cold Products not be used for Infants and Children under 2 Years of Age. 2008 [cited 2017 Nov 9]. Available from: http://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm051137.html</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lokker N, Sanders L, Perrin EM, et al. Parental misinterpretations of over-the-counter pediatric cough and cold medication labels. Pediatrics. 2009;123(6):1464–1471. doi: 10.1542/peds.2008-0854.</mixed-citation><mixed-citation xml:lang="en">Lokker N, Sanders L, Perrin EM, et al. Parental misinterpretations of over-the-counter pediatric cough and cold medication labels. Pediatrics. 2009;123(6):1464–1471. doi: 10.1542/peds.2008-0854.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mallet P, Mourdi N, Dubus JC, et al. Respiratory paradoxical adverse drug reactions associated with acetylcysteine and carbocysteine systemic use in paediatric patients: a national survey. PLoS One. 2011;6(7):e22792. doi: 10.1371/journal.pone.0022792.</mixed-citation><mixed-citation xml:lang="en">Mallet P, Mourdi N, Dubus JC, et al. Respiratory paradoxical adverse drug reactions associated with acetylcysteine and carbocysteine systemic use in paediatric patients: a national survey. PLoS One. 2011;6(7):e22792. doi: 10.1371/journal.pone.0022792.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">ema.europa.eu [Internet]. Revised assessment report. Ambroxol and bromhexine containing medicinal products (EMEA/H/A-31/1397) [cited 2017 Nov 9]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Ambroxol_and_bromhexine_31/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment_Committee/WC500184106.pdf</mixed-citation><mixed-citation xml:lang="en">ema.europa.eu [Internet]. Revised assessment report. Ambroxol and bromhexine containing medicinal products (EMEA/H/A-31/1397) [cited 2017 Nov 9]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Ambroxol_and_bromhexine_31/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment_Committee/WC500184106.pdf</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014;(11):CD001831. doi: 10.1002/14651858.CD001831.pub5.</mixed-citation><mixed-citation xml:lang="en">Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014;(11):CD001831. doi: 10.1002/14651858.CD001831.pub5.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bennett S, Hoffman N, Monga M. Ephedrine- and guaifenesininduced nephrolithiasis. J Altern Complement Med. 2004;10(6):967–969. doi: 10.1089/acm.2004.10.967.</mixed-citation><mixed-citation xml:lang="en">Bennett S, Hoffman N, Monga M. Ephedrine- and guaifenesininduced nephrolithiasis. J Altern Complement Med. 2004;10(6):967–969. doi: 10.1089/acm.2004.10.967.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Friedrichsdorf SJ, Nugent AP, Strobl AQ. Codeine-associated pediatric deaths despite using recommended dosing guidelines: three case reports. J Opioid Manag. 2013;9(2):151–155. doi: 10.5055/jom.2013.0156.</mixed-citation><mixed-citation xml:lang="en">Friedrichsdorf SJ, Nugent AP, Strobl AQ. Codeine-associated pediatric deaths despite using recommended dosing guidelines: three case reports. J Opioid Manag. 2013;9(2):151–155. doi: 10.5055/jom.2013.0156.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006;368(9536):704. doi: 10.1016/S0140-6736(06)69255-6.</mixed-citation><mixed-citation xml:lang="en">Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006;368(9536):704. doi: 10.1016/S0140-6736(06)69255-6.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">European Medicines Agency. Codeine not to be used in children below 12 years for cough and cold [Internet]. London, UK: European Medicines Agency; 2015. [cited 2017 Nov 9]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Codeine_cough_or_cold_in_children/Position_provided_by_CMDh/WC500186159.pdf</mixed-citation><mixed-citation xml:lang="en">European Medicines Agency. Codeine not to be used in children below 12 years for cough and cold [Internet]. London, UK: European Medicines Agency; 2015. [cited 2017 Nov 9]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Codeine_cough_or_cold_in_children/Position_provided_by_CMDh/WC500186159.pdf</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Benefit/Risk Assessment of Prescription Opioid Antitussive Products for Treatment of Cough in Pediatric Patients [Internet]. Background Document Pediatric Advisory Committee Meeting September 11, 2017 [cited 2017 Nov 9]. Available from: https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM575013.pdf</mixed-citation><mixed-citation xml:lang="en">Benefit/Risk Assessment of Prescription Opioid Antitussive Products for Treatment of Cough in Pediatric Patients [Internet]. Background Document Pediatric Advisory Committee Meeting September 11, 2017 [cited 2017 Nov 9]. Available from: https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM575013.pdf</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Dolansky G, Rieder M. What is the evidence for the safety and efficacy of over-the-counter cough and cold preparations for children younger than six years of age? Paediatr Child Health. 2008;13(2):125–127. doi: 10.1093/pch/13.2.125.