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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v10i6.897</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-158</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>BIS-МОНИТОРИНГ ПРИ АНЕСТЕЗИИ КСЕНОНОМ У ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>XENON ANESTHESIA IN CHILDREN: BIS-MONITORING</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багаев</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagaev</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, ведущий научный сотрудник отделения анестезиологии и реанимации НИИ НДХиТ</p></bio><bio xml:lang="en"><p>MD, leading research scientist at the Department of Anesthesiology and Intensive Care of Research institute of urgent pediatric surgery and traumatology</p></bio><email xlink:type="simple">bagaev61@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Девайкин</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Devaykin</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амчеславский</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Amcheslavskiy</surname><given-names>V. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукьянов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukyanov</surname><given-names>V. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдов</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydov</surname><given-names>M. Y.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быков</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bykov</surname><given-names>M. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ неотложной детской хирургии и травматологии, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research institute of urgent pediatric surgery and traumatology, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Областная детская клиническая больница № 1 г. Екатеринбурга, Российская Федерация</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Children’s Clinical Hospital № 1, Yekaterinburg, Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>НИИ неотложной детской хирургии и травматологии, Москва, Российская Федерация</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Urgent Surgery and Traumatology, Moscow, Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>02</day><month>12</month><year>2013</year></pub-date><volume>10</volume><issue>6</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>61</fpage><lpage>64</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Багаев В.Г., Девайкин Е.В., Амчеславский В.Г., Лукьянов В.И., Давыдов М.Ю., Быков М.В., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Багаев В.Г., Девайкин Е.В., Амчеславский В.Г., Лукьянов В.И., Давыдов М.Ю., Быков М.В.</copyright-holder><copyright-holder xml:lang="en">Bagaev V.G., Devaykin E.V., Amcheslavskiy V.G., Lukyanov V.I., Davydov M.Y., Bykov M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/158">https://www.pedpharma.ru/jour/article/view/158</self-uri><abstract/><trans-abstract xml:lang="en"><p>We conducted 60 low-flow xenon anesthesias in children of 1-18 years of age. We measured the sedation level using bispectral (BIS) index and clinically on the stage of induction, xenon anesthesia maintenance and during recovery. The trial showed that, according to the clinical and BIS-monitoring data, sevoflurane inhalational induction in children of 1-5 years of age and propofol intravenous induction in children of 6-18 years of age provides children with the required sedation level. BIS index objectively reflects intensity of the sedative component of an anesthesia both in the junior and the senior age groups on the stages of xenon anesthesia maintenance and during recovery.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ксенон</kwd><kwd>низкопоточная анестезия</kwd><kwd>анестезия у детей</kwd></kwd-group><kwd-group xml:lang="en"><kwd>xenon</kwd><kwd>low-flow anesthesia</kwd><kwd>anesthesia in children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Goto T., Suwa K., Uezono S. et al. The blood-gas partition coefficient of xenon may be lower than generally accepted. British Journal of Anaesthesia. 1998; 80: 255–256.</mixed-citation><mixed-citation xml:lang="en">Goto T., Suwa K., Uezono S. et al. The blood-gas partition coefficient of xenon may be lower than generally accepted. British Journal of Anaesthesia. 1998; 80: 255–256.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Goto T., Saito H., Shinkai M. et al. Xenon provides faster emergence from anesthesia than does nitrous oxide-sevoflurane or nitrous oxide-isoflurane. Anesthesiology. 1997; 86: 1273–1278.</mixed-citation><mixed-citation xml:lang="en">Goto T., Saito H., Shinkai M. et al. Xenon provides faster emergence from anesthesia than does nitrous oxide-sevoflurane or nitrous oxide-isoflurane. Anesthesiology. 1997; 86: 1273–1278.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nakata Y., Goto T., Ishiguro Y. et al. Minimum alveolar concentrationawake of Xenon alone and in combination with isoflurane or sevoflurane. Anesthesiology. 2000; 93 (5): 1188–1193.</mixed-citation><mixed-citation xml:lang="en">Nakata Y., Goto T., Ishiguro Y. et al. Minimum alveolar concentration-awake of Xenon alone and in combination with isoflurane or sevoflurane. Anesthesiology. 2000; 93 (5): 1188–1193.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Luttropp H. H., Romner B., Perhag L. et al. Left ventricular performance and cerebral haemodynamics during xenon anaesthesia. A transoesophageal echocardiography and transcranial Doppler sonography study. Anaesthesia. 1993; 48: 1045–1049.</mixed-citation><mixed-citation xml:lang="en">Luttropp H. H., Romner B., Perhag L. et al. Left ventricular performance and cerebral haemodynamics during xenon anaesthesia. A transoesophageal echocardiography and transcranial Doppler sonography study. Anaesthesia. 1993; 48: 1045–1049.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dingley J., King R., Hughes L. et al. Exploration of xenon as a potential cardiostable sedative: a comparison with propofol after cardiac surgery. Anaesthesia. 2001; 56: 829–835.</mixed-citation><mixed-citation xml:lang="en">Dingley J., King R., Hughes L. et al. Exploration of xenon as a potential cardiostable sedative: a comparison with propofol after cardiac surgery. Anaesthesia. 2001; 56: 829–835.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wilhelm S., Ma D., Maze M. et al. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 2002; 96: 1485–1491.</mixed-citation><mixed-citation xml:lang="en">Wilhelm S., Ma D., Maze M. et al. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 2002; 96: 1485–1491.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ma D., Wilhelm S., Maze M. et al. Neuroprotective and neurotoxic properties of the ‘inert’ gas, xenon. British Journal of Anaesthesia. 2002; 89: 739–746.</mixed-citation><mixed-citation xml:lang="en">Ma D., Wilhelm S., Maze M. et al. Neuroprotective and neurotoxic properties of the ‘inert’ gas, xenon. British Journal of Anaesthesia. 2002; 89: 739–746.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Суслов Н. И., Потапов В. Н., Шписман М. Н. и др. Применение ксенона в медицине. Томск: Изд-во Томского университета. 2009. С. 300.</mixed-citation><mixed-citation xml:lang="en">Suslov N. I., Potapov V. N., Shpisman M. N. et al. Primenenie ksenona v meditsine [Xenon in Medicine]. Tomsk, Izd-vo Tomskogo universiteta, 2009. 300 p.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов И. А., Воронин С. В., Степанова О. В. Ксеноновая анестезия у больных высокого риска. В сб.: Ксенон и ксенонсберегающие технологии в медицине-2005. М.: НИКИЭТ. 2005. С. 68–72.</mixed-citation><mixed-citation xml:lang="en">Kozlov I. A., Voronin S. V., Stepanova O. V. Ksenonovaya anesteziya u bol'nykh vysokogo riska. V sb.: Ksenon i ksenonsberegayushchie tekhnologii v meditsine-2005 [Xenon Anesthesia in Patients at High Risk. Proc .: Xenon and Xenon-saving Technologies in Medicine-2005]. Moscow, NIKIET, 2005. pp. 68–72.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Dinse A., Fohr K. J., Georgieff M. et al. Xenon reduces glutamate-, AMPA, and kainate-induced membrane currents in cortical neurones. British Journal of Anaesthesia. 2005; 94: 479–485.</mixed-citation><mixed-citation xml:lang="en">Dinse A., Fohr K. J., Georgieff M. et al. Xenon reduces glutamate-, AMPA, and kainate-induced membrane currents in cortical neurones. British Journal of Anaesthesia. 2005; 94: 479–485.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fahlenkamp A. V., Krebber F., Rex S. et al. Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients. British Journal of Anaesthesia. 2010; 27 (10): 906–911.</mixed-citation><mixed-citation xml:lang="en">Fahlenkamp A. V., Krebber F., Rex S. et al. Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients. British Journal of Anaesthesia. 2010; 27 (10): 906–911.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Лихванцев В. В., Субботин В. В., Петров О. В. и др. Мониторинг BIS и ИНЭЭГ при анестезии ксеноном. Сб.: Альманах анестезиологии и реаниматологии № 1. Материалы 2-й сессии. 2001. С. 29.</mixed-citation><mixed-citation xml:lang="en">Likhvantsev V. V., Subbotin V. V., Petrov O. V. et al. Monitoring BIS i INEEG pri anestezii ksenonom. Sb.: Al'manakh anesteziologii i reanimatologii № 1. Materialy 2-i sessii [BIS Monitoring during Anesthesia and INEEG Xenon. Coll.: Almanac Anesthesiology and Intensive Care № 1. Proceedings of the 2nd Session]. 2001. p. 29.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Morita M. J., LattaW., Hambro K., Snider M. Accumulation of methane, acetone and nitrogen in the inspired gas during closed circuit anesthesia. Anesth Analg. 1985; 64: 343–347.</mixed-citation><mixed-citation xml:lang="en">Morita M. J., LattaW., Hambro K., Snider M. Accumulation of methane, acetone and nitrogen in the inspired gas during closed circuit anesthesia. Anesth Analg. 1985; 64: 343–347.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fahlenkamp A. V., Krebber F., Rex S. et al. Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients. Eur J Anaesthesiol. 2010 Oct; 27 (10): 906–911.</mixed-citation><mixed-citation xml:lang="en">Fahlenkamp A. V., Krebber F., Rex S. et al. Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients. Eur. J. Anaesthesiol. 2010 Oct; 27 (10): 906–911.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nakata Y., Goto T., Morita S. Comparison of inhalation inductions with xenon and sevoflurane. Acta Anaesthesiol Scand. 1997; 41: 1157–1161.</mixed-citation><mixed-citation xml:lang="en">Nakata Y., Goto T., Morita S. Comparison of inhalation inductions with xenon and sevoflurane. Acta Anaesthesiol Scand. 1997; 41: 1157–1161.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