</mixed-citation><mixed-citation xml:lang="en">Dolansky G, Rieder M. What is the evidence for the safety and efficacy of over-the-counter cough and cold preparations for children younger than six years of age? Paediatr Child Health. 2008;13(2):125–127. doi: 10.1093/pch/13.2.125.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Morice A, Kardos P. Comprehensive evidence-based review on European antitussives. BMJ Open Resp Res. 2016;3(1):e000137. doi: 10.1136/bmjresp-2016-000137.</mixed-citation><mixed-citation xml:lang="en">Morice A, Kardos P. Comprehensive evidence-based review on European antitussives. BMJ Open Resp Res. 2016;3(1):e000137. doi: 10.1136/bmjresp-2016-000137.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bayram E, Karakaya P, Topcu Y, et al. Acute cervical dystonia after the first dose of butamirate citrate. Pediatr Emerg Care. 2013;29(1):80–81. doi: 10.1097/PEC.0b013e31827b5635.</mixed-citation><mixed-citation xml:lang="en">Bayram E, Karakaya P, Topcu Y, et al. Acute cervical dystonia after the first dose of butamirate citrate. Pediatr Emerg Care. 2013;29(1):80–81. doi: 10.1097/PEC.0b013e31827b5635.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Faruqi S, Wright C, Thompson R, Morice AH. A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. Br J Clin Pharmacol. 2014;78(6):1272–1280. doi: 10.1111/bcp.12458.</mixed-citation><mixed-citation xml:lang="en">Faruqi S, Wright C, Thompson R, Morice AH. A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. Br J Clin Pharmacol. 2014;78(6):1272–1280. doi: 10.1111/bcp.12458.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Основы доказательной медицины. Учебное пособие / Под общей ред. Р.Г. Оганова. — М.: Силицея-Полиграф; 2010. — 136 с. [Osnovy dokazatel’noi meditsiny. Uchebnoe posobie. Ed by R.G. Oganov. Moscow: Silitseya-Poligraf; 2010. 136 p. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Основы доказательной медицины. Учебное пособие / Под общей ред. Р.Г. Оганова. — М.: Силицея-Полиграф; 2010. — 136 с. [Osnovy dokazatel’noi meditsiny. Uchebnoe posobie. Ed by R.G. Oganov. Moscow: Silitseya-Poligraf; 2010. 136 p. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chalumeau M, Duijvestijn YCM. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013;(5):CD003124. doi: 10.1002/14651858.CD003124.pub4.</mixed-citation><mixed-citation xml:lang="en">Chalumeau M, Duijvestijn YCM. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013;(5):CD003124. doi: 10.1002/14651858.CD003124.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Holzinger F, Chenot JF. Systematic review of clinical trials assessing the effectiveness of ivy leaf (Hedera Helix) for acute upper respiratory tract infections. Evid Based Complement Alternat Med. 2011;(2011):382789. doi: 10.1155/2011/382789.</mixed-citation><mixed-citation xml:lang="en">Holzinger F, Chenot JF. Systematic review of clinical trials assessing the effectiveness of ivy leaf (Hedera Helix) for acute upper respiratory tract infections. Evid Based Complement Alternat Med. 2011;(2011):382789. doi: 10.1155/2011/382789.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014;(12):CD007094. doi: 10.1002/14651858.CD007094.pub4.</mixed-citation><mixed-citation xml:lang="en">Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014;(12):CD007094. doi: 10.1002/14651858.CD007094.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mulholland S, Chang AB. Honey and lozenges for children with non-specific cough. Cochrane Database Syst Rev. 2009;(2):CD007523. doi: 10.1002/14651858.CD007523.pub2.</mixed-citation><mixed-citation xml:lang="en">Mulholland S, Chang AB. Honey and lozenges for children with non-specific cough. Cochrane Database Syst Rev. 2009;(2):CD007523. doi: 10.1002/14651858.CD007523.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson SK, Sadofsky LR, Morice AH. How does rhinovirus cause the common cold cough? BMJ Open Resp Res. 2016;3(1):e000118. doi: 10.1136/bmjresp-2015-000118.</mixed-citation><mixed-citation xml:lang="en">Atkinson SK, Sadofsky LR, Morice AH. How does rhinovirus cause the common cold cough? BMJ Open Resp Res. 2016;3(1):e000118. doi: 10.1136/bmjresp-2015-000118.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Abdullah H, Heaney LG, Cosby SL, McGarvey LP. Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity. Thorax. 2014;69(1):46–54. doi: 10.1136/thoraxjnl-2013-203894.</mixed-citation><mixed-citation xml:lang="en">Abdullah H, Heaney LG, Cosby SL, McGarvey LP. Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity. Thorax. 2014;69(1):46–54. doi: 10.1136/thoraxjnl-2013-203894.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Morice AH, Kantar A, Dicpinigaitis PV, et al. Treating acute cough: wet versus dry — have we got the paradigm wrong? ERJ Open Res. 2015;1(2):00055-2015. doi: 10.1183/23120541.00055-2015.</mixed-citation><mixed-citation xml:lang="en">Morice AH, Kantar A, Dicpinigaitis PV, et al. Treating acute cough: wet versus dry — have we got the paradigm wrong? ERJ Open Res. 2015;1(2):00055-2015. doi: 10.1183/23120541.00055-2015.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
